Structure information

mGlu5 receptor

PROTEIN CLASS

Class C (Glutamate)

PDB CODE

4OO9

SPECIES

Homo sapiens

RESOLUTION

2.600

PREFERRED CHAIN

A

REFERENCE

10.1038/NATURE13396

PUBLICATION DATE

July 2, 2014

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
MAVOGLURANT I625 2.46x46 TM2 hydrophobic
MAVOGLURANT I651 3.36x36 TM3 hydrophobic
MAVOGLURANT P655 3.40x40 TM3 hydrophobic
MAVOGLURANT Y659 3.44x44 TM3 hydrophobic
MAVOGLURANT P743 5.43x43 TM5 Van der Waals
MAVOGLURANT P743 5.43x43 TM5 polar (hydrogen bond with backbone)
MAVOGLURANT L744 5.44x44 TM5 Van der Waals
MAVOGLURANT L744 5.44x44 TM5 hydrophobic
MAVOGLURANT N747 5.47x47 TM5 polar (hydrogen bond)
MAVOGLURANT N747 5.47x47 TM5 Van der Waals
MAVOGLURANT W785 6.50x50 TM6 Van der Waals
MAVOGLURANT F788 6.53x53 TM6 Van der Waals
MAVOGLURANT F788 6.53x53 TM6 hydrophobic
MAVOGLURANT M802 7.32x33 TM7 Van der Waals
MAVOGLURANT S805 7.35x36 TM7 polar (hydrogen bond)
MAVOGLURANT S805 7.35x36 TM7 Van der Waals
MAVOGLURANT S805 7.35x36 TM7 polar (hydrogen bond with backbone)
MAVOGLURANT V806 7.36x37 TM7 hydrophobic
MAVOGLURANT V806 7.36x37 TM7 Van der Waals
MAVOGLURANT S809 7.39x40 TM7 polar (hydrogen bond)
MAVOGLURANT S809 7.39x40 TM7 Van der Waals
MAVOGLURANT A810 7.40x41 TM7 Van der Waals
MAVOGLURANT A810 7.40x41 TM7 hydrophobic

Ligands

MAVOGLURANT

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Residue Diagrams

L T A L L G L C A F V V A A I P E P 1 Y I I L A G I C L G Y L C T F C L I 2 T V L A S Y S M A P S L G I G I R Q L Y 3 Q L V I A F I L I C I Q L G I I V A L F 4 A Y F T C S L I L L G N Y G L P T V V G 5 A F T M Y T T C I I W L A F V P I Y F G 6 G L A V T A S L S V S F C M T I I K Y 7
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ICL1 T R D P V V K S S ICL1ECL1 A K P ECL1ICL2 A G S K K K I C T K K P R F M ICL2ECL2 P P D I M H D Y P S I R E V Y L I C N T ECL2ICL3 R N V P A N F N ICL3ECL3 N ECL3N-term M V L L L I L S V L L L K E D V R G S A Q S S E R R V V A H M P G D I I I G A L F S V H H Q P T V D K V H E R K C G A V R E Q Y G I Q R V E A M L H T L E R I N S D P T L L P N I T L G C E I R D S C W H S A V A L E Q S I E F I R D S L I S S E E E E G L V R C V D G S S S S F R S K K P I V G V I G P G S S S V A I Q V Q N L L Q L F N I P Q I A Y S A T S M D L S D K T L F K Y F M R V V P S D A Q Q A R A M V D I V K R Y N W T Y V S A V H T E G N Y G E S G M E A F K D M S A K E G I C I A H S Y K I Y S N A G E Q S F D K L L K K L T S H L P K A R V V A C F C E G M T V R G L L M A M R R L G L A G E F L L L G S D G W A D R Y D V T D G Y Q R E A V G G I T I K L Q S P D V K W F D D Y Y L K L R P E T N H R N P W F Q E F W Q H R F Q C R L E G F P Q E N S K Y N K T C N S S L T L K T H H V Q D S K M G F V I N A I Y S M A Y G L H N M Q M S L C P G Y A G L C D A M K P I D G R K L L E S L M K T N F T G V S G D T I L F D E N G D S P G R Y E I M N F K E M G K D Y F D Y I N V G S W D N G E L K M D D D E V W S K K S N I I R S V C S E P C E K G Q I K V I R K G E V S C C W T C T P C K E N E Y V F D E Y T C K A C Q L G S W P T D D L T G C D L I P V Q Y L R W G D N-termC-term T V V R M H V G D G K S S S A A S R S S S L V N L W K R R G S S G E T L R Y K D R R L A Q H K S E I E C F T P K G S M G N G G R A T M S S S N G K S V T W A Q N E K S S R G Q H L W Q R L S I H I N K K E N P N Q T A V I K P F P K S T E S R G L G A G A G A G G S A G G V G A T G G A G C A G A G P G G P E S P D A G P K A L Y D V A E A E E H F P A P A R P R S P S P I S T L S H R A G S A S R T D D D V P S L H S E P V A R S S S S Q G S L M E Q I S S V V T R F T A N I S E L N S M M L S T A A P S P G V G A P L C S S Y L I P K E I Q L P T T M T T F A E I Q P L P A I E V T G G A Q P A A G A Q A A G D A A R E S P A A G P E A A A A K P D L E E L V A L T P P S P F R D S V D S G S T T P N S P V S E S A L C I P S S P K Y D T L I I R D Y T Q S S S S L C-term P E P I A A V V F A C L G L L A T L F V T V V F I I Y S R E L C Y I I L A G I C L G Y L C T F C L I K Q I Y C Y L Q R I G I G L S P A M S Y S A L V T K T N R I A R I L S A C A Q L V I A F I L I C I Q L G I I V A L F I M E T N L G V V T P L G Y N G L L I L S C T F Y A F K T E A K Y I A F T M Y T T C I I W L A F V P I Y F G S Y K I I T M C F S V S L S A T V A L G C M F V P K V Y I I L A K P E R A F T N V R S T S
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Residue Table


GPCRdb(A)
GPCRdb(C)
mGlu5 receptor
TM2
2x50 2.46x46 I625
TM3
3x32 3.36x36 I651
3x36 3.40x40 P655
3x40 3.44x44 Y659
TM5
5x43 5.43x43 P743
5x44 5.44x44 L744
5x47 5.47x47 N747
TM6
6x48 6.50x50 W785
6x51 6.53x53 F788
TM7
7x38 7.32x33 M802
7x41 7.35x36 S805
7x42 7.36x37 V806
7x45 7.39x40 S809
7x46 7.40x41 A810