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Construct Crystallization Sequence modifications
PDB UniProt Receptor Rec. Family Class Species Method Mutations Deletions Modifications Insertions PDB Resolution Reference Date
5TVN 5HT2B 5-HT2B 5-Hydroxytryptamine A (Rhodopsin) Human in meso/LCP 1 3 0 5 5TVN 2.9 10.1016/J.CELL.2016.12.033 2017-02-01
5YQZ GLR glucagon Glucagon B1 (Secretin) Human in meso/LCP 1 3 0 5 5YQZ 3.0 10.1038/NATURE25153 2018-01-17
5XR8 CNR1 CB1 Cannabinoid A (Rhodopsin) Human in meso/LCP 4 3 0 5 5XR8 3.0 10.1038/NATURE23272 2017-07-12
5VEX GLP1R GLP-1 Glucagon B1 (Secretin) Human in meso/LCP 10 4 0 5 5VEX 3.0 10.1038/NATURE22378 2017-05-17
5V57 SMO SMO Frizzled F (Frizzled) Human in meso/LCP 0 3 0 6 5V57 3.0 10.1038/NCOMMS15383 2017-05-24
5U09 CNR1 CB1 Cannabinoid A (Rhodopsin) Human in meso/LCP 1 3 0 5 5U09 2.6 10.1038/NATURE20613 2016-12-07
2YDV AA2AR A2A Adenosine A (Rhodopsin) Human vapour diffusion 5 1 0 2 2YDV 2.6 10.1038/NATURE10136 2011-05-18
3EML AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 0 3 0 5 3EML 2.6 10.1126/SCIENCE.1164772 2008-10-14
3PXO OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 3PXO 3.0 10.1038/NATURE09789 2011-03-09
5O9H C5AR1 C5a1 Complement peptide A (Rhodopsin) Human in meso/LCP 11 2 0 1 5O9H 2.7 10.1038/NATURE25025 2018-01-10
5K2D AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 0 3 0 4 5K2D 1.9 10.1126/SCIADV.1600292 2016-09-21
4U14 ACM3 M3 Acetylcholine (muscarinic) A (Rhodopsin) Rat sponge mesophase 0 3 0 4 4U14 3.6 10.1016/J.STR.2014.08.022 2014-11-26
5UNH AGTR2 AT2 Angiotensin A (Rhodopsin) Human in meso/LCP 0 2 0 6 5UNH 2.9 10.1038/NATURE22035 2017-04-05
3AYN OPSD Rhodopsin Opsins A (Rhodopsin) Japanese flying squid vapour diffusion 0 0 0 0 3AYN 2.7 10.1016/J.JMB.2011.08.044 2011-08-17
4AMJ ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 3 0 1 4AMJ 2.3 10.1016/J.STR.2012.03.014 2012-05-23
4ZUD AGTR1 AT1 Angiotensin A (Rhodopsin) Human in meso/LCP 0 3 0 5 4ZUD 2.8 10.1074/JBC.M115.689000 2015-10-07
4PXZ P2Y12 P2Y12 P2Y A (Rhodopsin) Human in meso/LCP 1 1 0 5 4PXZ 2.5 10.1038/NATURE13288 2014-04-30
5GLI EDNRB ETB Endothelin A (Rhodopsin) Human in meso/LCP 0 3 0 7 5GLI 2.5 10.1038/NATURE19319 2016-09-07
4GBR ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 3 3 0 5 4GBR 4.0 10.1371/JOURNAL.PONE.0046039 2012-10-24
3OE6 CXCR4 CXCR4 Chemokine A (Rhodopsin) Human in meso/LCP 1 2 0 7 3OE6 3.2 10.1126/SCIENCE.1194396 2010-10-27
4O9R SMO SMO Frizzled F (Frizzled) Human in meso/LCP 0 3 0 1 4O9R 3.2 10.1038/NCOMMS4309 2014-03-05
4IB4 5HT2B 5-HT2B 5-Hydroxytryptamine A (Rhodopsin) Human in meso/LCP 1 3 0 5 4IB4 2.7 10.1126/SCIENCE.1232808 2013-03-13
5VBL APJ apelin Apelin A (Rhodopsin) Human in meso/LCP 5 3 0 5 5VBL 2.6 10.1016/J.STR.2017.04.008 2017-05-31
4RWS CXCR4 CXCR4 Chemokine A (Rhodopsin) Human in meso/LCP 3 3 0 5 4RWS 3.1 10.1126/SCIENCE.1261064 2015-02-11
5V54 5HT1B 5-HT1B 5-Hydroxytryptamine A (Rhodopsin) Human in meso/LCP 1 2 0 5 5V54 3.9 2018-02-07
3ZPQ ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 3 0 1 3ZPQ 2.8 10.1021/JM400140Q 2013-04-03
5DHG OPRX NOP Opioid A (Rhodopsin) Human in meso/LCP 0 2 0 5 5DHG 3.0 10.1016/J.STR.2015.07.024 2015-10-21
5K2C AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 0 3 0 4 5K2C 1.9 10.1126/SCIADV.1600292 2016-09-21
5UEN AA1R A1 Adenosine A (Rhodopsin) Human in meso/LCP 1 3 0 8 5UEN 3.2 10.1016/J.CELL.2017.01.042 2017-03-01
4N6H OPRD δ Opioid A (Rhodopsin) Human in meso/LCP 1 2 0 5 4N6H 1.8 10.1038/NATURE12944 2013-12-25
5EN0 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 3 0 0 0 5EN0 2.8 10.15252/EMBR.201642671 2016-08-10
4IAR 5HT1B 5-HT1B 5-Hydroxytryptamine A (Rhodopsin) Human in meso/LCP 1 2 0 5 4IAR 2.7 10.1126/SCIENCE.1232807 2013-03-13
2Y01 ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 3 0 1 2Y01 2.6 10.1038/NATURE09746 2011-03-30
4AMI ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 3 0 1 4AMI 3.2 10.1016/J.STR.2012.03.014 2012-05-23
4N4W SMO SMO Frizzled F (Frizzled) Human in meso/LCP 0 2 0 5 4N4W 2.8 10.1038/NCOMMS5355 2014-01-22
4Z9G CRFR1 CRF1 Corticotropin-releasing factor B1 (Secretin) Human in meso/LCP 11 3 0 3 4Z9G 3.2 10.2174/1874467210666170110114727 2016-06-29
5NM2 AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5NM2 2.0 10.1038/S41467-017-00630-4 2017-09-27
2I36 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 2I36 4.1 10.1073/PNAS.0608022103 2006-10-17
4MQT ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human in meso/LCP 6 1 0 3 4MQT 3.7 10.1038/NATURE12735 2013-11-27
4WW3 OPSD Rhodopsin Opsins A (Rhodopsin) Japanese flying squid vapour diffusion 0 2 0 1 4WW3 2.8 10.1371/JOURNAL.PONE.0126970 2015-06-17
5OLZ AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 3 5OLZ 1.9 10.1038/S41598-017-18570-W 2018-01-17
4LDO ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 4 3 0 3 4LDO 3.2 10.1038/NATURE12572 2013-09-25
