Variation Browser

Download
Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
5ht1a_human 420 C-term C => R missense 8.237e-06 1 121400 0 0.51 0.671
5ht1a_human 413 8.56x56 H8 K => N missense 8.236e-06 1 121412 0 0.0 0.999
5ht1a_human 410 8.53x53 H8 A => G missense 8.236e-06 1 121412 0 0.01 0.998
5ht1a_human 397 7.50x50 TM7 P => L missense 8.236e-06 1 121412 0 0.0 1.0 SodiumPocket MicroSwitch
5ht1a_human 390 7.43x42 TM7 Y => H missense 8.236e-06 1 121412 0 0.0 1.0
5ht1a_human 389 7.42x41 TM7 G => D missense 8.236e-06 1 121412 0 0.03 1.0
5ht1a_human 387 7.40x39 TM7 W => R missense 8.236e-06 1 121412 0 0.0 1.0
5ht1a_human 382 7.35x34 TM7 G => S missense 8.237e-06 1 121410 0 0.48 0.524
5ht1a_human 379 7.32x31 TM7 T => N missense 8.236e-06 1 121412 0 0.41 0.004
5ht1a_human 370 6.60x60 TM6 F => C missense 8.236e-06 1 121412 0 0.0 1.0
5ht1a_human 369 6.59x59 TM6 P => L missense 8.236e-06 1 121412 0 0.0 0.943
5ht1a_human 367 6.57x57 TM6 V => I missense 1.647e-05 2 121412 0 0.2 0.099
5ht1a_human 364 6.54x54 TM6 V => M missense 8.237e-06 1 121408 0 0.24 0.984
5ht1a_human 363 6.53x53 TM6 I => L missense 8.237e-06 1 121406 0 0.08 0.454
5ht1a_human 361 6.51x51 TM6 F => L missense 8.237e-06 1 121406 0 0.0 0.559
5ht1a_human 356 6.46x46 TM6 L => I missense 8.238e-06 1 121386 0 0.49 0.645
5ht1a_human 346 6.36x36 TM6 T => M missense 8.24e-06 1 121352 0 0.0 0.996 GP (contact)
5ht1a_human 341 6.31x31 TM6 R => K missense 8.242e-06 1 121328 0 0.1 0.12
5ht1a_human 341 6.31x31 TM6 R => M missense 8.242e-06 1 121328 0 0.0 0.981
5ht1a_human 339 6.29x29 TM6 R => P missense 2.473e-05 3 121324 0 0.0 0.997 GP (contact)
5ht1a_human 335 6.25x25 TM6 M => I missense 5.771e-05 7 121294 0 0.59 0.01 GP (contact)
5ht1a_human 334 6.24x24 TM6 K => Q missense 0.0002639 32 121278 0 0.02 0.955 PTM (Ubiquitylation)
5ht1a_human 333 ICL3 R => L missense 8.248e-06 1 121244 0 0.0 0.982
5ht1a_human 332 ICL3 K => T missense 8.248e-06 1 121242 0 0.04 0.93
5ht1a_human 331 ICL3 A => G missense 8.25e-06 1 121216 0 0.03 0.182
5ht1a_human 330 ICL3 E => D missense 8.251e-06 1 121194 0 0.21 0.097
5ht1a_human 325 ICL3 N => T missense 8.259e-06 1 121086 0 0.26 0.61
5ht1a_human 324 ICL3 K => E missense 8.262e-06 1 121036 0 0.24 0.314 PTM (Acetylation)
5ht1a_human 317 ICL3 A => V missense 8.283e-06 1 120732 0 0.59 0.004
5ht1a_human 317 ICL3 A => P missense 8.286e-06 1 120692 0 0.41 0.006
5ht1a_human 315 ICL3 P => R missense 8.288e-06 1 120658 0 0.05 0.723
5ht1a_human 315 ICL3 P => L missense 1.658e-05 2 120658 0 0.03 0.305
5ht1a_human 314 ICL3 T => N missense 1.658e-05 2 120640 0 0.54 0.003
5ht1a_human 311 ICL3 A => T missense 1.66e-05 2 120502 0 0.43 0.077
5ht1a_human 310 ICL3 E => K missense 1.66e-05 2 120494 0 0.82 0.052
