Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
acm2_human 3 N-term N => S missense 8.294e-06 1 120566 0 0.43 0.0 PTM (N-linked Glycosylation)
acm2_human 6 N-term N => K missense 1.657e-05 2 120668 0 0.18 0.0 PTM (N-linked Glycosylation)
acm2_human 9 N-term N => D missense 8.285e-06 1 120696 0 0.39 0.0
acm2_human 11 N-term S => C missense 8.283e-06 1 120736 0 0.02 0.0
acm2_human 13 N-term A => D missense 1.656e-05 2 120774 0 0.62 0.0
acm2_human 15 N-term T => S missense 8.279e-06 1 120794 0 0.73 0.0
acm2_human 16 N-term S => N missense 8.278e-06 1 120808 0 0.09 0.0
acm2_human 17 N-term P => L missense 8.277e-06 1 120824 0 0.02 1.0
acm2_human 19 1.28x28 TM1 K => E missense 8.275e-06 1 120846 0 0.47 0.009
acm2_human 20 1.29x29 TM1 T => I missense 8.274e-06 1 120860 0 0.44 0.548
acm2_human 25 1.34x34 TM1 F => L missense 8.271e-06 1 120910 0 1.0 0.016
acm2_human 31 1.40x40 TM1 G => A missense 8.267e-06 1 120960 0 0.34 0.082
acm2_human 36 1.45x45 TM1 V => L missense 8.265e-06 1 120998 0 0.04 0.085
acm2_human 38 1.47x47 TM1 I => T missense 8.263e-06 1 121020 0 0.01 0.005
acm2_human 52 12.48x48 ICL1 R => H missense 1.651e-05 2 121158 0 0.01 0.998
acm2_human 57 2.38x38 TM2 V => I missense 7.427e-05 9 121176 0 0.03 0.927
acm2_human 78 2.59x58 TM2 N => K missense 8.244e-06 1 121300 0 0.0 1.0
acm2_human 79 2.60x59 TM2 L => F missense 8.245e-06 1 121290 0 0.01 0.942
acm2_human 80 2.61x60 TM2 Y => F missense 8.244e-06 1 121300 0 0.1 0.999 LB (polar (hydrogen bond))
acm2_human 86 2.67x66 TM2 I => T missense 8.243e-06 1 121314 0 0.06 0.159
acm2_human 133 34.55x55 ICL2 V => L missense 8.257e-06 1 121112 0 0.01 0.643 GP (contact)
acm2_human 142 4.44x44 TM4 M => I missense 8.273e-06 1 120870 0 0.92 0.01
acm2_human 154 4.56x56 TM4 L => V missense 8.286e-06 1 120684 0 0.0 0.999
acm2_human 158 4.60x60 TM4 A => D missense 8.282e-06 1 120742 0 0.0 1.0
acm2_human 172 ECL2 E => D missense 1.654e-05 2 120902 0 0.04 0.09
acm2_human 174 ECL2 G => E missense 8.269e-06 1 120932 0 0.32 0.236
acm2_human 197 5.49x49 TM5 L => F missense 8.275e-06 1 120846 0 0.01 0.998
acm2_human 199 5.51x51 TM5 V => M missense 8.276e-06 1 120830 0 0.0 0.996
acm2_human 210 5.62x62 TM5 S => T missense 8.303e-06 1 120432 0 0.02 0.934
acm2_human 211 5.63x63 TM5 R => Q missense 1.662e-05 2 120328 0 0.23 0.015
acm2_human 211 5.63x63 TM5 R => L missense 8.311e-06 1 120328 0 0.29 0.007
acm2_human 225 ICL3 V => D missense 8.35e-05 10 119764 0 0.51 0.016
acm2_human 227 ICL3 N => S missense 8.352e-06 1 119736 0 0.69 0.004
acm2_human 227 ICL3 N => K missense 8.353e-06 1 119714 0 0.84 0.009
acm2_human 229 ICL3 D => G missense 1.671e-05 2 119694 0 0.45 0.004
acm2_human 230 ICL3 P => S missense 8.355e-06 1 119690 0 0.88 0.014