2YCX ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 4 0 1 2YCX 3.3 10.1073/PNAS.1100185108 2011-06-01
5IU7 AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5IU7 1.9 10.1021/ACS.JMEDCHEM.6B00653 2016-06-29
2Y00 ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 3 0 1 2Y00 2.5 2011-01-12
4DAJ ACM3 M3 Acetylcholine (muscarinic) A (Rhodopsin) Rat in meso/LCP 0 2 0 4 4DAJ 3.4 10.1038/NATURE10867 2012-02-22
5ZKP PTAFR PAF Platelet-activating factor A (Rhodopsin) Human N/A 0 3 0 0 5ZKP 2.8 10.1038/S41594-018-0068-Y 2018-06-20
5ZBQ NPY1R Y1 Neuropeptide Y A (Rhodopsin) Human N/A 0 2 0 0 5ZBQ 2.7 10.1038/S41586-018-0046-X 2018-04-25
6D32 Q98SW5 SMO Frizzled F (Frizzled) African clawed frog N/A 0 3 0 0 6D32 3.8 10.1016/J.CELL.2018.04.029 2018-05-23
6D35 Q98SW5 SMO Frizzled F (Frizzled) African clawed frog N/A 0 3 0 0 6D35 3.9 10.1016/J.CELL.2018.04.029 2018-05-23
5ZBH NPY1R Y1 Neuropeptide Y A (Rhodopsin) Human N/A 0 3 0 0 5ZBH 3.0 10.1038/S41586-018-0046-X 2018-04-25
5KW2 FFAR1 FFA1 Free fatty acid A (Rhodopsin) Human N/A 3 1 0 0 5KW2 2.8 10.1038/S41467-017-01240-W 2018-05-02
5WB1 Q80KM9 US28 Unclassified A (Rhodopsin) strain AD169 in meso/LCP 0 1 0 9 5WB1 3.5 2018-06-13
4U16 ACM3 M3 Acetylcholine (muscarinic) A (Rhodopsin) Rat sponge mesophase 0 3 0 4 4U16 3.7 10.1016/J.STR.2014.08.022 2014-11-26
3REY AA2AR A2A Adenosine A (Rhodopsin) Human vapour diffusion 8 1 0 1 3REY 3.3 10.1016/J.STR.2011.06.014 2011-09-07
3DQB OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 3DQB 3.2 10.1038/NATURE07330 2008-09-23
4UG2 AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 5 1 0 3 4UG2 2.6 10.1124/MOL.114.097360 2015-04-08
5UZ7 CALCR CT Calcitonin B1 (Secretin) Human Cryo-EM 0 1 0 5 5UZ7 4.1 10.1038/NATURE22327 2017-05-03
3NY9 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 4 2 0 3 3NY9 2.8 10.1021/JA105108Q 2010-08-11
6FK9 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A 0 0 0 0 6FK9 2.6 10.1073/PNAS.1718084115 2018-04-04
1L9H OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 1L9H 2.6 10.1073/PNAS.082666399 2002-05-15
4YAY AGTR1 AT1 Angiotensin A (Rhodopsin) Human in meso/LCP 0 3 0 5 4YAY 2.9 10.1016/J.CELL.2015.04.011 2015-04-22
3C9L OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NA 0 0 0 0 3C9L 2.7 10.1107/S0907444908017162 2008-08-05
2R4S ADRB2 β2 Adrenoceptors A (Rhodopsin) Human vapour diffusion 1 2 0 3 2R4S 3.4 10.1038/NATURE06325 2007-11-06
4UHR AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 5 1 0 2 4UHR 2.6 10.1124/MOL.114.097360 2015-04-08
3C9M OPSD Rhodopsin Opsins A (Rhodopsin) Bovine NA 2 0 0 0 3C9M 3.4 10.1107/S0907444908017162 2008-08-05
2R4R ADRB2 β2 Adrenoceptors A (Rhodopsin) Human vapour diffusion 2 1 0 4 2R4R 3.4 10.1038/NATURE06325 2007-11-06
5T04 NTR1 NTS1 Neurotensin A (Rhodopsin) Rat in meso/LCP 4 3 0 5 5T04 3.3 10.1038/SREP38564 2016-12-21
5EE7 GLR glucagon Glucagon B1 (Secretin) Human in meso/LCP 11 3 0 2 5EE7 2.5 10.1038/NATURE17414 2016-04-20
4QIN SMO SMO Frizzled F (Frizzled) Human in meso/LCP 0 3 0 5 4QIN 2.6 10.1038/NCOMMS5355 2014-07-23
5DHH OPRX NOP Opioid A (Rhodopsin) Human in meso/LCP 0 2 0 5 5DHH 3.0 10.1016/J.STR.2015.07.024 2015-10-21
2YCZ ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 4 0 1 2YCZ 3.7 10.1073/PNAS.1100185108 2011-06-01
4LDE ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 4 3 0 3 4LDE 2.8 10.1038/NATURE12572 2013-09-25
6FKC OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A 0 0 0 0 6FKC 2.5 10.1073/PNAS.1718084115 2018-04-04
4EA3 OPRX NOP Opioid A (Rhodopsin) Human in meso/LCP 0 2 0 5 4EA3 3.0 10.1038/NATURE11085 2012-04-25
4XEE NTR1 NTS1 Neurotensin A (Rhodopsin) Rat in meso/LCP 3 3 0 5 4XEE 2.9 10.1038/NCOMMS8895 2015-07-29
3KJ6 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human vapour diffusion 3 2 0 3 3KJ6 3.4 10.1038/NATURE08650 2010-02-16
4U15 ACM3 M3 Acetylcholine (muscarinic) A (Rhodopsin) Rat in meso/LCP 0 3 0 4 4U15 2.8 10.1016/J.STR.2014.08.022 2014-11-26
6B3J GLP1R GLP-1 Glucagon B1 (Secretin) Human Cryo-EM 0 1 0 5 6B3J 3.3 10.1038/NATURE25773 2018-02-21
5WS3 OX2R OX2 Orexin A (Rhodopsin) Human in meso/LCP 1 3 0 4 5WS3 2.3 2017-12-13
5DSG ACM4 M4 Acetylcholine (muscarinic) A (Rhodopsin) Human in meso/LCP 0 3 0 3 5DSG 2.6 10.1038/NATURE17188 2016-03-16
5X33 Q9WTK1 BLT1 Leukotriene A (Rhodopsin) Guinea pig in meso/LCP 4 1 0 5 5X33 3.7 10.1038/NCHEMBIO.2547 2018-01-03
5LWE CCR9 CCR9 Chemokine A (Rhodopsin) Human in meso/LCP 10 2 0 2 5LWE 2.8 10.1038/NATURE20606 2016-12-07
2VT4 ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 4 0 1 2VT4 2.7 10.1038/NATURE07101 2008-06-24
5D5A ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 3 2 0 2 5D5A 2.5 10.1107/S2059798315021683 2016-01-13
3VG9 AA2AR A2A Adenosine A (Rhodopsin) Human vapour diffusion 1 1 0 3 3VG9 2.7 10.1038/NATURE10750 2012-02-01
5OLH AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 3 5OLH 2.6 10.1038/S41598-017-18570-W 2018-01-17
