Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
ada1b_human 4 N-term D => V missense 8.682e-06 1 115176 0 nan 0.007
ada1b_human 4 N-term D => E missense 8.667e-06 1 115380 0 nan 0.001
ada1b_human 7 N-term T => A missense 0.0001969 23 116822 0 nan 0.0
ada1b_human 7 N-term T => S missense 8.56e-06 1 116822 0 nan 0.002
ada1b_human 8 N-term G => S missense 8.497e-06 1 117692 0 nan 0.002
ada1b_human 9 N-term H => Y missense 6.759e-05 8 118356 0 nan 0.001
ada1b_human 14 N-term P => S missense 8.333e-06 1 120000 0 nan 0.002
ada1b_human 17 N-term W => R missense 8.284e-06 1 120718 0 nan 0.031
ada1b_human 19 N-term E => Q missense 4.134e-05 5 120950 0 nan 0.032
ada1b_human 24 N-term N => T missense 8.248e-05 10 121246 0 0.12 0.057
ada1b_human 24 N-term N => S missense 1.65e-05 2 121246 0 0.17 0.002
ada1b_human 26 N-term T => S missense 3.298e-05 4 121276 0 0.56 0.001
ada1b_human 29 N-term N => S missense 8.243e-06 1 121320 0 0.14 0.069
ada1b_human 30 N-term Q => R missense 8.242e-06 1 121330 0 0.41 0.001
ada1b_human 33 N-term S => R missense 3.296e-05 4 121342 0 0.05 0.0
ada1b_human 38 N-term P => T missense 8.241e-06 1 121346 0 0.09 0.115
ada1b_human 43 1.30x30 TM1 T => I missense 0.0005521 67 121356 0 0.04 0.276
ada1b_human 45 1.32x32 TM1 A => T missense 8.24e-06 1 121356 0 0.06 0.996
ada1b_human 46 1.33x33 TM1 I => T missense 8.24e-06 1 121356 0 0.01 0.185
ada1b_human 48 1.35x35 TM1 V => M missense 8.24e-06 1 121354 0 0.02 0.757
ada1b_human 53 1.40x40 TM1 G => D missense 8.24e-06 1 121360 0 0.0 0.988
ada1b_human 57 1.44x44 TM1 L => V missense 8.241e-06 1 121340 0 0.34 0.002
ada1b_human 61 1.48x48 TM1 V => L missense 2.472e-05 3 121340 0 0.34 0.162
ada1b_human 61 1.48x48 TM1 V => M missense 8.241e-06 1 121340 0 0.06 0.657
ada1b_human 67 1.54x54 TM1 I => N missense 8.24e-06 1 121354 0 0.0 0.999
ada1b_human 69 1.56x56 TM1 S => F missense 1.648e-05 2 121346 0 0.0 0.989
ada1b_human 74 12.48x48 ICL1 R => P missense 3.297e-05 4 121336 0 0.03 0.958
ada1b_human 77 12.51x51 ICL1 R => W missense 4.121e-05 5 121326 0 0.0 1.0
ada1b_human 78 2.37x37 TM2 T => M missense 8.241e-06 1 121342 0 0.0 0.846
ada1b_human 80 2.39x39 TM2 T => I missense 8.24e-06 1 121352 0 0.02 1.0
ada1b_human 82 2.41x41 TM2 Y => C missense 8.24e-06 1 121362 0 0.0 1.0
ada1b_human 90 2.49x49 TM2 A => D missense 8.239e-06 1 121372 0 0.0 1.0
ada1b_human 91 2.50x50 TM2 D => N missense 1.648e-05 2 121374 0 0.0 0.999
ada1b_human 96 2.55x55 TM2 F => S missense 3.296e-05 4 121374 0 0.25 0.036
ada1b_human 101 2.60x59 TM2 F => L missense 8.239e-06 1 121374 0 0.01 0.695
ada1b_human 109 2.68x67 TM2 G => S missense 1.648e-05 2 121358 0 0.06 0.907
ada1b_human 113 23.52x52 ECL1 L => P missense 8.24e-06 1 121362 0 0.0 0.983
ada1b_human 124 3.31x31 TM3 V => M missense 1.648e-05 2 121360 0 0.03 0.82
ada1b_human 126 3.33x33 TM3 V => I missense 8.24e-06 1 121358 0 0.0 0.998
ada1b_human 138 3.45x45 TM3 A => T missense 8.242e-06 1 121334 0 0.34 0.157
ada1b_human 141 3.48x48 TM3 I => T missense 8.241e-06 1 121350 0 0.0 0.999
ada1b_human 143 3.50x50 TM3 R => H missense 8.241e-06 1 121344 0 0.0 0.999 SodiumPocket MicroSwitch GP (contact)
ada1b_human 147 3.54x54 TM3 V => A missense 1.648e-05 2 121350 0 0.0 0.998 GP (contact)
