Data showed in this table is continously collected from the Guide to Pharmacology database. Ref

RECEPTOR ENDOGENOUS LIGANDS pEC50 pKi REFERENCES
Class Receptor family UniProt IUPHAR Species Ligand GtP
Classification		 Potency
Ranking		 Type Min Mid Max Min Mid Max
A (Rhodopsin) 5-Hydroxytryptamine 5HT1F 5-HT1F Human 5-Hydroxytryptamine Principal 1 Small molecule 7.7 7.9 8.0 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT4R 5-HT4 Rat 5-Hydroxytryptamine Principal 1 Small molecule 6.7 7.5 8.2 Refs
A (Rhodopsin) Thyrotropin-releasing hormone TRFR TRH1 Human Trh Principal 1 Peptide 7.4 7.4 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR3 LPA3 Human Farnesyl Monophosphate None 2 Small molecule Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl2 1 Peptide Refs
A (Rhodopsin) Dopamine DRD3 D3 Human Dopamine Principal 1 Small molecule 6.4 6.9 7.3 Refs
A (Rhodopsin) Galanin GALR2 GAL2 Rat Galanin 2 Peptide 8.3 8.3 8.3 8.4 8.4 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl3 5 Peptide 8.0 8.5 8.9 Refs
C (Glutamate) Metabotropic glutamate GRM8 mGlu8 Human L-Glutamic Acid None 1 Small molecule 4.9 5.3 5.6 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR3 S1P3 Human Sphingosylphosphorylcholine 2 Small molecule
A (Rhodopsin) Leukotriene OXER1 OXE Human 5-Oxo-20-Hete None 6 Small molecule 6.5 6.5 Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl16 7 Peptide
C (Glutamate) Metabotropic glutamate GRM4 mGlu4 Rat L-Glutamic Acid None 2 Small molecule 4.7 5.1 5.5 4.9 5.2 5.5 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Prrp-31 3 Peptide
A (Rhodopsin) Class A orphan GPR35 GPR35 Human Kynurenic Acid None 2 Small molecule 3.9 5.0 5.0 Refs
A (Rhodopsin) Leukotriene CLTR1 CysLT1 Human Ltc4 None 2 Small molecule 7.4 7.6 7.7 7.0 7.6 8.1 Refs
A (Rhodopsin) Melatonin MTR1B MT2 Human Melatonin Principal 1 Small molecule 9.4 9.6 9.8 Refs
A (Rhodopsin) P2Y P2RY4 P2Y4 Human Atp None 2 Small molecule 5.7 5.4 5.4 Refs
A (Rhodopsin) Prostanoid PD2R DP1 Mouse Pgd2 None 2 Small molecule 7.8 8.5 9.2 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Human Srif-14 1 Peptide 8.7 9.4 10.0 Refs
A (Rhodopsin) Proteinase-activated PAR4 PAR4 Human Cathepsin G Peptide
A (Rhodopsin) Vasopressin and oxytocin OXYR OT Human Vasopressin 2 Peptide 7.3 8.3 9.3 Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Rat Srif-14 1 Peptide 9.0 9.1 9.1 8.9 9.7 10.5 Refs
A (Rhodopsin) Chemokine CX3C1 CX3CR1 Human Cx3Cl1 Principal 1 Peptide
A (Rhodopsin) Class A orphan LGR5 LGR5 Human R-Spondin-3 3 Peptide 11.0 11.0 Refs
A (Rhodopsin) Proteinase-activated PAR4 PAR4 Human Cathepsin G Peptide
A (Rhodopsin) Prolactin-releasing peptide PRLHR PrRP Human Prrp-31 4 Peptide
A (Rhodopsin) Class A orphan LGR5 LGR5 Human R-Spondin-2 1 Peptide 12.0 12.0 Refs
A (Rhodopsin) Proteinase-activated PAR4 PAR4 Human Thrombin Peptide
A (Rhodopsin) Adren ADRB3 β3-adren Rat (&Plusmn;)-Adrenaline None 1 Small molecule 3.9 5.3 5.3 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Rat Pge1 None 2 Small molecule 7.0 7.0 Refs
A (Rhodopsin) Somatostatin SSR4 SST4 Human Srif-14 2 Peptide 8.4 8.9 9.3 Refs
A (Rhodopsin) Class A orphan GPR17 GPR17 Mouse Ltd4 None 3 Small molecule 8.1 8.3 8.4 Refs
A (Rhodopsin) Opioid OPRD δ Human Dynorphin A 5 Peptide 7.4 7.4 Refs
A (Rhodopsin) Class A orphan GPR39 GPR39 Human Zn2+ None Small molecule Refs
A (Rhodopsin) Chemokine CXCR4 CXCR4 Human Cxcl12Γ 3 Peptide Refs
A (Rhodopsin) Orexin OX2R OX2 Human Orexin-B 1 Peptide 6.5 8.3 10.0 Refs
A (Rhodopsin) Neuromedin U NMUR1 NMU1 Human Neuromedin S-36 3 Peptide
A (Rhodopsin) Prostanoid PE2R4 EP4 Rat Pge2 None 3 Small molecule 6.1 6.1 8.5 8.6 8.7 Refs
A (Rhodopsin) Chemerin CML1 hemerin Human 18r-Hepe 2 Small molecule
A (Rhodopsin) Class A orphan GPR17 GPR17 Mouse Udp-Glucose None 6 Small molecule 7.1 7.2 7.3 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Rat Pgf2Α None 2 Small molecule 8.4 8.4 7.4 7.4 Refs
A (Rhodopsin) Opioid OPRD δ Human Β-Endorphin 7 Peptide
A (Rhodopsin) Opioid OPRK κ Mouse Dynorphin B 5 Peptide 8.1 9.0 9.9 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1E 5-HT1E Human 5-Hydroxytryptamine None 1 Small molecule 8.0 8.1 8.2 Refs
A (Rhodopsin) GPR18, GPR55 and GPR119 GPR55 GPR55 Human Lysophosphatidylinositol None 4 Small molecule 5.5 6.4 7.3 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT2B 5-HT2B Human 5-Hydroxytryptamine Principal 1 Small molecule 7.9 8.2 8.4 Refs
A (Rhodopsin) Galanin GALR3 GAL3 Rat Galanin-Like Peptide 2 Peptide Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR5 LPA5 Human Lpa None 3 Small molecule 4.3 6.1 7.9 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Rat Vip 3 Peptide 6.0 7.0 8.7 6.0 6.9 8.4 Refs
A (Rhodopsin) Tachykinin NK1R NK1 Human Neuropeptide-Γ None 4 Peptide Refs
A (Rhodopsin) Adren ADA2B α2B-adren Human (-)-Adrenaline None 2 Small molecule 5.2 5.2 Refs
A (Rhodopsin) Peptide P518 QRFPR QRFP Human Qrfp26 (26rfa) 2 Peptide 8.1 8.1 Refs
A (Rhodopsin) Leukotriene CLTR1 CysLT1 Human Lte4 None 3 Small molecule 6.4 6.7 7.2 7.1 7.5 7.8 Refs
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Vip 1 Peptide 7.9 9.0 10.0 8.5 9.2 9.8 Refs
A (Rhodopsin) Galanin GALR1 GAL1 Rat Galanin 1 Peptide 9.8 9.8 9.3 9.8 10.3 Refs
A (Rhodopsin) Class A orphan LGR6 LGR6 Human R-Spondin-1 Peptide Refs
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Rat Pacap-27 2 Peptide 7.6 8.6 9.9 8.9 8.9 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Rat Pge2 None 2 Small molecule 7.5 7.9 8.3 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl7 4 Peptide Refs
A (Rhodopsin) Free fatty acid FFAR2 FFA2 Human Butyric Acid None 4 Small molecule 2.9 3.8 4.6 Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Mouse Srif-28 2 Peptide 8.4 9.3 10.2 Refs
A (Rhodopsin) Vasopressin and oxytocin V1AR V1A Human Vasopressin 1 Peptide 8.5 8.9 9.3 Refs
A (Rhodopsin) Prolactin-releasing peptide PRLHR PrRP Human Prrp-20 1 Peptide 9.0 9.3 9.6 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Human Vip 3 Peptide 6.0 7.0 8.7 6.0 6.9 8.4 Refs
A (Rhodopsin) Relaxin family peptide RL3R1 RXFP3 Human Insl5 3 Peptide 7.0 7.0 Refs
B1 (Secretin) Glucagon receptor family GIPR GIP Human Gastric Inhibitory Polypeptide Principal 1 Peptide 9.1 9.1 Refs
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Rat Vip 1 Peptide 7.9 9.0 10.0 8.5 9.2 9.8 Refs
A (Rhodopsin) Galanin GALR1 GAL1 Human Galanin 2 Peptide 9.1 9.8 10.5 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR5 S1P5 Rat Sphingosine 1-Phosphate None 1 Small molecule 7.4 8.2 8.9 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR4 S1P4 Human Dihydrosphingosine 1-Phosphate None 2 Small molecule
A (Rhodopsin) Vasopressin and oxytocin V1BR V1B Rat Vasopressin 1 Peptide 9.0 9.3 9.5 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR3 S1P3 Mouse Sphingosine 1-Phosphate None 1 Small molecule 8.4 8.6 8.6 Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Human Thromboxane A2 6 Small molecule
C (Glutamate) Metabotropic glutamate GRM4 mGlu4 Rat L-Serine-O-Phosphate None 1 Small molecule 5.9 5.9 Refs
A (Rhodopsin) Chemokine CCR10 CCR10 Human Ccl28 Peptide
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl7 8 Peptide
B1 (Secretin) Glucagon receptor family GIPR GIP Human Gastric Inhibitory Polypeptide Principal 1 Peptide
A (Rhodopsin) Histamine HRH3 H3 Mouse Histamine Principal 1 Small molecule 7.1 7.5 7.8 Refs
A (Rhodopsin) Orexin OX2R OX2 Human Orexin-A 1 Peptide 6.5 8.3 10.0 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Mouse Pge2 None 1 Small molecule 7.3 7.7 7.7 Refs
A (Rhodopsin) Chemokine XCR1 XCR1 Human Xcl1 1 Peptide 7.3 7.3 Refs
A (Rhodopsin) Galanin GALR1 GAL1 Mouse Galanin 1 Peptide 9.8 9.8 9.3 9.8 10.3 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Mouse Peptide Yy 5 Peptide 6.3 7.0 8.5 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1B 5-HT1B Human 5-Hydroxytryptamine None 1 Small molecule 7.4 8.1 8.1 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT7R 5-HT7 Rat 5-Hydroxytryptamine Principal 1 Small molecule 8.1 8.9 9.6 Refs
A (Rhodopsin) P2Y P2RY2 P2Y2 Human Utp None 1 Small molecule 8.1 8.1 Refs
A (Rhodopsin) Galanin GALR3 GAL3 Human Galanin 2 Peptide 8.1 8.5 8.8 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR2 LPA2 Human Farnesyl Diphosphate None 2 Small molecule Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR4 LPA4 Mouse Lpa None 1 Small molecule Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Human Srif-28 2 Peptide 8.4 9.3 10.2 Refs
A (Rhodopsin) Opioid OPRM μ Human Dynorphin A-(1-8) 3 Peptide 8.4 8.4 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Pacap-27 2 Peptide 7.6 8.5 9.4 Refs
A (Rhodopsin) Orexin OX1R OX1 Human Orexin-A 1 Peptide 6.5 8.4 10.2 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT4R 5-HT4 Mouse 5-Hydroxytryptamine Principal 1 Small molecule 6.7 7.5 8.2 Refs
A (Rhodopsin) Vasopressin and oxytocin V2R V2 Human Vasopressin 1 Peptide 7.9 8.5 9.1 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR1 CRF1 Human Corticotrophin-Releasing Hormone 2 Peptide Refs
A (Rhodopsin) Adren ADA2C α2C-adren Human (-)-Adrenaline None 2 Small molecule 5.8 5.8 Refs
A (Rhodopsin) Vasopressin and oxytocin V1AR V1A Rat Oxytocin 2 Peptide 6.9 6.1 6.1 Refs
A (Rhodopsin) Vasopressin and oxytocin V1BR V1B Human Vasopressin 1 Peptide 9.0 9.3 9.5 Refs
C (Glutamate) Metabotropic glutamate GRM3 mGlu3 Human L-Glutamic Acid None 1 Small molecule 5.3 5.4 5.4 6.4 6.4 Refs
A (Rhodopsin) Adren ADA1D α1D-adren Human (-)-Adrenaline None 1 Small molecule 7.2 7.2 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Rat Pgf2Α None 3 Small molecule 6.1 6.1 9.1 9.3 9.5 Refs
A (Rhodopsin) Chemokine CXCR6 CXCR6 Human Cxcl16 Principal 1 Peptide
A (Rhodopsin) 5-Hydroxytryptamine 5HT5A 5-HT5A Rat 5-Hydroxytryptamine Principal 1 Small molecule 6.0 6.3 6.6 Refs
A (Rhodopsin) Free fatty acid FFAR4 FFA4 Human Linoleic Acid None 1 Small molecule 5.9 5.9 Refs
A (Rhodopsin) Tachykinin NK1R NK1 Human Neurokinin A 2 Peptide 6.2 7.8 9.3 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Mouse Tyramine None 2 Small molecule 6.9 7.1 7.2 6.4 6.4 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Rat Pge2 None 1 Small molecule 7.3 7.7 7.7 Refs
A (Rhodopsin) Somatostatin SSR1 SST1 Human Srif-14 2 Peptide 8.6 9.1 9.5 Refs
A (Rhodopsin) Free fatty acid FFAR2 FFA2 Human Acetic Acid None 2 Small molecule 3.1 3.9 4.6 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR4 S1P4 Human Sphingosine 1-Phosphate None 1 Small molecule 7.2 7.1 7.1 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Human Pge2 None 1 Small molecule 7.3 7.7 7.7 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT4R 5-HT4 Human 5-Hydroxytryptamine Principal 1 Small molecule 6.7 7.5 8.2 Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Human Cst-17 2 Peptide 8.5 9.4 10.2 Refs
A (Rhodopsin) Class A orphan GPR34 GPR34 Human Lysophosphatidylserine Principal 1 Small molecule 6.6 7.3 7.3 Refs
A (Rhodopsin) Dopamine DRD1 D1 Human Noradrenaline None 3 Small molecule 4.3 4.3 Refs
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl14 Peptide
B1 (Secretin) VIP and PACAP PACR PAC1 Human Pacap-27 1 Peptide 10.0 10.1 10.1 8.5 8.7 8.8 Refs
A (Rhodopsin) Prostanoid PD2R DP1 Human Thromboxane A2 6 Small molecule
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl8 3 Peptide Refs
A (Rhodopsin) Chemokine CXCR1 CXCR1 Human Cxcl8 1 Peptide 8.8 9.2 9.5 Refs
A (Rhodopsin) Prostanoid PF2R FP Mouse Pgf2Α None 1 Small molecule 7.9 8.2 8.5 Refs
A (Rhodopsin) Galanin GALR2 GAL2 Human Spexin-1 3 Peptide 6.8 6.8 Refs
A (Rhodopsin) Opioid OPRK κ Human Dynorphin A-(1-8) 6 Peptide 8.0 9.0 9.9 Refs
A (Rhodopsin) Histamine HRH3 H3 Rat Histamine Principal 1 Small molecule 7.1 7.5 7.8 Refs
A (Rhodopsin) Free fatty acid FFAR4 FFA4 Human Α-Linolenic Acid None 3 Small molecule 5.1 5.1 Refs
A (Rhodopsin) P2Y P2RY4 P2Y4 Rat Atp None 2 Small molecule 5.7 5.4 5.4 Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Mouse Bradykinin 5 Peptide 5.1 5.2 5.3 Refs
B1 (Secretin) Calcitonin CALCR CT Human Calcitonin (Salmon) None 2 Peptide 7.6 9.4 11.1 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Mouse Corticotrophin-Releasing Hormone 1 Peptide 7.8 7.8 Refs
A (Rhodopsin) Chemokine CXCR6 CXCR6 Human Cxcl16 Principal 1 Peptide Refs
B1 (Secretin) Glucagon receptor family GLP2R GLP-2 Human Glucagon-Like Peptide 2 4 Peptide Refs
A (Rhodopsin) P2Y P2RY4 P2Y4 Human Utp None 1 Small molecule 5.6 5.6 Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Human Udp-Glucose None 1 Small molecule 7.6 7.6 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Rfrp-3 2 Peptide 7.8 7.8 Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl1 2 Peptide 8.4 9.1 9.7 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Rat Pgd2 None 2 Small molecule 8.8 8.8 8.7 8.9 9.0 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Rat Pacap-27 1 Peptide 10.0 10.1 10.1 8.5 8.7 8.8 Refs
A (Rhodopsin) Relaxin family peptide RL3R2 RXFP4 Human Insl5 3 Peptide 7.0 7.7 8.9 7.3 8.1 8.8 Refs
A (Rhodopsin) Gonadotrophin-releasing hormone GNRHR GnRH1 Rat Gnrh I 1 Peptide 7.8 10.0 10.0 7.3 8.0 8.4 Refs