4XT3 US28 US28 Unclassified A (Rhodopsin) strain AD169 in meso/LCP 0 2 0 1 4XT3 3.8 10.1126/SCIENCE.AAA5026 2015-03-04
5VEW GLP1R GLP-1 Glucagon B1 (Secretin) Human in meso/LCP 10 4 0 5 5VEW 2.7 10.1038/NATURE22378 2017-05-24
5TE3 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 5TE3 2.7 10.1073/PNAS.1617446114 2017-03-15
2PED OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 2PED 3.0 10.1529/BIOPHYSJ.107.108225 2007-10-30
3NY8 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 4 2 0 3 3NY8 2.8 10.1021/JA105108Q 2010-08-11
6CM4 DRD2 D2 Dopamine A (Rhodopsin) Human in meso/LCP 3 2 0 5 6CM4 2.9 10.1038/NATURE25758 2018-03-14
5L7I SMO SMO Frizzled F (Frizzled) Human in meso/LCP 1 3 0 2 5L7I 3.3 10.1038/NATURE18934 2016-07-20
5MZP AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5MZP 2.1 10.1016/J.STR.2017.06.012 2017-07-26
4MQS ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human in meso/LCP 6 1 0 3 4MQS 3.5 10.1038/NATURE12735 2013-11-27
4Z35 LPAR1 LPA1 Lysophospholipid (LPA) A (Rhodopsin) Human in meso/LCP 0 3 0 5 4Z35 2.9 10.1016/J.CELL.2015.06.002 2015-06-03
4OR2 GRM1 mGlu1 Metabotropic glutamate C (Glutamate) Human in meso/LCP 0 2 0 5 4OR2 2.8 10.1126/SCIENCE.1249489 2014-03-19
5JTB AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 0 3 0 4 5JTB 2.8 10.1126/SCIADV.1602952 2017-05-31
4GRV NTR1 NTS1 Neurotensin A (Rhodopsin) Rat in meso/LCP 6 3 0 5 4GRV 2.8 10.1038/NATURE11558 2012-10-17
3VW7 PAR1 PAR1 Proteinase-activated A (Rhodopsin) Human in meso/LCP 2 3 0 5 3VW7 2.2 10.1038/NATURE11701 2012-12-12
5TGZ CNR1 CB1 Cannabinoid A (Rhodopsin) Human in meso/LCP 4 3 0 5 5TGZ 2.8 10.1016/J.CELL.2016.10.004 2016-11-02
2Z73 OPSD Rhodopsin Opsins A (Rhodopsin) Japanese flying squid vapour diffusion 0 0 0 0 2Z73 2.5 10.1038/NATURE06925 2008-05-13
3RZE HRH1 H1 Histamine A (Rhodopsin) Human in meso/LCP 0 2 0 4 3RZE 3.1 10.1038/NATURE10236 2011-06-15
3PBL DRD3 D3 Dopamine A (Rhodopsin) Human in meso/LCP 1 2 0 5 3PBL 2.9 10.1126/SCIENCE.1197410 2010-11-03
5V56 SMO SMO Frizzled F (Frizzled) Human in meso/LCP 0 3 0 6 5V56 2.9 10.1038/NCOMMS15383 2017-05-24
5JQH ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 4 3 0 4 5JQH 3.2 10.1038/NATURE18636 2016-07-13
4ZJC OX1R OX1 Orexin A (Rhodopsin) Human in meso/LCP 1 2 0 4 4ZJC 2.8 10.1038/NSMB.3183 2016-03-09
4BUO NTR1 NTS1 Neurotensin A (Rhodopsin) Rat vapour diffusion 11 3 0 8 4BUO 2.8 10.1073/PNAS.1317903111 2014-01-29
5N2R AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5N2R 2.8 10.1016/J.STR.2017.06.012 2017-07-26
5W0P OPSD Rhodopsin Opsins A (Rhodopsin) Human in meso/LCP 6 0 0 7 5W0P 3.0 10.1016/J.CELL.2017.07.002 2017-08-09
5UIW CCR5 CCR5 Chemokine A (Rhodopsin) Human in meso/LCP 4 3 0 5 5UIW 2.2 10.1016/J.IMMUNI.2017.05.002 2017-06-28
5NX2 GLP1R GLP-1 Glucagon B1 (Secretin) Human vapour diffusion 12 2 0 5 5NX2 3.7 10.1038/NATURE22800 2017-06-14
4L6R GLR glucagon Glucagon B1 (Secretin) Human in meso/LCP 0 2 0 5 4L6R 3.3 10.1038/NATURE12393 2013-07-24
5G53 AA2AR A2A Adenosine A (Rhodopsin) Human vapour diffusion 1 1 0 2 5G53 3.4 10.1038/NATURE18966 2016-08-03
4IAQ 5HT1B 5-HT1B 5-Hydroxytryptamine A (Rhodopsin) Human in meso/LCP 1 2 0 5 4IAQ 2.8 10.1126/SCIENCE.1232807 2013-03-13
5NDD PAR2 PAR2 Proteinase-activated A (Rhodopsin) Human in meso/LCP 10 3 0 4 5NDD 2.8 10.1038/NATURE22309 2017-05-03
3PDS ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 3 3 0 3 3PDS 3.5 10.1038/NATURE09665 2011-01-12
5MZJ AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5MZJ 2.0 10.1016/J.STR.2017.06.012 2017-07-26
5X93 EDNRB ETB Endothelin A (Rhodopsin) Human in meso/LCP 8 3 0 7 5X93 2.2 10.1038/NSMB.3450 2017-08-16
6AQF AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 0 3 0 3 6AQF 2.5 10.1016/J.CELL.2017.12.004 2018-01-10
6BQG 5HT2C 5-HT2C 5-Hydroxytryptamine A (Rhodopsin) Human in meso/LCP 1 3 0 5 6BQG 3.0 10.1016/J.CELL.2018.01.001 2018-02-14
5XSZ Q08BG4 LPA6 Lysophospholipid (LPA) A (Rhodopsin) Zebrafish in meso/LCP 0 2 0 6 5XSZ 3.2 10.1038/NATURE23448 2017-08-16
3VGA AA2AR A2A Adenosine A (Rhodopsin) Human vapour diffusion 1 1 0 3 3VGA 3.1 10.1038/NATURE10750 2012-02-01
5VRA AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 0 3 0 4 5VRA 2.4 10.1038/NPROT.2017.135 2017-12-13
2Y04 ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 3 0 1 2Y04 3.1 10.1038/NATURE09746 2011-01-12
3UON ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human in meso/LCP 4 1 0 1 3UON 3.0 10.1038/NATURE10753 2012-02-01
5F8U ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 4 0 2 5F8U 3.4 10.1038/NSMB.3130 2015-12-23
3OAX OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 3OAX 2.6 10.1016/J.BPJ.2010.08.003 2011-01-19
3SN6 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human sponge mesophase 3 2 0 4 3SN6 3.2 10.1038/NATURE10361 2011-07-20
6D9H AA1R A1 Adenosine A (Rhodopsin) Human Cryo-EM 0 1 0 6 6D9H 3.6 10.1038/S41586-018-0236-6 2018-06-20
