Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
acm5_human 6 N-term Y => H missense 8.625e-06 1 115946 0 nan 0.001
acm5_human 6 N-term Y => C missense 8.612e-06 1 116116 0 nan 0.267
acm5_human 9 N-term A => G missense 8.502e-06 1 117626 0 nan 0.021
acm5_human 12 N-term V => I missense 1.68e-05 2 119080 0 nan 0.001
acm5_human 13 N-term N => S missense 4.18e-05 5 119628 0 nan 0.477
acm5_human 16 N-term P => S missense 0.000807 97 120204 1 nan 0.001
acm5_human 16 N-term P => L missense 0.0001912 23 120262 1 nan 0.001
acm5_human 19 N-term H => Q missense 8.274e-06 1 120866 0 0.33 0.003
acm5_human 21 N-term P => S missense 8.264e-06 1 121002 0 0.03 0.002
acm5_human 24 N-term R => C missense 8.251e-06 1 121202 0 0.0 0.28
acm5_human 29 1.31x31 TM1 E => K missense 1.648e-05 2 121364 0 0.09 0.583
acm5_human 31 1.33x33 TM1 I => V missense 1.648e-05 2 121376 0 0.91 0.009
acm5_human 32 1.34x34 TM1 T => N missense 8.238e-06 1 121388 0 0.02 0.642
acm5_human 35 1.37x37 TM1 A => T missense 8.238e-06 1 121392 0 0.67 0.001
acm5_human 37 1.39x39 TM1 T => N missense 8.237e-06 1 121400 0 0.0 0.23
acm5_human 39 1.41x41 TM1 V => M missense 1.647e-05 2 121406 0 0.21 0.779
acm5_human 42 1.44x44 TM1 L => M missense 8.237e-06 1 121408 0 0.0 0.11
acm5_human 50 1.52x52 TM1 L => F missense 8.237e-06 1 121410 0 0.0 0.367
acm5_human 52 1.54x54 TM1 M => I missense 8.237e-06 1 121410 0 0.48 0.019
acm5_human 53 1.55x55 TM1 I => F missense 0.0005848 71 121410 1 0.03 0.47
acm5_human 54 1.56x56 TM1 S => P missense 8.237e-06 1 121408 0 0.0 0.961
acm5_human 61 12.50x50 ICL1 L => F missense 8.237e-06 1 121404 0 0.0 1.0
acm5_human 76 2.50x50 TM2 D => E missense 8.249e-06 1 121230 0 0.0 1.0
acm5_human 86 2.60x59 TM2 L => I missense 2.478e-05 3 121066 0 0.0 0.999
acm5_human 95 23.49x49 ECL1 R => C missense 1.652e-05 2 121098 0 0.02 0.893
acm5_human 98 23.52x52 ECL1 L => F missense 2.475e-05 3 121202 0 0.0 0.995
acm5_human 98 23.52x52 ECL1 L => P missense 8.251e-06 1 121200 0 0.01 0.651
acm5_human 102 3.24x24 TM3 A => V missense 8.242e-06 1 121336 0 0.11 0.992
acm5_human 104 3.26x26 TM3 D => H missense 8.24e-06 1 121358 0 0.0 1.0
acm5_human 106 3.28x28 TM3 W => R missense 8.239e-06 1 121370 0 0.0 1.0
acm5_human 109 3.31x31 TM3 L => P missense 8.238e-06 1 121384 0 0.0 0.98
acm5_human 112 3.34x34 TM3 V => M missense 1.648e-05 2 121388 0 0.0 1.0
acm5_human 119 3.41x41 TM3 M => L missense 8.237e-06 1 121404 0 0.0 0.997
acm5_human 125 3.47x47 TM3 S => N missense 1.647e-05 2 121406 0 0.0 1.0
acm5_human 128 3.50x50 TM3 R => C missense 8.237e-06 1 121406 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
acm5_human 128 3.50x50 TM3 R => H missense 8.237e-06 1 121406 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