ada1b_human 148 3.55x55 TM3 R => H missense 8.24e-06 1 121356 0 0.01 0.954 GP (contact)
ada1b_human 155 34.55x55 ICL2 T => M missense 8.24e-06 1 121362 0 0.17 0.192 GP (contact)
ada1b_human 159 4.39x39 TM4 R => W missense 8.242e-06 1 121336 0 0.0 0.991
ada1b_human 159 4.39x39 TM4 R => Q missense 8.24e-06 1 121352 0 0.18 0.841
ada1b_human 162 4.42x42 TM4 A => T missense 8.239e-06 1 121376 0 0.02 0.773
ada1b_human 164 4.44x44 TM4 L => F missense 8.239e-06 1 121374 0 0.05 1.0
ada1b_human 167 4.47x47 TM4 L => F missense 4.943e-05 6 121380 0 0.06 0.956
ada1b_human 168 4.48x48 TM4 S => G missense 1.648e-05 2 121380 0 0.58 0.003
ada1b_human 175 4.55x55 TM4 V => I missense 2.472e-05 3 121382 0 0.1 0.708
ada1b_human 176 4.56x56 TM4 I => V missense 8.238e-06 1 121384 0 0.15 0.996
ada1b_human 178 4.58x58 TM4 I => L missense 8.238e-06 1 121384 0 0.01 0.996
ada1b_human 179 4.59x59 TM4 G => E missense 1.648e-05 2 121382 0 0.0 1.0
ada1b_human 182 4.62x62 TM4 L => I missense 8.238e-06 1 121390 0 0.01 0.953
ada1b_human 183 ECL2 G => E missense 8.238e-06 1 121390 0 0.0 1.0
ada1b_human 186 ECL2 E => G missense 1.648e-05 2 121386 0 0.0 0.976
ada1b_human 186 ECL2 E => D missense 8.239e-06 1 121380 0 0.05 0.892
ada1b_human 188 ECL2 A => E missense 8.24e-06 1 121366 0 0.37 0.976
ada1b_human 191 ECL2 D => N missense 1.648e-05 2 121370 0 0.07 0.999
ada1b_human 191 ECL2 D => E missense 8.24e-06 1 121366 0 0.0 0.998
ada1b_human 194 ECL2 E => G missense 8.24e-06 1 121364 0 0.42 0.574
ada1b_human 194 ECL2 E => V missense 8.24e-06 1 121364 0 0.43 0.011
ada1b_human 196 45.51x51 ECL2 G => R missense 2.472e-05 3 121342 0 0.67 0.006
ada1b_human 201 5.36x37 TM5 P => S missense 8.241e-06 1 121346 0 0.0 0.995
ada1b_human 214 5.49x49 TM5 I => V missense 8.239e-06 1 121372 0 0.15 0.996
ada1b_human 217 5.52x52 TM5 A => V missense 0.000173 21 121370 0 0.67 0.033
ada1b_human 221 5.56x56 TM5 V => A missense 8.238e-06 1 121388 0 0.31 0.151
ada1b_human 225 5.60x60 TM5 R => G missense 8.238e-06 1 121396 0 0.0 0.999
ada1b_human 225 5.60x60 TM5 R => H missense 1.647e-05 2 121398 0 0.0 0.999
ada1b_human 238 5.73x73 TM5 E => G missense 8.238e-06 1 121390 0 0.0 0.999
ada1b_human 244 ICL3 E => V missense 8.24e-06 1 121364 0 0.07 0.995
ada1b_human 245 ICL3 M => L missense 3.296e-05 4 121358 0 0.21 0.233
ada1b_human 262 ICL3 E => K missense 8.256e-06 1 121130 0 0.16 0.93
ada1b_human 264 ICL3 T => P missense 8.26e-06 1 121068 0 0.36 0.005
ada1b_human 269 ICL3 K => N missense 8.269e-06 1 120940 0 0.13 0.66
ada1b_human 272 ICL3 G => S missense 8.274e-06 1 120862 0 0.19 0.052
ada1b_human 275 ICL3 P => A missense 8.29e-06 1 120622 0 0.57 0.011
ada1b_human 277 ICL3 S => I missense 8.306e-06 1 120402 0 0.01 0.87
ada1b_human 279 ICL3 I => T missense 1.664e-05 2 120192 0 0.0 0.318
ada1b_human 281 ICL3 V => I missense 5.003e-05 6 119932 0 0.03 0.067
ada1b_human 287 6.28x28 TM6 S => C missense 8.389e-06 1 119208 0 0.0 0.999 GP (contact)
ada1b_human 295 6.36x36 TM6 T => P missense 8.494e-06 1 117730 0 0.0 1.0 GP (contact)
ada1b_human 295 6.36x36 TM6 T => M missense 4.251e-05 5 117622 0 0.0 1.0 GP (contact)
ada1b_human 301 6.42x42 TM6 G => S missense 4.329e-05 5 115502 0 0.02 1.0