6FK7 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A 0 0 0 0 6FK7 2.6 10.1073/PNAS.1718084115 2018-04-04
6G79 5HT1B 5-HT1B 5-Hydroxytryptamine A (Rhodopsin) Human Cryo-EM 1 1 0 2 6G79 3.8 10.1038/S41586-018-0241-9 2018-06-20
5ZKQ PTAFR PAF Platelet-activating factor A (Rhodopsin) Human N/A 0 3 0 0 5ZKQ 2.9 10.1038/S41594-018-0068-Y 2018-06-20
6B73 OPRK κ Opioid A (Rhodopsin) Human in meso/LCP 1 2 0 6 6B73 3.1 10.1016/J.CELL.2017.12.011 2018-01-17
4ZJ8 OX1R OX1 Orexin A (Rhodopsin) Human in meso/LCP 1 2 0 4 4ZJ8 2.8 10.1038/NSMB.3183 2016-03-09
4NTJ P2Y12 P2Y12 P2Y A (Rhodopsin) Human in meso/LCP 1 1 0 5 4NTJ 2.6 10.1038/NATURE13083 2014-03-26
4PXF OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 4PXF 2.8 10.1038/NCOMMS5801 2014-09-17
5XRA CNR1 CB1 Cannabinoid A (Rhodopsin) Human in meso/LCP 4 3 0 5 5XRA 2.8 10.1038/NATURE23272 2017-07-12
6DDF OPRM μ Opioid A (Rhodopsin) Mouse Cryo-EM 0 2 0 4 6DDF 3.5 10.1038/S41586-018-0219-7 2018-06-13
5CXV ACM1 M1 Acetylcholine (muscarinic) A (Rhodopsin) Human in meso/LCP 3 2 0 4 5CXV 2.7 10.1038/NATURE17188 2016-03-09
6FK6 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A 0 1 0 0 6FK6 2.4 10.1073/PNAS.1718084115 2018-04-04
5C1M OPRM μ Opioid A (Rhodopsin) Mouse in meso/LCP 0 2 0 4 5C1M 2.1 10.1038/NATURE14886 2015-08-05
3PQR OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 3PQR 2.9 10.1038/NATURE09789 2011-03-09
6BQH 5HT2C 5-HT2C 5-Hydroxytryptamine A (Rhodopsin) Human in meso/LCP 1 3 0 5 6BQH 2.7 10.1016/J.CELL.2018.01.001 2018-02-14
2G87 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 2G87 2.6 10.1002/ANIE.200600595 2006-09-02
3D4S ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 4 2 0 3 3D4S 2.8 10.1016/J.STR.2008.05.001 2008-06-17
4XES NTR1 NTS1 Neurotensin A (Rhodopsin) Rat in meso/LCP 4 3 0 5 4XES 2.6 10.1038/NCOMMS8895 2015-07-29
4EJ4 OPRD δ Opioid A (Rhodopsin) Mouse in meso/LCP 0 3 0 4 4EJ4 3.4 10.1038/NATURE11111 2012-05-16
1GZM OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 1GZM 2.7 10.1016/J.JMB.2004.08.090 2003-11-20
3ODU CXCR4 CXCR4 Chemokine A (Rhodopsin) Human in meso/LCP 1 2 0 7 3ODU 2.5 10.1126/SCIENCE.1194396 2010-10-27
4XNW P2RY1 P2Y1 P2Y A (Rhodopsin) Human in meso/LCP 1 2 0 5 4XNW 2.7 10.1038/NATURE14287 2015-04-01
4RWA OPRD δ Opioid A (Rhodopsin) Human in meso/LCP 0 2 0 5 4RWA 3.3 10.1038/NSMB.2965 2015-01-14
3NYA ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 4 2 0 3 3NYA 3.2 10.1021/JA105108Q 2010-08-11
3AYM OPSD Rhodopsin Opsins A (Rhodopsin) Japanese flying squid vapour diffusion 0 0 0 0 3AYM 2.8 10.1016/J.JMB.2011.08.044 2011-08-17
6DDE OPRM μ Opioid A (Rhodopsin) Mouse Cryo-EM 0 2 0 4 6DDE 3.5 10.1038/S41586-018-0219-7 2018-06-13
4K5Y CRFR1 CRF1 Corticotropin-releasing factor B1 (Secretin) Human in meso/LCP 11 3 0 3 4K5Y 3.0 10.1038/NATURE12357 2013-07-17
5XEZ GLR glucagon Glucagon B1 (Secretin) Human in meso/LCP 0 3 0 5 5XEZ 3.0 10.1038/NATURE22363 2017-05-24
5NDZ PAR2 PAR2 Proteinase-activated A (Rhodopsin) Human in meso/LCP 10 3 0 4 5NDZ 3.6 10.1038/NATURE22309 2017-05-03
5TUD 5HT2B 5-HT2B 5-Hydroxytryptamine A (Rhodopsin) Human in meso/LCP 1 3 0 5 5TUD 3.0 10.1073/PNAS.1700891114 2017-07-26
5NM4 AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5NM4 1.7 10.1038/S41467-017-00630-4 2017-09-27
4PHU FFAR1 FFA1 Free fatty acid A (Rhodopsin) Human in meso/LCP 4 1 0 6 4PHU 2.3 10.1038/NATURE13494 2014-07-16
1F88 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 1F88 2.8 10.1126/SCIENCE.289.5480.739 2000-08-04
5TZR FFAR1 FFA1 Free fatty acid A (Rhodopsin) Human in meso/LCP 4 1 0 6 5TZR 2.2 10.1038/NSMB.3417 2017-06-07
3P0G ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 3 2 0 3 3P0G 3.5 10.1038/NATURE09648 2011-01-19
5WF6 AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 1 3 0 4 5WF6 2.9 10.1016/J.STR.2017.12.013 2018-02-21
5WKT OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 5WKT 3.2 10.1038/NPROT.2017.135 2017-12-13
3CAP OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 3CAP 2.9 10.1038/NATURE07063 2008-06-24
5OLG AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5OLG 1.9 10.1038/S41598-017-18570-W 2018-01-17
5DYS OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 3 0 0 0 5DYS 2.3 10.15252/EMBR.201642671 2016-08-10
3OE9 CXCR4 CXCR4 Chemokine A (Rhodopsin) Human in meso/LCP 2 3 0 6 3OE9 3.1 10.1126/SCIENCE.1194396 2010-10-27
4XT1 US28 US28 Unclassified A (Rhodopsin) strain AD169 in meso/LCP 0 2 0 1 4XT1 2.9 10.1126/SCIENCE.AAA5026 2015-03-04
4DJH OPRK κ Opioid A (Rhodopsin) Human in meso/LCP 1 3 0 5 4DJH 2.9 10.1038/NATURE10939 2012-03-21
5TE5 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 5TE5 4.0 10.1073/PNAS.1617446114 2017-03-15
5X7D ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 3 2 0 2 5X7D 2.7 10.1038/NATURE23652 2017-08-16
5WIV DRD4 D4 Dopamine A (Rhodopsin) Human in meso/LCP 0 1 0 5 5WIV 2.1 10.1126/SCIENCE.AAN5468 2017-10-18
