Variation Browser

Download
Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
5ht1b_human 389 C-term T => A missense 8.297e-06 1 120532 0 nan 0.001
5ht1b_human 385 C-term R => P missense 1.656e-05 2 120794 0 0.07 0.01
5ht1b_human 385 C-term R => C missense 1.655e-05 2 120850 0 0.03 0.028
5ht1b_human 384 8.58x58 H8 I => M missense 8.273e-06 1 120882 0 0.14 0.011
5ht1b_human 368 7.52x52 TM7 I => T missense 8.238e-06 1 121392 0 0.0 0.994
5ht1b_human 367 7.51x51 TM7 I => V missense 2.471e-05 3 121394 0 0.54 0.014
5ht1b_human 366 7.50x50 TM7 P => R missense 8.238e-06 1 121394 0 0.0 1.0 SodiumPocket MicroSwitch
5ht1b_human 362 7.46x46 TM7 S => C missense 8.237e-06 1 121402 0 0.0 1.0
5ht1b_human 362 7.46x46 TM7 S => F missense 1.647e-05 2 121402 0 0.0 1.0
5ht1b_human 359 7.43x42 TM7 Y => C missense 8.237e-06 1 121402 0 0.0 1.0 LB (polar (charge-assisted hydrogen bond))
5ht1b_human 350 7.34x33 TM7 I => V missense 2.471e-05 3 121402 0 0.25 0.006
5ht1b_human 346 ECL3 F => L missense 0.0001153 14 121400 0 0.43 0.01
5ht1b_human 337 6.58x58 TM6 M => L missense 2.471e-05 3 121384 0 0.58 0.001 LB (hydrophobic)
5ht1b_human 328 6.49x49 TM6 L => P missense 8.238e-06 1 121390 0 0.0 1.0
5ht1b_human 325 6.46x46 TM6 V => M missense 1.648e-05 2 121390 0 0.03 0.314
5ht1b_human 322 6.43x43 TM6 A => D missense 8.238e-06 1 121386 0 0.0 0.903
5ht1b_human 318 6.39x39 TM6 I => V missense 1.648e-05 2 121382 0 0.11 0.074
5ht1b_human 317 6.38x38 TM6 G => R missense 8.24e-06 1 121366 0 0.0 0.999
5ht1b_human 310 6.31x31 TM6 R => L missense 1.648e-05 2 121376 0 0.0 0.99
5ht1b_human 310 6.31x31 TM6 R => P missense 8.239e-06 1 121376 0 0.0 0.995
5ht1b_human 307 6.28x28 TM6 A => S missense 1.648e-05 2 121368 0 0.34 0.985 GP (contact)
5ht1b_human 307 6.28x28 TM6 A => T missense 8.239e-06 1 121368 0 0.28 0.85 GP (contact)
5ht1b_human 305 6.26x26 TM6 M => T missense 8.239e-06 1 121368 0 0.25 0.004 GP (contact)
5ht1b_human 294 ICL3 V => I missense 8.243e-06 1 121312 0 0.2 0.005
5ht1b_human 292 ICL3 V => M missense 8.243e-06 1 121310 0 0.06 0.542
5ht1b_human 286 ICL3 Y => F missense 1.65e-05 2 121244 0 0.73 0.01
5ht1b_human 286 ICL3 Y => S missense 8.248e-06 1 121244 0 0.46 0.03
5ht1b_human 279 ICL3 S => R missense 8.252e-06 1 121178 0 0.04 0.244
5ht1b_human 270 ICL3 I => M missense 8.261e-06 1 121046 0 0.24 0.016
5ht1b_human 270 ICL3 I => V missense 8.261e-06 1 121054 0 0.59 0.003
5ht1b_human 267 ICL3 V => I missense 8.263e-06 1 121016 0 0.45 0.014
5ht1b_human 262 ICL3 G => R missense 7.439e-05 9 120978 0 0.17 0.615
5ht1b_human 260 ICL3 S => Y missense 8.264e-06 1 121012 0 0.01 0.992
5ht1b_human 253 ICL3 R => Q missense 1.653e-05 2 121024 0 0.58 0.108
5ht1b_human 246 ICL3 R => G missense 8.26e-06 1 121072 0 0.14 0.063
5ht1b_human 244 5.74x74 TM5 P => R missense 8.259e-06 1 121084 0 0.03 0.179 GP (contact)
5ht1b_human 244 5.74x74 TM5 P => L missense 8.259e-06 1 121084 0 0.01 0.3 GP (contact)
5ht1b_human 244 5.74x74 TM5 P => A missense 8.259e-06 1 121082 0 0.31 0.542 GP (contact)
5ht1b_human 233 5.63x63 TM5 V => L missense 5.776e-05 7 121186 0 0.78 0.015
5ht1b_human 233 5.63x63 TM5 V => L missense 8.252e-06 1 121186 0 0.78 0.015
5ht1b_human 233 5.63x63 TM5 V => I missense 8.252e-06 1 121186 0 0.45 0.025