5ht1a_human 309 ICL3 S => R missense 2.491e-05 3 120444 0 0.54 0.023
5ht1a_human 306 ICL3 P => L missense 1.661e-05 2 120384 0 0.14 0.939
5ht1a_human 306 ICL3 P => S missense 8.306e-06 1 120388 0 0.41 0.483
5ht1a_human 304 ICL3 H => Q missense 8.307e-06 1 120382 0 0.45 0.906
5ht1a_human 301 ICL3 S => F missense 4.154e-05 5 120362 0 0.0 0.25
5ht1a_human 300 ICL3 N => S missense 8.31e-05 10 120344 0 0.6 0.002
5ht1a_human 300 ICL3 N => I missense 8.31e-06 1 120344 0 0.05 0.005
5ht1a_human 298 ICL3 V => L missense 8.312e-06 1 120312 0 0.65 0.001
5ht1a_human 297 ICL3 R => G missense 8.312e-06 1 120304 0 0.45 0.134
5ht1a_human 295 ICL3 V => L missense 8.31e-06 1 120342 0 0.48 0.07
5ht1a_human 294 ICL3 E => Q missense 1.662e-05 2 120320 0 0.13 0.99
5ht1a_human 285 ICL3 D => E missense 1.661e-05 2 120414 0 1.0 0.005
5ht1a_human 285 ICL3 D => E missense 8.305e-06 1 120414 0 1.0 0.005
5ht1a_human 275 ICL3 L => V missense 8.31e-06 1 120336 0 0.38 0.002
5ht1a_human 274 ICL3 A => G missense 6.649e-05 8 120322 0 0.4 0.002
5ht1a_human 273 ICL3 G => D missense 0.001571 189 120328 3 0.56 0.243
5ht1a_human 273 ICL3 G => V missense 8.311e-06 1 120328 0 0.3 0.016
5ht1a_human 273 ICL3 G => S missense 1.662e-05 2 120336 0 0.84 0.016
5ht1a_human 272 ICL3 G => R missense 8.312e-06 1 120304 0 0.53 0.034
5ht1a_human 269 ICL3 S => R missense 8.316e-06 1 120256 0 0.47 0.005
5ht1a_human 269 ICL3 S => T missense 8.316e-06 1 120252 0 0.55 0.003
5ht1a_human 267 ICL3 V => L missense 8.319e-06 1 120206 0 0.34 0.006
5ht1a_human 262 ICL3 N => S missense 8.323e-06 1 120146 0 1.0 0.002
5ht1a_human 251 ICL3 K => N missense 8.351e-06 1 119744 0 0.33 0.261
5ht1a_human 250 ICL3 P => S missense 5.012e-05 6 119712 0 0.76 0.003
5ht1a_human 247 ICL3 A => V missense 8.356e-06 1 119678 0 0.26 0.028
5ht1a_human 247 ICL3 A => T missense 1.671e-05 2 119706 0 0.28 0.029
5ht1a_human 245 ICL3 S => F missense 8.356e-06 1 119670 0 0.1 0.649
5ht1a_human 244 ICL3 A => T missense 3.343e-05 4 119664 0 0.68 0.003
5ht1a_human 243 ICL3 G => A missense 8.374e-06 1 119416 0 0.72 0.003
5ht1a_human 242 ICL3 H => Q missense 8.394e-06 1 119130 0 0.63 0.011
5ht1a_human 237 ICL3 G => R missense 6.709e-05 8 119234 0 0.48 0.003
5ht1a_human 236 ICL3 T => I missense 8.368e-06 1 119498 0 0.14 0.0
5ht1a_human 223 5.66x66 TM5 R => H missense 8.302e-06 1 120452 0 0.03 0.998 GP (contact)
5ht1a_human 223 5.66x66 TM5 R => C missense 8.299e-06 1 120498 0 0.0 0.998 GP (contact)
5ht1a_human 222 5.65x65 TM5 A => V missense 8.297e-06 1 120528 0 0.0 0.997 GP (contact)
5ht1a_human 220 5.63x63 TM5 R => L missense 0.003612 436 120694 1 0.15 0.647
5ht1a_human 219 5.62x62 TM5 F => L missense 8.279e-06 1 120788 0 0.02 0.593
5ht1a_human 218 5.61x61 TM5 I => K missense 8.271e-06 1 120904 0 0.0 0.993 GP (contact)