acm2_human 231 ICL3 V => I missense 0.002983 357 119660 1 0.21 0.009
acm2_human 235 ICL3 L => M missense 0.0002924 35 119718 0 0.28 0.726
acm2_human 238 ICL3 G => A missense 6.677e-05 8 119810 0 0.35 0.023
acm2_human 240 ICL3 I => R missense 1.669e-05 2 119844 0 0.4 0.024
acm2_human 241 ICL3 V => M missense 8.346e-06 1 119822 0 0.14 0.026
acm2_human 242 ICL3 K => R missense 1.669e-05 2 119862 0 0.3 0.05
acm2_human 243 ICL3 P => S missense 8.344e-06 1 119848 0 0.42 0.004
acm2_human 246 ICL3 N => D missense 1.668e-05 2 119932 0 0.49 0.188
acm2_human 246 ICL3 N => K missense 3.335e-05 4 119926 0 0.66 0.135
acm2_human 253 ICL3 D => N missense 0.000125 15 119998 0 0.45 0.146
acm2_human 254 ICL3 G => V missense 1.666e-05 2 120072 0 0.24 0.014
acm2_human 255 ICL3 L => V missense 8.328e-06 1 120076 0 0.34 0.014
acm2_human 258 ICL3 N => S missense 0.001449 174 120100 0 0.74 0.004
acm2_human 258 ICL3 N => K missense 8.328e-06 1 120084 0 0.62 0.009
acm2_human 262 ICL3 N => S missense 8.324e-06 1 120140 0 0.95 0.377
acm2_human 274 ICL3 C => R missense 8.309e-06 1 120356 0 0.17 0.02
acm2_human 274 ICL3 C => S missense 8.309e-06 1 120354 0 0.48 0.216
acm2_human 275 ICL3 V => A missense 8.308e-06 1 120372 0 0.59 0.005
acm2_human 277 ICL3 G => E missense 1.66e-05 2 120464 0 0.44 0.691
acm2_human 287 ICL3 T => S missense 0.000174 21 120718 0 1.0 0.015 PTM (Phosphorylation)
acm2_human 292 ICL3 V => A missense 8.277e-06 1 120814 0 0.74 0.002
acm2_human 296 ICL3 M => T missense 8.275e-06 1 120840 0 0.59 0.002
acm2_human 303 ICL3 Q => P missense 8.271e-06 1 120910 0 0.27 0.002
acm2_human 304 ICL3 D => V missense 8.27e-06 1 120914 0 0.17 0.004
acm2_human 311 ICL3 S => Y missense 8.263e-06 1 121024 0 0.04 0.903 PTM (Phosphorylation)
acm2_human 312 ICL3 L => Q missense 8.262e-06 1 121034 0 0.62 0.004
acm2_human 312 ICL3 L => P missense 8.262e-06 1 121034 0 0.3 0.18
acm2_human 321 ICL3 K => T missense 8.258e-06 1 121102 0 0.2 0.201
acm2_human 325 ICL3 I => F missense 2.477e-05 3 121138 0 0.54 0.03
acm2_human 326 ICL3 R => K missense 1.651e-05 2 121126 0 1.0 0.004
acm2_human 329 ICL3 T => S missense 8.256e-06 1 121130 0 0.7 0.402
acm2_human 331 ICL3 T => S missense 0.001651 200 121132 3 0.85 0.004
acm2_human 337 ICL3 C => Y missense 8.257e-06 1 121114 0 0.65 0.004
acm2_human 343 ICL3 T => I missense 8.26e-06 1 121072 0 0.2 0.148
acm2_human 344 ICL3 V => M missense 2.478e-05 3 121084 0 0.23 0.327
acm2_human 344 ICL3 V => G missense 5.78e-05 7 121098 0 0.37 0.493
acm2_human 344 ICL3 V => A missense 8.258e-06 1 121098 0 0.58 0.02
acm2_human 348 ICL3 G => R missense 8.259e-06 1 121086 0 0.51 0.756
acm2_human 352 ICL3 Q => K missense 8.258e-06 1 121088 0 1.0 0.027
acm2_human 358 ICL3 Q => H missense 8.257e-06 1 121104 0 0.18 0.91
