Structure information

GLP-1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

5NX2

SPECIES

Homo sapiens

RESOLUTION

3.700

PREFERRED CHAIN

A

REFERENCE

10.1038/NATURE22800

PUBLICATION DATE

June 14, 2017

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Truncated protein agonist L32 N-term Van der Waals
Truncated protein agonist L32 N-term polar (hydrogen bond with backbone)
Truncated protein agonist W33 N-term polar (hydrogen bond with backbone)
Truncated protein agonist W33 N-term Van der Waals
Truncated protein agonist P137 N-term Van der Waals
Truncated protein agonist P137 N-term hydrophobic
Truncated protein agonist L141 1.36x36 TM1 Van der Waals
Truncated protein agonist L141 1.36x36 TM1 hydrophobic
Truncated protein agonist L142 1.37x37 TM1 Van der Waals
Truncated protein agonist L142 1.37x37 TM1 hydrophobic
Truncated protein agonist Y145 1.40x40 TM1 Van der Waals
Truncated protein agonist Y145 1.40x40 TM1 hydrophobic
Truncated protein agonist Y148 1.43x43 TM1 hydrophobic
Truncated protein agonist Y148 1.43x43 TM1 Van der Waals
Truncated protein agonist Y152 1.47x47 TM1 polar (hydrogen bond)
Truncated protein agonist R190 2.60x60 TM2 polar (charge-assisted hydrogen bond)
Truncated protein agonist V194 2.64x64 TM2 Van der Waals
Truncated protein agonist K197 2.67x67 TM2 Van der Waals
Truncated protein agonist D198 2.68x68 TM2 Van der Waals
Truncated protein agonist L201 2.71x71 TM2 hydrophobic
Truncated protein agonist L201 2.71x71 TM2 Van der Waals
Truncated protein agonist K202 2.72x72 TM2 Van der Waals
Truncated protein agonist M204 2.74x74 TM2 Van der Waals
Truncated protein agonist Y205 2.75x75 TM2 polar (hydrogen bond)
Truncated protein agonist Y205 2.75x75 TM2 polar (hydrogen bond)
Truncated protein agonist L217 ECL1 hydrophobic
Truncated protein agonist L217 ECL1 Van der Waals
Truncated protein agonist Q221 ECL1 Van der Waals
Truncated protein agonist A295 ECL2 Van der Waals
Truncated protein agonist A295 ECL2 hydrophobic
Truncated protein agonist C296 45.50x50 ECL2 Van der Waals
Truncated protein agonist C296 45.50x50 ECL2 hydrophobic
Truncated protein agonist A298 45.52x52 ECL2 Van der Waals
Truncated protein agonist R299 ECL2 polar (charge-assisted hydrogen bond)
Truncated protein agonist N300 ECL2 polar (hydrogen bond)
Truncated protein agonist N300 ECL2 Van der Waals
Truncated protein agonist N300 ECL2 polar (hydrogen bond with backbone)
Truncated protein agonist W306 5.36x37 TM5 hydrophobic
Truncated protein agonist W306 5.36x37 TM5 Van der Waals
Truncated protein agonist I313 5.43x43 TM5 Van der Waals
Truncated protein agonist D372 ECL3 polar (charge-assisted hydrogen bond)
Truncated protein agonist R380 7.35x34 TM7 polar (charge-assisted hydrogen bond)
Truncated protein agonist L384 7.39x38 TM7 Van der Waals
Truncated protein agonist L384 7.39x38 TM7 hydrophobic
Truncated protein agonist E387 7.42x41 TM7 polar (charge-assisted hydrogen bond)
Truncated protein agonist L388 7.43x42 TM7 Van der Waals
Truncated protein agonist L388 7.43x42 TM7 hydrophobic

Ligands

Truncated protein agonist

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Residue Diagrams

V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7
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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
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Residue Table


GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x32 1.36x36 L141
1x33 1.37x37 L142
1x36 1.40x40 Y145
1x39 1.43x43 Y148
1x43 1.47x47 Y152
TM2
2x53 2.60x60 R190
2x57 2.64x64 V194
2x60 2.67x67 K197
2x61 2.68x68 D198
2x64 2.71x71 L201
2x65 2.72x72 K202
2x67 2.74x74 M204
2x68 2.75x75 Y205
ECL2
45x50 45.50x50 C296
45x52 45.52x52 T298
TM5
5x41 5.36x37 W306
5x47 5.43x43 I313
TM7
7x30 7.35x34 R380
7x34 7.39x38 L384
7x37 7.42x41 E387
7x38 7.43x42 L388