A (Rhodopsin) Prostanoid PF2R FP Human Pgf2Α None 1 Small molecule 7.9 8.2 8.5 Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl3 3 Peptide Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Mouse Udp N-Acetyl-Glucosamine None 4 Small molecule 6.8 6.8 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Secretin 4 Peptide
C (Glutamate) Calcium-sensing CASR CaS Mouse Ca2+ None 2 Small molecule Refs
C (Glutamate) Calcium-sensing CASR CaS Human L-Tryptophan None 1 Small molecule Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Rat Peptide Yy 5 Peptide 6.3 7.0 8.5 Refs
A (Rhodopsin) Relaxin family peptide RL3R1 RXFP3 Human Relaxin 2 Peptide 7.1 7.8 8.4 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1D 5-HT1D Human 5-Hydroxytryptamine None 1 Small molecule 8.0 8.5 9.0 Refs
A (Rhodopsin) Galanin GALR3 GAL3 Human Spexin-1 1 Peptide 6.2 6.2 Refs
A (Rhodopsin) Melanocortin MC5R MC5 Human Agouti-Related Protein 2 Peptide Refs
A (Rhodopsin) Opioid OPRK κ Human Β-Endorphin 9 Peptide
A (Rhodopsin) Complement peptide C5AR1 C5a1 Human C3a 2 Peptide
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide W-23 5 Peptide
A (Rhodopsin) Somatostatin SSR1 SST1 Human Srif-28 3 Peptide 8.6 9.0 9.4 Refs
A (Rhodopsin) Bombesin NMBR BB1 Human Neuromedin B 1 Peptide 8.1 9.2 10.3 Refs
A (Rhodopsin) Ghrelin GHSR ghrelin Human Ghrelin 1 Peptide 7.2 8.1 9.5 7.8 8.0 8.1 Refs
A (Rhodopsin) Melanocortin MC4R MC4 Human Γ-Msh 3 Peptide
A (Rhodopsin) Urotensin UR2R UT Human Urotensin Ii-Related Peptide 4 Peptide Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Cck-33 2 Peptide Refs
C (Glutamate) Metabotropic glutamate GRM6 mGlu6 Human L-Glutamic Acid None 2 Small molecule 4.8 5.0 5.2 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl24 5 Peptide Refs
A (Rhodopsin) Bombesin GRPR BB2 Human Grp-(18-27) 3 Peptide
B1 (Secretin) Glucagon receptor family GLR glucagon Human Glucagon Principal 1 Peptide 9.0 9.0 Refs
A (Rhodopsin) Prostanoid PD2R DP1 Rat Pgd2 None 2 Small molecule 7.8 8.5 9.2 Refs
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Cck-33 2 Peptide
A (Rhodopsin) Relaxin family peptide RXFP1 RXFP1 Human Relaxin-3 3 Peptide 7.5 7.8 8.0 Refs
A (Rhodopsin) Complement peptide C5AR2 C5a2 Human C5a Des-Arg 2 Peptide 8.6 8.6 Refs
A (Rhodopsin) Adren ADRB1 β1-adren Human (-)-Adrenaline None 3 Small molecule 5.4 5.7 6.0 Refs
A (Rhodopsin) Formylpeptide FPR3 FPR3 Human F2l 4 Peptide
A (Rhodopsin) Opioid OPRK κ Mouse Dynorphin A 1 Peptide 10.0 10.2 10.3 Refs
A (Rhodopsin) Melanin-concentrating hormon MCHR1 MCH1 Rat Melanin-Concentrating Hormone Principal 1 Peptide 9.8 9.9 10.0 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Rat Pacap-38 2 Peptide 7.5 8.9 10.3 6.9 8.2 9.0 Refs
A (Rhodopsin) Melatonin MTR1A MT1 Human Melatonin Principal 1 Small molecule 9.1 9.4 9.7 Refs
A (Rhodopsin) Vasopressin and oxytocin V1AR V1A Rat Vasopressin 1 Peptide 8.5 8.9 9.3 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Neuropeptide Af 3 Peptide
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW2 NPBW2 Human Neuropeptide B-29 3 Peptide Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Rat Pge2 None 1 Small molecule 9.4 9.4 9.1 9.1 Refs
A (Rhodopsin) Bombesin GRPR BB2 Human Gastrin-Releasing Peptide 1 Peptide 6.3 7.3 8.2 Refs
B1 (Secretin) Glucagon receptor family GIPR GIP Rat Gastric Inhibitory Polypeptide Principal 1 Peptide Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Human Pge2 None 2 Small molecule 7.5 7.9 8.3 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Human Pgf2Α None 2 Small molecule 8.4 8.4 7.4 7.4 Refs
A (Rhodopsin) Dopamine DRD1 D1 Human 5-Hydroxytryptamine None 1 Small molecule 5.0 5.0 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Human Pgf2Α None 3 Small molecule 6.2 5.9 5.9 Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Human Phi 4 Peptide
A (Rhodopsin) Chemokine CCR3 CCR3 Human Cxcl9 5 Peptide
A (Rhodopsin) Class A orphan GPR17 GPR17 Mouse Lte4 None 1 Small molecule 9.5 9.5 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Human Β-Phenylethylamine None 3 Small molecule 6.2 6.6 7.0 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR2 LPA2 Human Farnesyl Monophosphate None 2 Small molecule Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Human Srif-14 3 Peptide 8.4 9.2 9.9 Refs
A (Rhodopsin) Tachykinin NK2R NK2 Human Substance P 2 Peptide 5.9 6.4 6.9 Refs
A (Rhodopsin) Histamine HRH4 H4 Human Histamine None 1 Small molecule 7.8 7.2 7.2 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Vip 3 Peptide 7.3 8.3 9.3 7.8 8.4 8.8 Refs
A (Rhodopsin) Leukotriene CLTR2 CysLT2 Human Ltd4 None 2 Small molecule 6.8 7.6 8.6 7.3 7.7 8.1 Refs
A (Rhodopsin) Vasopressin and oxytocin V1AR V1A Human Oxytocin 2 Peptide 6.9 6.1 6.1 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Mouse Srif-14 1 Peptide 8.7 9.4 10.0 Refs
A (Rhodopsin) Bile acid GPBAR GPBA Human Deoxycholic Acid None 2 Small molecule 6.2 6.2 Refs
A (Rhodopsin) Galanin GALR3 GAL3 Human Galanin-Like Peptide 2 Peptide
A (Rhodopsin) Histamine HRH3 H3 Human Histamine Principal 1 Small molecule 7.1 7.5 7.8 Refs
A (Rhodopsin) Adren ADA1A α1A-adren Human (-)-Adrenaline None 1 Small molecule 6.3 6.4 6.5 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR3 S1P3 Human Sphingosine 1-Phosphate None 1 Small molecule 8.4 8.6 8.6 Refs
A (Rhodopsin) Chemokine ACKR1 ACKR1 Human Cxcl6 Peptide
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM2 M2 Human Acetylcholine Principal 1 Small molecule 4.3 5.4 6.5 Refs
B1 (Secretin) Calcitonin CALCR CT Human Adrenomedullin 5 Peptide 6.7 7.2 7.7 Refs
C (Glutamate) Metabotropic glutamate GRM4 mGlu4 Human L-Serine-O-Phosphate None 1 Small molecule 5.9 5.9 Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl3 3 Peptide
A (Rhodopsin) Lysophospholipid (LPA) LPAR5 LPA5 Human N-Arachidonoylglycine None 4 Small molecule 4.3 4.3 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT5A 5-HT5A Human 5-Hydroxytryptamine Principal 1 Small molecule 6.0 6.3 6.6 Refs
A (Rhodopsin) Motilin MTLR motilin Human Motilin Principal 1 Peptide 8.4 8.6 8.7 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl2 8 Peptide
A (Rhodopsin) Opioid OPRK κ Rat Β-Neoendorphin 4 Peptide 9.1 9.1 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Mouse Β-Phenylethylamine None 3 Small molecule 6.2 6.6 7.0 Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Des-Br-Neuropeptide B-29 3 Peptide Refs
A (Rhodopsin) Gonadotrophin-releasing hormone GNRHR GnRH1 Mouse Gnrh I 1 Peptide 7.8 10.0 10.0 7.3 8.0 8.4 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT7R 5-HT7 Mouse 5-Hydroxytryptamine Principal 1 Small molecule 8.1 8.9 9.6 Refs
A (Rhodopsin) Tachykinin NK1R NK1 Human Substance P 1 Peptide 8.5 9.4 10.3 Refs
A (Rhodopsin) Melanin-concentrating hormon MCHR1 MCH1 Human Melanin-Concentrating Hormone Principal 1 Peptide 9.8 9.9 10.0 Refs
A (Rhodopsin) Leukotriene LT4R1 BLT1 Human 12r-Hete None 3 Small molecule 7.5 7.5 Refs
A (Rhodopsin) Urotensin UR2R UT Rat Urotensin-Ii 1 Peptide 8.8 8.8 Refs
A (Rhodopsin) Chemokine CCR7 CCR7 Human Ccl21 2 Peptide Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Human Srif-28 1 Peptide 9.8 9.9 9.9 Refs
A (Rhodopsin) Prostanoid PF2R FP Human Pgd2 None 2 Small molecule 7.7 7.7 Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl13 7 Peptide
A (Rhodopsin) Melanocortin MC5R MC5 Human Β-Msh 2 Peptide
A (Rhodopsin) Adren ADA1D α1D-adren Rat (-)-Adrenaline None 1 Small molecule 7.2 7.2 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Rfrp-3 1 Peptide 9.2 9.3 9.3 Refs
A (Rhodopsin) Somatostatin SSR4 SST4 Human Srif-28 3 Peptide 8.1 8.7 9.2 Refs
A (Rhodopsin) Vasopressin and oxytocin V1BR V1B Human Oxytocin 2 Peptide 5.7 6.4 7.0 Refs
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Pacap-27 2 Peptide 7.6 8.6 9.9 8.9 8.9 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Rat Srif-14 1 Peptide 8.7 9.4 10.0 Refs
A (Rhodopsin) Chemokine ACKR1 ACKR1 Human Ccl14 Peptide
A (Rhodopsin) Prostanoid PE2R2 EP2 Mouse Pge2 None 2 Small molecule 7.5 7.9 8.3 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Rat Corticotrophin-Releasing Hormone 1 Peptide 7.8 7.8 Refs
A (Rhodopsin) Opioid OPRK κ Mouse Dynorphin A-(1-8) 6 Peptide 8.0 9.0 9.9 Refs
A (Rhodopsin) Bombesin GRPR BB2 Mouse Neuromedin B 2 Peptide 6.4 6.6 6.6 Refs
B2 (Adhesion) ADGRL AGRL1 ADGRL1 Human Lasso D Principal 1 Peptide
A (Rhodopsin) Prostanoid PD2R DP1 Human Pgj2 None 1 Small molecule 9.0 9.0 Refs
A (Rhodopsin) Leukotriene OXER1 OXE Human 5-Oxo-Ete None 1 Small molecule 8.3 8.4 8.5 Refs
A (Rhodopsin) Opioid OPRK κ Rat [Leu]Enkephalin 8 Peptide 6.0 6.0 Refs
A (Rhodopsin) Oxoglutarate OXGR1 xoglutarate Human Α-Ketoglutaric Acid Principal 1 Small molecule 3.3 3.9 4.5 Refs
A (Rhodopsin) Prostanoid PD2R DP1 Human Pgf2Α None 5 Small molecule 6.1 6.3 6.4 Refs
A (Rhodopsin) Histamine HRH4 H4 Rat Histamine None 1 Small molecule 7.8 7.2 7.2 Refs
A (Rhodopsin) Tachykinin NK3R NK3 Mouse Substance P 3 Peptide 5.0 5.5 6.0 Refs
A (Rhodopsin) Apelin APJ apelin Human Elabela/Toddler-21 2 Peptide
A (Rhodopsin) Opioid OPRM μ Human Endomorphin-1 4 Peptide 8.3 8.3 Refs
A (Rhodopsin) Class A orphan GPR87 GPR87 Human Lpa Principal 1 Small molecule 7.4 7.4 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT2C 5-HT2C Rat 5-Hydroxytryptamine Principal 1 Small molecule 6.8 7.7 8.6 Refs
A (Rhodopsin) Galanin GALR3 GAL3 Human Galanin-Like Peptide 2 Peptide Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl6 3 Peptide Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR5 LPA5 Human Farnesyl Diphosphate None 2 Small molecule 5.8 6.2 6.5 Refs
A (Rhodopsin) Chemokine CXCR5 CXCR5 Human Cxcl13 Principal 1 Peptide Refs
A (Rhodopsin) Adenosine AA2BR A2B Rat Adenosine Principal 1 Small molecule 5.3 5.3 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Rat Β-Phenylethylamine None 3 Small molecule 6.2 6.6 7.0 Refs
A (Rhodopsin) Kisspeptin KISSR kisspeptin Human Kisspeptin-14 3 Peptide 8.8 8.8 Refs
A (Rhodopsin) Adren ADA1D α1D-adren Human (-)-Noradrenaline None 2 Small molecule 6.3 6.3 Refs
F (Frizzled) Frizzled FZD1 FZD1 Human Wnt-2 Peptide
A (Rhodopsin) Leukotriene LT4R2 BLT2 Human 12-Hydroxyheptadecatrienoic Acid None 1 Small molecule 7.7 7.7 Refs
A (Rhodopsin) Prostanoid TA2R TP Human Pgf2Α None 1 Small molecule 5.1 5.1 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Rat Phv 4 Peptide Refs
A (Rhodopsin) P2Y P2RY6 P2Y6 Human Adp None 3 Small molecule 4.5 4.5 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Rat Pge1 None 1 Small molecule 8.0 8.0 Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Mouse Srif-14 3 Peptide 8.4 9.2 9.9 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Human Pgf2Α None 3 Small molecule 5.2 5.6 6.0 Refs
A (Rhodopsin) Vasopressin and oxytocin OXYR OT Rat Oxytocin 1 Peptide 8.2 8.9 9.6 Refs
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM4 M4 Human Acetylcholine Principal 1 Small molecule 4.5 5.1 5.6 Refs
B1 (Secretin) Calcitonin CALCR CT Human Β-Cgrp 7 Peptide
A (Rhodopsin) 5-Hydroxytryptamine 5HT7R 5-HT7 Human 5-Hydroxytryptamine Principal 1 Small molecule 8.1 8.9 9.6 Refs
A (Rhodopsin) Free fatty acid FFAR2 FFA2 Human Propanoic Acid None 1 Small molecule 3.0 4.0 4.9 Refs
A (Rhodopsin) Glycoprotein hormone LSHR LH Human Hcg 1 Peptide Refs
A (Rhodopsin) Neuromedin U NMUR1 NMU1 Human Neuromedin S-33 1 Peptide 10.2 10.2 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl11 6 Peptide Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Mouse Urocortin 2 2 Peptide Refs
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Annexin I 9 Peptide
A (Rhodopsin) Prostanoid PE2R2 EP2 Mouse Pge1 None 1 Small molecule 8.0 8.0 Refs
A (Rhodopsin) Relaxin family peptide RL3R2 RXFP4 Mouse Insl5 2 Peptide 7.8 8.6 9.4 8.5 8.7 8.8 Refs
A (Rhodopsin) Neuromedin U NMUR2 NMU2 Human Neuromedin S-36 3 Peptide
A (Rhodopsin) Neurotensin NTR2 NTS2 Human Neurotensin 1 Peptide 8.8 8.8 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl13 5 Peptide Refs
A (Rhodopsin) Gonadotrophin-releasing hormone GNRHR GnRH1 Human Gnrh I 1 Peptide 7.8 10.0 10.0 7.3 8.0 8.4 Refs
A (Rhodopsin) Prokineticin PKR1 PKR1 Human Prokineticin-2 1 Peptide Refs
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Cck-58 2 Peptide
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Ccl19 8 Peptide 5.9 5.9 Refs
A (Rhodopsin) Hydroxycarboxylic acid HCAR1 HCA1 Mouse L-Lactic Acid Principal 1 Small molecule 1.3 2.1 2.9 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR2 S1P2 Mouse Sphingosine 1-Phosphate None 1 Small molecule 8.1 8.7 8.7 Refs
A (Rhodopsin) Neuropeptide Y NPY5R Y5 Human Peptide Yy 2 Peptide 9.0 9.0 Refs
A (Rhodopsin) Melanocortin MSHR MC1 Human Β-Msh 2 Peptide
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl28 5 Peptide
A (Rhodopsin) Prostanoid PD2R DP1 Human Pge2 None 4 Small molecule 6.5 6.8 7.0 Refs
A (Rhodopsin) Adren ADRB1 β1-adren Human (-)-Noradrenaline None 2 Small molecule 5.5 5.8 6.0 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Rat Pgd2 None 4 Small molecule 5.2 5.2 Refs
A (Rhodopsin) Relaxin family peptide RL3R1 RXFP3 Human Relaxin-3 1 Peptide 8.3 9.1 9.9 7.8 8.4 8.9 Refs
