Structure information

FFA1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

4PHU

SPECIES

Homo sapiens

RESOLUTION

2.330

PREFERRED CHAIN

A

REFERENCE

10.1038/NATURE13494

PUBLICATION DATE

July 16, 2014

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
fasiglifam P80 3.26x26 TM3 hydrophobic
fasiglifam A83 3.29x29 TM3 hydrophobic
fasiglifam V84 3.30x30 TM3 hydrophobic
fasiglifam F87 3.33x33 TM3 hydrophobic
fasiglifam Y91 3.37x37 TM3 Van der Waals
fasiglifam Y91 3.37x37 TM3 polar (hydrogen bond)
fasiglifam L135 4.54x54 TM4 Van der Waals
fasiglifam L138 4.57x57 TM4 polar (hydrogen bond with backbone)
fasiglifam L138 4.57x57 TM4 Van der Waals
fasiglifam G139 4.58x58 TM4 Van der Waals
fasiglifam F142 4.61x61 TM4 hydrophobic
fasiglifam F142 4.61x61 TM4 Van der Waals
fasiglifam G143 4.62x62 TM4 Van der Waals
fasiglifam L158 ECL2 Van der Waals
fasiglifam L158 ECL2 hydrophobic
fasiglifam W174 ECL2 Van der Waals
fasiglifam W174 ECL2 hydrophobic
fasiglifam R183 5.39x40 TM5 polar (charge-assisted hydrogen bond)
fasiglifam Y2240 6.51x51 TM6 Van der Waals
fasiglifam Y2240 6.51x51 TM6 polar (hydrogen bond)
fasiglifam R2258 7.35x34 TM7 polar (charge-assisted hydrogen bond)

Ligands

fasiglifam

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Residue Diagrams

V N L P F G L A F A A V Y L G F S L Q P 1 L N L G C S D L L L T V S L P L K A V E 2 A A L F G G G A Y L P F F H A V A F V P 3 S W G V C A A I W A L V L C H L G L V F 4 Y C F A T I A L P L F F L L L S L S F R A 5 A G G A L L T L L L C V G P Y N A S N V A 6 L P N L V V S W A G T I L G L K R W S 7
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ICL1 L ICL1ECL1 G A W P L ECL1ICL2 P L G Y Q A F R ICL2ECL2 P G G W L D H S N T S L G I N T P V N G S P V C L E A W ECL2ICL3 S G L T H ICL3ECL3 P N L G ECL3N-term M D L N-termC-term G G K S Q K C-term P P Q L S F G L Y V A A F A L G F P L N V L A I R G A T A H A R L R T P S L V Y A L N L G C S D L L L T V S L P L K A V E A L A S P A S L C P V F A V A H F F P L Y A G G G F L A A L S A G R Y L G A A F R P C Y S W G V C A A I W A L V L C H L G L V F G L E A D P A S A G P A R F S L S L L L F F L P L A I T A F C Y V G C L R A L A R R R K L R A A W V A G G A L L T L L L C V G P Y N A S N V A S F L Y G S W R K L G L I T G A W S V V L N P L V T G Y L G R G T V C Q P G L K A A R T
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Residue Table


GPCRdb(A)
GPCRdb(A)
FFA1 receptor
TM3
3x26 3.26x26 P80
3x29 3.29x29 A83
3x30 3.30x30 V84
3x33 3.33x33 F87
3x37 3.37x37 Y91
TM4
4x54 4.54x54 L135
4x57 4.57x57 L138
4x58 4.58x58 G139
4x61 4.61x61 F142
4x62 4.62x62 G143
TM5
5x40 5.39x40 R183
TM6
6x51 6.51x51 Y240
TM7
7x34 7.35x34 R258