Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
5ht1f_human 8 N-term D => G missense 1.653e-05 2 120986 0 0.4 0.0
5ht1f_human 11 N-term L => M missense 8.253e-06 1 121164 0 0.22 0.061
5ht1f_human 15 N-term E => Q missense 0.0002719 33 121346 0 0.22 0.02
5ht1f_human 15 N-term E => A missense 8.241e-06 1 121340 0 0.32 0.007
5ht1f_human 20 1.29x29 TM1 M => T missense 8.238e-06 1 121386 0 0.26 0.014
5ht1f_human 28 1.37x37 TM1 L => F missense 8.237e-06 1 121408 0 0.03 0.003
5ht1f_human 31 1.40x40 TM1 S => C missense 4.942e-05 6 121410 0 0.02 0.928
5ht1f_human 34 1.43x43 TM1 A => V missense 2.471e-05 3 121406 0 0.08 0.698
5ht1f_human 36 1.45x45 TM1 M => I missense 8.237e-06 1 121400 0 0.15 0.165
5ht1f_human 37 1.46x46 TM1 T => I missense 8.237e-06 1 121398 0 0.01 0.999
5ht1f_human 38 1.47x47 TM1 T => A missense 2.471e-05 3 121398 0 0.12 0.885 PTM (Phosphorylation)
5ht1f_human 38 1.47x47 TM1 T => P missense 8.237e-06 1 121398 0 0.0 0.982 PTM (Phosphorylation)
5ht1f_human 46 1.55x55 TM1 A => T missense 0.002002 243 121402 1 0.67 0.004
5ht1f_human 47 1.56x56 TM1 A => T missense 8.237e-06 1 121400 0 0.88 0.654
5ht1f_human 52 12.48x48 ICL1 R => W missense 4.119e-05 5 121394 0 0.0 0.98
5ht1f_human 52 12.48x48 ICL1 R => Q missense 2.471e-05 3 121392 0 0.02 0.183
5ht1f_human 66 2.47x47 TM2 A => T missense 8.239e-06 1 121378 0 0.0 1.0
5ht1f_human 70 2.51x51 TM2 F => I missense 8.239e-06 1 121374 0 0.01 0.643
5ht1f_human 72 2.53x53 TM2 V => M missense 8.239e-06 1 121368 0 0.0 1.0
5ht1f_human 80 2.61x60 TM2 S => T missense 1.648e-05 2 121352 0 0.0 0.988
5ht1f_human 83 2.64x63 TM2 Y => H missense 0.0001236 15 121350 0 0.0 1.0
5ht1f_human 86 2.67x66 TM2 R => K missense 0.0003461 42 121342 0 0.92 0.001
5ht1f_human 87 2.68x67 TM2 E => Q missense 5.769e-05 7 121342 0 0.32 0.474
5ht1f_human 91 23.52x52 ECL1 M => T missense 8.242e-06 1 121334 0 0.0 0.698
5ht1f_human 106 3.35x35 TM3 C => Y missense 8.245e-06 1 121280 0 0.01 1.0
5ht1f_human 112 3.41x41 TM3 L => V missense 8.246e-06 1 121266 0 0.0 0.999
5ht1f_human 112 3.41x41 TM3 L => W missense 8.247e-06 1 121260 0 0.0 1.0
5ht1f_human 121 3.50x50 TM3 R => Q missense 8.248e-06 1 121246 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
5ht1f_human 123 3.52x52 TM3 R => Q missense 2.475e-05 3 121228 0 0.02 0.974
5ht1f_human 131 34.53x53 ICL2 Y => D missense 8.252e-06 1 121182 0 0.0 1.0 PTM (Phosphorylation) GP (contact)
5ht1f_human 133 34.55x55 ICL2 R => G missense 8.253e-06 1 121174 0 0.01 0.765 GP (contact)
5ht1f_human 133 34.55x55 ICL2 R => K missense 8.253e-06 1 121164 0 1.0 0.5 GP (contact)
5ht1f_human 137 4.39x39 TM4 P => S missense 8.257e-06 1 121104 0 0.2 0.023
5ht1f_human 139 4.41x41 TM4 H => N missense 8.259e-06 1 121084 0 0.01 0.003
5ht1f_human 146 4.48x48 TM4 I => L missense 8.269e-06 1 120936 0 0.61 0.026
5ht1f_human 147 4.49x49 TM4 V => I missense 5.79e-05 7 120894 0 0.03 0.92
5ht1f_human 149 4.51x51 TM4 I => V missense 8.274e-06 1 120860 0 1.0 0.002
5ht1f_human 151 4.53x53 TM4 S => P missense 8.28e-06 1 120776 0 0.01 0.991