acm5_human 139 34.54x54 ICL2 R => Q missense 2.471e-05 3 121410 0 0.0 1.0 GP (contact)
acm5_human 139 34.54x54 ICL2 R => L missense 8.237e-06 1 121410 0 0.0 1.0 GP (contact)
acm5_human 141 34.56x56 ICL2 K => M missense 3.295e-05 4 121408 0 0.0 1.0 GP (contact)
acm5_human 142 34.57x57 ICL2 R => C missense 5.766e-05 7 121408 0 0.0 1.0 GP (contact)
acm5_human 142 34.57x57 ICL2 R => G missense 8.237e-06 1 121408 0 0.0 1.0 GP (contact)
acm5_human 144 4.39x39 TM4 P => L missense 8.237e-06 1 121408 0 0.01 1.0
acm5_human 145 4.40x40 TM4 K => E missense 8.237e-06 1 121408 0 0.0 0.838
acm5_human 167 4.62x62 TM4 L => F missense 9.061e-05 11 121406 0 0.0 0.908
acm5_human 176 ECL2 R => W missense 1.647e-05 2 121400 0 0.0 1.0
acm5_human 176 ECL2 R => Q missense 2.471e-05 3 121402 0 0.02 0.997
acm5_human 178 ECL2 V => D missense 3.295e-05 4 121402 0 0.0 1.0
acm5_human 192 5.37x38 TM5 T => I missense 1.648e-05 2 121390 0 1.0 0.022
acm5_human 197 5.42x43 TM5 T => A missense 8.239e-06 1 121380 0 0.0 0.999
acm5_human 199 5.44x45 TM5 I => V missense 2.472e-05 3 121382 0 0.03 0.998
acm5_human 211 5.56x56 TM5 I => T missense 8.241e-06 1 121346 0 0.08 0.132
acm5_human 214 5.59x59 TM5 C => Y missense 8.242e-06 1 121332 0 0.02 0.988
acm5_human 215 5.60x60 TM5 R => Q missense 3.297e-05 4 121322 0 0.0 0.975
acm5_human 218 5.63x63 TM5 R => W missense 7.419e-05 9 121308 0 0.08 0.981
acm5_human 218 5.63x63 TM5 R => Q missense 1.649e-05 2 121302 0 0.21 0.558
acm5_human 219 5.64x64 TM5 E => K missense 8.244e-06 1 121298 0 0.0 1.0 GP (contact)
acm5_human 227 5.72x72 TM5 L => P missense 8.249e-06 1 121224 0 0.0 1.0 GP (contact)
acm5_human 229 5.74x74 TM5 D => E missense 1.65e-05 2 121206 0 0.81 0.014 GP (contact)
acm5_human 230 5.75x75 TM5 L => F missense 4.126e-05 5 121192 0 0.05 1.0 GP (contact)
acm5_human 232 ICL3 G => C missense 8.252e-06 1 121186 0 0.0 1.0
acm5_human 241 ICL3 K => R missense 5.781e-05 7 121078 0 0.52 0.002
acm5_human 242 ICL3 R => K missense 8.259e-06 1 121080 0 0.93 0.001
acm5_human 255 ICL3 R => C missense 9.096e-05 11 120930 0 0.02 0.436
acm5_human 255 ICL3 R => L missense 8.27e-06 1 120922 0 0.09 0.055
acm5_human 255 ICL3 R => H missense 1.654e-05 2 120922 0 0.2 0.001
acm5_human 258 ICL3 R => Q missense 8.274e-06 1 120864 0 0.8 0.002
acm5_human 264 ICL3 R => W missense 8.279e-06 1 120782 0 0.01 0.79
acm5_human 264 ICL3 R => Q missense 8.279e-06 1 120782 0 0.38 0.046
acm5_human 266 ICL3 R => K missense 8.279e-06 1 120786 0 0.72 0.029
acm5_human 268 ICL3 Q => K missense 1.656e-05 2 120746 0 0.57 0.403
acm5_human 269 ICL3 A => P missense 1.657e-05 2 120736 0 0.31 0.895
acm5_human 271 ICL3 W => S missense 8.285e-06 1 120702 0 0.1 1.0