A (Rhodopsin) Free fatty acid FFAR1 FFA1 Human Α-Linolenic Acid None 2 Small molecule 4.6 5.2 5.7 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Human Pge2 None 3 Small molecule 6.1 6.1 8.5 8.6 8.7 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR1 S1P1 Human Sphingosine 1-Phosphate None 1 Small molecule 7.1 8.7 9.5 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1F 5-HT1F Rat 5-Hydroxytryptamine Principal 1 Small molecule 7.7 7.9 8.0 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Mouse Pgf2Α None 2 Small molecule 8.4 8.4 7.4 7.4 Refs
A (Rhodopsin) Proteinase-activated PAR1 PAR1 Human Thrombin Principal 1 Peptide
A (Rhodopsin) Hydroxycarboxylic acid HCAR1 HCA1 Human L-Lactic Acid Principal 1 Small molecule 1.3 2.1 2.9 Refs
A (Rhodopsin) Opioid OPRD δ Human Endomorphin-1 6 Peptide 6.1 6.1 Refs
A (Rhodopsin) Melanocortin MC5R MC5 Human Acth 2 Peptide
A (Rhodopsin) Adren ADRB3 β3-adren Rat (-)-Noradrenaline None 2 Small molecule 4.7 4.2 4.2 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT5A 5-HT5A Mouse 5-Hydroxytryptamine Principal 1 Small molecule 6.0 6.3 6.6 Refs
A (Rhodopsin) Glycoprotein hormone FSHR FSH Human Fsh Principal 1 Peptide
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Gastrin-17 2 Peptide
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl11 8 Peptide
A (Rhodopsin) Adren ADRB3 β3-adren Human (&Plusmn;)-Adrenaline None 1 Small molecule 3.9 5.3 5.3 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Rat Srif-28 3 Peptide 8.1 9.0 9.9 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Mouse Pge1 None 2 Small molecule 7.0 7.0 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Pacap-38 1 Peptide 7.7 8.5 9.3 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Mouse Urocortin 1 2 Peptide Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Human Srif-28 3 Peptide 8.1 9.0 9.9 Refs
A (Rhodopsin) Kisspeptin KISSR kisspeptin Human Kisspeptin-10 5 Peptide
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Prrp-31 3 Peptide
A (Rhodopsin) Class A orphan GPR17 GPR17 Human Udp-Glucose None 6 Small molecule 7.1 7.2 7.3 Refs
A (Rhodopsin) Opioid OPRD δ Human Dynorphin A-(1-8) 2 Peptide 8.4 8.4 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Mouse Pge2 None 3 Small molecule 6.1 6.1 8.5 8.6 8.7 Refs
A (Rhodopsin) Opioid OPRK κ Human Β-Endorphin 7 Peptide 6.3 7.1 7.9 Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Human Cortistatin-14 2 Peptide
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide W-30 5 Peptide
A (Rhodopsin) Prostanoid PE2R3 EP3 Human Pgi2 4 Small molecule
A (Rhodopsin) Free fatty acid FFAR1 FFA1 Human Oleic Acid None 3 Small molecule 3.9 4.8 5.7 Refs
A (Rhodopsin) Hydroxycarboxylic acid HCAR2 HCA2 Human Β-D-Hydroxybutyric Acid None 1 Small molecule 3.5 3.5 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Mouse Srif-28 3 Peptide 8.1 9.0 9.9 Refs
A (Rhodopsin) Adren ADA2B α2B-adren Human (-)-Noradrenaline None 1 Small molecule 5.4 5.7 6.0 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Cxcl10 5 Peptide
A (Rhodopsin) Class A orphan GPR17 GPR17 Mouse Udp-Galactose None 5 Small molecule 6.0 7.2 7.2 Refs
A (Rhodopsin) Chemerin CML1 hemerin Human Epa 2 Small molecule
A (Rhodopsin) Glycoprotein hormone FSHR FSH Human Fsh Principal 1 Peptide
A (Rhodopsin) Prostanoid PE2R4 EP4 Human Pge1 None 1 Small molecule 9.5 9.5 8.7 8.7 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Ghrh 4 Peptide
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl5 2 Peptide 8.5 8.9 9.3 Refs
A (Rhodopsin) Somatostatin SSR4 SST4 Human Cst-17 1 Peptide 8.5 9.1 9.6 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT6R 5-HT6 Rat 5-Hydroxytryptamine Principal 1 Small molecule 6.8 7.2 7.5 Refs
A (Rhodopsin) Opioid OPRK κ Human Α-Neoendorphin 3 Peptide 8.9 9.5 10.0 Refs
A (Rhodopsin) Neuropeptide Y NPY2R Y2 Human Neuropeptide Y-(3-36) 5 Peptide
A (Rhodopsin) Orexin OX1R OX1 Human Orexin-B 3 Peptide
A (Rhodopsin) Class A orphan GPR35 GPR35 Mouse Kynurenic Acid None 2 Small molecule 3.9 5.0 5.0 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Human Tyramine None 2 Small molecule 6.9 7.1 7.2 6.4 6.4 Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Rat Udp N-Acetyl-Glucosamine None 4 Small molecule 6.8 6.8 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl5 2 Peptide 9.2 9.5 9.7 Refs
A (Rhodopsin) Apelin APJ apelin Human Elabela/Toddler-11 2 Peptide
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Human Tip39 2 Peptide Refs
A (Rhodopsin) Prolactin-releasing peptide PRLHR PrRP Human Prrp-31 2 Peptide 9.0 9.1 9.2 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Human Urocortin 2 2 Peptide Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Rat Srif-28 2 Peptide 8.4 9.3 10.2 Refs
C (Glutamate) Metabotropic glutamate GRM8 mGlu8 Human L-Serine-O-Phosphate None 2 Small molecule Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Human Thromboxane A2 4 Small molecule
A (Rhodopsin) Melanocortin MC3R MC3 Human Β-Msh 3 Peptide
A (Rhodopsin) Formylpeptide FPR1 FPR1 Human Spinorphin None 2 Peptide Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Human Pge2 None 1 Small molecule 9.4 9.4 9.1 9.1 Refs
A (Rhodopsin) Vasopressin and oxytocin OXYR OT Human Oxytocin 1 Peptide 8.2 8.9 9.6 Refs
C (Glutamate) Metabotropic glutamate GRM4 mGlu4 Human L-Glutamic Acid None 2 Small molecule 4.7 5.1 5.5 4.9 5.2 5.5 Refs
A (Rhodopsin) Neuromedin U NMUR1 NMU1 Human Neuromedin U-25 2 Peptide 8.4 8.9 9.4 9.5 9.5 Refs
A (Rhodopsin) Adren ADRB2 β2-adren Human (-)-Noradrenaline None 3 Small molecule 4.6 4.7 4.8 Refs
A (Rhodopsin) Somatostatin SSR2 SST2 Mouse Srif-14 1 Peptide 9.0 9.1 9.1 8.9 9.7 10.5 Refs
A (Rhodopsin) P2Y P2Y12 P2Y12 Human Atp 2 Small molecule
B1 (Secretin) Parathyroid hormone PTH1R PTH1 Human Pth 3 Peptide
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Rat Vip 3 Peptide 7.3 8.3 9.3 7.8 8.4 8.8 Refs
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Ccl7 6 Peptide 6.6 6.6 Refs
A (Rhodopsin) Chemokine CCR7 CCR7 Mouse Ccl19 2 Peptide Refs
A (Rhodopsin) Class A orphan Q33BM1 GPR35 Rat Kynurenic Acid None 2 Small molecule 3.9 5.0 5.0 Refs
A (Rhodopsin) Opioid OPRD δ Human [Met]Enkephalin 7 Peptide Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW2 NPBW2 Human Neuropeptide B-29 5 Peptide
A (Rhodopsin) Angiotensin AGTR2 AT2 Human Angiotensin-(1-7) 3 Peptide Refs
A (Rhodopsin) Neuropeptide Y NPY1R Y1 Rat Peptide Yy 2 Peptide 10.2 10.2 Refs
A (Rhodopsin) Hydroxycarboxylic acid HCAR2 HCA2 Mouse Β-D-Hydroxybutyric Acid None 1 Small molecule 3.5 3.5 Refs
A (Rhodopsin) Leukotriene LT4R1 BLT1 Human Ltb4 None 1 Small molecule 9.4 9.4
A (Rhodopsin) Tachykinin NK3R NK3 Human Neurokinin B 1 Peptide 8.4 8.4 7.7 8.5 9.2 Refs
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Phi 4 Peptide
A (Rhodopsin) Prostanoid PD2R DP1 Human Pgd2 None 2 Small molecule 7.8 8.5 9.2 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Rat Pge1 None 1 Small molecule 9.4 9.4 9.0 9.0 Refs
A (Rhodopsin) Melanocortin MSHR MC1 Human Acth 1 Peptide 8.6 8.6 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Cxcl11 5 Peptide
A (Rhodopsin) Lysophospholipid (S1P) S1PR5 S1P5 Mouse Sphingosine 1-Phosphate None 1 Small molecule 7.4 8.2 8.9 Refs
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl13 Peptide
A (Rhodopsin) Bombesin GRPR BB2 Human Neuromedin B 2 Peptide 6.4 6.6 6.6 Refs
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM3 M3 Rat Acetylcholine Principal 1 Small molecule 4.5 5.0 5.4 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR3 LPA3 Mouse Lpa None 1 Small molecule 6.6 6.6 Refs
A (Rhodopsin) Adren ADA2A α2A-adren Human (-)-Adrenaline None 1 Small molecule 5.8 6.6 7.4 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Human Peptide Yy 5 Peptide 6.3 7.0 8.5 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Human Urocortin 1 2 Peptide Refs
B1 (Secretin) Calcitonin CALCR CT Human Α-Cgrp 4 Peptide 6.2 7.3 8.4 Refs
A (Rhodopsin) Chemokine CCRL2 CCRL2 Human Ccl19 2 Peptide
A (Rhodopsin) Prostanoid PE2R1 EP1 Mouse Pgf2Α None 3 Small molecule 6.2 5.9 5.9 Refs
A (Rhodopsin) Neuromedin U NMUR2 NMU2 Human Neuromedin U-25 2 Peptide 8.4 8.9 9.4 9.6 9.6 Refs
A (Rhodopsin) Somatostatin SSR4 SST4 Rat Srif-14 2 Peptide 8.4 8.9 9.3 Refs
A (Rhodopsin) Neurotensin NTR1 NTS1 Human Large Neuromedin N 3 Peptide
A (Rhodopsin) Prostanoid PE2R4 EP4 Mouse Pge1 None 1 Small molecule 9.5 9.5 8.7 8.7 Refs
A (Rhodopsin) Opioid OPRK κ Rat Dynorphin B 5 Peptide 8.1 9.0 9.9 Refs
A (Rhodopsin) Angiotensin AGTR2 AT2 Human Angiotensin Iii 1 Peptide Refs
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Ccl13 4 Peptide 7.2 7.2 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Neuropeptide Sf 3 Peptide
A (Rhodopsin) Prostanoid PF2R FP Human Pge2 None 3 Small molecule 6.4 6.7 6.9 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl11 8 Peptide
A (Rhodopsin) P2Y P2Y14 P2Y14 Human Udp N-Acetyl-Glucosamine None 4 Small molecule
A (Rhodopsin) Melanocortin ACTHR MC2 Human Acth Principal 1 Peptide Refs
A (Rhodopsin) Class A orphan GPR6 GPR6 Mouse Sphingosine 1-Phosphate Principal 1 Small molecule 7.3 7.5 7.7 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Neuropeptide Sf 3 Peptide
A (Rhodopsin) Neurotensin NTR1 NTS1 Rat Neurotensin 1 Peptide 8.2 9.1 10.0 Refs
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Cck-8 1 Peptide Refs
A (Rhodopsin) Complement peptide C3AR C3a Human C5a 2 Peptide
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Rat Cck-8 1 Peptide Refs
A (Rhodopsin) Prostanoid PI2R IP Human Pgi2 None 1 Small molecule 7.8 7.8 Refs
A (Rhodopsin) Opioid OPRK κ Human [Leu]Enkephalin 8 Peptide 6.0 6.0 Refs
A (Rhodopsin) GPR18, GPR55 and GPR119 GP119 GPR119 Human N-Palmitoylethanolamine None 2 Small molecule
A (Rhodopsin) Free fatty acid FFAR3 FFA3 Human Butyric Acid None 2 Small molecule 3.8 4.4 4.9 Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Rat Udp-Galactose None 1 Small molecule 7.6 7.6 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1A 5-HT1A Human 5-Hydroxytryptamine Principal 1 Small molecule 9.1 9.4 9.7 Refs
A (Rhodopsin) Angiotensin AGTR1 AT1 Human Angiotensin A 1 Peptide 8.2 8.2 8.8 8.8 Refs
B1 (Secretin) Glucagon receptor family GLP2R GLP-2 Human Glucagon-Like Peptide 2 4 Peptide
A (Rhodopsin) Neuropeptide Y NPY2R Y2 Human Pancreatic Polypeptide 5 Peptide
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Pacap-38 3 Peptide 7.4 8.6 9.7 8.2 8.2 Refs
A (Rhodopsin) Adren ADA1B α1B-adren Human (-)-Adrenaline None 1 Small molecule 6.5 6.5 Refs
A (Rhodopsin) Chemerin CML1 hemerin Human Resolvin E1 None 2 Small molecule Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Rat Pgf2Α None 3 Small molecule 6.2 5.9 5.9 Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Human Pgd2 None 2 Small molecule 7.6 8.1 8.6 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl14 7 Peptide 7.2 7.2 Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Mouse Srif-28 1 Peptide 9.8 9.9 9.9 Refs
A (Rhodopsin) Leukotriene OXER1 OXE Human 5-Oxo-15-Hete None 3 Small molecule 7.7 7.7 Refs
A (Rhodopsin) Dopamine DRD4 D4 Human Dopamine Principal 1 Small molecule 7.4 7.4 Refs
A (Rhodopsin) Neuropeptide Y NPY1R Y1 Rat Neuropeptide Y 1 Peptide 10.5 10.5 Refs
A (Rhodopsin) Cannabinoid CNR1 CB1 Human Anandamide None 2 Small molecule 6.3 6.7 7.0 Refs
A (Rhodopsin) Apelin APJ apelin Human Apelin-13 2 Peptide Refs
B1 (Secretin) Glucagon receptor family GLP1R GLP-1 Human Glucagon-Like Peptide 1-(7-37) 3 Peptide Refs
A (Rhodopsin) Chemokine CXCR4 CXCR4 Human Cxcl12Α 1 Peptide Refs
A (Rhodopsin) Dopamine DRD2 D2 Rat Dopamine Principal 1 Small molecule 5.3 5.9 6.4 Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Rat Srif-28 1 Peptide 9.8 9.9 9.9 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Rat Tyramine None 2 Small molecule 6.9 7.1 7.2 6.4 6.4 Refs
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Human Tip39 1 Peptide Refs
A (Rhodopsin) Adren ADA1A α1A-adren Human (-)-Noradrenaline None 2 Small molecule 5.8 6.1 6.4 Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl7 3 Peptide 8.1 8.1 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Rat 3-Iodothyronamine None 1 Small molecule 7.5 7.7 7.9 Refs
A (Rhodopsin) Apelin APJ apelin Human [Pyr1]Apelin-13 2 Peptide Refs
A (Rhodopsin) Chemerin CML1 hemerin Human Chemerin 1 Peptide 7.6 8.0 8.5 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT2B 5-HT2B Rat 5-Hydroxytryptamine Principal 1 Small molecule 7.9 8.2 8.4 Refs
A (Rhodopsin) GPR18, GPR55 and GPR119 GPR18 GPR18 Human N-Arachidonoylglycine Principal 1 Small molecule 7.3 7.5 7.7 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl8 3 Peptide 9.3 9.3 Refs
A (Rhodopsin) Free fatty acid FFAR3 FFA3 Human Propanoic Acid None 1 Small molecule 3.9 4.8 5.7 Refs
C (Glutamate) Metabotropic glutamate GRM2 mGlu2 Rat L-Glutamic Acid Principal 1 Small molecule 4.7 5.1 5.4 5.4 4.9 4.9 Refs
A (Rhodopsin) Chemokine CXCR6 CXCR6 Human Cxcl16 Principal 1 Peptide
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Neuropeptide Af 3 Peptide
B1 (Secretin) Calcitonin CALCR CT Human Α-Cgrp 7 Peptide
A (Rhodopsin) Opioid OPRK κ Human Dynorphin B 5 Peptide 8.1 9.0 9.9 Refs
A (Rhodopsin) Glycoprotein hormone TSHR TSH Human Tsh Principal 1 Peptide
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Lxa4 None 1 Small molecule 12.0 12.0 Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Rat Udp-Glucuronic Acid None 3 Small molecule 7.0 7.0 Refs