5ht1b_human 230 5.60x60 TM5 R => H missense 0.0001816 22 121168 1 0.0 0.818
5ht1b_human 230 5.60x60 TM5 R => S missense 8.251e-06 1 121194 0 0.0 0.983
5ht1b_human 225 5.55x55 TM5 I => T missense 0.0002476 30 121164 0 0.0 0.643
5ht1b_human 225 5.55x55 TM5 I => V missense 8.252e-06 1 121188 0 0.23 0.123
5ht1b_human 221 5.51x51 TM5 T => N missense 8.252e-06 1 121180 0 0.06 0.493
5ht1b_human 220 5.50x50 TM5 P => S missense 8.252e-06 1 121186 0 0.0 1.0 SodiumPocket MicroSwitch
5ht1b_human 219 5.49x49 TM5 F => L missense 8.252e-06 1 121188 0 0.1 0.001
5ht1b_human 219 5.49x49 TM5 F => L missense 8.252e-06 1 121184 0 0.1 0.001
5ht1b_human 210 5.40x41 TM5 V => F missense 5.778e-05 7 121156 0 0.0 0.457
5ht1b_human 206 5.36x37 TM5 I => V missense 1.651e-05 2 121174 0 0.4 0.015
5ht1b_human 200 45.51x51 ECL2 V => M missense 8.253e-06 1 121172 0 0.22 0.01 LB (hydrophobic)
5ht1b_human 193 ECL2 E => Q missense 8.251e-06 1 121198 0 0.56 0.016
5ht1b_human 193 ECL2 E => K missense 8.251e-06 1 121198 0 0.71 0.108
5ht1b_human 186 4.62x62 TM4 F => L missense 8.251e-06 1 121200 0 0.16 0.614
5ht1b_human 174 4.50x50 TM4 W => C missense 8.251e-06 1 121200 0 0.0 1.0
5ht1b_human 173 4.49x49 TM4 V => A missense 1.65e-05 2 121192 0 0.2 0.498
5ht1b_human 167 4.43x43 TM4 A => V missense 8.251e-06 1 121194 0 0.02 0.126
5ht1b_human 166 4.42x42 TM4 A => T missense 8.251e-06 1 121204 0 0.0 0.912
5ht1b_human 163 4.39x39 TM4 P => T missense 8.251e-06 1 121194 0 0.18 0.159
5ht1b_human 161 34.57x57 ICL2 R => S missense 1.65e-05 2 121198 0 0.0 0.934 GP (contact)
5ht1b_human 160 34.56x56 ICL2 K => T missense 8.251e-06 1 121198 0 0.0 0.145 GP (contact)
5ht1b_human 156 34.52x52 ICL2 E => D missense 2.475e-05 3 121190 0 0.01 0.018 GP (contact)
5ht1b_human 155 34.51x51 ICL2 V => A missense 8.252e-06 1 121182 0 0.04 0.696 GP (contact)
5ht1b_human 155 34.51x51 ICL2 V => L missense 8.253e-06 1 121168 0 0.5 0.042 GP (contact)
5ht1b_human 151 3.54x54 TM3 I => F missense 8.252e-06 1 121180 0 0.0 0.996 GP (contact)
5ht1b_human 150 3.53x53 TM3 A => S missense 3.301e-05 4 121176 0 0.0 0.953 GP (contact)
5ht1b_human 142 3.45x45 TM3 V => A missense 8.249e-06 1 121226 0 0.47 0.105
5ht1b_human 141 3.44x44 TM3 C => S missense 8.251e-06 1 121194 0 0.13 0.993
5ht1b_human 127 3.30x30 TM3 S => L missense 4.122e-05 5 121298 0 0.05 0.597
5ht1b_human 124 3.27x27 TM3 F => C missense 0.009257 1123 121316 10 0.0 0.586
5ht1b_human 112 2.67x66 TM2 T => N missense 4.945e-05 6 121344 0 0.13 0.091
5ht1b_human 112 2.67x66 TM2 T => S missense 5.769e-05 7 121342 0 0.67 0.021
5ht1b_human 110 2.65x64 TM2 T => S missense 1.648e-05 2 121350 0 0.02 0.855
5ht1b_human 106 2.61x60 TM2 S => G missense 8.24e-06 1 121358 0 0.01 0.05
5ht1b_human 93 2.48x48 TM2 V => F missense 8.238e-06 1 121384 0 0.07 0.072
5ht1b_human 92 2.47x47 TM2 A => V missense 8.238e-06 1 121388 0 0.0 0.999
5ht1b_human 92 2.47x47 TM2 A => T missense 1.648e-05 2 121392 0 0.0 0.999
5ht1b_human 76 1.59x59 TM1 R => W missense 8.237e-06 1 121410 0 0.07 0.901
5ht1b_human 73 1.56x56 TM1 T => I missense 8.237e-06 1 121410 0 0.02 0.978
5ht1b_human 71 1.54x54 TM1 I => T missense 1.647e-05 2 121410 0 0.0 0.349
5ht1b_human 68 1.51x51 TM1 A => T missense 8.236e-06 1 121412 0 0.13 0.05
5ht1b_human 67 1.50x50 TM1 N => S missense 1.647e-05 2 121412 0 0.0 1.0
