Structure information

LPA1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

4Z34

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

A

REFERENCE

10.1016/J.CELL.2015.06.002

PUBLICATION DATE

June 3, 2015

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ONO-9780307 K39 N-term polar (charge-assisted hydrogen bond)
ONO-9780307 H40 N-term polar (hydrogen bond)
ONO-9780307 H40 N-term Van der Waals
ONO-9780307 T109 ECL1 Van der Waals
ONO-9780307 T113 23.50x50 ECL1 Van der Waals
ONO-9780307 T113 23.50x50 ECL1 polar (hydrogen bond)
ONO-9780307 R124 3.28x28 TM3 Van der Waals
ONO-9780307 Q125 3.29x29 TM3 Van der Waals
ONO-9780307 Q125 3.29x29 TM3 polar (hydrogen bond)
ONO-9780307 I128 3.32x32 TM3 hydrophobic
ONO-9780307 I128 3.32x32 TM3 Van der Waals
ONO-9780307 D129 3.33x33 TM3 Van der Waals
ONO-9780307 M198 ECL2 hydrophobic
ONO-9780307 M198 ECL2 Van der Waals
ONO-9780307 W210 5.43x43 TM5 Van der Waals
ONO-9780307 W271 6.48x48 TM6 Van der Waals
ONO-9780307 W271 6.48x48 TM6 hydrophobic
ONO-9780307 G274 6.51x51 TM6 Van der Waals
ONO-9780307 L277 6.54x54 TM6 Van der Waals
ONO-9780307 L278 6.55x55 TM6 Van der Waals
ONO-9780307 L278 6.55x55 TM6 hydrophobic
ONO-9780307 E293 7.35x34 TM7 Van der Waals
ONO-9780307 K294 7.36x35 TM7 Van der Waals
ONO-9780307 F296 7.38x37 TM7 hydrophobic
ONO-9780307 F296 7.38x37 TM7 Van der Waals
ONO-9780307 L297 7.39x38 TM7 Van der Waals
ONO-9780307 L297 7.39x38 TM7 hydrophobic

Ligands

ONO-9780307

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Residue Diagrams

L N A L M I F I C V T I G L G M V L K S 1 A N L A A A D F F A G L A Y F Y L M F N 2 A L L N A V S A T L S T D I L G Q R L L 3 V V V V I V V I W T M A I V M G A I P S 4 Y L V V M V V F T V L N F I A W F V L Y 5 V I V L G A F I I C W T P G L V L L L L 6 I P N M A S N F E A L L L F F K E Y A 7
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ICL1 R R F H ICL1ECL1 T G P N T R R L ECL1ICL2 M Q L H T R M ICL2ECL2 W N C I C D I E N C S N M A P L Y ECL2ICL3 R H S S ICL3ECL3 P Q C ECL3N-term M A A I S T S I P V I S Q P Q F T A M N E P Q C F Y N E S I A F F Y N R S G K H L A T E W N N-termC-term C Q R S E N P T G P T E G S D R S A S S L N H T I L A G V H S N D H S V V C-term T V S K L V M G L G I T V C I F I M L A N L L V M V A I Y V N F P I Y Y L M A N L A A A D F F A G L A Y F Y L M F N T V S T W L L R Q G L I D T S L T A S V A N L L A I A I E R H I T V F R S N R R V V V V I V V I W T M A I V M G A I P S V G S D S Y L V F W A I F N L V T F V V M V V L Y A H I F G Y V R Q R T M R M S G P R R N R D T M M S L L K T V V I V L G A F I I C W T P G L V L L L L D V C C D V L A Y E K F F L L L A E F N S A M N P I I Y S Y R D K E F R Q M S A T I L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
LPA1 receptor
ECL1
23x50 23.50x50 T113
TM3
3x28 3.28x28 R124
3x29 3.29x29 Q125
3x32 3.32x32 I128
3x33 3.33x33 D129
TM5
5x43 5.43x43 W210
TM6
6x48 6.48x48 W271
6x51 6.51x51 G274
6x54 6.54x54 L277
6x55 6.55x55 L278
TM7
7x34 7.35x34 E293
7x35 7.36x35 K294
7x37 7.38x37 F296
7x38 7.39x38 L297