A (Rhodopsin) Neurotensin NTR1 NTS1 Human Neurotensin 1 Peptide 8.2 9.1 10.0 Refs
A (Rhodopsin) Chemokine CCR6 CCR6 Human Ccl20 1 Peptide Refs
C (Glutamate) Calcium-sensing CASR CaS Human Ca2+ None 2 Small molecule Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Rat Neuropeptide Y 4 Peptide 6.4 7.2 8.8 Refs
A (Rhodopsin) Complement peptide C5AR1 C5a1 Human C5a 1 Peptide 8.0 8.5 9.0 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT2A 5-HT2A Human 5-Hydroxytryptamine None 2 Small molecule 6.0 6.3 6.5 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR4 LPA4 Human Farnesyl Diphosphate None 2 Small molecule Refs
A (Rhodopsin) Opioid OPRM μ Human Β-Endorphin 6 Peptide
A (Rhodopsin) Somatostatin SSR2 SST2 Human Cst-17 2 Peptide 8.8 9.1 9.3 Refs
A (Rhodopsin) P2Y P2RY2 P2Y2 Human Atp None 2 Small molecule 6.6 6.9 7.1 Refs
A (Rhodopsin) Class A orphan LGR5 LGR5 Human R-Spondin-4 4 Peptide 9.4 9.4 Refs
A (Rhodopsin) Peptide P518 QRFPR QRFP Mouse Qrfp26 1 Peptide 8.2 8.2 Refs
A (Rhodopsin) Orexin OX1R OX1 Human Orexin-B 2 Peptide 5.8 7.5 9.2 Refs
A (Rhodopsin) Bradykinin BKRB2 B2 Human [Des-Arg9]Bradykinin 2 Peptide Refs
B1 (Secretin) Glucagon receptor family SCTR secretin Human Vip 2 Peptide Refs
A (Rhodopsin) Adren ADRB2 β2-adren Human (-)-Adrenaline None 1 Small molecule 6.0 6.1 6.2 Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl4 5 Peptide 7.1 7.5 7.8 Refs
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Rat Tip39 2 Peptide Refs
A (Rhodopsin) Chemokine ACKR1 ACKR1 Human Ccl5 Peptide
A (Rhodopsin) Histamine HRH4 H4 Mouse Histamine None 1 Small molecule 7.8 7.2 7.2 Refs
C (Glutamate) Class C Orphan GPC6A GPRC6 Human L-Ornithine None 2 Small molecule 4.0 4.0 Refs
A (Rhodopsin) Class A orphan GP183 GPR183 Human 7Α,25-Dihydroxycholesterol None 1 Small molecule 8.1 9.0 9.9 Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Human Pgj2 None 1 Small molecule 8.2 8.2 Refs
A (Rhodopsin) Vasopressin and oxytocin V2R V2 Human Oxytocin 2 Peptide 5.4 6.1 6.8 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Rat Urocortin 3 2 Peptide Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Human Neuropeptide Y 4 Peptide 6.4 7.2 8.8 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Rat Pgf2Α None 3 Small molecule 5.2 5.6 6.0 Refs
A (Rhodopsin) Melanin-concentrating hormon MCHR2 MCH2 Human Melanin-Concentrating Hormone Principal 1 Peptide Refs
A (Rhodopsin) Bile acid GPBAR GPBA Human Cholic Acid None 4 Small molecule 5.0 5.0 Refs
A (Rhodopsin) Kisspeptin KISSR kisspeptin Human Kisspeptin-52 5 Peptide
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Cck-4 4 Peptide Refs
A (Rhodopsin) Leukotriene OXER1 OXE Human 5s-Hpete None 4 Small molecule 7.0 7.0 Refs
A (Rhodopsin) Opioid OPRK κ Rat Α-Neoendorphin 3 Peptide 8.9 9.5 10.0 Refs
A (Rhodopsin) P2Y P2RY4 P2Y4 Rat Utp None 1 Small molecule 5.6 5.6 Refs
C (Glutamate) Metabotropic glutamate GRM2 mGlu2 Human L-Glutamic Acid Principal 1 Small molecule 4.7 5.1 5.4 5.4 4.9 4.9 Refs
C (Glutamate) Calcium-sensing CASR CaS Human Mg2+ None 3 Small molecule
A (Rhodopsin) Class A orphan GP183 GPR183 Human 7Β, 25-Dihydroxycholesterol None 3 Small molecule 8.7 8.7 Refs
A (Rhodopsin) Neuropeptide Y NPY1R Y1 Human Pancreatic Polypeptide 4 Peptide
A (Rhodopsin) Chemokine CCR7 CCR7 Human Ccl19 1 Peptide Refs
A (Rhodopsin) Opioid OPRD δ Human Dynorphin A-(1-13) 4 Peptide 7.8 7.8 Refs
B1 (Secretin) Glucagon receptor family SCTR secretin Rat Secretin 2 Peptide 8.0 8.5 9.0 Refs
A (Rhodopsin) Free fatty acid FFAR1 FFA1 Human Myristic Acid None 3 Small molecule 4.5 4.8 5.1 Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Rat Bradykinin 5 Peptide 5.1 5.2 5.3 Refs
A (Rhodopsin) P2Y P2Y11 P2Y11 Human Atp None 2 Small molecule 4.2 4.9 5.6 Refs
A (Rhodopsin) Angiotensin AGTR1 AT1 Human Angiotensin Iii 3 Peptide
A (Rhodopsin) Class A orphan MRGX1 MRGPRX1 Human Bovine Adrenal Medulla Peptide 8-22 Principal 1 Peptide 5.3 6.6 7.8 7.7 7.7 Refs
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Ltc4 9 Small molecule
A (Rhodopsin) Histamine HRH2 H2 Human Histamine Principal 1 Small molecule
A (Rhodopsin) Somatostatin SSR2 SST2 Human Srif-14 1 Peptide 9.0 9.1 9.1 8.9 9.7 10.5 Refs
A (Rhodopsin) Galanin GALR1 GAL1 Human Galanin-Like Peptide 2 Peptide Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Secretin 4 Peptide
A (Rhodopsin) Prostanoid PD2R2 DP2 Mouse Pgd2 None 2 Small molecule 7.6 8.1 8.6 Refs
F (Frizzled) Frizzled FZD6 FZD6 Human Wnt-3a Peptide Refs
A (Rhodopsin) Leukotriene LT4R2 BLT2 Human 12s-Hpete 4 Small molecule
A (Rhodopsin) Prostanoid PI2R IP Human Pge1 None 2 Small molecule 6.5 6.7 6.8 Refs
A (Rhodopsin) Class A orphan GP139 GPR139 Human L-Phenylalanine None 2 Small molecule 3.5 3.5 3.1 3.1 Refs
A (Rhodopsin) Succinate SUCR1 succinate Human Succinic Acid Principal 1 Small molecule 3.1 3.9 4.7 Refs
A (Rhodopsin) Chemokine CXCR5 CXCR5 Human Cxcl13 Principal 1 Peptide
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl5 5 Peptide
A (Rhodopsin) Bradykinin BKRB1 B1 Mouse [Des-Arg9]Bradykinin 2 Peptide 5.7 9.2 9.2 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Mouse 3-Iodothyronamine None 1 Small molecule 7.5 7.7 7.9 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl24 5 Peptide
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW2 NPBW2 Human Neuropeptide W-30 5 Peptide
A (Rhodopsin) Prokineticin PKR1 PKR1 Human Prokineticin-2 4 Peptide
A (Rhodopsin) Histamine HRH1 H1 Human Histamine Principal 1 Small molecule 4.7 5.3 5.9 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl11 5 Peptide
A (Rhodopsin) Chemokine CCR6 CCR6 Human Beta-Defensin 4a 2 Peptide Refs
A (Rhodopsin) Bradykinin BKRB2 B2 Human Lys-[Hyp3]-Bradykinin 3 Peptide
B1 (Secretin) Calcitonin CALCR CT Human Amylin 7 Peptide
A (Rhodopsin) Endothelin EDNRB ETB Human Endothelin-3 1 Peptide Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl14 6 Peptide 7.4 7.4 Refs
A (Rhodopsin) Galanin GALR2 GAL2 Mouse Galanin 2 Peptide 8.3 8.3 8.3 8.4 8.4 Refs
A (Rhodopsin) Galanin GALR2 GAL2 Human Galanin-Like Peptide 4 Peptide Refs
A (Rhodopsin) Melanocortin MC4R MC4 Human Β-Msh 3 Peptide
A (Rhodopsin) Class A orphan GP139 GPR139 Human L-Tryptophan None 1 Small molecule 3.7 3.7 3.1 3.1 Refs
A (Rhodopsin) Neuropeptide Y Q9ERC0 Y2 Rat Neuropeptide Y 4 Peptide 9.3 9.4 9.5 Refs
A (Rhodopsin) Adren ADA1B α1B-adren Human (-)-Noradrenaline None 2 Small molecule 6.2 6.2 Refs
C (Glutamate) Class C Orphan GPC6A GPRC6 Human L-Glutamine None 5 Small molecule 3.2 3.2 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR5 S1P5 Human Sphingosine 1-Phosphate None 1 Small molecule 7.4 8.2 8.9 Refs
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Cxcl10 2 Peptide 7.8 8.8 9.8 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT2A 5-HT2A Human Tryptamine None 1 Small molecule 5.5 6.6 7.6 Refs
A (Rhodopsin) Adren ADRB3 β3-adren Mouse (&Plusmn;)-Adrenaline None 1 Small molecule 3.9 5.3 5.3 Refs
A (Rhodopsin) Adren ADRB3 β3-adren Rat (+)-Adrenaline None 1 Small molecule
A (Rhodopsin) Bombesin NMBR BB1 Human Grp-(18-27) 2 Peptide
A (Rhodopsin) Neuropeptide S NPSR1 NPS Human Neuropeptide S Principal 1 Peptide
B1 (Secretin) VIP and PACAP PACR PAC1 Human Pacap-38 2 Peptide 7.5 8.9 10.3 6.9 8.2 9.0 Refs
A (Rhodopsin) Class A orphan GPR39 GPR39 Human Obestatin Peptide
A (Rhodopsin) Melanocortin MC3R MC3 Human Agouti-Related Protein 3 Peptide Refs
A (Rhodopsin) Formylpeptide FPR1 FPR1 Human Annexin I 2 Peptide
A (Rhodopsin) Class A orphan GPR35 GPR35 Human 2-Oleoyl-Lpa None 1 Small molecule 7.3 7.4 7.5 Refs
A (Rhodopsin) Relaxin family peptide RXFP1 RXFP1 Human Relaxin-1 2 Peptide 8.8 8.8 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR1 CRF1 Human Urocortin 1 4 Peptide
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide W-30 1 Peptide Refs
A (Rhodopsin) Hydroxycarboxylic acid HCAR2 HCA2 Human Butyric Acid None 2 Small molecule 2.8 2.8
A (Rhodopsin) Histamine HRH4 H4 Human Ccl16 2 Peptide Refs
A (Rhodopsin) GPR18, GPR55 and GPR119 GP119 GPR119 Human N-Oleoylethanolamide None 1 Small molecule 5.4 5.9 6.3 Refs
A (Rhodopsin) Class A orphan LGR4 LGR4 Human R-Spondin-3 2 Peptide 10.7 10.7 Refs
A (Rhodopsin) Chemokine XCR1 XCR1 Human Xcl1 2 Peptide
A (Rhodopsin) Opioid OPRM μ Rat [Met]Enkephalin 1 Peptide 9.2 9.2 Refs
A (Rhodopsin) Neurotensin NTR1 NTS1 Human Large Neuromedin N 3 Peptide Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Human Urocortin 2 2 Peptide
B1 (Secretin) Calcitonin CALCR CT Human Calcitonin 1 Peptide 9.0 10.1 11.2 Refs
A (Rhodopsin) Bradykinin BKRB2 B2 Human Bradykinin 1 Peptide Refs
A (Rhodopsin) Dopamine DRD1 D1 Human Dopamine None 2 Small molecule 4.3 5.0 5.6 Refs
A (Rhodopsin) Class A orphan G37L1 GPR37L1 Human Prosaptide Principal 1 Peptide 8.3 8.3 Refs
A (Rhodopsin) Prokineticin PKR1 PKR1 Human Prokineticin-2Β 2 Peptide Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR2 LPA2 Human Lpa None 1 Small molecule 6.7 7.5 8.2 Refs
A (Rhodopsin) Chemokine ACKR1 ACKR1 Human Cxcl11 Peptide
A (Rhodopsin) Apelin APJ apelin Human Apelin Receptor Early Endogenous Ligand 2 Peptide
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Resolvin D1 None 2 Small molecule 11.9 11.9 Refs
A (Rhodopsin) Class A orphan MRGRD MRGPRD Human Β-Alanine Principal 1 Small molecule 4.8 4.8 Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl2 3 Peptide
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Ghrh 4 Peptide 6.2 6.2 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Human Pgf2Α None 3 Small molecule 6.1 6.1 9.1 9.3 9.5 Refs
A (Rhodopsin) Galanin GALR2 GAL2 Human Galanin 1 Peptide 7.9 8.5 9.1 8.6 8.9 9.1 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl2 8 Peptide
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Ghrh 4 Peptide
A (Rhodopsin) Adren ADA1D α1D-adren Rat (-)-Noradrenaline None 2 Small molecule 6.3 6.3 Refs
A (Rhodopsin) Leukotriene OXER1 OXE Human 5s-Hete None 5 Small molecule 6.5 6.9 7.2 Refs
A (Rhodopsin) Relaxin family peptide RL3R1 RXFP3 Human Relaxin-3 (B Chain) 3 Peptide Refs
A (Rhodopsin) Formylpeptide FPR1 FPR1 Human Fmet-Leu-Phe None 1 Peptide 10.1 10.2 10.2 Refs
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Cxcl10 9 Peptide
A (Rhodopsin) Prostanoid PD2R2 DP2 Rat Pgd2 None 2 Small molecule 7.6 8.1 8.6 Refs
A (Rhodopsin) Chemokine CCR4 CCR4 Human Ccl22 1 Peptide Refs
A (Rhodopsin) Prolactin-releasing peptide PRLHR PrRP Human Pthrp 4 Peptide
B1 (Secretin) Glucagon receptor family SCTR secretin Human Secretin 2 Peptide
A (Rhodopsin) Leukotriene LT4R1 BLT1 Human 20-Hydroxy-Ltb4 None 2 Small molecule 8.1 8.1 Refs
A (Rhodopsin) Prostanoid PF2R FP Mouse Pge2 None 3 Small molecule 6.4 6.7 6.9 Refs
A (Rhodopsin) Neuropeptide Y NPY2R Y2 Human Peptide Yy 2 Peptide 9.5 9.7 9.8 Refs
A (Rhodopsin) Bombesin NMBR BB1 Human Gastrin-Releasing Peptide 2 Peptide
C (Glutamate) Calcium-sensing CASR CaS Rat Ca2+ None 2 Small molecule Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl3 1 Peptide 7.8 9.0 10.2 Refs
A (Rhodopsin) Relaxin family peptide RXFP2 RXFP2 Human Relaxin 1 Peptide 9.1 9.1 8.3 8.4 8.5 Refs
A (Rhodopsin) Adren ADRB2 β2-adren Human Zn2+ None 4 Small molecule 3.3 4.3 5.3 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR4 S1P4 Human Sphingosylphosphorylcholine 2 Small molecule
A (Rhodopsin) 5-Hydroxytryptamine 5HT6R 5-HT6 Human 5-Hydroxytryptamine Principal 1 Small molecule 6.8 7.2 7.5 Refs
A (Rhodopsin) Dopamine DRD5 D5 Human Noradrenaline None 3 Small molecule 4.9 4.9 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR2 S1P2 Human Sphingosine 1-Phosphate None 1 Small molecule 8.1 8.7 8.7 Refs
A (Rhodopsin) Class A orphan GPR17 GPR17 Mouse Ltc4 None 2 Small molecule 7.8 9.1 9.1 Refs
A (Rhodopsin) Bradykinin BKRB2 B2 Human Kallidin 1 Peptide Refs
A (Rhodopsin) Chemokine ACKR1 ACKR1 Human Cxcl5 Peptide
A (Rhodopsin) Prostanoid PD2R2 DP2 Human Pgf2Α None 4 Small molecule 6.4 6.4 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Human Pgd2 None 4 Small molecule 5.0 5.0 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl16 8 Peptide
A (Rhodopsin) Class A orphan GPR63 GPR63 Human Dioleoylphosphatidic Acid None 1 Small molecule 6.3 6.3 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl26 5 Peptide Refs
A (Rhodopsin) Prokineticin PKR2 PKR2 Human Prokineticin-1 2 Peptide Refs
C (Glutamate) Metabotropic glutamate GRM3 mGlu3 Rat L-Glutamic Acid None 1 Small molecule 5.3 5.4 5.4 6.4 6.4 Refs
A (Rhodopsin) Opioid OPRM μ Human [Met]Enkephalin 1 Peptide 9.2 9.2 Refs
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Cck-39 2 Peptide
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Neuropeptide Ff 2 Peptide 8.5 9.2 9.9 Refs
A (Rhodopsin) P2Y P2RY1 P2Y1 Human Atp None 1 Small molecule 4.8 4.8 Refs
B1 (Secretin) Parathyroid hormone PTH1R PTH1 Human Pth 3 Peptide
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl1 3 Peptide
A (Rhodopsin) Proteinase-activated PAR4 PAR4 Human Thrombin Peptide
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM2 M2 Rat Acetylcholine Principal 1 Small molecule 4.3 5.4 6.5 Refs
A (Rhodopsin) Neurotensin NTR2 NTS2 Rat Neuromedin N 2 Peptide Refs
A (Rhodopsin) Dopamine DRD2 D2 Human Dopamine Principal 1 Small molecule 5.3 5.9 6.4 Refs
