Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
acm1_human 458 C-term R => H missense 5.004e-05 6 119916 0 nan 0.001
acm1_human 458 C-term R => C missense 1.664e-05 2 120216 0 nan 0.428
acm1_human 454 C-term R => H missense 1.656e-05 2 120770 0 nan 0.522
acm1_human 452 C-term V => M missense 1.652e-05 2 121080 0 nan 0.623
acm1_human 451 C-term S => P missense 1.65e-05 2 121192 0 nan 0.307
acm1_human 449 C-term P => L missense 8.246e-06 1 121268 0 nan 0.713
acm1_human 448 C-term R => H missense 8.246e-06 1 121276 0 nan 0.522
acm1_human 448 C-term R => C missense 8.244e-06 1 121296 0 nan 0.689
acm1_human 444 C-term K => E missense 8.24e-06 1 121354 0 nan 0.292
acm1_human 443 C-term R => H missense 8.24e-06 1 121356 0 0.01 0.202
acm1_human 443 C-term R => C missense 8.24e-06 1 121362 0 0.0 0.255
acm1_human 430 8.55x55 H8 R => G missense 8.237e-06 1 121402 0 0.0 0.079
acm1_human 426 8.51x51 H8 R => Q missense 8.237e-06 1 121398 0 0.16 0.602 GP (contact)
acm1_human 426 8.51x51 H8 R => W missense 8.237e-06 1 121400 0 0.0 0.876 GP (contact)
acm1_human 424 8.49x49 H8 A => G missense 8.237e-06 1 121400 0 0.0 0.066 GP (contact)
acm1_human 420 7.55x55 TM7 L => I missense 8.238e-06 1 121396 0 0.0 0.636 GP (contact)
acm1_human 409 7.44x43 TM7 V => G missense 2.471e-05 3 121402 0 0.0 0.908 SodiumPocket MicroSwitch
acm1_human 407 7.42x41 TM7 C => W missense 9.885e-05 12 121400 0 0.0 0.963 LB (hydrophobic)
acm1_human 397 7.32x31 TM7 E => K missense 8.238e-06 1 121392 0 0.68 0.378
acm1_human 392 ECL3 K => E missense 8.238e-06 1 121388 0 0.37 0.006
acm1_human 361 6.31x31 TM6 K => R missense 8.247e-06 1 121262 0 0.31 0.874
acm1_human 356 6.26x26 TM6 S => L missense 8.258e-06 1 121102 0 0.25 0.003 GP (contact)
acm1_human 354 6.24x24 TM6 T => N missense 7.437e-05 9 121020 0 0.58 0.291
acm1_human 353 ICL3 K => R missense 8.267e-06 1 120966 0 0.17 0.008
acm1_human 344 ICL3 R => H missense 3.325e-05 4 120288 0 0.12 0.079
acm1_human 339 ICL3 K => M missense 8.349e-06 1 119770 0 0.02 0.98 PTM (Acetylation)
acm1_human 338 ICL3 G => S missense 3.344e-05 4 119608 0 0.87 0.218
acm1_human 337 ICL3 A => V missense 8.369e-06 1 119482 0 0.35 0.016
acm1_human 334 ICL3 R => H missense 1.678e-05 2 119196 0 0.13 0.002
acm1_human 329 ICL3 P => L missense 1.686e-05 2 118594 0 0.21 0.003
acm1_human 329 ICL3 P => T missense 2.531e-05 3 118518 0 0.25 0.154
acm1_human 329 ICL3 P => S missense 8.438e-06 1 118518 0 0.42 0.291
acm1_human 324 ICL3 N => S missense 3.392e-05 4 117910 0 1.0 0.0
acm1_human 320 ICL3 R => Q missense 3.411e-05 4 117266 0 0.55 0.16
acm1_human 320 ICL3 R => W missense 1.706e-05 2 117200 0 0.01 0.748