5NLX AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5NLX 2.1 10.1038/S41467-017-00630-4 2017-09-27
4BEY OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 3 0 0 0 4BEY 2.9 10.1038/EMBOR.2013.44 2013-05-08
4DKL OPRM μ Opioid A (Rhodopsin) Mouse in meso/LCP 0 3 0 5 4DKL 2.8 10.1038/NATURE10954 2012-03-21
4JKV SMO SMO Frizzled F (Frizzled) Human in meso/LCP 0 2 0 5 4JKV 2.5 10.1038/NATURE12167 2013-04-24
5D6L ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 3 2 0 2 5D6L 3.2 10.1038/NPROT.2017.057 2016-08-17
4GPO ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 4 0 2 4GPO 3.5 10.1038/NSMB.2504 2013-02-27
6FFI GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human in meso/LCP 6 3 0 3 6FFI 2.2 10.1021/ACS.JMEDCHEM.7B01722 2018-03-07
5K2B AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 0 3 0 4 5K2B 2.5 10.1126/SCIADV.1600292 2016-09-21
5WIU DRD4 D4 Dopamine A (Rhodopsin) Human in meso/LCP 0 1 0 5 5WIU 2.0 10.1126/SCIENCE.AAN5468 2017-10-18
6FKD OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A 0 0 0 0 6FKD 2.5 10.1073/PNAS.1718084115 2018-04-04
4XNV P2RY1 P2Y1 P2Y A (Rhodopsin) Human in meso/LCP 1 2 0 5 4XNV 2.2 10.1038/NATURE14287 2015-04-01
5GLH EDNRB ETB Endothelin A (Rhodopsin) Human in meso/LCP 0 3 0 7 5GLH 2.8 10.1038/NATURE19319 2016-09-07
5XPR EDNRB ETB Endothelin A (Rhodopsin) Human in meso/LCP 7 3 0 7 5XPR 3.6 10.1038/NSMB.3450 2017-08-16
5UVI AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 0 3 0 4 5UVI 3.2 10.1107/S205225251700570X 2017-05-24
5CGD GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human in meso/LCP 6 2 0 3 5CGD 2.6 10.1021/ACS.JMEDCHEM.5B00892 2015-08-12
5IUB AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5IUB 2.1 10.1021/ACS.JMEDCHEM.6B00653 2016-06-29
4Z36 LPAR1 LPA1 Lysophospholipid (LPA) A (Rhodopsin) Human in meso/LCP 2 3 0 5 4Z36 2.9 10.1016/J.CELL.2015.06.002 2015-06-03
1U19 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 1U19 2.2 10.1016/J.JMB.2004.07.044 2004-10-12
6FFH GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human in meso/LCP 6 2 0 3 6FFH 2.7 10.1021/ACS.JMEDCHEM.7B01722 2018-03-07
6CMO OPSD Rhodopsin Opsins A (Rhodopsin) Human Cryo-EM 3 2 0 5 6CMO 4.5 2018-06-20
6C1Q C5AR1 C5a1 Complement peptide A (Rhodopsin) Human N/A 0 2 0 0 6C1Q 2.9 10.1038/S41594-018-0067-Z 2018-05-30
2J4Y OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 2 0 0 0 2J4Y 3.4 10.1016/J.JMB.2007.03.007 2007-09-25
5OM1 AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 3 5OM1 2.1 10.1038/S41598-017-18570-W 2018-01-17
5VAI G1SGD4 GLP-1 Glucagon B1 (Secretin) Rabbit Cryo-EM 3 2 0 5 5VAI 4.1 10.1038/NATURE22394 2017-05-24
5NJ6 PAR2 PAR2 Proteinase-activated A (Rhodopsin) Human in meso/LCP 10 3 0 2 5NJ6 4.0 10.1038/NATURE22309 2017-05-03
3V2W S1PR1 S1P1 Lysophospholipid (S1P) A (Rhodopsin) Human in meso/LCP 2 4 0 5 3V2W 3.4 10.1126/SCIENCE.1215904 2012-02-15
4MBS CCR5 CCR5 Chemokine A (Rhodopsin) Human in meso/LCP 4 2 0 5 4MBS 2.7 10.1126/SCIENCE.1241475 2013-09-11
5OLO AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5OLO 3.1 10.1038/S41598-017-18570-W 2018-01-17
2YCY ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 4 0 1 2YCY 3.2 10.1073/PNAS.1100185108 2011-06-08
3PWH AA2AR A2A Adenosine A (Rhodopsin) Human vapour diffusion 8 1 0 2 3PWH 3.3 10.1016/J.STR.2011.06.014 2011-09-07
5IU8 AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5IU8 2.0 2016-06-29
5DGY OPSD Rhodopsin Opsins A (Rhodopsin) Human in meso/LCP 4 0 0 7 5DGY 7.7 10.1038/SDATA.2016.21 2016-03-23
2RH1 ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 3 2 0 2 2RH1 2.4 10.1126/SCIENCE.1150577 2007-10-30
5UNF AGTR2 AT2 Angiotensin A (Rhodopsin) Human in meso/LCP 0 2 0 6 5UNF 2.8 10.1038/NATURE22035 2017-04-05
3QAK AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 0 3 0 5 3QAK 2.7 10.1126/SCIENCE.1202793 2011-03-09
4BEZ OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 3 0 0 0 4BEZ 3.3 10.1038/EMBOR.2013.44 2013-04-24
3OE0 CXCR4 CXCR4 Chemokine A (Rhodopsin) Human in meso/LCP 2 3 0 6 3OE0 2.9 10.1126/SCIENCE.1194396 2010-10-27
5IUA AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5IUA 2.2 10.1021/ACS.JMEDCHEM.6B00653 2016-06-29
5IU4 AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 4 5IU4 1.7 10.1021/ACS.JMEDCHEM.6B00653 2016-06-29
3ZPR ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 3 0 1 3ZPR 2.7 10.1021/JM400140Q 2013-04-03
4NC3 5HT2B 5-HT2B 5-Hydroxytryptamine A (Rhodopsin) Human in meso/LCP 1 3 0 5 4NC3 2.8 10.1126/SCIENCE.1244142 2013-12-18
5K2A AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 0 3 0 4 5K2A 2.5 10.1126/SCIADV.1600292 2016-09-21
3UZA AA2AR A2A Adenosine A (Rhodopsin) Human vapour diffusion 8 1 0 2 3UZA 3.3 10.1021/JM201376W 2012-03-21
6GDG AA2AR A2A Adenosine A (Rhodopsin) Human Cryo-EM 0 2 0 5 6GDG 4.1 10.7554/ELIFE.35946 2018-05-16