5ht1f_human 156 4.58x58 TM4 M => T missense 1.656e-05 2 120768 0 0.11 0.201
5ht1f_human 174 45.52x52 ECL2 I => M missense 8.293e-06 1 120584 0 0.02 0.859
5ht1f_human 177 ECL2 D => N missense 8.295e-06 1 120560 0 0.05 0.615
5ht1f_human 178 5.35x36 TM5 H => Y missense 1.659e-05 2 120544 0 0.0 0.936
5ht1f_human 178 5.35x36 TM5 H => R missense 8.295e-06 1 120552 0 0.01 0.788
5ht1f_human 187 5.44x45 TM5 F => C missense 4.986e-05 6 120344 0 0.31 0.316
5ht1f_human 194 5.51x51 TM5 L => P missense 8.322e-06 1 120158 0 0.02 0.999
5ht1f_human 198 5.55x55 TM5 L => S missense 8.327e-06 1 120098 0 0.0 1.0
5ht1f_human 198 5.55x55 TM5 L => F missense 8.328e-06 1 120078 0 0.01 1.0
5ht1f_human 200 5.57x57 TM5 L => F missense 8.329e-06 1 120060 0 0.0 0.996
5ht1f_human 204 5.61x61 TM5 I => V missense 8.333e-06 1 120008 0 0.0 0.999 GP (contact)
5ht1f_human 212 5.69x69 TM5 Y => N missense 1.666e-05 2 120028 0 0.13 0.976 GP (contact)
5ht1f_human 220 ICL3 I => T missense 8.323e-06 1 120150 0 0.42 0.063
5ht1f_human 220 ICL3 I => M missense 8.323e-06 1 120152 0 0.21 0.009
5ht1f_human 223 ICL3 E => Q missense 8.318e-06 1 120220 0 0.09 0.043
5ht1f_human 227 ICL3 G => D missense 1.661e-05 2 120386 0 0.1 0.982
5ht1f_human 230 ICL3 L => F missense 8.302e-06 1 120448 0 0.04 0.889
5ht1f_human 230 ICL3 L => P missense 8.301e-06 1 120464 0 0.02 0.943
5ht1f_human 233 ICL3 S => T missense 8.293e-06 1 120582 0 0.16 0.001 PTM (Phosphorylation)
5ht1f_human 239 ICL3 K => E missense 1.656e-05 2 120748 0 1.0 0.099
5ht1f_human 241 ICL3 V => A missense 8.28e-06 1 120778 0 0.41 0.004
5ht1f_human 242 ICL3 S => A missense 8.279e-06 1 120788 0 0.33 0.001
5ht1f_human 244 ICL3 S => T missense 8.275e-06 1 120850 0 0.78 0.027
5ht1f_human 246 ICL3 V => I missense 8.272e-06 1 120896 0 0.2 0.012
5ht1f_human 250 ICL3 S => P missense 8.267e-06 1 120966 0 0.06 0.976
5ht1f_human 259 ICL3 D => A missense 8.263e-06 1 121016 0 0.69 0.877
5ht1f_human 262 ICL3 H => R missense 8.261e-06 1 121056 0 0.34 0.002
5ht1f_human 265 ICL3 V => L missense 8.262e-06 1 121030 0 0.37 0.007
5ht1f_human 267 ICL3 S => G missense 1.652e-05 2 121068 0 0.56 0.099
5ht1f_human 267 ICL3 S => N missense 8.261e-06 1 121054 0 0.61 0.008
5ht1f_human 281 ICL3 Q => E missense 8.266e-06 1 120982 0 0.06 0.101
5ht1f_human 289 6.31x31 TM6 R => W missense 8.279e-06 1 120792 0 0.0 0.997
5ht1f_human 289 6.31x31 TM6 R => G missense 8.279e-06 1 120792 0 0.02 0.92
5ht1f_human 295 6.37x37 TM6 L => V missense 1.654e-05 2 120942 0 0.0 0.999 GP (contact)
5ht1f_human 298 6.40x40 TM6 I => T missense 8.271e-06 1 120898 0 0.0 1.0 GP (contact)
5ht1f_human 302 6.44x44 TM6 F => L missense 8.275e-06 1 120840 0 0.0 0.999 SodiumPocket MicroSwitch
5ht1f_human 304 6.46x46 TM6 I => V missense 8.277e-06 1 120812 0 0.99 0.123
5ht1f_human 313 6.55x55 TM6 E => G missense 8.279e-06 1 120786 0 0.12 1.0
5ht1f_human 316 6.58x58 TM6 V => I missense 8.279e-06 1 120782 0 0.17 0.957
5ht1f_human 322 ECL3 C => W missense 8.273e-06 1 120876 0 0.0 0.957
5ht1f_human 331 7.37x36 TM7 F => V missense 8.271e-06 1 120898 0 0.16 0.899