acm2_human 363 ICL3 R => C missense 8.258e-06 1 121088 0 0.15 0.12
acm2_human 363 ICL3 R => H missense 3.304e-05 4 121070 0 0.06 0.911
acm2_human 368 ICL3 M => T missense 8.257e-06 1 121116 0 0.45 0.216
acm2_human 372 ICL3 P => A missense 0.001263 153 121108 0 0.75 0.036
acm2_human 372 ICL3 P => H missense 8.257e-06 1 121106 0 0.13 0.873
acm2_human 373 ICL3 A => T missense 8.257e-06 1 121110 0 0.6 0.266
acm2_human 378 6.26x26 TM6 P => L missense 8.255e-06 1 121132 0 0.32 0.063 GP (contact)
acm2_human 379 6.27x27 TM6 P => A missense 8.256e-06 1 121128 0 0.83 0.004
acm2_human 390 6.38x38 TM6 L => S missense 8.257e-06 1 121106 0 0.11 0.836
acm2_human 397 6.45x45 TM6 I => V missense 3.303e-05 4 121096 0 0.19 0.107
acm2_human 410 6.58x58 TM6 N => S missense 8.264e-06 1 121012 0 0.97 0.145
acm2_human 411 6.59x59 TM6 T => N missense 8.264e-06 1 121008 0 0.0 0.756
acm2_human 420 7.33x32 TM7 T => S missense 8.259e-06 1 121086 0 0.48 0.223
acm2_human 456 8.59x59 H8 M => T missense 8.267e-06 1 120966 0 0.03 0.007
acm2_human 456 8.59x59 H8 M => R missense 8.267e-06 1 120966 0 0.04 0.003
acm2_human 462 C-term I => T missense 8.282e-06 1 120746 0 0.1 0.703
acm2_human 463 C-term G => S missense 8.291e-06 1 120610 0 0.18 0.77
acm2_human 464 C-term A => T missense 1.659e-05 2 120584 0 1.0 0.002
acm2_human 55 12.51x51 ICL1 Q => Ter stop gained 8.252e-06 1 121188 0 None None
acm2_human 288 ICL3 S => Ter stop gained 8.281e-06 1 120760 0 None None PTM (Phosphorylation)
acm2_human 375 ICL3 K => Ter stop gained 8.256e-06 1 121130 0 None None
acm2_human 403 6.51x51 TM6 Y => Ter stop gained 8.26e-06 1 121060 0 None None LB (hydrophobic)


Residue

Diagrams

R H L Q ICL1ECL1 G Y W P L ECL1 P L T Y P V K R ICL2ECL2 V R T V E D G E C Y I Q F F S ECL2ICL3 P V A N Q D P V S P S L V Q G R I V K P N N N N M P S S D D G L E H N K I Q N G K A P R D P V T E N C V Q G E E K E S S N D S T S V S A V A S N M R D D E I T Q D E N T V S T S L G H S K D E N S K Q T C I R I G T K T P K S D S C T P T N T T V E V V G S S G Q N G D E K Q N I V A R K I V K M T K Q P A K K ICL3ECL3 A P C I ECL3N-term M N N S T N S S N N S L A L T S P Y N-termC-term C H Y K N I G A T R C-term K T F E V V F I V L V A G S L S L V T I I G N I L V M V S I K V N T V N N Y F L F S L A C A D L I I G V F S M N L Y T L Y T V I G P V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G M M I A A A W V L S F I L W A P A I L F W Q F I V G N A A V T F G T A I A A F Y L P V I I M T V L Y W H I S R A S K S R I K K D K K E K P P P S R E K K V T R T I L A I L L A F I I T W A P Y N V M V L I N T F C P N T V W T I G Y W L C Y I N S T I N P A C Y A L C N A T F K H F K K T L L M
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