Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
acm3_human 9 N-term T => A missense 8.358e-06 1 119642 0 nan 0.0
acm3_human 10 N-term S => L missense 2.502e-05 3 119916 0 nan 0.001
acm3_human 15 N-term N => S missense 1.657e-05 2 120720 0 nan 0.4
acm3_human 22 N-term H => P missense 8.262e-06 1 121038 0 nan 0.0
acm3_human 23 N-term S => G missense 8.26e-06 1 121066 0 nan 0.0
acm3_human 26 N-term D => N missense 4.952e-05 6 121168 0 nan 0.002
acm3_human 26 N-term D => E missense 0.0002145 26 121198 0 1.0 0.0
acm3_human 27 N-term A => S missense 0.000165 20 121212 0 nan 0.0
acm3_human 28 N-term G => A missense 8.248e-06 1 121244 0 nan 0.075
acm3_human 34 N-term V => I missense 1.648e-05 2 121368 0 nan 0.001
acm3_human 37 N-term F => L missense 4.943e-05 6 121388 0 nan 0.0
acm3_human 38 N-term G => S missense 8.238e-06 1 121382 0 nan 0.002
acm3_human 41 N-term N => S missense 5.766e-05 7 121404 0 0.04 0.006
acm3_human 44 N-term R => G missense 8.237e-06 1 121406 0 0.4 0.0
acm3_human 44 N-term R => Q missense 5.766e-05 7 121400 0 0.8 0.0
acm3_human 44 N-term R => L missense 8.237e-06 1 121400 0 0.33 0.003
acm3_human 45 N-term A => E missense 8.237e-06 1 121408 0 0.61 0.001
acm3_human 49 N-term F => L missense 1.647e-05 2 121406 0 0.76 0.0
acm3_human 53 N-term D => G missense 8.237e-06 1 121408 0 0.23 0.0
acm3_human 53 N-term D => E missense 8.237e-06 1 121406 0 0.68 0.001
acm3_human 54 N-term G => C missense 8.237e-06 1 121402 0 0.01 0.018
acm3_human 54 N-term G => S missense 8.237e-06 1 121402 0 0.4 0.001
acm3_human 54 N-term G => V missense 4.118e-05 5 121406 0 0.11 0.001
acm3_human 57 N-term D => N missense 2.471e-05 3 121410 0 0.39 0.001
acm3_human 57 N-term D => E missense 8.237e-06 1 121408 0 0.43 0.001
acm3_human 59 N-term P => L missense 7.413e-05 9 121408 0 0.13 0.055
acm3_human 65 1.29x29 TM1 V => I missense 0.01802 2188 121410 31 0.29 0.001
acm3_human 72 1.36x36 TM1 A => T missense 8.237e-06 1 121406 0 0.01 0.441
acm3_human 74 1.38x38 TM1 L => S missense 8.237e-06 1 121404 0 0.0 0.253
acm3_human 84 1.48x48 TM1 I => V missense 8.238e-06 1 121392 0 1.0 0.008
acm3_human 100 12.51x51 ICL1 K => R missense 8.238e-06 1 121388 0 0.01 0.22
acm3_human 103 2.39x39 TM2 N => S missense 1.648e-05 2 121388 1 0.02 0.571
acm3_human 110 2.46x46 TM2 L => R missense 8.238e-06 1 121384 0 0.0 1.0
acm3_human 111 2.47x47 TM2 A => V missense 8.238e-06 1 121388 0 0.0 1.0
acm3_human 115 2.51x51 TM2 L => V missense 8.238e-06 1 121390 0 0.02 0.954
acm3_human 120 2.56x551 TM2 I => N missense 8.237e-06 1 121398 0 0.01 0.895
acm3_human 138 3.22x22 TM3 N => S missense 8.237e-06 1 121404 0 0.78 0.013
acm3_human 146 3.30x30 TM3 A => T missense 1.647e-05 2 121408 0 0.03 0.201
acm3_human 171 3.55x55 TM3 T => M missense 8.237e-06 1 121408 0 0.0 0.998 GP (contact)
acm3_human 175 34.52x52 ICL2 T => M missense 1.647e-05 2 121406 0 0.0 0.985 GP (contact)
acm3_human 177 34.54x54 ICL2 R => P missense 8.237e-06 1 121408 0 0.0 0.574 GP (contact)
acm3_human 183 4.40x40 TM4 K => Q missense 8.237e-06 1 121408 0 0.0 0.655