ada1b_human 316 6.57x57 TM6 L => F missense 9.166e-06 1 109094 0 0.08 0.986
ada1b_human 327 7.32x31 TM7 D => Y missense 9.084e-06 1 110080 0 0.0 0.902
ada1b_human 327 7.32x31 TM7 D => E missense 9.064e-06 1 110326 0 1.0 0.009
ada1b_human 332 7.37x36 TM7 V => L missense 0.0004788 54 112784 0 0.04 0.068
ada1b_human 344 7.49x49 TM7 N => D missense 8.575e-06 1 116622 0 0.02 0.809 SodiumPocket MicroSwitch
ada1b_human 345 7.50x50 TM7 P => T missense 8.567e-06 1 116732 0 0.0 0.999 SodiumPocket MicroSwitch
ada1b_human 346 7.51x51 TM7 I => T missense 8.564e-06 1 116770 0 0.0 0.998
ada1b_human 347 7.52x52 TM7 I => V missense 8.561e-06 1 116810 0 0.0 0.994
ada1b_human 351 7.56x56 TM7 S => P missense 8.561e-06 1 116808 0 0.12 0.276 GP (contact)
ada1b_human 351 7.56x56 TM7 S => C missense 8.56e-06 1 116818 0 0.09 0.533 GP (contact)
ada1b_human 352 8.47x47 H8 S => G missense 8.56e-06 1 116818 0 0.03 0.132 GP (contact)
ada1b_human 357 8.52x52 H8 R => C missense 5.172e-05 6 116008 0 0.0 0.549
ada1b_human 357 8.52x52 H8 R => S missense 5.172e-05 6 116008 0 0.0 0.103
ada1b_human 359 8.54x54 H8 F => L missense 8.655e-06 1 115536 0 0.0 0.433
ada1b_human 361 8.56x56 H8 R => H missense 1.753e-05 2 114062 0 0.03 0.635
ada1b_human 364 8.59x59 H8 G => R missense 1.792e-05 2 111632 0 1.0 0.0
ada1b_human 366 C-term Q => H missense 8.617e-05 9 104448 0 0.11 0.005
ada1b_human 366 C-term Q => H missense 9.574e-06 1 104448 0 0.11 0.005
ada1b_human 374 C-term R => Q missense 0.0008125 33 40614 0 0.39 0.238
ada1b_human 374 C-term R => P missense 2.462e-05 1 40614 0 0.1 0.453
ada1b_human 376 C-term R => C missense 5.378e-05 1 18596 0 0.01 0.183
ada1b_human 399 C-term R => H missense 0.000271 1 3690 0 nan 0.047 PTM (Methylation)
ada1b_human 434 C-term G => S missense 0.0002897 1 3452 0 nan 0.001
ada1b_human 466 C-term G => D missense 0.0002172 1 4604 0 nan 0.014
ada1b_human 366 C-term Q => Ter stop gained 2.807e-05 3 106860 0 None None
ada1b_human 462 C-term P => ArgfsTer? frameshift 0.0002695 1 3710 0 None None


Residue

Diagrams

R H L R ICL1ECL1 Y W V L ECL1 S L Q Y P T L V ICL2ECL2 G W K E P A P N D D K E C G V T E ECL2ICL3 G V M K E M S N S K E L T L R I H S K N F H E D T L S S T K A K G H N P R S S I A V K ICL3ECL3 S T L K P ECL3N-term M N P D L D T G H N T S A P A H W G E L K N A N F T G P N Q T S S N S T L P Q L D N-termC-term C Q C R G R G R R R R R R R R R L G G C A Y T Y R P W T R G G S L E R S Q S R K D S L D D S G S C L S G S Q R T L P S A S P S P G Y L G R G A P P P V E L C A F P E W K A P G A L L S L P A P E P P G R R G R H D S G P L F T F K L L T E P E S P G T D G G A S N G G C E A A A D V A N G Q P G F K S N M P L A P G Q F C-term I T R A I S V G L V L G A F I L F A I V G N I L V I L S V A C N T P T N Y F I V N L A M A D L L L S F T V L P F S A A L E V L G G R I F C D I W A A V D V L C C T A S I L S L C A I S I D R Y I G V R Y T R R K A I L A L L S V W V L S T V I S I G P L L E P F Y A L F S S L G S F Y I P L A V I L V M Y C R V Y I V A K R T T K N L E A L F K F S R E K K A A K T L G I V V G M F I L C W L P F F I A L P L G S L F P D A V F K V V F W L G Y F N S C L N P I I Y P C S S K E F V R F K R A I L G
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