2X72 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 3 0 0 0 2X72 3.0 10.1038/NATURE09795 2011-03-16
5CGC GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human in meso/LCP 6 2 0 3 5CGC 3.1 10.1021/ACS.JMEDCHEM.5B00892 2015-08-12
5WB2 Q80KM9 US28 Unclassified A (Rhodopsin) strain AD169 in meso/LCP 0 1 0 9 5WB2 3.5 2018-06-13
5N2S AA1R A1 Adenosine A (Rhodopsin) Human in meso/LCP 8 2 0 3 5N2S 3.3 10.1016/J.STR.2017.06.012 2017-07-26
4BWB NTR1 NTS1 Neurotensin A (Rhodopsin) Rat vapour diffusion 26 3 0 8 4BWB 3.6 10.1073/PNAS.1317903111 2014-01-29
3OE8 CXCR4 CXCR4 Chemokine A (Rhodopsin) Human in meso/LCP 1 2 0 7 3OE8 3.1 10.1126/SCIENCE.1194396 2010-10-27
6FKB OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A 0 1 0 0 6FKB 3.0 10.1073/PNAS.1718084115 2018-04-04
2I37 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 2I37 4.2 10.1073/PNAS.0608022103 2006-10-17
4Z34 LPAR1 LPA1 Lysophospholipid (LPA) A (Rhodopsin) Human in meso/LCP 0 3 0 5 4Z34 3.0 10.1016/J.CELL.2015.06.002 2015-06-03
2Y02 ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 3 0 1 2Y02 2.6 10.1038/NATURE09746 2011-01-12
4QKX ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 5 3 0 5 4QKX 3.3 10.1073/PNAS.1410415111 2014-07-23
4X1H OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 4X1H 2.3 10.1016/J.STR.2015.09.015 2015-11-04
6FK8 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A 0 0 0 0 6FK8 2.9 10.1073/PNAS.1718084115 2018-04-04
2HPY OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 2HPY 2.8 10.1073/PNAS.0601765103 2006-08-22
3UZC AA2AR A2A Adenosine A (Rhodopsin) Human vapour diffusion 8 1 0 2 3UZC 3.3 10.1021/JM201376W 2012-03-21
5L7D SMO SMO Frizzled F (Frizzled) Human in meso/LCP 1 3 0 2 5L7D 3.2 10.1038/NATURE18934 2016-07-20
5D5B ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 3 2 0 2 5D5B 3.8 10.1107/S2059798315021683 2016-01-13
4OO9 GRM5 mGlu5 Metabotropic glutamate C (Glutamate) Human in meso/LCP 6 3 0 3 4OO9 2.6 10.1038/NATURE13396 2014-07-02
4PY0 P2Y12 P2Y12 P2Y A (Rhodopsin) Human in meso/LCP 1 1 0 5 4PY0 3.1 10.1038/NATURE13288 2014-04-30
4BVN ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey in meso/LCP 11 3 0 1 4BVN 2.1 10.1371/JOURNAL.PONE.0092727 2014-04-02
2YDO AA2AR A2A Adenosine A (Rhodopsin) Human vapour diffusion 5 1 0 2 2YDO 3.0 10.1038/NATURE10136 2011-05-18
4RWD OPRD δ Opioid A (Rhodopsin) Human in meso/LCP 0 2 0 5 4RWD 2.7 10.1038/NSMB.2965 2015-01-14
4ZWJ OPSD Rhodopsin Opsins A (Rhodopsin) Human in meso/LCP 4 0 0 7 4ZWJ 3.3 10.1038/NATURE14656 2015-07-29
5T1A CCR2 CCR2 Chemokine A (Rhodopsin) Human in meso/LCP 0 3 0 6 5T1A 2.8 10.1038/NATURE20605 2016-12-14
5A8E ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey in meso/LCP 11 3 0 1 5A8E 2.4 10.1124/MOL.115.101030 2015-09-30
2Y03 ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 3 0 1 2Y03 2.9 10.1038/NATURE09746 2011-01-12
2I35 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 2I35 3.8 10.1073/PNAS.0608022103 2006-10-17
5UIG AA2AR A2A Adenosine A (Rhodopsin) Human vapour diffusion 0 2 0 5 5UIG 3.5 10.1073/PNAS.1621423114 2017-02-08
2YCW ADRB1 β1 Adrenoceptors A (Rhodopsin) Common turkey vapour diffusion 8 4 0 1 2YCW 3.0 10.1073/PNAS.1100185108 2011-06-01
4EIY AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 0 3 0 4 4EIY 1.8 10.1126/SCIENCE.1219218 2012-07-25
3ZEV NTR1 NTS1 Neurotensin A (Rhodopsin) Rat vapour diffusion 11 3 0 8 3ZEV 3.0 10.1073/PNAS.1317903111 2014-01-29
5OLV AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 3 5OLV 2.0 10.1038/S41598-017-18570-W 2018-01-17
6C1R C5AR1 C5a1 Complement peptide A (Rhodopsin) Human N/A 0 2 0 0 6C1R 2.2 10.1038/S41594-018-0067-Z 2018-05-30
5OM4 AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 9 3 0 3 5OM4 2.0 10.1038/S41598-017-18570-W 2018-01-17
5UNG AGTR2 AT2 Angiotensin A (Rhodopsin) Human in meso/LCP 0 2 0 6 5UNG 2.8 10.1038/NATURE22035 2017-04-05
5WF5 AA2AR A2A Adenosine A (Rhodopsin) Human in meso/LCP 1 3 0 4 5WF5 2.6 10.1016/J.STR.2017.12.013 2018-02-21
3RFM AA2AR A2A Adenosine A (Rhodopsin) Human vapour diffusion 8 1 0 2 3RFM 3.6 10.1016/J.STR.2011.06.014 2011-09-07
5WQC OX2R OX2 Orexin A (Rhodopsin) Human in meso/LCP 1 3 0 4 5WQC 2.0 10.1016/J.STR.2017.11.005 2017-11-29
4S0V OX2R OX2 Orexin A (Rhodopsin) Human in meso/LCP 1 3 0 4 4S0V 2.5 10.1038/NATURE14035 2015-01-14
2ZIY OPSD Rhodopsin Opsins A (Rhodopsin) Japanese flying squid vapour diffusion 1 2 0 0 2ZIY 3.7 10.1074/JBC.C800040200 2008-05-06
1HZX OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 1HZX 2.8 10.1021/BI0155091 2001-07-04
4BV0 NTR1 NTS1 Neurotensin A (Rhodopsin) Rat vapour diffusion 29 3 0 8 4BV0 3.1 10.1073/PNAS.1317903111 2014-01-29
5XF1 GLR glucagon Glucagon B1 (Secretin) Human in meso/LCP 0 3 0 5 5XF1 3.2 10.1038/NATURE22363 2017-05-24
4LDL ADRB2 β2 Adrenoceptors A (Rhodopsin) Human in meso/LCP 4 3 0 3 4LDL 3.1 10.1038/NATURE12572 2013-09-25
