Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
5ht5a_human 4 N-term P => L missense 8.462e-06 1 118176 0 nan 0.002
5ht5a_human 14 N-term T => S missense 8.26e-06 1 121072 0 0.6 0.002
5ht5a_human 15 N-term P => S missense 0.04337 5254 121142 140 0.52 0.001
5ht5a_human 15 N-term P => T missense 8.255e-06 1 121142 0 0.12 0.001
5ht5a_human 17 N-term P => R missense 8.249e-06 1 121220 0 0.01 0.068
5ht5a_human 20 N-term T => A missense 8.245e-06 1 121284 0 0.47 0.0
5ht5a_human 22 N-term H => Y missense 8.243e-06 1 121314 0 0.12 0.024
5ht5a_human 23 N-term S => T missense 4.945e-05 6 121340 0 0.36 0.001
5ht5a_human 25 N-term G => S missense 2.472e-05 3 121352 0 0.17 0.002
5ht5a_human 25 N-term G => R missense 8.24e-06 1 121352 0 0.04 0.171
5ht5a_human 27 N-term D => H missense 8.24e-06 1 121364 0 0.1 0.001
5ht5a_human 28 N-term D => N missense 1.648e-05 2 121374 0 0.57 0.001
5ht5a_human 30 N-term R => C missense 8.239e-06 1 121380 0 0.05 0.339
5ht5a_human 30 N-term R => S missense 1.648e-05 2 121380 0 0.73 0.001
5ht5a_human 30 N-term R => H missense 3.296e-05 4 121376 0 0.12 0.002
5ht5a_human 31 N-term P => L missense 8.238e-06 1 121388 0 0.14 0.004
5ht5a_human 35 N-term L => M missense 8.238e-06 1 121396 0 0.27 0.221
5ht5a_human 37 1.29x29 TM1 S => L missense 3.295e-05 4 121388 0 0.0 0.148
5ht5a_human 38 1.30x30 TM1 V => F missense 8.238e-06 1 121386 0 0.02 0.049
5ht5a_human 40 1.32x32 TM1 G => R missense 8.238e-06 1 121382 0 0.22 0.006
5ht5a_human 41 1.33x33 TM1 V => M missense 0.0001236 15 121384 0 0.06 0.059
5ht5a_human 44 1.36x36 TM1 L => F missense 1.648e-05 2 121384 0 0.29 0.062
5ht5a_human 52 1.44x44 TM1 A => T missense 8.242e-06 1 121328 0 1.0 0.695
5ht5a_human 52 1.44x44 TM1 A => V missense 1.649e-05 2 121316 0 0.27 0.682
5ht5a_human 139 3.50x50 TM3 R => C missense 8.27e-06 1 120922 0 0.0 0.999 SodiumPocket MicroSwitch GP (contact)
5ht5a_human 139 3.50x50 TM3 R => H missense 8.269e-06 1 120930 0 0.0 0.998 SodiumPocket MicroSwitch GP (contact)
5ht5a_human 141 3.52x52 TM3 W => L missense 8.265e-06 1 120986 0 0.01 0.651
5ht5a_human 143 3.54x54 TM3 I => T missense 8.263e-06 1 121018 0 0.0 0.72 GP (contact)
5ht5a_human 144 3.55x55 TM3 T => M missense 8.262e-06 1 121042 0 0.01 0.843 GP (contact)
5ht5a_human 144 3.55x55 TM3 T => K missense 1.652e-05 2 121042 0 0.01 0.591 GP (contact)
5ht5a_human 145 3.56x56 TM3 R => C missense 8.26e-06 1 121060 0 0.0 0.248 GP (contact)
5ht5a_human 145 3.56x56 TM3 R => H missense 5.783e-05 7 121050 0 0.06 0.178 GP (contact)
5ht5a_human 149 34.53x53 ICL2 Y => H missense 8.257e-05 10 121116 0 0.0 1.0 GP (contact)
5ht5a_human 150 34.54x54 ICL2 T => S missense 8.256e-06 1 121126 0 0.02 0.236 GP (contact)
5ht5a_human 150 34.54x54 ICL2 T => A missense 8.256e-06 1 121126 0 0.1 0.371 GP (contact)
5ht5a_human 153 34.57x57 ICL2 T => I missense 1.651e-05 2 121162 0 0.12 0.03 GP (contact)