acm1_human 315 ICL3 T => I missense 8.574e-06 1 116626 0 0.22 0.0
acm1_human 314 ICL3 P => T missense 8.581e-06 1 116540 0 0.31 0.117
acm1_human 312 ICL3 Q => H missense 8.602e-06 1 116252 0 0.16 0.001
acm1_human 310 ICL3 E => K missense 0.0001036 12 115838 0 0.79 0.163
acm1_human 308 ICL3 D => E missense 2.589e-05 3 115858 0 0.62 0.001
acm1_human 297 ICL3 G => C missense 8.619e-06 1 116024 0 0.07 0.802
acm1_human 295 ICL3 E => K missense 1.721e-05 2 116184 0 0.52 0.874
acm1_human 290 ICL3 S => F missense 4.281e-05 5 116808 0 0.01 0.951
acm1_human 285 ICL3 M => V missense 3.391e-05 4 117956 0 0.65 0.0
acm1_human 283 ICL3 G => V missense 3.384e-05 4 118218 0 0.07 0.451
acm1_human 282 ICL3 E => K missense 8.445e-06 1 118420 0 0.36 0.123
acm1_human 281 ICL3 D => N missense 8.434e-06 1 118574 0 0.41 0.278
acm1_human 273 ICL3 S => N missense 8.445e-06 1 118408 0 0.12 0.213
acm1_human 271 ICL3 A => T missense 5.086e-05 6 117966 0 0.6 0.001
acm1_human 264 ICL3 R => Q missense 2.553e-05 3 117518 0 0.56 0.0
acm1_human 264 ICL3 R => P missense 8.509e-06 1 117518 0 0.31 0.001
acm1_human 264 ICL3 R => W missense 0.0001107 13 117476 1 0.02 0.0
acm1_human 261 ICL3 R => H missense 8.518e-06 1 117394 0 0.14 0.002
acm1_human 259 ICL3 C => F missense 5.113e-05 6 117350 0 0.72 0.0
acm1_human 259 ICL3 C => R missense 8.522e-06 1 117346 0 0.47 0.0
acm1_human 258 ICL3 R => H missense 8.522e-06 1 117340 0 0.06 0.501
acm1_human 258 ICL3 R => C missense 1.704e-05 2 117354 0 0.02 0.575
acm1_human 257 ICL3 G => A missense 8.519e-06 1 117378 0 0.81 0.0
acm1_human 257 ICL3 G => C missense 8.522e-06 1 117338 0 0.1 0.014
acm1_human 254 ICL3 T => I missense 8.517e-06 1 117412 0 0.25 0.0
acm1_human 250 ICL3 G => D missense 8.518e-06 1 117398 0 0.77 0.0
acm1_human 250 ICL3 G => S missense 8.514e-06 1 117454 0 0.97 0.0
acm1_human 247 ICL3 G => E missense 8.509e-06 1 117522 0 0.54 0.001
acm1_human 246 ICL3 P => L missense 1.701e-05 2 117552 0 0.06 0.0
acm1_human 246 ICL3 P => S missense 8.505e-06 1 117574 0 0.36 0.0
acm1_human 243 ICL3 R => K missense 2.547e-05 3 117770 0 0.71 0.002
acm1_human 236 ICL3 G => S missense 8.448e-06 1 118366 0 0.84 0.117
acm1_human 230 ICL3 T => M missense 8.385e-06 1 119266 0 0.1 0.76
acm1_human 230 ICL3 T => A missense 8.382e-06 1 119310 0 0.38 0.102
acm1_human 225 5.75x75 TM5 L => F missense 8.307e-06 1 120382 0 0.05 0.398 GP (contact)
acm1_human 221 5.71x71 TM5 E => K missense 8.285e-06 1 120702 0 0.61 0.18 GP (contact)
acm1_human 216 5.66x66 TM5 E => Q missense 8.264e-06 1 121000 0 0.28 0.137 GP (contact)
acm1_human 213 5.63x63 TM5 R => Q missense 6.61e-05 8 121026 0 0.24 0.19
acm1_human 211 5.61x61 TM5 I => V missense 3.303e-05 4 121118 0 0.07 0.124 GP (contact)