acm5_human 271 ICL3 W => C missense 8.286e-06 1 120688 0 0.1 1.0
acm5_human 275 ICL3 R => C missense 2.487e-05 3 120614 0 0.05 0.004
acm5_human 275 ICL3 R => H missense 2.487e-05 3 120608 0 0.23 0.004
acm5_human 278 ICL3 T => P missense 8.294e-06 1 120570 0 0.18 0.745
acm5_human 285 ICL3 S => F missense 4.145e-05 5 120634 0 0.05 0.438
acm5_human 289 ICL3 G => V missense 8.287e-06 1 120676 0 0.22 0.112
acm5_human 292 ICL3 A => T missense 0.0001243 15 120690 0 0.42 0.001
acm5_human 293 ICL3 N => S missense 0.0001822 22 120754 0 1.0 0.0
acm5_human 293 ICL3 N => I missense 8.281e-06 1 120754 0 0.09 0.001
acm5_human 303 ICL3 C => R missense 8.272e-06 1 120890 0 0.29 0.748
acm5_human 310 ICL3 E => A missense 2.479e-05 3 120998 0 0.07 0.559
acm5_human 311 ICL3 D => N missense 8.264e-06 1 121000 0 0.19 0.87
acm5_human 313 ICL3 D => A missense 8.266e-06 1 120984 0 0.09 0.032
acm5_human 314 ICL3 K => Q missense 8.262e-06 1 121036 0 0.58 0.024
acm5_human 316 ICL3 A => T missense 0.0009741 118 121142 0 0.55 0.002
acm5_human 321 ICL3 L => F missense 3.3e-05 4 121208 0 0.83 0.0
acm5_human 322 ICL3 Q => R missense 8.249e-06 1 121226 0 0.34 0.023
acm5_human 323 ICL3 V => L missense 8.249e-06 1 121234 0 0.42 0.016
acm5_human 325 ICL3 Y => H missense 8.247e-06 1 121250 0 0.51 0.815
acm5_human 328 ICL3 Q => P missense 8.246e-06 1 121276 0 0.99 0.006
acm5_human 329 ICL3 G => C missense 0.0007091 86 121278 0 0.01 0.421
acm5_human 329 ICL3 G => D missense 1.649e-05 2 121274 0 0.17 0.002
acm5_human 330 ICL3 K => R missense 1.649e-05 2 121288 0 0.51 0.243
acm5_human 333 ICL3 P => L missense 2.473e-05 3 121312 0 0.07 0.898
acm5_human 335 ICL3 E => K missense 8.243e-06 1 121318 0 0.38 0.036
acm5_human 337 ICL3 F => C missense 1.648e-05 2 121336 0 0.17 0.8
acm5_human 342 ICL3 T => N missense 8.239e-06 1 121376 0 0.5 0.004
acm5_human 343 ICL3 E => V missense 2.472e-05 3 121378 0 0.21 0.002
acm5_human 349 ICL3 A => G missense 2.471e-05 3 121394 0 0.47 0.0
acm5_human 351 ICL3 T => I missense 4.119e-05 5 121394 0 0.18 0.049
acm5_human 353 ICL3 K => R missense 0.0001483 18 121398 0 0.56 0.049
acm5_human 355 ICL3 D => H missense 8.237e-06 1 121400 0 0.06 0.743
acm5_human 355 ICL3 D => G missense 1.647e-05 2 121398 0 0.27 0.002
acm5_human 359 ICL3 P => S missense 8.237e-06 1 121400 0 0.67 0.007
acm5_human 359 ICL3 P => L missense 8.237e-06 1 121402 0 0.18 0.049
acm5_human 365 ICL3 P => L missense 8.238e-06 1 121388 0 0.15 0.546
acm5_human 367 ICL3 A => G missense 8.238e-06 1 121394 0 0.37 0.077
acm5_human 368 ICL3 A => T missense 8.238e-06 1 121392 0 0.49 0.049
acm5_human 377 ICL3 V => G missense 0.0001236 15 121378 0 0.22 0.481
acm5_human 379 ICL3 Y => S missense 1.648e-05 2 121380 0 0.39 0.876