5ht5a_human 154 4.38x38 TM4 R => H missense 3.301e-05 4 121166 0 0.02 0.982
5ht5a_human 154 4.38x38 TM4 R => L missense 2.476e-05 3 121166 0 0.01 0.95
5ht5a_human 157 4.41x41 TM4 V => I missense 0.0003383 41 121190 0 0.51 0.001
5ht5a_human 159 4.43x43 TM4 N => S missense 8.25e-06 1 121206 0 0.4 0.155
5ht5a_human 161 4.45x45 TM4 M => I missense 8.25e-06 1 121210 0 0.04 0.734
5ht5a_human 163 4.47x47 TM4 A => V missense 0.000561 68 121212 0 0.15 0.027
5ht5a_human 169 4.53x53 TM4 S => Y missense 8.25e-06 1 121212 0 0.0 0.98
5ht5a_human 170 4.54x54 TM4 A => S missense 2.475e-05 3 121218 0 0.24 0.176
5ht5a_human 170 4.54x54 TM4 A => T missense 4.95e-05 6 121218 0 0.41 0.103
5ht5a_human 170 4.54x54 TM4 A => V missense 1.65e-05 2 121214 0 0.97 0.264
5ht5a_human 175 4.59x59 TM4 A => P missense 8.249e-06 1 121222 0 0.29 0.174
5ht5a_human 181 ECL2 W => C missense 8.251e-06 1 121200 0 0.0 1.0
5ht5a_human 183 ECL2 E => K missense 8.25e-06 1 121218 0 0.12 0.364
5ht5a_human 184 ECL2 T => M missense 0.000297 36 121214 0 0.06 0.148
5ht5a_human 196 ECL2 R => S missense 8.248e-06 1 121236 0 0.0 0.341
5ht5a_human 198 5.36x37 TM5 P => A missense 8.249e-06 1 121234 0 0.12 0.271
5ht5a_human 206 5.44x45 TM5 V => A missense 8.247e-06 1 121262 0 0.41 0.062
5ht5a_human 214 5.52x52 TM5 C => Y missense 8.243e-06 1 121310 0 0.33 0.392
5ht5a_human 230 5.68x68 TM5 R => C missense 8.242e-06 1 121336 0 0.01 0.643 GP (contact)
5ht5a_human 231 5.69x69 TM5 V => L missense 8.242e-06 1 121332 0 0.11 0.015 GP (contact)
5ht5a_human 231 5.69x69 TM5 V => M missense 1.648e-05 2 121332 0 0.06 0.045 GP (contact)
5ht5a_human 238 5.76x76 TM5 S => G missense 8.247e-06 1 121262 0 0.07 0.008
5ht5a_human 238 5.76x76 TM5 S => T missense 1.649e-05 2 121252 0 0.47 0.014
5ht5a_human 238 5.76x76 TM5 S => N missense 1.649e-05 2 121252 0 0.2 0.062
5ht5a_human 238 5.76x76 TM5 S => R missense 8.249e-06 1 121232 0 0.09 0.025
5ht5a_human 243 ICL3 S => F missense 1.654e-05 2 120944 0 0.05 0.17
5ht5a_human 244 ICL3 E => Q missense 0.0001489 18 120870 0 0.29 0.426
5ht5a_human 245 ICL3 A => D missense 1.656e-05 2 120768 0 0.08 0.02
5ht5a_human 250 ICL3 D => Y missense 9.234e-06 1 108290 0 0.02 0.005
5ht5a_human 254 ICL3 Q => K missense 7.096e-05 8 112738 0 0.46 0.003
5ht5a_human 255 ICL3 P => R missense 1.751e-05 2 114244 0 0.02 0.072
5ht5a_human 260 ICL3 T => M missense 2.553e-05 3 117518 0 0.04 0.291 PTM (Phosphorylation)
5ht5a_human 262 ICL3 R => C missense 3.366e-05 4 118852 0 0.01 0.021
5ht5a_human 263 ICL3 H => P missense 8.353e-06 1 119722 0 0.16 0.003
5ht5a_human 264 ICL3 A => T missense 0.0001834 22 119934 0 0.1 0.013
5ht5a_human 266 ICL3 V => F missense 1.661e-05 2 120436 0 0.09 0.619
5ht5a_human 266 ICL3 V => L missense 8.303e-06 1 120436 0 0.2 0.014
5ht5a_human 266 ICL3 V => I missense 3.321e-05 4 120436 0 0.24 0.023