5ht1a_human 217 5.60x60 TM5 R => L missense 8.27e-06 1 120916 0 0.0 0.932
5ht1a_human 208 5.51x51 TM5 L => P missense 1.653e-05 2 120968 0 0.0 1.0
5ht1a_human 205 5.48x48 TM5 Y => C missense 8.268e-06 1 120944 0 0.0 1.0 PTM (Phosphorylation)
5ht1a_human 199 5.42x43 TM5 S => P missense 8.276e-06 1 120826 0 0.01 1.0 PTM (Phosphorylation)
5ht1a_human 197 5.40x41 TM5 I => V missense 8.278e-06 1 120804 0 0.31 0.773
5ht1a_human 193 5.36x37 TM5 H => R missense 2.485e-05 3 120742 0 0.37 0.189
5ht1a_human 186 ECL2 A => E missense 8.292e-06 1 120604 0 0.46 0.247
5ht1a_human 186 ECL2 A => T missense 8.292e-06 1 120598 0 0.47 0.377
5ht1a_human 184 ECL2 P => T missense 8.295e-06 1 120558 0 0.2 0.895
5ht1a_human 182 ECL2 S => L missense 0.0005476 66 120532 0 0.25 0.008
5ht1a_human 171 4.60x60 TM4 P => L missense 8.3e-06 1 120478 0 0.0 1.0
5ht1a_human 168 4.57x57 TM4 S => F missense 1.66e-05 2 120460 0 0.0 1.0
5ht1a_human 167 4.56x56 TM4 I => M missense 8.302e-06 1 120458 0 0.0 1.0
5ht1a_human 167 4.56x56 TM4 I => L missense 4.152e-05 5 120420 0 0.01 0.999
5ht1a_human 167 4.56x56 TM4 I => F missense 8.304e-06 1 120420 0 0.0 1.0
5ht1a_human 155 4.44x44 TM4 A => G missense 0.0005568 67 120336 1 0.02 0.678
5ht1a_human 152 4.41x41 TM4 R => L missense 8.31e-06 1 120330 0 0.0 1.0
5ht1a_human 151 4.40x40 TM4 R => W missense 8.31e-06 1 120340 0 0.0 0.995
5ht1a_human 150 4.39x39 TM4 P => R missense 8.31e-06 1 120336 0 0.01 0.995
5ht1a_human 148 34.57x57 ICL2 R => S missense 8.31e-06 1 120342 0 0.02 1.0 GP (contact)
5ht1a_human 145 34.54x54 ICL2 V => M missense 8.316e-06 1 120246 0 0.27 0.265 GP (contact)
5ht1a_human 145 34.54x54 ICL2 V => L missense 8.316e-06 1 120246 0 0.1 0.129 GP (contact)
5ht1a_human 144 34.53x53 ICL2 Y => C missense 8.316e-06 1 120250 0 0.0 1.0 GP (contact)
5ht1a_human 142 34.51x51 ICL2 I => T missense 8.316e-06 1 120246 0 0.0 0.983 GP (contact)
5ht1a_human 139 3.55x55 TM3 T => M missense 1.665e-05 2 120146 0 0.0 1.0 GP (contact)
5ht1a_human 134 3.50x50 TM3 R => S missense 8.336e-06 1 119966 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
5ht1a_human 129 3.45x45 TM3 A => S missense 8.369e-06 1 119490 0 0.03 0.993
5ht1a_human 124 3.40x40 TM3 I => N missense 8.39e-06 1 119192 0 0.0 1.0 SodiumPocket MicroSwitch
5ht1a_human 115 3.31x31 TM3 L => F missense 2.537e-05 3 118270 0 0.28 1.0
5ht1a_human 111 3.27x27 TM3 L => V missense 3.387e-05 4 118094 0 0.1 0.351
5ht1a_human 99 2.67x66 TM2 L => F missense 0.0001355 16 118064 1 0.45 1.0
5ht1a_human 94 2.62x61 TM2 A => P missense 8.472e-06 1 118036 0 0.01 1.0
5ht1a_human 69 2.37x37 TM2 N => T missense 8.352e-06 1 119728 0 0.37 0.147
5ht1a_human 65 12.48x48 ICL1 R => S missense 8.338e-06 1 119936 0 0.0 1.0
5ht1a_human 62 1.58x58 TM1 A => V missense 8.333e-06 1 120004 0 1.0 0.012