5TZY FFAR1 FFA1 Free fatty acid A (Rhodopsin) Human in meso/LCP 3 1 0 6 5TZY 3.2 10.1038/NSMB.3417 2017-06-07
4A4M OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 3 0 0 0 4A4M 3.3 10.1073/PNAS.1114089108 2012-01-25
4QIM SMO SMO Frizzled F (Frizzled) Human in meso/LCP 0 3 0 5 4QIM 2.6 10.1038/NCOMMS5355 2014-07-23
4J4Q OPSD Rhodopsin Opsins A (Rhodopsin) Bovine vapour diffusion 0 0 0 0 4J4Q 2.7 10.1002/ANIE.201302374 2013-10-30
6FKA OPSD Rhodopsin Opsins A (Rhodopsin) Bovine N/A 0 0 0 0 6FKA 2.7 10.1073/PNAS.1718084115 2018-04-04
3V2Y S1PR1 S1P1 Lysophospholipid (S1P) A (Rhodopsin) Human in meso/LCP 2 4 0 5 3V2Y 2.8 10.1126/SCIENCE.1215904 2012-02-15
PDB UniProt Receptor
5TVN 5HT2B 5-HT2B
5YQZ GLR glucagon
5XR8 CNR1 CB1
5VEX GLP1R GLP-1
5V57 SMO SMO
5U09 CNR1 CB1
2YDV AA2AR A2A
3EML AA2AR A2A
3PXO OPSD Rhodopsin
5O9H C5AR1 C5a1
5K2D AA2AR A2A
4U14 ACM3 M3
5UNH AGTR2 AT2
3AYN OPSD Rhodopsin
4AMJ ADRB1 β1
4ZUD AGTR1 AT1
4PXZ P2Y12 P2Y12
5GLI EDNRB ETB
4GBR ADRB2 β2
3OE6 CXCR4 CXCR4
4O9R SMO SMO
4IB4 5HT2B 5-HT2B
5VBL APJ apelin
4RWS CXCR4 CXCR4
5V54 5HT1B 5-HT1B
3ZPQ ADRB1 β1
5DHG OPRX NOP
5K2C AA2AR A2A
5UEN AA1R A1
4N6H OPRD δ
5EN0 OPSD Rhodopsin
4IAR 5HT1B 5-HT1B
2Y01 ADRB1 β1
4AMI ADRB1 β1
4N4W SMO SMO
4Z9G CRFR1 CRF1
5NM2 AA2AR A2A
2I36 OPSD Rhodopsin
4MQT ACM2 M2
4WW3 OPSD Rhodopsin
5OLZ AA2AR A2A
4LDO ADRB2 β2
2YCX ADRB1 β1
5IU7 AA2AR A2A
2Y00 ADRB1 β1
4DAJ ACM3 M3
5ZKP PTAFR PAF
5ZBQ NPY1R Y1
6D32 Q98SW5 SMO
6D35 Q98SW5 SMO
5ZBH NPY1R Y1
5KW2 FFAR1 FFA1
5WB1 Q80KM9 US28
4U16 ACM3 M3
3REY AA2AR A2A
3DQB OPSD Rhodopsin
4UG2 AA2AR A2A
5UZ7 CALCR CT
3NY9 ADRB2 β2
6FK9 OPSD Rhodopsin
1L9H OPSD Rhodopsin
4YAY AGTR1 AT1
3C9L OPSD Rhodopsin
2R4S ADRB2 β2
4UHR AA2AR A2A
3C9M OPSD Rhodopsin
2R4R ADRB2 β2
5T04 NTR1 NTS1
5EE7 GLR glucagon
4QIN SMO SMO
5DHH OPRX NOP
2YCZ ADRB1 β1
4LDE ADRB2 β2
6FKC OPSD Rhodopsin
4EA3 OPRX NOP
4XEE NTR1 NTS1
3KJ6 ADRB2 β2
4U15 ACM3 M3
6B3J GLP1R GLP-1
5WS3 OX2R OX2
5DSG ACM4 M4
5X33 Q9WTK1 BLT1
5LWE CCR9 CCR9
2VT4 ADRB1 β1
5D5A ADRB2 β2
3VG9 AA2AR A2A
5OLH AA2AR A2A
4XT3 US28 US28
5VEW GLP1R GLP-1
5TE3 OPSD Rhodopsin
2PED OPSD Rhodopsin
3NY8 ADRB2 β2
6CM4 DRD2 D2
5L7I SMO SMO
5MZP AA2AR A2A
4MQS ACM2 M2
4Z35 LPAR1 LPA1
4OR2 GRM1 mGlu1
5JTB AA2AR A2A
4GRV NTR1 NTS1
3VW7 PAR1 PAR1
5TGZ CNR1 CB1
2Z73 OPSD Rhodopsin
3RZE HRH1 H1
3PBL DRD3 D3
5V56 SMO SMO
5JQH ADRB2 β2
4ZJC OX1R OX1
4BUO NTR1 NTS1
5N2R AA2AR A2A
5W0P OPSD Rhodopsin
5UIW CCR5 CCR5
5NX2 GLP1R GLP-1
4L6R GLR glucagon
5G53 AA2AR A2A
4IAQ 5HT1B 5-HT1B
5NDD PAR2 PAR2
3PDS ADRB2 β2
5MZJ AA2AR A2A
5X93 EDNRB ETB
6AQF AA2AR A2A
6BQG 5HT2C 5-HT2C
5XSZ Q08BG4 LPA6
3VGA AA2AR A2A
5VRA AA2AR A2A
2Y04 ADRB1 β1
3UON ACM2 M2
5F8U ADRB1 β1
3OAX OPSD Rhodopsin
3SN6 ADRB2 β2
6D9H AA1R A1
6FK7 OPSD Rhodopsin
6G79 5HT1B 5-HT1B
5ZKQ PTAFR PAF
6B73 OPRK κ
4ZJ8 OX1R OX1
4NTJ P2Y12 P2Y12
4PXF OPSD Rhodopsin
5XRA CNR1 CB1
6DDF OPRM μ
5CXV ACM1 M1
6FK6 OPSD Rhodopsin
5C1M OPRM μ
3PQR OPSD Rhodopsin
6BQH 5HT2C 5-HT2C
2G87 OPSD Rhodopsin
3D4S ADRB2 β2
4XES NTR1 NTS1
4EJ4 OPRD δ
1GZM OPSD Rhodopsin
3ODU CXCR4 CXCR4
4XNW P2RY1 P2Y1
4RWA OPRD δ
3NYA ADRB2 β2
3AYM OPSD Rhodopsin
6DDE OPRM μ
4K5Y CRFR1 CRF1
5XEZ GLR glucagon
5NDZ PAR2 PAR2
5TUD 5HT2B 5-HT2B
5NM4 AA2AR A2A
4PHU FFAR1 FFA1
1F88 OPSD Rhodopsin
5TZR FFAR1 FFA1
3P0G ADRB2 β2
5WF6 AA2AR A2A
5WKT OPSD Rhodopsin
3CAP OPSD Rhodopsin
5OLG AA2AR A2A
5DYS OPSD Rhodopsin
3OE9 CXCR4 CXCR4
4XT1 US28 US28
4DJH OPRK κ
5TE5 OPSD Rhodopsin
5X7D ADRB2 β2
5WIV DRD4 D4
5NLX AA2AR A2A
4BEY OPSD Rhodopsin
4DKL OPRM μ
4JKV SMO SMO
5D6L ADRB2 β2
4GPO ADRB1 β1
6FFI GRM5 mGlu5
5K2B AA2AR A2A
5WIU DRD4 D4
6FKD OPSD Rhodopsin
4XNV P2RY1 P2Y1
5GLH EDNRB ETB
5XPR EDNRB ETB
5UVI AA2AR A2A
5CGD GRM5 mGlu5
5IUB AA2AR A2A
4Z36 LPAR1 LPA1
1U19 OPSD Rhodopsin
6FFH GRM5 mGlu5
6CMO OPSD Rhodopsin
6C1Q C5AR1 C5a1
2J4Y OPSD Rhodopsin
5OM1 AA2AR A2A
5VAI G1SGD4 GLP-1
5NJ6 PAR2 PAR2
3V2W S1PR1 S1P1
4MBS CCR5 CCR5
5OLO AA2AR A2A
2YCY ADRB1 β1
3PWH AA2AR A2A
5IU8 AA2AR A2A
5DGY OPSD Rhodopsin
2RH1 ADRB2 β2
5UNF AGTR2 AT2
3QAK AA2AR A2A
4BEZ OPSD Rhodopsin
3OE0 CXCR4 CXCR4
5IUA AA2AR A2A
5IU4 AA2AR A2A
3ZPR ADRB1 β1
4NC3 5HT2B 5-HT2B
5K2A AA2AR A2A
3UZA AA2AR A2A
6GDG AA2AR A2A
2X72 OPSD Rhodopsin
5CGC GRM5 mGlu5
5WB2 Q80KM9 US28
5N2S AA1R A1
4BWB NTR1 NTS1
3OE8 CXCR4 CXCR4
6FKB OPSD Rhodopsin
2I37 OPSD Rhodopsin
4Z34 LPAR1 LPA1
2Y02 ADRB1 β1
4QKX ADRB2 β2
4X1H OPSD Rhodopsin
6FK8 OPSD Rhodopsin
2HPY OPSD Rhodopsin
3UZC AA2AR A2A
5L7D SMO SMO
5D5B ADRB2 β2
4OO9 GRM5 mGlu5
4PY0 P2Y12 P2Y12
4BVN ADRB1 β1
2YDO AA2AR A2A
4RWD OPRD δ
4ZWJ OPSD Rhodopsin
5T1A CCR2 CCR2
5A8E ADRB1 β1
2Y03 ADRB1 β1
2I35 OPSD Rhodopsin
5UIG AA2AR A2A
2YCW ADRB1 β1
4EIY AA2AR A2A
3ZEV NTR1 NTS1
5OLV AA2AR A2A
6C1R C5AR1 C5a1
5OM4 AA2AR A2A
5UNG AGTR2 AT2
5WF5 AA2AR A2A
3RFM AA2AR A2A
5WQC OX2R OX2
4S0V OX2R OX2
2ZIY OPSD Rhodopsin
1HZX OPSD Rhodopsin
4BV0 NTR1 NTS1
5XF1 GLR glucagon
4LDL ADRB2 β2
5TZY FFAR1 FFA1
4A4M OPSD Rhodopsin
4QIM SMO SMO
4J4Q OPSD Rhodopsin
6FKA OPSD Rhodopsin
3V2Y S1PR1 S1P1
 