acm3_human 186 4.43x43 TM4 G => V missense 1.647e-05 2 121406 0 0.04 0.355
acm3_human 186 4.43x43 TM4 G => A missense 8.237e-06 1 121406 0 0.58 0.057
acm3_human 190 4.47x47 TM4 G => R missense 1.647e-05 2 121404 0 0.0 0.991
acm3_human 190 4.47x47 TM4 G => S missense 1.647e-05 2 121404 0 0.04 0.402
acm3_human 197 4.54x54 TM4 F => L missense 2.471e-05 3 121400 0 0.3 0.022
acm3_human 206 4.63x63 TM4 F => L missense 8.237e-06 1 121400 0 0.66 0.151
acm3_human 218 ECL2 P => L missense 8.237e-06 1 121400 0 0.07 0.017
acm3_human 227 ECL2 S => R missense 8.238e-06 1 121394 0 0.0 0.356
acm3_human 232 5.39x40 TM5 T => I missense 8.238e-06 1 121382 0 0.0 0.963
acm3_human 242 5.49x49 TM5 M => I missense 8.255e-06 1 121146 0 0.48 0.002
acm3_human 253 5.60x60 TM5 R => K missense 8.272e-06 1 120888 0 0.19 0.49
acm3_human 261 5.68x68 TM5 R => H missense 8.28e-06 1 120766 0 0.0 0.965 GP (contact)
acm3_human 269 ICL3 Q => R missense 8.288e-06 1 120662 0 0.05 0.515
acm3_human 270 ICL3 A => T missense 8.288e-06 1 120658 0 0.0 0.945
acm3_human 274 ICL3 E => Q missense 8.29e-06 1 120628 0 0.52 0.027
acm3_human 276 ICL3 E => D missense 0.0001078 13 120624 0 0.21 0.036
acm3_human 278 ICL3 E => K missense 8.29e-06 1 120622 0 0.77 0.007
acm3_human 281 ICL3 V => A missense 2.488e-05 3 120576 0 0.8 0.044
acm3_human 281 ICL3 V => D missense 8.294e-06 1 120576 0 0.61 0.024
acm3_human 282 ICL3 H => P missense 8.294e-06 1 120562 0 0.5 0.0
acm3_human 282 ICL3 H => Q missense 2.488e-05 3 120564 0 0.66 0.003
acm3_human 284 ICL3 T => M missense 6.636e-05 8 120554 0 0.06 0.123
acm3_human 288 ICL3 R => Q missense 8.291e-06 1 120608 0 0.17 0.422
acm3_human 290 ICL3 C => Y missense 8.29e-06 1 120630 0 0.0 0.027
acm3_human 294 ICL3 E => K missense 2.486e-05 3 120670 0 0.39 0.046
acm3_human 294 ICL3 E => Q missense 8.287e-06 1 120670 0 0.13 0.078
acm3_human 300 ICL3 M => K missense 9.115e-05 11 120676 0 0.82 0.0
acm3_human 302 ICL3 R => C missense 1.657e-05 2 120676 0 0.01 0.505
acm3_human 302 ICL3 R => H missense 8.287e-06 1 120668 0 0.13 0.005
acm3_human 305 ICL3 R => G missense 8.289e-06 1 120646 0 0.38 0.005
acm3_human 306 ICL3 R => S missense 1.658e-05 2 120628 0 0.56 0.002
acm3_human 308 ICL3 Y => H missense 8.295e-06 1 120552 0 0.54 0.001
acm3_human 308 ICL3 Y => C missense 8.295e-06 1 120554 0 0.18 0.001
acm3_human 310 ICL3 R => C missense 5.809e-05 7 120502 0 0.13 0.002
acm3_human 318 ICL3 K => Q missense 8.336e-06 1 119962 0 0.36 0.126
acm3_human 318 ICL3 K => N missense 8.337e-06 1 119952 0 0.26 0.016
acm3_human 322 ICL3 P => R missense 8.382e-06 1 119310 0 0.08 0.016
acm3_human 323 ICL3 S => T missense 8.394e-06 1 119136 0 0.16 0.003
acm3_human 325 ICL3 E => K missense 1.683e-05 2 118818 0 0.88 0.003
acm3_human 329 ICL3 Q => R missense 8.478e-06 1 117950 0 0.52 0.013
acm3_human 334 ICL3 S => T missense 8.708e-06 1 114842 0 0.16 0.101
acm3_human 338 ICL3 N => D missense 8.98e-06 1 111358 0 0.1 0.223
acm3_human 339 ICL3 N => T missense 9.124e-06 1 109606 0 0.09 0.312
acm3_human 339 ICL3 N => K missense 4.593e-05 5 108866 0 0.64 0.101