5ht5a_human 273 ICL3 D => Y missense 6.612e-05 8 120998 0 0.0 0.759
5ht5a_human 273 ICL3 D => A missense 8.264e-06 1 121014 0 0.17 0.012
5ht5a_human 274 6.24x24 TM6 T => M missense 4.131e-05 5 121030 0 0.04 0.094
5ht5a_human 275 6.25x25 TM6 W => G missense 8.259e-06 1 121076 0 0.09 0.333 GP (contact)
5ht5a_human 275 6.25x25 TM6 W => R missense 8.259e-06 1 121076 0 0.13 0.467 GP (contact)
5ht5a_human 276 6.26x26 TM6 R => W missense 4.955e-05 6 121096 0 0.0 0.969 GP (contact)
5ht5a_human 276 6.26x26 TM6 R => Q missense 4.128e-05 5 121114 0 0.05 0.393 GP (contact)
5ht5a_human 280 6.30x30 TM6 E => D missense 1.649e-05 2 121264 0 0.01 0.314 SodiumPocket MicroSwitch
5ht5a_human 281 6.31x31 TM6 Q => E missense 8.246e-06 1 121270 0 0.02 0.232
5ht5a_human 282 6.32x32 TM6 R => W missense 8.244e-06 1 121294 0 0.0 0.958 GP (contact)
5ht5a_human 282 6.32x32 TM6 R => L missense 8.245e-05 10 121292 0 0.0 0.58 GP (contact)
5ht5a_human 282 6.32x32 TM6 R => Q missense 3.298e-05 4 121292 0 0.05 0.18 GP (contact)
5ht5a_human 284 6.34x34 TM6 A => T missense 8.242e-06 1 121328 0 0.01 0.7 SodiumPocket MicroSwitch
5ht5a_human 284 6.34x34 TM6 A => S missense 8.242e-06 1 121328 0 0.01 0.803 SodiumPocket MicroSwitch
5ht5a_human 286 6.36x36 TM6 M => T missense 8.24e-06 1 121358 0 0.77 0.019 GP (contact)
5ht5a_human 288 6.38x38 TM6 G => V missense 8.24e-06 1 121360 0 0.0 0.997
5ht5a_human 293 6.43x43 TM6 V => M missense 8.239e-06 1 121376 0 0.02 0.818
5ht5a_human 295 6.45x45 TM6 V => M missense 9.063e-05 11 121374 0 0.02 0.967
5ht5a_human 295 6.45x45 TM6 V => L missense 8.239e-06 1 121374 0 0.01 0.804
5ht5a_human 298 6.48x48 TM6 W => R missense 8.238e-06 1 121390 0 0.0 0.998 SodiumPocket MicroSwitch
5ht5a_human 299 6.49x49 TM6 I => T missense 9.062e-05 11 121392 0 0.08 0.021
5ht5a_human 302 6.52x52 TM6 F => L missense 8.238e-06 1 121396 0 0.0 1.0
5ht5a_human 305 6.55x55 TM6 E => K missense 1.647e-05 2 121398 0 0.06 0.981
5ht5a_human 306 6.56x56 TM6 L => F missense 8.237e-06 1 121398 0 0.03 0.656
5ht5a_human 307 6.57x57 TM6 I => L missense 8.237e-06 1 121400 0 0.38 0.003
5ht5a_human 308 6.58x58 TM6 S => N missense 4.118e-05 5 121404 0 0.56 0.021
5ht5a_human 309 6.59x59 TM6 P => S missense 2.471e-05 3 121398 0 0.03 0.989
5ht5a_human 312 ECL3 S => F missense 8.237e-06 1 121406 0 0.0 0.595
5ht5a_human 316 7.31x30 TM7 P => L missense 1.647e-05 2 121406 0 0.0 0.992
5ht5a_human 317 7.32x31 TM7 A => T missense 3.295e-05 4 121406 0 0.03 0.009
5ht5a_human 317 7.32x31 TM7 A => V missense 8.237e-06 1 121406 0 0.02 0.143
5ht5a_human 318 7.33x32 TM7 I => T missense 8.237e-06 1 121406 0 0.26 0.007
5ht5a_human 321 7.36x35 TM7 S => N missense 8.237e-06 1 121406 0 0.0 0.981
5ht5a_human 331 7.46x46 TM7 S => T missense 2.471e-05 3 121392 0 0.0 1.0
5ht5a_human 332 7.47x47 TM7 F => L missense 1.648e-05 2 121372 0 0.49 0.075