A (Rhodopsin) Opioid OPRK κ Human [Met]Enkephalin 8 Peptide 6.0 6.0 Refs
A (Rhodopsin) Chemokine ACKR1 ACKR1 Human Ccl2 Peptide
A (Rhodopsin) P2Y P2Y13 P2Y13 Human Atp None 2 Small molecule Refs
A (Rhodopsin) Tachykinin NK3R NK3 Human Neurokinin A 2 Peptide 7.4 7.4 5.5 5.9 6.3 Refs
A (Rhodopsin) Free fatty acid FFAR2 FFA2 Human Trans-2-Methylcrotonic Acid None 3 Small molecule 3.8 3.8 Refs
A (Rhodopsin) Class A orphan LGR5 LGR5 Human R-Spondin-1 2 Peptide 11.1 11.1 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Human Peptide Yy 3 Peptide 8.8 8.8 Refs
A (Rhodopsin) P2Y P2Y11 P2Y11 Human Utp None 1 Small molecule 5.2 5.2 Refs
C (Glutamate) Metabotropic glutamate GRM1 mGlu1 Rat L-Glutamic Acid Principal 1 Small molecule 4.8 4.9 5.0 6.4 6.5 6.5 Refs
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Ccl11 4 Peptide 7.2 7.2 Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW2 NPBW2 Human Neuropeptide B-23 5 Peptide
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl2 6 Peptide 7.5 7.5 Refs
A (Rhodopsin) Melanocortin MC5R MC5 Human Α-Msh 2 Peptide Refs
A (Rhodopsin) Tachykinin NK3R NK3 Mouse Neurokinin A 2 Peptide 7.4 7.4 5.5 5.9 6.3 Refs
A (Rhodopsin) Bile acid GPBAR GPBA Human Lithocholic Acid None 1 Small molecule 7.5 7.5 Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Rat T-Kinin 4 Peptide 5.0 5.2 5.2 Refs
A (Rhodopsin) Class A orphan GPR17 GPR17 Human Udp-Galactose None 5 Small molecule 6.0 7.2 7.2 Refs
A (Rhodopsin) Leukotriene LT4R2 BLT2 Human Ltb4 None 3 Small molecule 6.8 6.8 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT1B 5-HT1B Mouse 5-Hydroxytryptamine None 1 Small molecule 7.4 8.1 8.1 Refs
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl4 Peptide
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide B-29 5 Peptide
A (Rhodopsin) Dopamine DRD5 D5 Human Dopamine None 1 Small molecule 6.6 6.6 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Human Pgi2 5 Small molecule
A (Rhodopsin) Dopamine DRD1 D1 Human (-)-Noradrenaline None 3 Small molecule
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl7 3 Peptide 8.6 8.9 9.2 Refs
A (Rhodopsin) Leukotriene CLTR2 CysLT2 Human Ltc4 None 1 Small molecule 7.0 7.6 8.6 Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Mouse Pgf2Α None 4 Small molecule 6.4 6.4 Refs
A (Rhodopsin) Opioid OPRK κ Human Big Dynorphin 9 Peptide
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl4 7 Peptide
A (Rhodopsin) Opioid OPRD δ Mouse [Leu]Enkephalin 1 Peptide 8.7 8.7 Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl8 7 Peptide
A (Rhodopsin) Neuromedin U NMUR1 NMU1 Human Neuromedin U-23 3 Peptide
A (Rhodopsin) Chemokine CCR10 CCR10 Human Ccl28 Peptide
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Cck-33 5 Peptide
A (Rhodopsin) Class A orphan GPR17 GPR17 Human Lte4 None 1 Small molecule
A (Rhodopsin) Class A orphan TAAR2 TAAR2 Human Β-Phenylethylamine Small molecule
A (Rhodopsin) Chemokine CCR8 CCR8 Human Ccl1 1 Peptide Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Rat Udp None 2 Small molecule 7.1 7.1 Refs
A (Rhodopsin) Neuropeptide S NPSR1 NPS Human Neuropeptide S Principal 1 Peptide 7.3 7.7 8.0 Refs
A (Rhodopsin) Prokineticin PKR2 PKR2 Human Prokineticin-2 4 Peptide
A (Rhodopsin) P2Y P2Y14 P2Y14 Mouse Udp-Glucuronic Acid None 3 Small molecule 7.0 7.0 Refs
A (Rhodopsin) Class A orphan TAAR3 TAAR3 Human Isoamylamine Principal 1 Small molecule
A (Rhodopsin) Prolactin-releasing peptide PRLHR PrRP Human Neuropeptide Y 3 Peptide 5.4 5.4 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Ghrh 4 Peptide
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl8 7 Peptide
A (Rhodopsin) Class A orphan LGR4 LGR4 Human R-Spondin-4 3 Peptide 10.1 10.1 Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Rat Srif-14 3 Peptide 8.4 9.2 9.9 Refs
A (Rhodopsin) Thyrotropin-releasing hormone TRHR TRH1 Rat Trh Principal 1 Peptide 7.4 7.4 Refs
A (Rhodopsin) Bombesin GRPR BB2 Human Gastrin Releasing Peptide(14-27) (Human) None 3 Peptide Refs
A (Rhodopsin) Bombesin GRPR BB2 Human Grp-(18-27) 3 Peptide
A (Rhodopsin) Neuropeptide Y NPY2R Y2 Human Peptide Yy 1 Peptide 10.0 10.0 Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Human Cst-17 2 Peptide 8.7 9.3 9.9 Refs
A (Rhodopsin) Angiotensin AGTR1 AT1 Human Angiotensin Iv 2 Peptide 5.9 5.9 Refs
A (Rhodopsin) Class A orphan LGR4 LGR4 Human R-Spondin-2 1 Peptide 12.5 12.5 Refs
A (Rhodopsin) Tachykinin NK3R NK3 Mouse Neurokinin B 1 Peptide 8.4 8.4 7.7 8.5 9.2 Refs
A (Rhodopsin) Apelin APJ apelin Human Apelin-36 2 Peptide
A (Rhodopsin) Dopamine DRD5 D5 Human (-)-Noradrenaline None 3 Small molecule
A (Rhodopsin) Lysophospholipid (LPA) LPAR2 LPA2 Mouse Lpa None 1 Small molecule 6.7 7.5 8.2 Refs
A (Rhodopsin) P2Y P2Y12 P2Y12 Human Adp None 1 Small molecule 5.9 5.9 Refs
A (Rhodopsin) Chemokine CXCR1 CXCR1 Human Cxcl6 2 Peptide 7.0 7.0 Refs
A (Rhodopsin) Tachykinin NK3R NK3 Mouse Hemokinin 1 3 Peptide 9.2 9.3 9.3 Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl15 7 Peptide Refs
A (Rhodopsin) Free fatty acid FFAR4 FFA4 Rat Α-Linolenic Acid None 3 Small molecule 5.1 5.1 Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW2 NPBW2 Human Neuropeptide W-30 5 Peptide
B1 (Secretin) Glucagon receptor family GHRHR GHRH Human Ghrh Principal 1 Peptide
C (Glutamate) Class C Orphan GPC6A GPRC6 Human L-Arginine None 1 Small molecule 4.4 4.4 Refs
A (Rhodopsin) Neurotensin NTR2 NTS2 Mouse Neuromedin N 2 Peptide Refs
A (Rhodopsin) Chemokine CCR9 CCR9 Human Ccl25 Principal 1 Peptide
A (Rhodopsin) Neuropeptide Y NPY2R Y2 Human Neuropeptide Y 4 Peptide 9.3 9.4 9.5 Refs
A (Rhodopsin) Peptide P518 QRFPR QRFP Human Qrfp43 (43rfa) 3 Peptide 6.9 7.8 8.6 Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Human Udp-Galactose None 1 Small molecule 7.6 7.6 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Human Pgd2 None 2 Small molecule 8.8 8.8 8.7 8.9 9.0 Refs
A (Rhodopsin) Galanin GALR3 GAL3 Rat Galanin 2 Peptide 8.1 8.5 8.8 Refs
B1 (Secretin) Calcitonin CALCR CT Human Amylin 3 Peptide 8.0 8.6 9.2 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl5 8 Peptide
A (Rhodopsin) Prostanoid PE2R3 EP3 Mouse Pge1 None 1 Small molecule 9.4 9.4 9.0 9.0 Refs
A (Rhodopsin) Tachykinin NK2R NK2 Human Neurokinin B 3 Peptide 5.0 6.4 7.7 Refs
A (Rhodopsin) Melanocortin MC4R MC4 Human Β-Msh 3 Peptide
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Fmet-Leu-Phe None 9 Peptide
A (Rhodopsin) Leukotriene CLTR2 CysLT2 Human Lte4 None 3 Small molecule 5.6 6.3 7.1 6.5 6.5 Refs
B1 (Secretin) Calcitonin CALCR CT Human Β-Cgrp 7 Peptide
A (Rhodopsin) 5-Hydroxytryptamine 5HT5B 5HT5B Mouse 5-Hydroxytryptamine Principal 1 Small molecule
A (Rhodopsin) Relaxin family peptide RL3R2 RXFP4 Human Relaxin-3 1 Peptide 8.7 9.2 9.7 8.8 8.9 9.0 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR3 LPA3 Human Lpa None 1 Small molecule 6.6 6.6 Refs
A (Rhodopsin) Adren ADRB3 β3-adren Mouse (-)-Noradrenaline None 2 Small molecule 4.7 4.2 4.2 Refs
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Human Pth 5 Peptide
A (Rhodopsin) Chemokine ACKR3 ACKR3 Human Cxcl12Α 1 Peptide 7.5 7.7 7.9 Refs
A (Rhodopsin) Class A orphan GP183 GPR183 Human 7Β, 27-Dihydroxycholesterol None 4 Small molecule 7.3 7.3 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Human Pancreatic Polypeptide 7 Peptide
A (Rhodopsin) Chemokine CCR3 CCR3 Human Cxcl10 5 Peptide
A (Rhodopsin) Cannabinoid CNR2 CB2 Human 2-Arachidonoylglycerol None 1 Small molecule 5.8 6.3 6.8 Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Desulfated Gastrin-17 5 Peptide
A (Rhodopsin) Adren ADA2A α2A-adren Human (-)-Noradrenaline None 2 Small molecule 5.6 6.5 7.4 Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl7 7 Peptide
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Cxcl9 3 Peptide 7.3 7.8 8.3 Refs
A (Rhodopsin) Class A orphan GP183 GPR183 Human 27-Hydroxycholesterol None 8 Small molecule 5.5 5.5 Refs
A (Rhodopsin) Melanocortin MC4R MC4 Human Α-Msh 1 Peptide 7.4 7.7 8.0 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl8 8 Peptide
A (Rhodopsin) Melanocortin ACTHR MC2 Mouse Acth Principal 1 Peptide Refs
A (Rhodopsin) Chemokine CCR7 CCR7 Mouse Ccl21b 2 Peptide Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Human Kallidin 3 Peptide 7.0 8.0 8.9 Refs
A (Rhodopsin) Class A orphan LGR6 LGR6 Human R-Spondin-3 Peptide Refs
A (Rhodopsin) Opioid OPRD δ Mouse [Met]Enkephalin 7 Peptide Refs
A (Rhodopsin) Bradykinin BKRB2 B2 Mouse Bradykinin 1 Peptide Refs
A (Rhodopsin) Bombesin GRPR BB2 Rat Neuromedin B 2 Peptide 6.4 6.6 6.6 Refs
A (Rhodopsin) Neuropeptide Y NPY1R Y1 Human Neuropeptide Y 1 Peptide 10.5 10.5 Refs
A (Rhodopsin) Bombesin GRPR BB2 Human Neuromedin C None 3 Peptide Refs
A (Rhodopsin) Melanocortin MSHR MC1 Human Α-Msh 2 Peptide Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Rat Pgd2 None 4 Small molecule 5.0 5.0 Refs
A (Rhodopsin) Cannabinoid CNR2 CB2 Human Anandamide None 2 Small molecule 5.7 6.1 6.4 Refs
A (Rhodopsin) Adenosine AA3R A3 Rat Adenosine Principal 1 Small molecule 6.5 6.5 Refs
C (Glutamate) Calcium-sensing CASR CaS Rat Mg2+ None 3 Small molecule Refs
A (Rhodopsin) Tachykinin NK2R NK2 Human Neurokinin A 1 Peptide 8.0 8.6 9.1 Refs
A (Rhodopsin) Opioid OPRD δ Human Β-Endorphin 3 Peptide 8.3 8.3 Refs
A (Rhodopsin) Class A orphan GPR75 GPR75 Human Ccl5 Principal 1 Peptide 9.6 9.6 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Human Pgd2 None 4 Small molecule 5.2 5.2 Refs
A (Rhodopsin) Prolactin-releasing peptide PRLHR PrRP Human Prrp-20 4 Peptide
A (Rhodopsin) Somatostatin SSR1 SST1 Rat Srif-14 2 Peptide 8.6 9.1 9.5 Refs
A (Rhodopsin) Melanocortin MSHR MC1 Mouse Agouti 2 Peptide Refs
A (Rhodopsin) Adren ADRB3 β3-adren Human (-)-Noradrenaline None 2 Small molecule 4.7 4.2 4.2 Refs
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Gastrin-17 2 Peptide
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Secretin 4 Peptide
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide B-29 5 Peptide
F (Frizzled) Frizzled FZD6 FZD6 Human Wnt-4 Peptide Refs
A (Rhodopsin) Apelin APJ apelin Human Apelin Receptor Early Endogenous Ligand 1 Peptide Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Mouse Pgj2 None 1 Small molecule 8.2 8.2 Refs
A (Rhodopsin) Prostanoid PF2R FP Mouse Pgd2 None 2 Small molecule 7.7 7.7 Refs
A (Rhodopsin) Prokineticin PKR1 PKR1 Human Prokineticin-1 4 Peptide
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Rat Pthrp-(1-34) (Human) None 3 Peptide Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Human Phv 4 Peptide
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Human Corticotrophin-Releasing Hormone 1 Peptide 7.8 7.8 Refs
A (Rhodopsin) Opioid OPRX NOP Human Nociceptin/Orphanin Fq Principal 1 Peptide 8.4 9.1 9.8 9.7 10.1 10.4 Refs
A (Rhodopsin) Prostanoid PE2R3 EP3 Rat Pgd2 None 3 Small molecule 7.9 7.9 5.9 7.4 8.9 Refs
A (Rhodopsin) Adenosine AA2BR A2B Human Adenosine Principal 1 Small molecule 5.3 5.3 Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Desulfated Cholecystokinin-8 None 3 Peptide Refs
A (Rhodopsin) Class A orphan GP183 GPR183 Human 7Α-Hydroxycholesterol None 5 Small molecule 7.1 7.1 Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Human [Des-Arg10]Kallidin 1 Peptide 9.6 9.8 10.0 Refs
C (Glutamate) Metabotropic glutamate GRM6 mGlu6 Rat L-Glutamic Acid None 2 Small molecule 4.8 5.0 5.2 Refs
A (Rhodopsin) Class A orphan GPR39 GPR39 Human Obestatin Peptide
A (Rhodopsin) P2Y P2Y13 P2Y13 Human Adp None 1 Small molecule Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Human Lys-[Hyp3]-Bradykinin 6 Peptide
A (Rhodopsin) Chemokine ACKR4 ACKR4 Human Ccl21 2 Peptide 7.9 8.2 8.5 6.9 6.9 Refs
A (Rhodopsin) Proteinase-activated PAR3 PAR3 Human Thrombin Principal 1 Peptide
B1 (Secretin) Calcitonin CALCR CT Human Β-Cgrp 5 Peptide 7.2 7.2 Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Human Pgi2 None 4 Small molecule 5.1 5.1 Refs
A (Rhodopsin) Opioid OPRK κ Mouse Α-Neoendorphin 3 Peptide 8.9 9.5 10.0 Refs
A (Rhodopsin) Melanocortin MSHR MC1 Human Β-Msh 2 Peptide
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl8 1 Peptide 8.8 9.2 9.5 Refs
A (Rhodopsin) Neurotensin NTR1 NTS1 Rat Neuromedin N 2 Peptide 8.7 8.7 Refs
A (Rhodopsin) Class A orphan LGR6 LGR6 Human R-Spondin-2 Peptide Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl11 1 Peptide 9.7 9.9 10.0 Refs
A (Rhodopsin) 5-Hydroxytryptamine 5HT2C 5-HT2C Human 5-Hydroxytryptamine Principal 1 Small molecule 6.8 7.7 8.6 Refs
A (Rhodopsin) Tachykinin NK1R NK1 Human Hemokinin 1 4 Peptide
A (Rhodopsin) Chemokine CCR10 CCR10 Human Ccl27 Peptide
A (Rhodopsin) 5-Hydroxytryptamine 5HT1B 5-HT1B Human Tryptamine None 2 Small molecule 6.3 6.3 Refs
A (Rhodopsin) Bile acid GPBAR GPBA Human Chenodeoxycholic Acid None 3 Small molecule 5.4 5.4 Refs
B1 (Secretin) Glucagon receptor family GHRHR GHRH Human Ghrh Principal 1 Peptide
A (Rhodopsin) Class A orphan GP174 GPR174 Human Lysophosphatidylserine Principal 1 Small molecule 7.1 7.1 Refs
A (Rhodopsin) Prostanoid PI2R IP Human Thromboxane A2 3 Small molecule
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl2 Peptide
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Cck-8 1 Peptide Refs
