Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
5ht2c_human 3 N-term N => S missense 0.000105 6 57125 0 nan 0.899
5ht2c_human 7 N-term A => V missense 0.0003345 19 56802 0 nan 0.004
5ht2c_human 7 N-term A => E missense 1.761e-05 1 56802 0 nan 0.333
5ht2c_human 9 N-term H => R missense 1.768e-05 1 56551 0 nan 0.001
5ht2c_human 11 N-term F => L missense 1.796e-05 1 55676 0 nan 0.001
5ht2c_human 12 N-term L => F missense 1.8e-05 1 55559 0 nan 0.766
5ht2c_human 13 N-term V => A missense 1.185e-05 1 84369 0 nan 0.122
5ht2c_human 16 N-term I => T missense 2.356e-05 2 84898 0 nan 0.541
5ht2c_human 17 N-term G => V missense 1.176e-05 1 85032 0 nan 0.471
5ht2c_human 23 N-term C => S missense 0.1544 13292 86103 847 nan 0.005
5ht2c_human 25 N-term I => V missense 2.318e-05 2 86298 0 nan 0.01
5ht2c_human 30 N-term V => A missense 1.149e-05 1 87015 0 nan 0.015
5ht2c_human 31 N-term A => T missense 1.148e-05 1 87094 0 nan 0.015
5ht2c_human 31 N-term A => V missense 1.148e-05 1 87129 0 nan 0.095
5ht2c_human 33 N-term I => T missense 1.145e-05 1 87356 0 nan 0.002
5ht2c_human 33 N-term I => M missense 4.578e-05 4 87371 0 nan 0.002
5ht2c_human 42 N-term D => H missense 0.0002849 25 87738 0 nan 0.718
5ht2c_human 43 N-term G => C missense 1.14e-05 1 87739 0 nan 0.758
5ht2c_human 46 N-term F => S missense 1.14e-05 1 87742 0 nan 0.013
5ht2c_human 47 N-term K => E missense 3.419e-05 3 87748 0 nan 0.009
5ht2c_human 52 N-term V => L missense 1.14e-05 1 87750 0 nan 0.221
5ht2c_human 59 1.38x38 TM1 S => P missense 1.14e-05 1 87756 0 nan 0.005
5ht2c_human 61 1.40x40 TM1 V => I missense 0.0001254 11 87754 0 nan 0.03
5ht2c_human 62 1.41x41 TM1 I => T missense 1.14e-05 1 87755 0 nan 0.011
5ht2c_human 63 1.42x42 TM1 I => V missense 1.14e-05 1 87755 0 nan 0.034
5ht2c_human 79 1.58x58 TM1 S => R missense 2.279e-05 2 87741 0 nan 0.771
5ht2c_human 103 2.54x54 TM2 G => R missense 1.158e-05 1 86361 0 nan 0.993
5ht2c_human 114 2.65x64 TM2 I => V missense 1.188e-05 1 84169 0 nan 0.173
5ht2c_human 117 2.68x67 TM2 D => G missense 1.168e-05 1 85585 0 nan 0.048
5ht2c_human 119 23.49x49 ECL1 V => I missense 1.166e-05 1 85763 0 nan 0.18
5ht2c_human 119 23.49x49 ECL1 V => D missense 1.166e-05 1 85794 0 nan 0.055
5ht2c_human 129 3.27x27 TM3 V => I missense 1.145e-05 1 87325 0 nan 0.131
5ht2c_human 159 34.50x50 ICL2 P => S missense 1.142e-05 1 87583 0 nan 0.982 GP (contact)
5ht2c_human 160 34.51x51 ICL2 I => V missense 1.142e-05 1 87578 0 nan 0.042 GP (contact)
5ht2c_human 166 34.57x57 ICL2 N => S missense 2.285e-05 2 87511 0 nan 0.42 GP (contact)
5ht2c_human 168 4.39x39 TM4 R => Q missense 3.429e-05 3 87479 0 nan 0.928
5ht2c_human 171 4.42x42 TM4 A => V missense 0.0005493 48 87385 0 nan 0.402
5ht2c_human 172 4.43x43 TM4 I => V missense 9.16e-05 8 87332 0 nan 0.105
5ht2c_human 217 5.41x42 TM5 I => T missense 2.282e-05 2 87624 0 nan 0.367
5ht2c_human 269 ICL3 R => K missense 1.14e-05 1 87719 0 nan 0.001
5ht2c_human 280 ICL3 P => L missense 2.279e-05 2 87740 0 nan 0.043
5ht2c_human 282 ICL3 Q => H missense 2.279e-05 2 87743 0 nan 0.001
5ht2c_human 283 ICL3 D => Y missense 1.14e-05 1 87739 0 nan 0.696
5ht2c_human 287 ICL3 R => C missense 1.14e-05 1 87731 0 nan 0.001
5ht2c_human 287 ICL3 R => H missense 1.14e-05 1 87726 0 nan 0.008
5ht2c_human 288 ICL3 R => Q missense 1.141e-05 1 87674 0 nan 0.006
5ht2c_human 289 ICL3 R => K missense 1.141e-05 1 87665 0 nan 0.003
5ht2c_human 294 ICL3 R => K missense 2.28e-05 2 87723 0 nan 0.0
5ht2c_human 295 ICL3 R => G missense 7.98e-05 7 87718 0 nan 0.018
5ht2c_human 295 ICL3 R => C missense 1.14e-05 1 87718 0 nan 0.157
5ht2c_human 300 6.24x24 TM6 M => I missense 1.14e-05 1 87729 0 nan 0.27
5ht2c_human 304 6.28x28 TM6 N => S missense 1.14e-05 1 87729 0 nan 0.055 GP (contact)
5ht2c_human 305 6.29x29 TM6 N => D missense 1.14e-05 1 87734 0 nan 0.823 GP (contact)
5ht2c_human 314 6.38x38 TM6 G => R missense 1.14e-05 1 87734 0 nan 1.0
5ht2c_human 323 6.47x47 TM6 M => T missense 1.14e-05 1 87742 0 nan 0.42
5ht2c_human 329 6.53x53 TM6 I => V missense 1.14e-05 1 87746 0 nan 0.177
5ht2c_human 337 6.61x61 TM6 C => F missense 1.14e-05 1 87737 0 nan 0.999
5ht2c_human 337 6.61x61 TM6 C => Y missense 1.14e-05 1 87737 0 nan 0.999
5ht2c_human 344 7.29x28 TM7 K => Q missense 1.14e-05 1 87726 0 nan 0.01
5ht2c_human 352 7.37x36 TM7 V => L missense 1.14e-05 1 87713 0 nan 0.267
5ht2c_human 356 7.41x40 TM7 I => S missense 1.14e-05 1 87696 0 nan 0.944
5ht2c_human 372 8.47x47 H8 N => S missense 1.141e-05 1 87662 0 nan 0.925 GP (contact)
5ht2c_human 373 8.48x48 H8 K => N missense 1.141e-05 1 87662 0 nan 0.666 GP (contact)
5ht2c_human 374 8.49x49 H8 I => L missense 0.000308 27 87664 0 nan 0.004 GP (contact)
5ht2c_human 376 8.51x51 H8 R => Q missense 1.141e-05 1 87648 0 nan 0.996 GP (contact)
5ht2c_human 384 8.59x59 H8 R => H missense 1.141e-05 1 87609 0 nan 0.112
5ht2c_human 384 8.59x59 H8 R => L missense 1.141e-05 1 87609 0 nan 0.142
5ht2c_human 389 C-term V => A missense 6.85e-05 6 87596 0 nan 0.0
5ht2c_human 395 C-term V => G missense 1.142e-05 1 87595 0 nan 0.001
5ht2c_human 400 C-term R => K missense 1.142e-05 1 87591 0 nan 0.148
5ht2c_human 401 C-term V => A missense 3.425e-05 3 87604 0 nan 0.001
5ht2c_human 409 C-term R => K missense 6.846e-05 6 87639 0 nan 0.004
5ht2c_human 415 C-term I => N missense 1.141e-05 1 87651 0 nan 0.001
5ht2c_human 419 C-term T => A missense 0.0008326 73 87675 0 nan 0.013
5ht2c_human 430 C-term N => S missense 1.14e-05 1 87711 0 nan 0.0
5ht2c_human 431 C-term E => K missense 1.14e-05 1 87715 0 nan 0.621
5ht2c_human 433 C-term G => A missense 1.14e-05 1 87709 0 nan 0.006
5ht2c_human 434 C-term I => T missense 3.421e-05 3 87704 0 nan 0.573
5ht2c_human 438 C-term V => L missense 1.14e-05 1 87681 0 nan 0.006
5ht2c_human 442 C-term E => G missense 1.142e-05 1 87551 0 nan 0.343
5ht2c_human 454 C-term R => M missense 1.154e-05 1 86648 0 nan 0.928
5ht2c_human 455 C-term I => N missense 1.156e-05 1 86542 0 nan 0.573
5ht2c_human 172 4.43x43 TM4 I => Ter stop gained 1.176e-05 1 85009 0 None None
5ht2c_human 179 4.50x50 TM4 W => Ter stop gained 1.151e-05 1 86912 0 None None
5ht2c_human 222 5.46x461 TM5 A => Ter stop gained 3.42e-05 3 87714 0 None None
5ht2c_human 238 5.62x62 TM5 I => Ter stop gained 1.14e-05 1 87726 0 None None
5ht2c_human 425 C-term E => Ter stop gained 1.14e-05 1 87693 0 None None