5ht1b_human 66 1.49x49 TM1 S => F missense 8.236e-06 1 121412 0 0.2 0.179
5ht1b_human 60 1.43x43 TM1 T => I missense 1.647e-05 2 121412 0 0.0 0.991 PTM (Phosphorylation)
5ht1b_human 58 1.41x41 TM1 L => V missense 8.236e-06 1 121412 0 1.0 0.021
5ht1b_human 51 1.34x34 TM1 L => P missense 8.236e-06 1 121412 0 0.14 0.424
5ht1b_human 50 1.33x33 TM1 V => I missense 8.236e-06 1 121412 0 1.0 0.007
5ht1b_human 49 1.32x32 TM1 K => T missense 8.236e-06 1 121412 0 0.01 0.703
5ht1b_human 47 1.30x30 TM1 P => T missense 8.237e-06 1 121410 0 0.29 0.039
5ht1b_human 47 1.30x30 TM1 P => S missense 8.237e-06 1 121410 0 0.52 0.001
5ht1b_human 45 1.28x28 TM1 S => P missense 8.237e-06 1 121410 0 0.3 0.0
5ht1b_human 39 N-term I => V missense 2.471e-05 3 121402 0 0.84 0.0
5ht1b_human 35 N-term A => V missense 8.237e-06 1 121400 0 0.18 0.001
5ht1b_human 35 N-term A => T missense 8.237e-06 1 121400 0 0.43 0.017
5ht1b_human 30 N-term S => C missense 8.238e-06 1 121388 0 0.01 0.315
5ht1b_human 29 N-term P => S missense 8.238e-06 1 121388 0 0.68 0.001
5ht1b_human 28 N-term A => T missense 8.239e-06 1 121378 0 0.65 0.002
5ht1b_human 27 N-term S => F missense 0.0001236 15 121374 1 0.23 0.085
5ht1b_human 22 N-term Q => P missense 1.649e-05 2 121310 0 nan 0.0
5ht1b_human 21 N-term P => S missense 8.247e-06 1 121258 0 nan 0.001
5ht1b_human 19 N-term W => C missense 8.253e-06 1 121172 0 nan 0.0
5ht1b_human 16 N-term S => F missense 8.272e-06 1 120892 0 nan 0.07
5ht1b_human 13 N-term P => L missense 0.0001329 16 120392 0 nan 0.001
5ht1b_human 13 N-term P => S missense 8.305e-06 1 120416 0 nan 0.001
5ht1b_human 12 N-term P => S missense 8.329e-06 1 120068 0 nan 0.001
5ht1b_human 9 N-term A => V missense 8.367e-06 1 119514 0 nan 0.739
5ht1b_human 5 N-term G => D missense 8.474e-06 1 118004 0 nan 0.013
5ht1b_human 5 N-term G => S missense 8.475e-06 1 117992 0 nan 0.0
5ht1b_human 3 N-term E => Q missense 8.536e-06 1 117146 0 nan 0.008
5ht1b_human 251 ICL3 L => Ter stop gained 8.261e-06 1 121054 0 None None


Residue

Diagrams

R K L H ICL1ECL1 R W T L ECL1 A V E Y S A K R ICL2ECL2 R Q A K A E E E V S E C V V N T D ECL2ICL3 N R T G K R L T R A Q L I T D S P G S T S S V T S I N S R V P D V P S E S G S P V Y V N Q V K V R V S D A L L E K K ICL3ECL3 C K D A C W F ECL3N-term M E E P G A Q C A P P P P A G S E T W V P Q A N L S S A P S Q N C S A K D Y I Y Q D S I N-termC-term R F K C T S C-term S L P W K V L L V M L L A L I T L A T T L S N A F V I A T V Y R T T P A N Y L I A S L A V T D L L V S I L V M P I S T M Y T V T G G Q V V C D F W L S S D I T C C T A S I L H L C V I A L D R Y W A I T D T P K R A A V M I A L V W V F S I S I S L P P F F W H I L Y T V Y S T V G A F Y F P T L L L I A L Y G R I Y V E A R S R I L K Q T P K L M A A R E R K A T K T L G I I L G A F I V C W L P F F I I S L V M P I H L A I F D F F T W L G Y L N S L I N P I I Y T M S N E D F H K F K Q A L I
SnakePlot Download: PNG | SVG A N S L T T A L T I L A L L M V L L V K 1 A S L A V T D L L V S L I V M P I S T M Y 2 V C L H L I S A T C C T I D S S L W F D 3 A A V M I A L V W V F S I S I S L P P F 4 Y L A I L L L T P F Y F A G V T S Y V T Y 5 G I I L G A F I V C W L P F F I I S L V 6 I P N I L S N L Y G L W T F F D F I A 7
HelixBox Download: PNG | SVG