acm1_human 206 5.56x56 TM5 T => M missense 5.777e-05 7 121172 0 0.01 0.451
acm1_human 203 5.53x53 TM5 V => I missense 8.251e-06 1 121202 0 1.0 0.124
acm1_human 188 5.38x39 TM5 I => L missense 8.251e-06 1 121202 0 0.07 0.124
acm1_human 169 4.69x69 TM4 G => V missense 1.652e-05 2 121094 0 0.0 0.985
acm1_human 147 4.47x47 TM4 G => S missense 8.255e-06 1 121136 0 0.11 0.19
acm1_human 141 4.41x41 TM4 R => W missense 8.258e-06 1 121092 0 0.03 0.993
acm1_human 140 4.40x40 TM4 R => H missense 8.258e-06 1 121102 0 0.01 0.189
acm1_human 140 4.40x40 TM4 R => C missense 8.257e-06 1 121110 0 0.0 0.983
acm1_human 139 4.39x39 TM4 P => S missense 8.255e-06 1 121138 0 0.37 0.636
acm1_human 134 34.54x54 ICL2 R => H missense 8.254e-06 1 121156 0 0.0 0.997 GP (contact)
acm1_human 94 3.21x21 TM3 G => V missense 8.244e-06 1 121306 0 0.0 1.0
acm1_human 90 23.49x49 ECL1 H => N missense 8.241e-06 1 121344 0 0.1 0.498
acm1_human 55 12.49x49 ICL1 E => K missense 8.237e-06 1 121402 0 0.05 0.038
acm1_human 54 12.48x48 ICL1 T => M missense 2.471e-05 3 121402 0 0.0 0.071
acm1_human 48 1.55x55 TM1 I => V missense 8.237e-06 1 121400 0 0.82 0.004
acm1_human 46 1.53x53 TM1 V => I missense 8.238e-06 1 121396 0 0.0 0.977
acm1_human 28 1.35x35 TM1 I => T missense 1.648e-05 2 121342 0 0.0 0.833
acm1_human 26 1.33x33 TM1 A => S missense 8.243e-06 1 121314 0 0.0 0.244
acm1_human 20 N-term K => N missense 8.249e-06 1 121222 0 0.02 0.213
acm1_human 15 N-term V => I missense 4.134e-05 5 120956 0 0.27 0.056
acm1_human 6 N-term P => L missense 1.676e-05 2 119318 0 0.28 0.0


Residue

Diagrams

T E L K ICL1ECL1 G H W A L ECL1 P L S Y R A K R ICL2ECL2 E R T V L A G Q C Y I Q F L S ECL2ICL3 Q G S E T P G K G G G S S S S S E R S Q P G A E G S P E T P P G R C C R C C R A P R L L Q A Y S W K E E E E E D E G S M E S L T S S E G E E P G S E V V I K M P M V D P E A Q A P T K Q P P R S S P N T V K R P T K K G R D R A G K G Q K P R G K E Q L A K R K ICL3ECL3 K D C V ECL3N-term M N T S A P P A V S P N I T V L A P G K G N-termC-term C R W D K R R W R K I P K R P G S V H R T P S R Q C C-term P W Q V A F I G I T T G L L S L A T V T G N L L V L I S F K V N T V N N Y F L L S L A C A D L I I G T F S M N L Y T T Y L L M G T L A C D L W L A L D Y V A S N A S V M N L L L I S F D R Y F S V T R T P R R A A L M I G L A W L V S F V L W A P A I L F W Q Y L V G Q P I I T F G T A M A A F Y L P V T V M C T L Y W R I Y R E T E N R A R E L A A L T F S L V K E K K A A R T L S A I L L A F I L T W T P Y N I M V L V S T F C P E T L W E L G Y W L C Y V N S T I N P M C Y A L C N K A F R L F R D T L L L
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