acm5_human 382 ICL3 R => Q missense 0.0002719 33 121376 1 0.26 0.029
acm5_human 385 ICL3 V => I missense 6.591e-05 8 121376 0 0.29 0.178
acm5_human 387 ICL3 A => S missense 2.472e-05 3 121370 0 0.58 0.438
acm5_human 387 ICL3 A => T missense 8.239e-06 1 121370 0 0.58 0.697
acm5_human 389 ICL3 G => R missense 0.0002307 28 121368 0 0.1 0.931
acm5_human 393 ICL3 T => S missense 8.239e-06 1 121374 0 0.89 0.02
acm5_human 406 ICL3 P => A missense 8.237e-06 1 121400 0 0.77 0.02
acm5_human 412 ICL3 E => K missense 0.008295 1007 121398 46 0.93 0.049
acm5_human 413 ICL3 P => T missense 2.471e-05 3 121396 0 0.63 0.002
acm5_human 415 ICL3 T => M missense 1.647e-05 2 121398 0 0.04 0.398
acm5_human 423 ICL3 S => N missense 8.237e-06 1 121408 0 0.19 0.014
acm5_human 427 ICL3 T => S missense 8.237e-06 1 121408 0 0.18 0.999 PTM (Phosphorylation)
acm5_human 428 ICL3 K => T missense 0.001779 216 121406 1 0.0 1.0
acm5_human 429 ICL3 R => Q missense 8.237e-06 1 121408 0 0.02 1.0
acm5_human 431 6.24x24 TM6 R => T missense 1.647e-05 2 121408 0 0.12 1.0
acm5_human 432 6.25x25 TM6 V => L missense 8.237e-06 1 121408 0 0.25 0.0 GP (contact)
acm5_human 432 6.25x25 TM6 V => G missense 8.237e-06 1 121408 0 0.05 0.017 GP (contact)
acm5_human 435 6.28x28 TM6 V => F missense 8.237e-06 1 121408 0 0.0 0.815 GP (contact)
acm5_human 437 6.30x30 TM6 E => Q missense 8.237e-06 1 121408 0 0.0 1.0 SodiumPocket MicroSwitch
acm5_human 437 6.30x30 TM6 E => D missense 8.237e-06 1 121408 0 0.08 0.999 SodiumPocket MicroSwitch
acm5_human 443 6.36x36 TM6 T => I missense 0.0002801 34 121406 0 0.03 1.0 GP (contact)
acm5_human 447 6.40x40 TM6 I => V missense 4.119e-05 5 121400 0 0.0 0.998 GP (contact)
acm5_human 450 6.43x43 TM6 A => V missense 2.471e-05 3 121396 0 0.02 1.0
acm5_human 464 6.57x57 TM6 V => I missense 1.647e-05 2 121398 0 0.62 0.039
acm5_human 464 6.57x57 TM6 V => A missense 8.237e-06 1 121400 0 0.1 0.741
acm5_human 467 6.60x60 TM6 F => L missense 8.237e-06 1 121402 0 0.01 0.372
acm5_human 470 ECL3 K => E missense 8.237e-06 1 121406 0 0.33 0.016
acm5_human 470 ECL3 K => Q missense 8.237e-06 1 121406 0 0.19 0.048
acm5_human 477 7.35x34 TM7 W => R missense 8.237e-06 1 121410 0 0.0 1.0
acm5_human 478 7.36x35 TM7 H => L missense 8.237e-06 1 121410 0 0.15 0.991
acm5_human 480 7.38x37 TM7 G => D missense 8.237e-06 1 121410 0 0.0 1.0
acm5_human 488 7.46x46 TM7 S => R missense 1.647e-05 2 121412 0 0.0 1.0
acm5_human 492 7.50x50 TM7 P => R missense 8.237e-06 1 121408 0 0.0 1.0 SodiumPocket MicroSwitch
acm5_human 503 8.51x51 H8 R => S missense 8.238e-06 1 121390 0 0.0 0.73 GP (contact)
acm5_human 510 8.58x58 H8 L => F missense 2.475e-05 3 121204 0 0.0 0.985