acm3_human 353 ICL3 D => N missense 1.142e-05 1 87538 0 0.02 0.418
acm3_human 357 ICL3 I => V missense 1.19e-05 1 84052 0 0.33 0.016
acm3_human 360 ICL3 E => K missense 1.249e-05 1 80054 0 0.32 0.227
acm3_human 361 ICL3 T => M missense 2.524e-05 2 79252 0 0.09 0.34
acm3_human 376 ICL3 T => A missense 1.316e-05 1 75978 0 1.0 0.001
acm3_human 379 ICL3 N => T missense 3.899e-05 3 76946 0 0.11 0.044
acm3_human 379 ICL3 N => S missense 1.3e-05 1 76946 0 0.2 0.079
acm3_human 390 ICL3 Q => H missense 1.141e-05 1 87670 0 0.19 0.005
acm3_human 396 ICL3 L => M missense 0.0006454 61 94514 0 0.23 0.063
acm3_human 401 ICL3 L => M missense 4.003e-05 4 99932 0 0.13 0.005
acm3_human 403 ICL3 R => K missense 9.847e-06 1 101552 0 1.0 0.001
acm3_human 405 ICL3 A => V missense 1.951e-05 2 102494 0 0.3 0.063
acm3_human 406 ICL3 D => N missense 3.879e-05 4 103122 0 0.58 0.003
acm3_human 406 ICL3 D => G missense 9.664e-06 1 103480 0 0.43 0.0
acm3_human 410 ICL3 A => S missense 9.527e-06 1 104970 0 1.0 0.001
acm3_human 410 ICL3 A => V missense 9.516e-06 1 105086 0 0.19 0.003
acm3_human 414 ICL3 V => M missense 5.652e-05 6 106154 0 0.14 0.006
acm3_human 415 ICL3 D => H missense 1.877e-05 2 106576 0 0.14 0.315
acm3_human 416 ICL3 D => N missense 7.493e-05 8 106772 0 0.68 0.067
acm3_human 416 ICL3 D => E missense 9.32e-06 1 107300 0 0.59 0.003
acm3_human 417 ICL3 G => E missense 9.301e-06 1 107516 0 1.0 0.016
acm3_human 430 ICL3 Q => R missense 8.769e-05 10 114032 0 0.26 0.006
acm3_human 430 ICL3 Q => H missense 2.629e-05 3 114102 0 0.11 0.063
acm3_human 431 ICL3 L => V missense 8.751e-06 1 114274 0 0.45 0.026
acm3_human 431 ICL3 L => P missense 0.00163 187 114692 2 0.33 0.004
acm3_human 434 ICL3 A => G missense 1.726e-05 2 115884 0 0.35 0.005
acm3_human 435 ICL3 V => M missense 0.000163 19 116598 0 0.25 0.023
acm3_human 436 ICL3 D => A missense 8.516e-06 1 117430 0 0.49 0.007
acm3_human 437 ICL3 T => A missense 8.495e-06 1 117714 0 0.9 0.003
acm3_human 441 ICL3 S => F missense 8.403e-06 1 119004 0 0.04 0.285
acm3_human 442 ICL3 D => E missense 1.676e-05 2 119320 0 0.91 0.003
acm3_human 443 ICL3 V => I missense 0.0001172 14 119448 1 0.2 0.003
acm3_human 444 ICL3 N => T missense 0.0001085 13 119788 0 0.63 0.001
acm3_human 445 ICL3 S => F missense 3.333e-05 4 120026 0 0.0 0.063
acm3_human 451 ICL3 T => M missense 0.0005219 63 120716 0 0.05 0.023
acm3_human 452 ICL3 A => S missense 0.000149 18 120816 0 0.9 0.001
acm3_human 459 ICL3 K => R missense 8.252e-06 1 121176 0 0.17 0.345
acm3_human 461 ICL3 A => P missense 1.649e-05 2 121250 0 0.03 0.093
acm3_human 461 ICL3 A => G missense 6.598e-05 8 121254 1 0.08 0.081
acm3_human 465 ICL3 K => T missense 8.243e-06 1 121318 0 0.01 0.173
acm3_human 468 ICL3 A => T missense 8.241e-06 1 121346 0 0.19 0.559
acm3_human 469 ICL3 L => P missense 8.24e-06 1 121364 0 0.3 0.001
acm3_human 471 ICL3 T => N missense 8.239e-06 1 121380 0 0.44 0.817
acm3_human 472 ICL3 R => K missense 8.238e-06 1 121382 0 0.98 0.124
acm3_human 473 ICL3 S => C missense 8.238e-06 1 121386 0 0.05 0.932