N-term
TM1
ICL1
TM2
ECL1
TM3
ICL2
TM4
ECL2
TM5
ICL3
TM6
ECL3
TM7
H8
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
 
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
 
 
TM5
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ICL3
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
 
 
TM2
 
ECL1
 
TM3
 
 
 
 
 
ICL2
 
TM4
 
ECL2
 
TM5
 
ICL3
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
 
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
 
 
 
 
TM5
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ICL3
 
 
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
 
 
 
 
TM2
 
 
 
 
 
 
 
 
 
 
 
ECL1
 
 
 
 
TM3
 
 
 
 
ICL2
 
 
 
TM4
 
ECL2
 
 
 
TM5
 
ICL3
 
 
 
 
 
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
TM5
 
 
 
 
 
 
 
 
ICL3
 
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
 
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
 
 
 
 
TM5
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ICL3
 
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
TM1
 
ICL1
 
 
 
 
 
 
 
TM2
 
ECL1
 
 
 
TM3
 
ICL2
 
TM4
 
 
 
ECL2
 
TM5
 
ICL3
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
 
TM5
 
 
 
 
 
ICL3
 
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
TM5
 
ICL3
 
TM6
 
ECL3
 
TM7
 
H8
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
 
 
 
 
TM2
 
ECL1
 
TM3
 
 
 
 
 
ICL2
 
 
 
 
 
TM4
 
ECL2
 
 
TM5
 
 
 
ICL3
 
TM6
 
ECL3
 
TM7
 
 
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
 
TM5
 
 
 
 
 
ICL3
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
 
 
TM5
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ICL3
 
 
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
TM5
 
ICL3
 
TM6
 
ECL3
 
TM7
 
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
TM5
 
ICL3
 
TM6
 
ECL3
 
TM7
 
H8
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
 
 
TM1
 
ICL1
 
 
 
TM2
 
ECL1
 
 
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
 
TM5
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ICL3
 
 
 
TM6
 
ECL3
 
 
 
 
 
TM7
 
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
TM5
 
ICL3
 
TM6
 
ECL3
 
TM7
 
 
 
 
 
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
TM5
 
ICL3
 
TM6
 
ECL3
 
 
 
TM7
 
H8
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
TM5
 
 
 
 
ICL3
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
 
 
TM1
 
ICL1
 
 
TM2
 
 
 
ECL1
 
TM3
 
ICL2
 
TM4
 
 
 
ECL2
 
 
 
TM5
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ICL3
 
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
 
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
TM5
 
ICL3
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
TM5
 
 
 
 
 
 
 
 
ICL3
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
 
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
 
 
TM5
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ICL3
 
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
 
 
TM3
 
ICL2
 
TM4
 
 
 
ECL2
 
 
 
 
TM5
 
 
 
 
 
 
ICL3
 
 
 
 
TM6
 
ECL3
 
TM7
 
 
 
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
 
 
TM3
 
ICL2
 
TM4
 
 
 
ECL2
 
 
TM5
 
 
ICL3
 
 
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
 
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
 
TM5
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ICL3
 
 
TM6
 
ECL3
 
TM7
 
H8
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
 
 
TM1
 
ICL1
 
 
 
TM2
 
ECL1
 
 
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
 
TM5
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ICL3
 
 
 
TM6
 
ECL3
 
 
 
 
 
TM7
 
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
TM5
 
ICL3
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
 
TM5
 
 
 
 
 
ICL3
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
 
 
ECL2
 
 
 
TM5
 
 
 
 
 
ICL3
 
 
 
 
 
TM6
 
ECL3
 
TM7
 
 
 
 
 
H8
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
TM5
 
ICL3
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
N-term
 
TM1
 
ICL1
 
 
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
TM5
 
ICL3
 
TM6
 
 
 
ECL3
 
TM7
 
H8
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
 
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
 
TM5
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ICL3
 
 
 
TM6
 
ECL3
 
TM7
 
H8
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
 
 
TM1
 
ICL1
 
 
 
TM2
 
ECL1
 
 
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
 
TM5
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ICL3
 
 
 
TM6
 
ECL3
 
 
 
 
 
TM7
 
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
 
 
TM1
 
ICL1
 
 
 
TM2
 
ECL1
 
 
 
TM3
 
ICL2
 
TM4
 
ECL2
 
 
 
 
TM5
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ICL3
 
 
 
TM6
 
ECL3
 
 
 
 
 
TM7
 
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
TM1
 
ICL1
 
TM2
 
ECL1
 
TM3
 
ICL2
 
TM4
 
ECL2
 
TM5
 
ICL3
 
TM6
 
ECL3
 
TM7
 
H8
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
C-term
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
N-term
 
 
 
 
 
TM1
 
ICL1
 
 
 
 
 
TM2
 
ECL1
 
TM3
 
 
 
 
ICL2
 
 
 
TM4
 
 
 
ECL2
 
 
 
TM5
 
ICL3
 
 
 
 
TM6