acm5_human 513 C-term R => Q missense 3.31e-05 4 120830 0 1.0 0.001
acm5_human 516 C-term K => R missense 8.296e-06 1 120534 0 0.12 0.034
acm5_human 518 C-term K => N missense 1.672e-05 2 119646 0 0.0 0.193
acm5_human 519 C-term V => M missense 1.672e-05 2 119628 0 0.14 0.018
acm5_human 522 C-term K => M missense 8.517e-06 1 117408 0 0.0 0.976
acm5_human 523 C-term L => M missense 0.0009331 109 116820 1 0.11 0.93
acm5_human 528 C-term N => S missense 9.144e-06 1 109364 0 0.13 0.028
acm5_human 528 C-term N => K missense 9.153e-06 1 109250 0 0.05 0.231
acm5_human 530 C-term K => Q missense 9.275e-06 1 107818 0 nan 0.717
acm5_human 183 45.50x50 ECL2 C => Ter stop gained 3.295e-05 4 121400 0 None None
acm5_human 210 5.55x55 TM5 T => AsnfsTer20 frameshift 8.24e-06 1 121360 0 None None
acm5_human 215 5.60x60 TM5 R => Ter stop gained 1.648e-05 2 121330 0 None None
acm5_human 220 5.65x65 TM5 T => AlafsTer7 frameshift 8.243e-06 1 121308 0 None None GP (contact)
acm5_human 276 ICL3 R => LysfsTer23 frameshift 1.658e-05 2 120608 0 None None
acm5_human 336 ICL3 E => Ter stop gained 3.297e-05 4 121324 0 None None
acm5_human 429 ICL3 R => Ter stop gained 8.237e-06 1 121408 0 None None
acm5_human 518 C-term K => SerfsTer26 frameshift 1.664e-05 2 120204 0 None None
acm5_human 519 C-term V => TrpfsTer32 frameshift 8.319e-06 1 120204 0 None None
acm5_human 525 C-term W => Ter stop gained 8.767e-06 1 114060 0 None None
acm5_human 526 C-term Q => Ter stop gained 8.843e-06 1 113080 0 None None


Residue

Diagrams

S Q L K ICL1ECL1 G R W A L ECL1 P L T Y R A K R ICL2ECL2 K R T V P L D E C Q I Q F L S ECL2ICL3 Q G S D S V T K A E K R K P A H R A L F R S C L R C P R P T L A Q R E R N Q A S W S S S R R S T S T T G K P S Q A T G P S A N W A K A E Q L T T C S S Y P S S E D E D K P A T D P V L Q V V Y K S Q G K E S P G E E F S A E E T E E T F V K A E T E K S D Y D T P N Y L L S P A A A H R P K S Q K C V A Y K F R L V V K A D G N Q E T N N G C H K V K I M P C P F P V A K E P S T K G L N P N P S H Q M T K R K ICL3ECL3 D K C V ECL3N-term M E G D S Y H N A T T V N G T P V N H Q P L E R H R N-termC-term L C R W K K K K V E E K L Y W Q G N S K L P C-term L W E V I T I A A V T A V V S L I T I V G N V L V M I S F K V N T V N N Y Y L L S L A C A D L I I G I F S M N L Y T T Y I L M G S L A C D L W L A L D Y V A S N A S V M N L L V I S F D R Y F S I T R T P K R A G I M I G L A W L I S F I L W A P A I L C W Q Y L V G E P T I T F G T A I A A F Y I P V S V M T I L Y C R I Y R E T E K R T K D L A D L R V V L V K E R K A A Q T L S A I L L A F I I T W T P Y N I M V L V S T F C P V T L W H L G Y W L C Y V N S T V N P I C Y A L C N R T F K M F R K T L L
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