acm3_human 478 ICL3 R => W missense 9.061e-05 11 121400 0 0.0 0.998
acm3_human 478 ICL3 R => Q missense 2.471e-05 3 121402 0 0.02 0.786
acm3_human 481 6.25x25 TM6 M => T missense 8.237e-06 1 121406 0 0.01 0.102 GP (contact)
acm3_human 495 6.39x39 TM6 A => S missense 8.237e-06 1 121408 0 0.0 0.966
acm3_human 496 6.40x40 TM6 I => T missense 8.237e-06 1 121406 0 0.0 0.998 GP (contact)
acm3_human 498 6.42x42 TM6 L => P missense 8.237e-06 1 121406 0 0.0 0.971
acm3_human 517 6.61x61 TM6 C => S missense 8.237e-06 1 121402 0 0.0 0.896
acm3_human 524 7.33x32 TM7 T => I missense 0.0002306 28 121402 0 0.06 0.082
acm3_human 535 7.44x43 TM7 I => L missense 1.648e-05 2 121386 0 0.01 0.431 SodiumPocket MicroSwitch
acm3_human 539 7.48x48 TM7 V => A missense 8.239e-06 1 121378 0 0.0 0.902
acm3_human 542 7.51x51 TM7 V => M missense 8.24e-06 1 121360 0 1.0 0.027
acm3_human 562 C-term Q => H missense 1.653e-05 2 120984 0 0.05 0.019
acm3_human 563 C-term C => Y missense 8.267e-06 1 120956 0 0.01 0.273
acm3_human 569 C-term R => C missense 8.311e-06 1 120328 0 0.01 0.983
acm3_human 569 C-term R => H missense 8.316e-06 1 120244 0 0.02 0.964
acm3_human 570 C-term K => T missense 0.0001498 18 120146 0 0.01 0.316
acm3_human 581 C-term F => L missense 8.6e-06 1 116280 0 0.05 0.002
acm3_human 584 C-term R => C missense 8.777e-06 1 113940 0 0.04 0.01
acm3_human 584 C-term R => H missense 4.411e-05 5 113358 0 0.09 0.66
acm3_human 585 C-term A => T missense 0.000115 13 113008 0 0.14 0.0
acm3_human 586 C-term P => L missense 8.927e-06 1 112022 0 0.0 0.743
acm3_human 587 C-term E => K missense 2.685e-05 3 111730 0 nan 0.022
acm3_human 589 C-term A => D missense 0.0001269 14 110312 0 nan 0.003
acm3_human 588 C-term Q => Ter stop gained 9.015e-06 1 110922 0 None None


Residue

Diagrams

K Q L K ICL1ECL1 N R W A L ECL1 P L T Y R A K R ICL2ECL2 K R T V P P G E C F I Q F L S ECL2ICL3 Q A S G T E A E T E N F V H P T G S S R S C S S Y E L Q Q Q S M K R S N R R K Y G R C H F W F T T K S W K P S S E Q M D Q D H S S S D S W N N N D A A A S L E N S A S S D E E D I G S E T R A I Y S I V L K L P G H S T I L N S T K L P S S D N L Q V P E E E L G M V D L E R K A D K L Q A Q K S V D D G G S F P K S F S K L P I Q L E S A V D T A K T S D V N S S V G K S T A T L P L S F K E A T L A K R F A L K T R S Q I T K R K ICL3ECL3 D S C I ECL3N-term M T L H N N S T T S P L F P N I S S S W I H S P S D A G L P P G T V T H F G S Y N V S R A A G N F S S P D G T T D D P L G G H T N-termC-term L C Q C D K K K R R K Q Q Y Q Q R Q S V I F H K R A P E Q A L C-term V W Q V V F I A F L T G I L A L V T I I G N I L V I V S F K V N T V N N Y F L L S L A C A D L I I G V I S M N L F T T Y I I M G N L A C D L W L A I D Y V A S N A S V M N L L V I S F D R Y F S I T R T T K R A G V M I G L A W V I S F V L W A P A I L F W Q Y F V G E P T I T F G T A I A A F Y M P V T I M T I L Y W R I Y K E T E K R T K E L A G L R M S L V K E K K A A Q T L S A I L L A F I I T W T P Y N I M V L V N T F C P K T F W N L G Y W L C Y I N S T V N P V C Y A L C N K T F K M F R T T L L
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