A (Rhodopsin) Prostanoid PE2R4 EP4 Rat Pge1 None 1 Small molecule 9.5 9.5 8.7 8.7 Refs
C (Glutamate) Metabotropic glutamate GRM1 mGlu1 Human L-Glutamic Acid Principal 1 Small molecule 4.8 4.9 5.0 6.4 6.5 6.5 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Human Pge1 None 2 Small molecule 7.0 7.0 Refs
A (Rhodopsin) Bradykinin BKRB2 B2 Human [Des-Arg10]Kallidin 3 Peptide
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM1 M1 Human Acetylcholine Principal 1 Small molecule 4.3 4.6 4.9 Refs
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Cxcl9 9 Peptide
A (Rhodopsin) Opioid OPRK κ Rat [Met]Enkephalin 8 Peptide 6.0 6.0 Refs
A (Rhodopsin) Neurotensin NTR2 NTS2 Mouse Neurotensin 1 Peptide 8.8 8.8 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR1 CRF1 Human Urocortin 2 3 Peptide Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Human [Des-Arg9]Bradykinin 2 Peptide 5.7 9.2 9.2 Refs
A (Rhodopsin) Class A orphan GPR12 GPR12 Human Sphingosine 1-Phosphate Principal 1 Small molecule 5.5 6.3 7.0 Refs
A (Rhodopsin) Opioid OPRD δ Mouse Α-Neoendorphin 7 Peptide Refs
A (Rhodopsin) Melanocortin MC5R MC5 Mouse Agouti 2 Peptide Refs
A (Rhodopsin) Chemokine CCR4 CCR4 Human Ccl17 2 Peptide Refs
A (Rhodopsin) Class A orphan GP132 GPR132 Human 9-Hydroxyoctadecadienoic Acid Principal 1 Small molecule 5.7 5.7 Refs
A (Rhodopsin) Leukotriene LT4R2 BLT2 Human 12r-Hete 4 Small molecule
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human 15-Deoxy-Lxa4 9 Small molecule
A (Rhodopsin) Formylpeptide FPR1 FPR1 Human Annexin I 2 Peptide
A (Rhodopsin) Prostanoid PI2R IP Mouse Pge1 None 2 Small molecule 6.5 6.7 6.8 Refs
A (Rhodopsin) Neuropeptide Y NPY1R Y1 Human Peptide Yy 2 Peptide 10.2 10.2 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Human Pgi2 None 5 Small molecule 4.8 4.8 Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Human Cortistatin-14 4 Peptide 8.7 9.1 9.4 Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Human Dopamine 4 Small molecule
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Cck-33 2 Peptide
B1 (Secretin) Parathyroid hormone PTH1R PTH1 Human Pth 3 Peptide
A (Rhodopsin) Urotensin UR2R UT Human Urotensin-Ii 2 Peptide 8.6 8.6 Refs
A (Rhodopsin) Chemokine ACKR3 ACKR3 Human Cxcl11 3 Peptide
A (Rhodopsin) Formylpeptide FPR3 FPR3 Human Annexin I-(2-26) 3 Peptide 5.0 6.0 7.0 Refs
A (Rhodopsin) Galanin GALR2 GAL2 Human Galanin-Like Peptide 4 Peptide
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Cck-58 5 Peptide
C (Glutamate) Calcium-sensing CASR CaS Human Spermine None 1 Small molecule Refs
A (Rhodopsin) Opioid OPRD δ Human [Leu]Enkephalin 1 Peptide 8.7 8.7 Refs
A (Rhodopsin) Adenosine AA1R A1 Rat Adenosine Principal 1 Small molecule 7.0 7.0 Refs
A (Rhodopsin) Formylpeptide FPR1 FPR1 Human Cathepsin G 2 Peptide
B1 (Secretin) Glucagon receptor family GHRHR GHRH Human Ghrh Principal 1 Peptide
A (Rhodopsin) Class A orphan GPR17 GPR17 Human Udp None 4 Small molecule 6.0 7.4 8.8 Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Human [Hyp3]Bradykinin 6 Peptide
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Rfrp-1 3 Peptide
A (Rhodopsin) 5-Hydroxytryptamine 5HT1E 5-HT1E Human Tryptamine None 2 Small molecule 5.6 6.1 6.5 Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl2 3 Peptide
A (Rhodopsin) Opioid OPRX NOP Mouse Nociceptin/Orphanin Fq Principal 1 Peptide 8.4 9.1 9.8 9.7 10.1 10.4 Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Des-Br-Neuropeptide B-23 4 Peptide Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl24 7 Peptide Refs
C (Glutamate) Class C Orphan GPC6A GPRC6 Human Glycine None 4 Small molecule 3.6 3.6 Refs
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Cxcl11 9 Peptide
A (Rhodopsin) Class A orphan GPR63 GPR63 Human Sphingosine 1-Phosphate None 3 Small molecule 6.1 6.2 6.2 Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Mouse Urocortin 3 2 Peptide Refs
A (Rhodopsin) Chemokine CXCR4 CXCR4 Human Cxcl12 3 Peptide
A (Rhodopsin) Chemokine CCR8 CCR8 Mouse Ccl8 2 Peptide
A (Rhodopsin) Prostanoid PE2R3 EP3 Human Pge1 None 1 Small molecule 9.4 9.4 9.0 9.0 Refs
A (Rhodopsin) Chemokine CXCR4 CXCR4 Human Cxcl12Ε 3 Peptide Refs
A (Rhodopsin) P2Y P2Y11 P2Y11 Human Adp None 3 Small molecule Refs
A (Rhodopsin) Glycoprotein hormone FSHR FSH Human Fsh Principal 1 Peptide
A (Rhodopsin) Neurotensin NTR2 NTS2 Human Xenin 2 Peptide Refs
A (Rhodopsin) Chemokine ACKR4 ACKR4 Human Ccl19 1 Peptide 8.5 8.8 9.1 8.4 8.4 Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Rat Pacap-27 2 Peptide 7.6 8.5 9.4 Refs
A (Rhodopsin) Melanocortin ACTHR MC2 Human Acth Principal 1 Peptide
A (Rhodopsin) Leukotriene CLTR1 CysLT1 Human Ltd4 None 1 Small molecule 7.3 8.6 9.4 Refs
A (Rhodopsin) Cannabinoid CNR1 CB1 Rat 2-Arachidonoylglycerol None 1 Small molecule 6.3 6.8 7.2 Refs
A (Rhodopsin) Somatostatin SSR1 SST1 Human Cst-17 1 Peptide 9.1 9.4 9.6 Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Human Pge2 None 5 Small molecule 5.5 5.5 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Neuropeptide Sf 3 Peptide
B1 (Secretin) Corticotropin-releasing factor CRFR1 CRF1 Human Urocortin 1 1 Peptide Refs
A (Rhodopsin) Class A orphan GP183 GPR183 Human 25-Hydroxycholesterol None 6 Small molecule 6.9 6.9 Refs
A (Rhodopsin) Prostanoid TA2R TP Human Thromboxane A2 3 Small molecule
C (Glutamate) Metabotropic glutamate GRM3 mGlu3 Human Naag None 2 Small molecule 4.7 4.7 Refs
A (Rhodopsin) Adenosine AA3R A3 Human Adenosine Principal 1 Small molecule 6.5 6.5 Refs
A (Rhodopsin) Chemokine ACKR1 ACKR1 Human Ccl7 Peptide
A (Rhodopsin) Tachykinin NK2R NK2 Human Neuropeptide K 4 Peptide
A (Rhodopsin) Opioid OPRM μ Human Β-Endorphin 6 Peptide
A (Rhodopsin) Free fatty acid FFAR1 FFA1 Human Docosahexaenoic Acid None 1 Small molecule 5.4 5.7 6.0 Refs
A (Rhodopsin) Complement peptide C5AR1 C5a1 Human C5a Des-Arg 2 Peptide Refs
A (Rhodopsin) Complement peptide C5AR1 C5a1 Human C3a 2 Peptide
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW2 NPBW2 Human Neuropeptide W-23 5 Peptide
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW2 NPBW2 Human Neuropeptide W-23 1 Peptide Refs
A (Rhodopsin) Prostanoid TA2R TP Human Pgh2 3 Small molecule
A (Rhodopsin) Chemokine ACKR4 ACKR4 Human Ccl25 3 Peptide 7.9 8.1 8.3 7.6 7.6 Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl7 3 Peptide Refs
A (Rhodopsin) Histamine HRH2 H2 Rat Histamine Principal 1 Small molecule 3.8 3.8 Refs
A (Rhodopsin) Class A orphan GP183 GPR183 Human 7Α,27-Dihydroxycholesterol None 2 Small molecule 8.9 8.9 Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide B-23 5 Peptide
A (Rhodopsin) Lysophospholipid (LPA) LPAR6 LPA6 Human Lpa Principal 1 Small molecule 6.0 6.0 Refs
A (Rhodopsin) Tachykinin NK2R NK2 Human Hemokinin 1 4 Peptide
A (Rhodopsin) Prostanoid PE2R3 EP3 Mouse Pge2 None 1 Small molecule 9.4 9.4 9.1 9.1 Refs
A (Rhodopsin) Formylpeptide FPR3 FPR3 Human Humanin 1 Peptide 8.9 8.9 Refs
A (Rhodopsin) Melanocortin MC5R MC5 Human Γ-Msh 2 Peptide
A (Rhodopsin) Chemokine CCR3 CCR3 Human Cxcl10 5 Peptide
A (Rhodopsin) Peptide P518 QRFPR QRFP Human Qrfp43 5 Peptide
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Phi 4 Peptide
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Human Pancreatic Polypeptide 2 Peptide 8.7 9.8 10.9 Refs
A (Rhodopsin) Adenosine AA2AR A2A Human Adenosine Principal 1 Small molecule 6.5 6.5 Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Mouse Udp-Galactose None 1 Small molecule 7.6 7.6 Refs
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM3 M3 Human Acetylcholine Principal 1 Small molecule 4.5 5.0 5.4 Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Mouse Udp-Glucose None 1 Small molecule 7.6 7.6 Refs
A (Rhodopsin) Prostanoid PF2R FP Human Pgi2 4 Small molecule
A (Rhodopsin) Class A orphan GPR3 GPR3 Human Sphingosine 1-Phosphate Principal 1 Small molecule 7.1 7.4 7.7 Refs
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Cxcl12Α 7 Peptide 6.4 6.4 Refs
A (Rhodopsin) Chemokine CX3C1 CX3CR1 Human Cx3Cl1 Principal 1 Peptide Refs
A (Rhodopsin) Complement peptide C3AR C3a Human C3a 2 Peptide
A (Rhodopsin) Complement peptide C5AR2 C5a2 Human C5a 1 Peptide 8.9 8.9 Refs
A (Rhodopsin) Adren ADA2C α2C-adren Human (-)-Noradrenaline None 1 Small molecule 5.7 6.3 6.8 Refs
A (Rhodopsin) Chemokine ACKR3 ACKR3 Rat Adrenomedullin 2 Peptide 7.0 7.0 Refs
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Prp106-126 None 8 Peptide 4.6 4.6 Refs
A (Rhodopsin) Dopamine DRD5 D5 Human 5-Hydroxytryptamine None 2 Small molecule 5.5 5.5 Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Desulfated Gastrin-34 5 Peptide
A (Rhodopsin) Endothelin EDNRA ETA Human Endothelin-2 1 Peptide Refs
A (Rhodopsin) Chemokine XCR1 XCR1 Human Xcl2 1 Peptide 7.3 7.3 Refs
A (Rhodopsin) Formylpeptide FPR1 FPR1 Human Cathepsin G 2 Peptide
A (Rhodopsin) Adren ADRB2 β2-adren Human Noradrenaline None 2 Small molecule 5.4 5.4 Refs
A (Rhodopsin) Prostanoid PE2R2 EP2 Human Pge1 None 1 Small molecule 8.0 8.0 Refs
A (Rhodopsin) Class A orphan GPR17 GPR17 Human Ltc4 None 2 Small molecule 7.8 9.1 9.1 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl3 8 Peptide
A (Rhodopsin) Neuropeptide Y NPY2R Y2 Human Pancreatic Polypeptide 5 Peptide
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Neuropeptide Ff 1 Peptide 9.7 9.7 Refs
A (Rhodopsin) Prostanoid TA2R TP Human Pgd2 3 Small molecule
A (Rhodopsin) Adren ADRB3 β3-adren Mouse (+)-Adrenaline None 1 Small molecule
A (Rhodopsin) Opioid OPRD δ Human Dynorphin B 4 Peptide 7.8 7.8 Refs
A (Rhodopsin) Prokineticin PKR2 PKR2 Human Prokineticin-2 1 Peptide Refs
A (Rhodopsin) Chemerin CML2 hemerin receptor 2 Human Chemerin Principal 1 Peptide 8.8 9.2 9.6 Refs
B2 (Adhesion) ADGRB AGRB1 ADGRB1 Human Phosphatidylserine Principal 1 Small molecule Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Neuropeptide Sf 3 Peptide
A (Rhodopsin) Melanocortin MC3R MC3 Human Β-Msh 3 Peptide
A (Rhodopsin) Melanocortin MC3R MC3 Human Β-Msh 3 Peptide
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl5 7 Peptide
A (Rhodopsin) Relaxin family peptide RXFP1 RXFP1 Human Relaxin 1 Peptide 10.4 10.4 9.2 9.7 10.2 Refs
B1 (Secretin) Glucagon receptor family GLP1R GLP-1 Human Glucagon 2 Peptide 6.9 7.0 7.0 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl4 1 Peptide 9.4 9.5 9.6 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR2 S1P2 Human Dihydrosphingosine 1-Phosphate 2 Small molecule
A (Rhodopsin) Opioid OPRD δ Human Α-Neoendorphin 7 Peptide Refs
A (Rhodopsin) Somatostatin SSR4 SST4 Human Cortistatin-14 4 Peptide
A (Rhodopsin) Formylpeptide FPR1 FPR1 Human Annexin I 2 Peptide
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Neuropeptide Af 3 Peptide
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Serum Amyloid A 6 Peptide 6.6 6.6 Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl2 3 Peptide Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl8 8 Peptide
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Gastrin-71 5 Peptide
A (Rhodopsin) Galanin GALR3 GAL3 Human Galanin 2 Peptide 7.2 7.2 Refs
B1 (Secretin) Calcitonin CALCR CT Human Adrenomedullin 2/Intermedin 6 Peptide 6.5 6.5 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR3 LPA3 Human Farnesyl Diphosphate None 2 Small molecule Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl5 3 Peptide
A (Rhodopsin) Chemokine CCRL2 CCRL2 Human Chemerin C-Terminal Peptide 2 Peptide
A (Rhodopsin) Neurotensin NTR1 NTS1 Human Large Neurotensin 3 Peptide Refs
A (Rhodopsin) Class A orphan MRGX2 MRGPRX2 Human Pamp-20 Principal 1 Peptide Refs
A (Rhodopsin) Formylpeptide FPR1 FPR1 Human Cathepsin G 2 Peptide
A (Rhodopsin) Prostanoid PD2R2 DP2 Mouse Pgd3 None 3 Small molecule 7.4 7.4 Refs
A (Rhodopsin) Adren ADRB3 β3-adren Rat (-)-Adrenaline None 1 Small molecule
A (Rhodopsin) Leukotriene OXER1 OXE Human 5-Oxo-12-Hete None 7 Small molecule Refs
A (Rhodopsin) Bradykinin BKRB1 B1 Human Bradykinin 5 Peptide 5.1 5.2 5.3 Refs
A (Rhodopsin) Urotensin UR2R UT Mouse Urotensin-Ii 3 Peptide 8.4 8.5 8.6 Refs
A (Rhodopsin) Opioid OPRK κ Rat Dynorphin A-(1-13) 2 Peptide 9.3 9.9 9.9 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Rat Pancreatic Polypeptide 1 Peptide 10.3 10.6 10.8 Refs
A (Rhodopsin) Prokineticin PKR1 PKR1 Human Prokineticin-1 4 Peptide
A (Rhodopsin) Leukotriene OXER1 OXE Human 5-Oxo-Ode None 2 Small molecule 8.0 8.0 Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl5 3 Peptide Refs
A (Rhodopsin) Gonadotrophin-releasing hormone GNRHR GnRH1 Human Gnrh Ii 2 Peptide Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Desulfated Gastrin-14 5 Peptide
F (Frizzled) Frizzled FZD1 FZD1 Human Wnt-3a Peptide
A (Rhodopsin) Galanin GALR1 GAL1 Rat Galanin-Like Peptide 2 Peptide Refs
A (Rhodopsin) Free fatty acid FFAR4 FFA4 Human Oleic Acid None 4 Small molecule 4.7 4.7 Refs
C (Glutamate) GABAB GABR1 GABAB1 Human Gaba Principal 1 Small molecule
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl11 Peptide
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Gastrin-17 5 Peptide
A (Rhodopsin) P2Y P2Y14 P2Y14 Rat Udp-Glucose None 1 Small molecule 7.6 7.6 Refs
A (Rhodopsin) Class A orphan GPR37 GPR37 Human Prosaptide Principal 1 Peptide 8.1 8.1 Refs