5ht1f_human 337 7.43x42 TM7 Y => C missense 8.28e-06 1 120770 0 0.0 1.0
5ht1f_human 340 7.46x46 TM7 S => P missense 1.657e-05 2 120672 0 0.0 1.0
5ht1f_human 341 7.47x47 TM7 L => P missense 8.29e-06 1 120630 0 0.0 1.0
5ht1f_human 342 7.48x48 TM7 I => V missense 8.291e-06 1 120612 0 0.05 0.116
5ht1f_human 346 7.52x52 TM7 I => S missense 8.322e-06 1 120166 0 0.0 0.985
5ht1f_human 349 7.55x55 TM7 I => T missense 8.342e-06 1 119872 0 0.15 0.04 GP (contact)
5ht1f_human 362 8.58x58 H8 V => L missense 8.596e-06 1 116336 0 0.23 0.002
5ht1f_human 363 C-term R => Q missense 5.191e-05 6 115590 0 0.11 0.002
5ht1f_human 364 C-term C => R missense 8.67e-06 1 115344 0 0.03 0.957
5ht1f_human 365 C-term R => Q missense 8.741e-06 1 114408 0 0.03 0.063
5ht1f_human 366 C-term C => S missense 8.767e-06 1 114068 0 0.0 0.788
5ht1f_human 366 C-term C => R missense 8.767e-06 1 114068 0 0.0 0.902
5ht1f_human 16 N-term L => ThrfsTer82 frameshift 8.241e-06 1 121346 0 None None
5ht1f_human 18 N-term N => LysfsTer80 frameshift 8.239e-06 1 121370 0 None None PTM (N-linked Glycosylation)
5ht1f_human 99 3.28x28 TM3 W => Ter stop gained 8.243e-06 1 121314 0 None None
5ht1f_human 123 3.52x52 TM3 R => Ter stop gained 8.249e-06 1 121228 0 None None
5ht1f_human 134 34.56x56 ICL2 K => Ter stop gained 1.651e-05 2 121146 1 None None GP (contact)
5ht1f_human 167 ECL2 S => ArgfsTer30 frameshift 8.283e-06 1 120724 0 None None
5ht1f_human 251 ICL3 L => PhefsTer3 frameshift 8.266e-06 1 120972 0 None None
5ht1f_human 299 6.41x41 TM6 L => PhefsTer19 frameshift 8.273e-06 1 120872 0 None None
5ht1f_human 306 6.48x48 TM6 W => Ter stop gained 8.284e-06 1 120718 0 None None SodiumPocket MicroSwitch
5ht1f_human 363 C-term R => Ter stop gained 8.658e-06 1 115504 0 None None
5ht1f_human 364 C-term C => SerfsTer23 frameshift 8.651e-06 1 115590 0 None None


Residue

Diagrams

R K L H ICL1ECL1 S W I M ECL1 A V E Y A R K R ICL2ECL2 R H Q G T S R D D E C I I K H D ECL2ICL3 I A K E E V N G Q V L L E S G E K S T K S V S T S Y V L E K S L S D P S T D F D K I H S T V R S L R S E F K H E K S W R R Q ICL3ECL3 D K C K I ECL3N-term M D F L N S S D Q N L T S E E L L N N-termC-term R C R C C-term R M P S K I L V S L T L S G L A L M T T T I N S L V I A A I I V T H P A N Y L I C S L A V T D F L V A V L V M P F S I V Y I V R E G Q V V C D I W L S V D I T C C T C S I L H L S A I A L D R Y R A I T D T P K H A G I M I T I V W I I S V F I S M P P L F W H I V S T I Y S T F G A F Y I P L A L I L I L Y Y K I Y R A A K T L Y H K R Q A S R K I S G T R E R K A A T T L G L I L G A F V I C W L P F F V K E L V V N V C S E E M S N F L A W L G Y L N S L I N P L I Y T I F N E D F Q K F K K A L V
SnakePlot Download: PNG | SVG S N I T T T M L A L G S L T L S V L I K 1 C S L A V T D F L V A L V V M P F S I V Y 2 A S L H L I S C T C C T I D V S L W I D 3 A G I M I T I V W I I S V F I S M P P L 4 Y L I L I L A L P I Y F A G F T S Y I T S 5 G L I L G A F V I C W L P F F V K E L V 6 L P N I L S N L Y G L W A L F N S M E 7
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