Residue

Diagrams

K K L H ICL1ECL1 Y V W P L ECL1 P I E H S R F N ICL2ECL2 E E K V F V N N T T C V L N ECL2ICL3 G H T E E P P G L S L D F L K C C K R N T A E E E N S A N P N Q D Q N A R R R K K K E R R P R G T ICL3ECL3 E K S C ECL3N-term M V N L R N A V H S F L V H L I G L L V W Q C D I S V S P V A A I V T D I F N T S D G G R F K F P D G V Q N-termC-term N Y K V E K K P P V R Q I P R V A A T A L S G R E L N V N I Y R H T N E P V I E K A S D N E P G I E M Q V E N L E L P V N P S S V V S E R I S S V C-term N W P A L S I V I I I I M T I G G N I L V I M A V S M E N A T N Y F L M S L A I A D M L V G L L V M P L S L L A I L Y D P R Y L C P V W I S L D V L F S T A S I M H L C A I S L D R Y V A I R N S R T K A I M K I A I V W A I S I G V S V P I P V I G L R D D P N F V L I G S F V A F F I P L T I M V I T Y C L T I Y V L R R Q A L M L L H M Q A I N N E R K A S K V L G I V F F V F L I M W C P F F I T N I L S V L C N Q K L M E K L L N V F V W I G Y V C S G I N P L V Y T L F N K I F S N Y R R A Y L R C
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