A (Rhodopsin) Relaxin family peptide Q5Y986 RXFP3 Rat Relaxin-3 3 Peptide Refs
A (Rhodopsin) Endothelin EDNRB ETB Human Endothelin-1 2 Peptide
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Human Pthrp-(1-36) 4 Peptide Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl8 5 Peptide
A (Rhodopsin) Complement peptide C3AR C3a Human C5a 2 Peptide
A (Rhodopsin) Melanocortin MC4R MC4 Human Acth 3 Peptide
A (Rhodopsin) Neuromedin U NMUR2 NMU2 Human Neuromedin U-23 3 Peptide
B1 (Secretin) VIP and PACAP PACR PAC1 Human Phv 4 Peptide
B1 (Secretin) Parathyroid hormone PTH1R PTH1 Human Pthrp-(1-36) 2 Peptide Refs
A (Rhodopsin) Somatostatin SSR3 SST3 Human Cortistatin-14 4 Peptide
Other GPCRs Other GPCR orphan GP107 GPR107 Human Neuronostatin Principal 1 Peptide
B1 (Secretin) Parathyroid hormone PTH1R PTH1 Human Pthrp 3 Peptide
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Phm 4 Peptide 5.7 5.7 Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl23 2 Peptide 8.9 8.9 Refs
A (Rhodopsin) Melanocortin MC4R MC4 Human Agouti-Related Protein 3 Peptide Refs
A (Rhodopsin) Endothelin EDNRA ETA Human Endothelin-3 3 Peptide
A (Rhodopsin) Neurotensin NTR2 NTS2 Rat Neurotensin 1 Peptide 8.8 8.8 Refs
A (Rhodopsin) Neuropeptide S NPSR1 NPS Human Neuropeptide S Principal 1 Peptide
C (Glutamate) Metabotropic glutamate GRM7 mGlu7 Human L-Serine-O-Phosphate None 1 Small molecule 4.5 4.5 4.4 4.4 Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl1 3 Peptide
A (Rhodopsin) Class A orphan GPR32 GPR32 Human Lxa4 None 2 Small molecule 9.7 9.7 Refs
A (Rhodopsin) Neuropeptide Y NPY5R Y5 Human Pyy-(3-36) 3 Peptide 8.4 8.4 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Neuropeptide Af 3 Peptide
A (Rhodopsin) Prokineticin PKR1 PKR1 Human Prokineticin-1 3 Peptide Refs
A (Rhodopsin) Prokineticin PKR2 PKR2 Human Prokineticin-1 4 Peptide
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Annexin I 9 Peptide
A (Rhodopsin) Prostanoid PD2R2 DP2 Mouse Pge2 None 5 Small molecule 5.5 5.5 Refs
A (Rhodopsin) Proteinase-activated PAR1 PAR1 Human Thrombin Principal 1 Peptide
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide B-23 5 Peptide
A (Rhodopsin) Endothelin EDNRA ETA Human Endothelin-2 3 Peptide
A (Rhodopsin) Chemokine ACKR1 ACKR1 Human Ccl17 Peptide
A (Rhodopsin) Prostanoid PE2R3 EP3 Mouse Pgd2 None 3 Small molecule 7.9 7.9 5.9 7.4 8.9 Refs
A (Rhodopsin) Complement peptide C5AR1 C5a1 Human Ribosomal Protein S19 2 Peptide Refs
A (Rhodopsin) Chemerin CML1 hemerin Human Chemerin C-Terminal Peptide None 2 Peptide
A (Rhodopsin) Lysophospholipid (S1P) S1PR5 S1P5 Human Dihydrosphingosine 1-Phosphate 2 Small molecule
A (Rhodopsin) Complement peptide C3AR C3a Human C5a 2 Peptide
A (Rhodopsin) Class A orphan TAAR2 TAAR2 Human Tryptamine Small molecule
A (Rhodopsin) Kisspeptin KISSR kisspeptin Human Kisspeptin-13 4 Peptide 8.4 8.4 Refs
A (Rhodopsin) P2Y P2Y14 P2Y14 Human Udp None 2 Small molecule 7.1 7.1 Refs
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl7 Peptide
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl11 8 Peptide
A (Rhodopsin) Class A orphan GPR63 GPR63 Human Dihydrosphingosine 1-Phosphate None 2 Small molecule 6.2 6.2 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR1 S1P1 Human Dihydrosphingosine 1-Phosphate 2 Small molecule
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl3 7 Peptide
A (Rhodopsin) Class A orphan GPR17 GPR17 Human Ltd4 None 3 Small molecule 8.1 8.3 8.4 Refs
A (Rhodopsin) Endothelin EDNRB ETB Human Endothelin-2 2 Peptide
C (Glutamate) Metabotropic glutamate GRM5 mGlu5 Rat L-Glutamic Acid Principal 1 Small molecule 5.0 5.3 5.5 Refs
A (Rhodopsin) Opioid OPRM μ Human Β-Endorphin 6 Peptide
C (Glutamate) GABAB GABR1 GABAB1 Rat Gaba Principal 1 Small molecule Refs
A (Rhodopsin) Adren ADRB3 β3-adren Mouse (-)-Adrenaline None 1 Small molecule
C (Glutamate) Class C Orphan GPC6A GPRC6 Human L-Serine None 5 Small molecule 3.2 3.2 Refs
A (Rhodopsin) Hydroxycarboxylic acid HCAR3 HCA3 Human 3-Hydroxyoctanoic Acid Principal 1 Small molecule 5.1 5.1 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl26 5 Peptide Refs
A (Rhodopsin) Galanin GALR2 GAL2 Human Galanin-Like Peptide 4 Peptide
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Qrfp43 (43rfa) 3 Peptide
A (Rhodopsin) Lysophospholipid (S1P) S1PR1 S1P1 Human Sphingosylphosphorylcholine 2 Small molecule
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Human Pyy-(3-36) 6 Peptide 6.2 6.2 Refs
A (Rhodopsin) Neurotensin NTR1 NTS1 Human Large Neuromedin N 3 Peptide
A (Rhodopsin) GPR18, GPR55 and GPR119 GPR55 GPR55 Human 2-Arachidonoylglycerolphosphoinositol None 5 Small molecule Refs
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Secretin 4 Peptide
A (Rhodopsin) Leukotriene LT4R2 BLT2 Human 20-Hydroxy-Ltb4 4 Small molecule
A (Rhodopsin) Lysophospholipid (LPA) LPAR6 LPA6 Mouse Lpa Principal 1 Small molecule 6.0 6.0 Refs
A (Rhodopsin) Complement peptide C3AR C3a Human C3a 1 Peptide 7.3 8.5 9.6 Refs
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Cxcl10 9 Peptide
A (Rhodopsin) Neurotensin NTR1 NTS1 Human Neuromedin N 2 Peptide 8.7 8.7 Refs
A (Rhodopsin) Chemokine CCRL2 CCRL2 Human Ccl19 1 Peptide Refs
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Human Pthrp-(1-34) (Human) None 3 Peptide Refs
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Human Urocortin 3 2 Peptide Refs
A (Rhodopsin) Chemokine CCR8 CCR8 Human Ccl1 2 Peptide
A (Rhodopsin) GPR18, GPR55 and GPR119 GP119 GPR119 Human Sea None 2 Small molecule
A (Rhodopsin) Prostanoid TA2R TP Human Pgi2 3 Small molecule
A (Rhodopsin) Relaxin family peptide RXFP2 RXFP2 Human Relaxin-3 2 Peptide 7.0 7.0 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl13 2 Peptide Refs
B1 (Secretin) Calcitonin CALCR CT Human Calcitonin 7 Peptide
A (Rhodopsin) Class A orphan P2Y10 P2RY10 Human Sphingosine 1-Phosphate None 1 Small molecule 7.3 7.3 Refs
A (Rhodopsin) Tachykinin NK1R NK1 Human Neurokinin B 3 Peptide 6.1 6.3 6.4 Refs
A (Rhodopsin) Class A orphan GPR31 GPR31 Mouse 12s-Hete Principal 1 Small molecule 9.6 9.6 Refs
A (Rhodopsin) Neuropeptide Y NPY4R Y4 Rat Pyy-(3-36) 6 Peptide 6.2 6.2 Refs
A (Rhodopsin) Prostanoid PD2R2 DP2 Human Pgi2 6 Small molecule
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl7 5 Peptide
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl15 5 Peptide Refs
A (Rhodopsin) Class A orphan GP183 GPR183 Human 7Β-Hydroxycholesterol None 7 Small molecule 5.8 5.8 Refs
A (Rhodopsin) Leukotriene OXER1 OXE Human 5-Oxo-C20:3 None 2 Small molecule 8.0 8.0 Refs
A (Rhodopsin) Chemokine CCR4 CCR4 Human Ccl22 3 Peptide
C (Glutamate) Metabotropic glutamate GRM5 mGlu5 Human L-Glutamic Acid Principal 1 Small molecule 5.0 5.3 5.5 Refs
A (Rhodopsin) Melanocortin MSHR MC1 Human Γ-Msh 2 Peptide
A (Rhodopsin) GPR18, GPR55 and GPR119 GP119 GPR119 Human Anandamide 2 Small molecule
A (Rhodopsin) Melanocortin MC4R MC4 Human Β-Msh 3 Peptide
A (Rhodopsin) Melanocortin MSHR MC1 Human Acth 2 Peptide
A (Rhodopsin) 5-Hydroxytryptamine 5HT1B 5-HT1B Human 5-Ht-Moduline None 3 Peptide Refs
F (Frizzled) Frizzled FZD4 FZD4 Mouse Norrin Principal 1 Peptide Refs
A (Rhodopsin) Ghrelin GHSR ghrelin Human Ghrelin 2 Peptide
A (Rhodopsin) Lysophospholipid (LPA) LPAR1 LPA1 Mouse Lpa Principal 1 Small molecule 7.9 8.1 8.3 Refs
C (Glutamate) Metabotropic glutamate GRM7 mGlu7 Human L-Glutamic Acid None 2 Small molecule 3.0 3.0 3.1 3.1 Refs
A (Rhodopsin) Opioid OPRM μ Human Dynorphin A-(1-13) 4 Peptide 8.3 8.3 Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide W-30 5 Peptide
A (Rhodopsin) Leukotriene LT4R2 BLT2 Human 12-Epi Ltb4 None 2 Small molecule 7.5 7.5 Refs
C (Glutamate) Metabotropic glutamate GRM6 mGlu6 Human L-Serine-O-Phosphate None 1 Small molecule 6.4 6.4 Refs
A (Rhodopsin) Neuropeptide Y NPY5R Y5 Human Neuropeptide Y 1 Peptide 9.1 9.1 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl8 5 Peptide
A (Rhodopsin) Neuromedin U NMUR2 NMU2 Human Neuromedin S-33 1 Peptide 10.0 10.0 Refs
A (Rhodopsin) Galanin GALR1 GAL1 Human Galanin-Like Peptide 2 Peptide
A (Rhodopsin) GPR18, GPR55 and GPR119 GPR55 GPR55 Human 2-Arachidonoylglycerol None 1 Small molecule 8.5 8.5 Refs
A (Rhodopsin) Relaxin family peptide RL3R2 RXFP4 Human Relaxin-3 (B Chain) 4 Peptide 7.0 7.0 Refs
F (Frizzled) Frizzled FZD1 FZD1 Human Wnt-7b Peptide
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl5 4 Peptide 6.8 7.5 8.2 Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Gastrin-34 5 Peptide
A (Rhodopsin) Bradykinin BKRB2 B2 Human T-Kinin 3 Peptide
A (Rhodopsin) Melanocortin MC3R MC3 Human Acth 2 Peptide 7.1 7.1 Refs
A (Rhodopsin) Formylpeptide FPR3 FPR3 Human F2l 2 Peptide 8.0 8.1 8.2 Refs
A (Rhodopsin) Ghrelin GHSR ghrelin Human [Des-Gln14]Ghrelin 2 Peptide
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl5 Peptide
B1 (Secretin) Glucagon receptor family GLP1R GLP-1 Human Glucagon-Like Peptide 1-(7-36) Amide 1 Peptide 9.2 9.2 Refs
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Ll-37 7 Peptide 6.0 6.0 Refs
A (Rhodopsin) Proteinase-activated PAR4 PAR4 Human Cathepsin G Peptide
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl3 Peptide
B1 (Secretin) Glucagon receptor family GLP2R GLP-2 Human Glucagon-Like Peptide 2-(3-33) 4 Peptide Refs
A (Rhodopsin) Class A orphan LGR4 LGR4 Human R-Spondin-1 2 Peptide 10.7 10.7 Refs
A (Rhodopsin) Bombesin NMBR BB1 Human Gastrin Releasing Peptide(14-27) (Human) None 2 Peptide Refs
A (Rhodopsin) Class A orphan GPR31 GPR31 Human 12s-Hete Principal 1 Small molecule
F (Frizzled) Frizzled FZD6 FZD6 Human Wnt-5a Peptide Refs
B1 (Secretin) VIP and PACAP VIPR2 VPAC2 Human Secretin 4 Peptide
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl11 5 Peptide
A (Rhodopsin) Chemokine XCR1 XCR1 Human Xcl1 2 Peptide
A (Rhodopsin) Adren ADRB1 β1-adren Human Noradrenaline None 1 Small molecule 6.0 6.0 Refs
A (Rhodopsin) Complement peptide C5AR1 C5a1 Human C5a 2 Peptide
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW2 NPBW2 Human Neuropeptide W-30 2 Peptide Refs
A (Rhodopsin) Prostanoid PI2R IP Human Pge2 3 Small molecule
A (Rhodopsin) Melanocortin MC3R MC3 Human Γ-Msh 3 Peptide Refs
A (Rhodopsin) Prostanoid PD2R DP1 Human Pgi2 6 Small molecule
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM1 M1 Rat Acetylcholine Principal 1 Small molecule 4.3 4.6 4.9 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl16 8 Peptide
B2 (Adhesion) ADGRL AGRL3 ADGRL3 Rat Flrt3 Principal 1 Peptide Refs
A (Rhodopsin) Chemokine CXCR4 CXCR4 Human Cxcl12Δ 3 Peptide Refs
A (Rhodopsin) Opioid OPRM μ Human Endomorphin-2 6 Peptide
A (Rhodopsin) Platelet-activating factor PTAFR PAF Human Paf Principal 1 Small molecule 7.5 7.7 7.9 Refs
A (Rhodopsin) Neuromedin U NMUR1 NMU1 Human Neuromedin U-23 3 Peptide
A (Rhodopsin) Class A orphan TAAR3 TAAR3 Mouse Isoamylamine Principal 1 Small molecule 5.0 5.0 Refs
A (Rhodopsin) Proteinase-activated PAR3 PAR3 Human Thrombin Principal 1 Peptide
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW2 NPBW2 Human Neuropeptide B-23 5 Peptide
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Humanin 4 Peptide 8.5 8.5 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR2 S1P2 Human Sphingosylphosphorylcholine 2 Small molecule
A (Rhodopsin) Lysophospholipid (LPA) LPAR4 LPA4 Human Lpa None 1 Small molecule Refs
A (Rhodopsin) Prostanoid PD2R DP1 Human Pge1 None 3 Small molecule 7.3 7.3 Refs
A (Rhodopsin) Opioid OPRK κ Human Β-Neoendorphin 4 Peptide 9.1 9.1 Refs
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Desulfated Cholecystokinin-8 2 Peptide
A (Rhodopsin) Prostanoid PI2R IP Human Pgf2Α 3 Small molecule
A (Rhodopsin) Neurotensin NTR2 NTS2 Human Neuromedin N 2 Peptide
A (Rhodopsin) Apelin APJ apelin Human Apelin-17 2 Peptide Refs
A (Rhodopsin) Bombesin NMBR BB1 Human Gastrin-Releasing Peptide 2 Peptide
A (Rhodopsin) Apelin APJ apelin Human Apelin-36 2 Peptide Refs
C (Glutamate) Class C Orphan GPC6A GPRC6 Human L-Citrulline None 4 Small molecule 3.6 3.6 Refs
A (Rhodopsin) Bombesin NMBR BB1 Human Grp-(18-27) 2 Peptide
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl13 4 Peptide 9.1 9.1 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl2 8 Peptide
A (Rhodopsin) Class A orphan GPR34 GPR34 Mouse Lysophosphatidylserine Principal 1 Small molecule 6.6 7.3 7.3 Refs
A (Rhodopsin) Melanocortin MC3R MC3 Human Α-Msh 1 Peptide 8.0 8.2 8.4 Refs
A (Rhodopsin) Angiotensin AGTR2 AT2 Human Angiotensin Ii 2 Peptide
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Cck-39 5 Peptide
A (Rhodopsin) Neuropeptide Y Q9ERC0 Y2 Rat Peptide Yy 1 Peptide 10.0 10.0 Refs
A (Rhodopsin) Prostanoid TA2R TP Human Pge2 None 2 Small molecule 4.5 4.5 Refs
A (Rhodopsin) Neurotensin NTR2 NTS2 Mouse Xenin 2 Peptide Refs
A (Rhodopsin) Apelin APJ apelin Human Elabela/Toddler-32 2 Peptide
A (Rhodopsin) Neuromedin U NMUR1 NMU1 Human Neuromedin S-36 3 Peptide
A (Rhodopsin) Bombesin NMBR BB1 Human Gastrin-Releasing Peptide 2 Peptide
B1 (Secretin) Glucagon receptor family SCTR secretin Rat Vip 2 Peptide Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide B-23 5 Peptide
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl2 5 Peptide
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl2 8 Peptide