5ht1a_human 61 1.57x57 TM1 I => M missense 8.332e-06 1 120024 0 0.0 0.997
5ht1a_human 61 1.57x57 TM1 I => V missense 8.33e-06 1 120046 0 0.13 0.721
5ht1a_human 53 1.49x49 TM1 G => V missense 8.327e-06 1 120088 0 0.0 1.0
5ht1a_human 51 1.47x47 TM1 V => L missense 8.327e-06 1 120092 0 0.03 0.004
5ht1a_human 50 1.46x46 TM1 A => G missense 2.498e-05 3 120094 0 0.09 0.019
5ht1a_human 39 1.35x35 TM1 T => I missense 5.002e-05 6 119942 0 0.05 0.839
5ht1a_human 33 1.29x29 TM1 V => I missense 1.669e-05 2 119816 0 0.07 0.008
5ht1a_human 31 N-term V => M missense 8.348e-06 1 119796 0 0.02 0.022
5ht1a_human 30 N-term D => E missense 8.348e-06 1 119794 0 1.0 0.004
5ht1a_human 28 N-term I => V missense 0.008885 1064 119752 12 0.66 0.0
5ht1a_human 25 N-term T => A missense 8.355e-06 1 119682 0 0.96 0.0
5ht1a_human 23 N-term G => D missense 8.354e-06 1 119702 0 nan 0.001
5ht1a_human 22 N-term G => S missense 0.0001921 23 119704 0 0.4 0.002
5ht1a_human 18 N-term P => L missense 8.356e-06 1 119672 0 nan 0.001
5ht1a_human 18 N-term P => S missense 1.671e-05 2 119674 0 nan 0.001
5ht1a_human 17 N-term A => S missense 8.357e-06 1 119662 0 nan 0.001
5ht1a_human 16 N-term P => L missense 0.001646 197 119648 2 nan 0.0
5ht1a_human 12 N-term T => S missense 1.672e-05 2 119624 0 nan 0.556
5ht1a_human 11 N-term N => S missense 8.361e-06 1 119610 0 nan 0.043
5ht1a_human 11 N-term N => T missense 4.18e-05 5 119610 0 nan 0.342
5ht1a_human 9 N-term G => S missense 3.345e-05 4 119564 0 nan 0.001
5ht1a_human 3 N-term V => M missense 0.0007373 88 119352 0 nan 0.007
5ht1a_human 2 N-term D => G missense 8.386e-06 1 119250 0 nan 0.282


Residue

Diagrams

R S L Q ICL1ECL1 K W T L ECL1 P I D Y V N K R ICL2ECL2 W R T P E D R S D P D A C T I S K ECL2ICL3 E K T G A D T R H G A S P A P Q P K K S V N G E S G S R N W R L G V E S K A G G A L C A N G A V R Q G D D G A A L E V I E V H R V G N S K E H L P L P S E A G P T P C A P A S F E R K N E R N A E A K R ICL3ECL3 C E S S C H M ECL3N-term M D V L S P G Q G N N T T S P P A P F E T G G N T T G I S D V N-termC-term K C K F C R Q C-term T V S Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N G Q V T C D L F I A L D V L C C T S S I L H L C A I A L D R Y W A I T D T P R R A A A L I S L T W L I G F L I S I P P M L G D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K T V K K V K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F K K F Q N A I I
SnakePlot Download: PNG | SVG A N G L V A C F I L T G L L L S T I V Q 1 G S L A V T D L M V S L V V L P M A A L Y 2 A C L H L I S S T C C L V D L A I F L D 3 A A A L I S L T W L I G F L I S I P P M 4 Y L V L M L L L P I Y F A G F T S Y I T Y 5 G I I M G T F I L C W L P F F I V A L V 6 V P N L L S N S Y G L W N I I A G L L 7
HelixBox Download: PNG | SVG