5ht5a_human 335 7.50x50 TM7 P => R missense 8.241e-06 1 121348 0 0.0 0.999 SodiumPocket MicroSwitch
5ht5a_human 338 7.53x53 TM7 Y => C missense 8.244e-06 1 121298 0 0.0 1.0 SodiumPocket MicroSwitch
5ht5a_human 339 7.54x54 TM7 T => M missense 2.474e-05 3 121270 0 0.02 0.849
5ht5a_human 339 7.54x54 TM7 T => R missense 1.649e-05 2 121270 0 0.0 0.989
5ht5a_human 340 7.55x55 TM7 A => T missense 1.649e-05 2 121266 0 0.13 0.968 GP (contact)
5ht5a_human 344 8.49x49 H8 N => S missense 8.258e-06 1 121090 0 0.09 0.005 GP (contact)
5ht5a_human 344 8.49x49 H8 N => K missense 8.264e-06 1 121002 0 0.02 0.012 GP (contact)
5ht5a_human 348 8.53x53 H8 A => T missense 1.659e-05 2 120556 0 0.04 0.984
5ht5a_human 348 8.53x53 H8 A => D missense 8.301e-06 1 120464 0 0.0 0.993
5ht5a_human 350 8.55x55 H8 K => Q missense 3.325e-05 4 120288 0 0.01 0.083
5ht5a_human 351 8.56x56 H8 N => K missense 8.338e-06 1 119938 0 1.0 0.007
5ht5a_human 357 C-term H => L missense 8.474e-06 1 118008 0 0.01 0.017
5ht5a_human 16 N-term S => ProfsTer81 frameshift 8.261e-06 1 121052 0 None None
5ht5a_human 181 ECL2 W => Ter stop gained 8.25e-06 1 121210 0 None None
5ht5a_human 210 5.48x48 TM5 Y => Ter stop gained 8.244e-06 1 121298 0 None None
5ht5a_human 223 5.61x61 TM5 I => SerfsTer26 frameshift 8.241e-06 1 121342 0 None None GP (contact)
5ht5a_human 292 6.42x42 TM6 G => AlafsTer45 frameshift 8.239e-06 1 121374 0 None None
5ht5a_human 310 6.60x60 TM6 L => SerfsTer27 frameshift 2.471e-05 3 121404 0 None None
5ht5a_human 313 ECL3 C => LeufsTer3 frameshift 8.237e-06 1 121406 0 None None
5ht5a_human 338 7.53x53 TM7 Y => Ter stop gained 8.244e-06 1 121294 0 None None SodiumPocket MicroSwitch


Residue

Diagrams

R T F H ICL1ECL1 R R W Q L ECL1 H M E Y T L R T ICL2ECL2 G W G E T Y S E G S E E C Q V S R ECL2ICL3 V S P I S E A V E V K D S A K Q P Q M V F T V R H A T V T F Q P E G D ICL3ECL3 S C D I ECL3N-term M D L P V N L T S F S L S T P S P L E T N H S L G K D D L R P S S P L N-termC-term S R Q H C-term L S V F G V L I L T L L G F L V A A T F A W N L L V L A T I L R V R V P H N L V A S M A V S D V L V A A L V M P L S L V H E L S G G R R L C Q L W I A C D V L C C T A S I W N V T A I A L D R Y W S I T R R K C V S N V M I A L T W A L S A V I S L A P L L F E P S Y A V F S T V G A F Y L P L C V V L F V Y W K I Y K A A K F R V G S R K T N S T W R E Q K E Q R A A L M V G I L I G V F V L C W I P F F L T E L I S P L C P A I W K S I F L W L G Y S N S F F N P L I Y T A F N K N F K N Y N S A F F
SnakePlot Download: PNG | SVG L N W A F T A A V L F G L L T L I L V G 1 A S M A V S D V L V A L A V M P L S L V H 2 A T V N W I S A T C C L V D C A I W L Q 3 S N V M I A L T W A L S A V I S L A P L 4 Y V F L V V C L P L Y F A G V T S F V A Y 5 G I L I G V F V L C W I P F F L T E L I 6 L P N F F S N S Y G L W L F I S K W I 7
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