A (Rhodopsin) P2Y P2RY6 P2Y6 Human Udp None 1 Small molecule 6.5 6.5 Refs
A (Rhodopsin) Chemokine CCR3 CCR3 Human Cxcl9 5 Peptide
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Ghrh 4 Peptide
A (Rhodopsin) Prostanoid PE2R2 EP2 Human Thromboxane A2 5 Small molecule
A (Rhodopsin) Adren ADRB3 β3-adren Human (-)-Adrenaline None 3 Small molecule 3.9 3.9 Refs
A (Rhodopsin) Complement peptide C5AR1 C5a1 Human C5a 2 Peptide
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Aspirin Triggered Lipoxin A4 None 9 Small molecule
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl28 5 Peptide
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl2 5 Peptide
A (Rhodopsin) Glycoprotein hormone LSHR LH Human Lh 2 Peptide Refs
A (Rhodopsin) Melanocortin MC5R MC5 Human Acth 1 Peptide 5.0 5.0 Refs
A (Rhodopsin) Lysophospholipid (S1P) S1PR5 S1P5 Human Sphingosylphosphorylcholine 2 Small molecule
A (Rhodopsin) Endothelin EDNRB ETB Rat Endothelin-3 1 Peptide Refs
A (Rhodopsin) P2Y P2RY1 P2Y1 Human Adp None 2 Small molecule Refs
A (Rhodopsin) Chemokine CCR6 CCR6 Human Ccl20 2 Peptide
B1 (Secretin) Glucagon receptor family GLP2R GLP-2 Rat Glucagon-Like Peptide 2-(3-33) 2 Peptide 6.6 6.6 Refs
Other GPCRs Other GPCR orphan GP143 GPR143 Human Levodopa Principal 1 Small molecule Refs
A (Rhodopsin) Trace amine TAAR1 TA1 Human Octopamine None 4 Small molecule
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl8 Peptide
A (Rhodopsin) Trace amine TAAR1 TA1 Human 3-Iodothyronamine None 1 Small molecule
A (Rhodopsin) Endothelin EDNRB ETB Human Endothelin-2 2 Peptide
A (Rhodopsin) Class A orphan P2Y10 P2RY10 Human Lpa None 2 Small molecule 6.9 6.9 Refs
A (Rhodopsin) Prokineticin PKR2 PKR2 Human Prokineticin-1 4 Peptide
A (Rhodopsin) Chemokine ACKR1 ACKR1 Human Cxcl8 Peptide
F (Frizzled) Frizzled FZD1 FZD1 Human Wnt-1 Peptide
A (Rhodopsin) Angiotensin AGTR1 AT1 Human Angiotensin Ii 3 Peptide
A (Rhodopsin) Tachykinin NK2R NK2 Human Neuropeptide Γ 4 Peptide
A (Rhodopsin) Opioid OPRD δ Human Β-Endorphin 7 Peptide
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Cck-33 2 Peptide
A (Rhodopsin) Chemokine CCR6 CCR6 Human Ccl20 2 Peptide
A (Rhodopsin) Endothelin EDNRA ETA Human Endothelin-1 2 Peptide Refs
A (Rhodopsin) Kisspeptin KISSR kisspeptin Human Kisspeptin-52 5 Peptide
A (Rhodopsin) Relaxin family peptide RXFP2 RXFP2 Human Relaxin-1 2 Peptide 8.8 8.8 Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Gastrin-14 5 Peptide
A (Rhodopsin) Prostanoid PE2R3 EP3 Human Pgd2 None 3 Small molecule 7.9 7.9 5.9 7.4 8.9 Refs
A (Rhodopsin) Class A orphan GPR32 GPR32 Human Resolvin D1 None 1 Small molecule 11.1 11.1 Refs
A (Rhodopsin) Neuropeptide Y NPY5R Y5 Rat Peptide Yy 2 Peptide 9.0 9.0 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl7 8 Peptide
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Rfrp-1 3 Peptide
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl17 Peptide
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl7 5 Peptide
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Mouse Cramp 5 Peptide 6.7 6.9 7.0 Refs
A (Rhodopsin) Relaxin family peptide RXFP2 RXFP2 Human Insl3 2 Peptide 9.3 9.5 9.7 Refs
A (Rhodopsin) Orexin OX2R OX2 Human Orexin-B 2 Peptide
A (Rhodopsin) Proteinase-activated PAR4 PAR4 Human Thrombin Peptide
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl7 6 Peptide 7.5 7.5 Refs
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Human Pth 5 Peptide
A (Rhodopsin) P2Y P2RY6 P2Y6 Human Utp None 2 Small molecule 5.2 5.2 Refs
A (Rhodopsin) Chemokine CXCR4 CXCR4 Human Cxcl12Φ 3 Peptide Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Desulfated Gastrin-71 5 Peptide
B2 (Adhesion) ADGRL AGRL1 ADGRL1 Rat Lasso D Principal 1 Peptide Refs
A (Rhodopsin) Adren ADRB3 β3-adren Human (+)-Adrenaline None 1 Small molecule
A (Rhodopsin) Neuropeptide Y NPY5R Y5 Rat Neuropeptide Y 1 Peptide 9.1 9.1 Refs
A (Rhodopsin) Proteinase-activated PAR3 PAR3 Human Thrombin Principal 1 Peptide
B1 (Secretin) Glucagon receptor family GLP2R GLP-2 Rat Glucagon-Like Peptide 2-(2-33) 3 Peptide 6.1 6.1 Refs
A (Rhodopsin) Prostanoid PE2R1 EP1 Human Thromboxane A2 6 Small molecule
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Secretin 4 Peptide
A (Rhodopsin) Chemokine CCR7 CCR7 Mouse Ccl21a 2 Peptide Refs
A (Rhodopsin) Class A orphan GPR6 GPR6 Human Sphingosine 1-Phosphate Principal 1 Small molecule
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide B-29 3 Peptide Refs
B1 (Secretin) Parathyroid hormone PTH1R PTH1 Human Tip39 1 Peptide Refs
C (Glutamate) Class C Orphan GPC6A GPRC6 Human L-Alanine None 3 Small molecule 3.8 3.8 Refs
A (Rhodopsin) Estrogen (G protein-coupled) GPER1 GPER Human 17Β-Estradiol Principal 1 Small molecule 8.2 8.4 8.5 Refs
A (Rhodopsin) Chemokine CCR9 CCR9 Human Ccl25 Principal 1 Peptide
A (Rhodopsin) Tachykinin NK1R NK1 Human Neuropeptide K 4 Peptide Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW2 NPBW2 Human Neuropeptide B-23 4 Peptide Refs
A (Rhodopsin) Class A orphan GPR17 GPR17 Human Atp None 4 Small molecule 7.4 7.4 Refs
A (Rhodopsin) Neuropeptide Y NPY1R Y1 Human Peptide Yy 4 Peptide
A (Rhodopsin) Kisspeptin KISSR kisspeptin Human Kisspeptin-54 2 Peptide 8.8 9.2 9.5 Refs
A (Rhodopsin) Opioid OPRM μ Human [Leu]Enkephalin 5 Peptide 8.1 8.1 Refs
A (Rhodopsin) Neuropeptide Y NPY5R Y5 Rat Pyy-(3-36) 3 Peptide 8.4 8.4 Refs
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Annexin I 9 Peptide Refs
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Gastrin-17 5 Peptide
A (Rhodopsin) Leukotriene LT4R2 BLT2 Human 15s-Hete None 2 Small molecule 7.5 7.5 Refs
A (Rhodopsin) Neurotensin NTR1 NTS1 Human Neuromedin N 3 Peptide
A (Rhodopsin) Neuropeptide Y NPY5R Y5 Human Pancreatic Polypeptide 4 Peptide 8.0 8.0 Refs
A (Rhodopsin) Opioid OPRM μ Human Dynorphin B 2 Peptide 8.5 8.5 Refs
A (Rhodopsin) Neuropeptide Y NPY1R Y1 Rat Pancreatic Polypeptide 3 Peptide 7.0 7.0 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl4 8 Peptide
A (Rhodopsin) Dopamine DRD4 D4 Rat Dopamine Principal 1 Small molecule 7.4 7.4 Refs
A (Rhodopsin) Neuromedin U NMUR2 NMU2 Human Neuromedin S-36 3 Peptide
A (Rhodopsin) Peptide P518 QRFPR QRFP Rat Qrfp26 5 Peptide Refs
A (Rhodopsin) Somatostatin SSR1 SST1 Human Cortistatin-14 4 Peptide
A (Rhodopsin) Opioid OPRK κ Rat Dynorphin A 1 Peptide 10.0 10.2 10.3 Refs
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Ltd4 9 Small molecule
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Neuropeptide Af 3 Peptide
A (Rhodopsin) Kisspeptin KISSR kisspeptin Human Kisspeptin-10 1 Peptide 8.6 9.5 10.4 Refs
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl4 7 Peptide
A (Rhodopsin) Melanocortin MSHR MC1 Human Β-Msh 2 Peptide
A (Rhodopsin) Adenosine AA1R A1 Human Adenosine Principal 1 Small molecule 7.0 7.0 Refs
A (Rhodopsin) Neuropeptide Y NPY2R Y2 Human Pancreatic Polypeptide 5 Peptide
A (Rhodopsin) Chemokine CCR3 CCR3 Human Cxcl11 5 Peptide
B1 (Secretin) Corticotropin-releasing factor CRFR2 CRF2 Human Urocortin 1 2 Peptide Refs
A (Rhodopsin) Formylpeptide FPR2 FPR2/ALX Human Aspirin-Triggered Resolvin D1 None 3 Small molecule 11.1 11.1 Refs
A (Rhodopsin) Chemokine CXCR4 CXCR4 Human Cxcl12Β 2 Peptide Refs
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Rat Phv 4 Peptide Refs
A (Rhodopsin) Class A orphan GP182 GPR182 Rat Adrenomedullin Principal 1 Peptide 8.1 8.1 Refs
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW2 NPBW2 Human Neuropeptide B-29 5 Peptide
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Cxcl11 1 Peptide 10.4 10.5 10.5 Refs
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Gastrin-17 2 Peptide
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl11 8 Peptide
A (Rhodopsin) Chemokine CXCR1 CXCR1 Human Cytokine Domain Of Tyrosyl Trna Synthetase 3 Peptide
A (Rhodopsin) P2Y P2Y14 P2Y14 Human Udp-Glucuronic Acid None 3 Small molecule
A (Rhodopsin) Chemokine CX3C1 CX3CR1 Human Cx3Cl1 Principal 1 Peptide
A (Rhodopsin) Bradykinin BKRB1 B1 Human T-Kinin 4 Peptide 5.0 5.2 5.2 Refs
A (Rhodopsin) Complement peptide C3AR C3a Human C3a 2 Peptide
A (Rhodopsin) Melanocortin MC5R MC5 Human Β-Msh 2 Peptide
A (Rhodopsin) Neuropeptide Y NPY5R Y5 Human Peptide Yy 6 Peptide
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Cck-33 5 Peptide
A (Rhodopsin) Lysophospholipid (S1P) S1PR3 S1P3 Human Dihydrosphingosine 1-Phosphate 2 Small molecule
A (Rhodopsin) Neuropeptide Y NPY2R Y2 Human Pyy-(3-36) 3 Peptide 9.2 9.5 9.7 Refs
A (Rhodopsin) Cholecystokinin CCKAR CCK1 Human Cck-4 2 Peptide
A (Rhodopsin) Neuropeptide Y NPY5R Y5 Human Pancreatic Polypeptide 6 Peptide
A (Rhodopsin) Class A orphan LGR6 LGR6 Human R-Spondin-4 Peptide Refs
A (Rhodopsin) Free fatty acid FFAR4 FFA4 Human Myristic Acid None 2 Small molecule 5.2 5.2 Refs
A (Rhodopsin) Lysophospholipid (LPA) LPAR5 LPA5 Human Farnesyl Monophosphate None 1 Small molecule 7.3 7.3 Refs
B1 (Secretin) Glucagon receptor family GLP2R GLP-2 Human Glucagon-Like Peptide 2-(3-33) 4 Peptide
F (Frizzled) Frizzled FZD1 FZD1 Human Wnt-5a Peptide
A (Rhodopsin) Neuropeptide W/neuropeptide B NPBW1 NPBW1 Human Neuropeptide W-23 2 Peptide Refs
A (Rhodopsin) Proteinase-activated PAR1 PAR1 Human Thrombin Principal 1 Peptide
A (Rhodopsin) Tachykinin NK3R NK3 Human Substance P 3 Peptide 5.0 5.5 6.0 Refs
A (Rhodopsin) Opioid OPRK κ Human Β-Endorphin 9 Peptide
A (Rhodopsin) Prostanoid PE2R3 EP3 Human Thromboxane A2 4 Small molecule
A (Rhodopsin) Prostanoid PD2R2 DP2 Human Pgd3 None 3 Small molecule
A (Rhodopsin) Neuropeptide Y NPY1R Y1 Human Pancreatic Polypeptide 4 Peptide
A (Rhodopsin) Chemokine CCR10 CCR10 Human Ccl27 Peptide Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl4 8 Peptide
A (Rhodopsin) GPR18, GPR55 and GPR119 GPR55 GPR55 Human Anandamide None 3 Small molecule 7.7 7.7 Refs
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Human Pthrp 5 Peptide
A (Rhodopsin) Leukotriene LT4R2 BLT2 Human 12s-Hete None 2 Small molecule 7.5 7.5 Refs
A (Rhodopsin) Melanocortin MC5R MC5 Human Β-Msh 2 Peptide
A (Rhodopsin) Cholecystokinin GASR CCK2 Human Gastrin-17 5 Peptide
A (Rhodopsin) Opioid OPRM μ Human Dynorphin A 5 Peptide 8.1 8.1 Refs
A (Rhodopsin) Chemokine CCR2 CCR2 Human Ccl7 8 Peptide
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl3 8 Peptide
A (Rhodopsin) 5-Hydroxytryptamine 5HT1D 5-HT1D Human 5-Ht-Moduline None 2 Peptide Refs
A (Rhodopsin) Complement peptide C5AR1 C5a1 Human C3a 2 Peptide
A (Rhodopsin) Ghrelin GHSR ghrelin Human [Des-Gln14]Ghrelin 2 Peptide
A (Rhodopsin) Chemokine ACKR2 ACKR2 Human Ccl22 Peptide
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Ccl5 7 Peptide 6.4 6.4 Refs
A (Rhodopsin) Chemokine ACKR1 ACKR1 Human Ccl11 Peptide
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl3 7 Peptide
A (Rhodopsin) Acetylcholine receptors (muscarinic) ACM5 M5 Human Acetylcholine Principal 1 Small molecule 6.1 6.1 Refs
A (Rhodopsin) Prostanoid PF2R FP Human Thromboxane A2 4 Small molecule
B1 (Secretin) VIP and PACAP VIPR1 VPAC1 Human Ghrh 4 Peptide
B1 (Secretin) Parathyroid hormone PTH2R PTH2 Human Pth 5 Peptide
A (Rhodopsin) Bradykinin BKRB2 B2 Mouse [Des-Arg9]Bradykinin 2 Peptide Refs
A (Rhodopsin) Prostanoid PI2R IP Human Pgd2 3 Small molecule
A (Rhodopsin) Neuropeptide Y NPY5R Y5 Rat Pancreatic Polypeptide 5 Peptide 6.5 6.5 Refs
A (Rhodopsin) Opioid OPRK κ Human Dynorphin A 1 Peptide 10.0 10.2 10.3 Refs
A (Rhodopsin) Melanocortin MC3R MC3 Human Acth 3 Peptide
A (Rhodopsin) GPR18, GPR55 and GPR119 GPR55 GPR55 Human N-Palmitoylethanolamine None 2 Small molecule 8.4 8.4 Refs
A (Rhodopsin) Melanocortin MC4R MC4 Mouse Agouti 3 Peptide Refs
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl3 3 Peptide
A (Rhodopsin) Melanocortin MC4R MC4 Human Acth 2 Peptide 6.2 6.2 Refs
B1 (Secretin) Glucagon receptor family GLP2R GLP-2 Rat Glucagon-Like Peptide 2 1 Peptide 10.2 10.2 Refs
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 Human Qrfp43 (43rfa) 3 Peptide
A (Rhodopsin) Chemokine CCR3 CCR3 Human Ccl2 4 Peptide 7.2 7.5 7.8 Refs
C (Glutamate) Class C Orphan GPC6A GPRC6 Human L-Lysine None 3 Small molecule 3.8 3.8 Refs
A (Rhodopsin) Bradykinin BKRB2 B2 Human [Hyp3]Bradykinin 3 Peptide
A (Rhodopsin) Chemokine CCR1 CCR1 Human Ccl7 7 Peptide
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl7 8 Peptide
F (Frizzled) Frizzled FZD2 FZD2 Human Wnt-5a Principal 1 Peptide
A (Rhodopsin) Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 Human Neuropeptide Af 3 Peptide
A (Rhodopsin) Chemokine CXCR3 CXCR3 Human Ccl20 5 Peptide 6.8 6.8 Refs
A (Rhodopsin) Prokineticin PKR2 PKR2 Human Prokineticin-2Β 3 Peptide Refs
B1 (Secretin) VIP and PACAP PACR PAC1 Human Phm 4 Peptide
B1 (Secretin) Glucagon receptor family SCTR secretin Human Secretin 1 Peptide 9.7 9.7 Refs
A (Rhodopsin) Somatostatin SSR5 SST5 Mouse Cortistatin-14 4 Peptide 8.7 9.1 9.4 Refs
A (Rhodopsin) Cannabinoid CNR1 CB1 Human 2-Arachidonoylglycerol None 1 Small molecule
A (Rhodopsin) Chemokine CXCR2 CXCR2 Human Cxcl5 3 Peptide
A (Rhodopsin) Melanocortin MC3R MC3 Mouse Agouti 3 Peptide Refs
A (Rhodopsin) Opioid OPRK κ Human Dynorphin A-(1-13) 2 Peptide 9.3 9.9 9.9 Refs
A (Rhodopsin) Chemokine CCR5 CCR5 Human Ccl11 8 Peptide Refs
A (Rhodopsin) Peptide P518 QRFPR QRFP Mouse Qrfp43 4 Peptide 6.7 7.0 7.2 Refs