Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
ada1d_human 572 C-term I => V missense 3.426e-05 4 116764 0 nan 0.978
ada1d_human 568 C-term R => L missense 3.395e-05 4 117804 0 nan 0.196
ada1d_human 566 C-term N => H missense 8.47e-06 1 118068 0 nan 0.002
ada1d_human 564 C-term Y => H missense 8.467e-06 1 118106 0 nan 0.243
ada1d_human 563 C-term D => Y missense 7.625e-05 9 118028 0 nan 0.826
ada1d_human 562 C-term A => G missense 2.542e-05 3 118038 0 nan 0.003
ada1d_human 560 C-term E => Q missense 8.481e-06 1 117916 0 nan 0.13
ada1d_human 559 C-term Y => C missense 2.545e-05 3 117896 0 nan 0.956
ada1d_human 554 C-term A => G missense 8.525e-06 1 117302 0 nan 0.022
ada1d_human 552 C-term E => K missense 2.564e-05 3 117012 0 nan 0.285
ada1d_human 548 C-term H => Y missense 8.56e-06 1 116816 0 nan 0.036
ada1d_human 543 C-term S => F missense 4.3e-05 5 116268 0 nan 0.001
ada1d_human 534 C-term A => V missense 8.73e-06 1 114542 0 nan 0.197
ada1d_human 533 C-term C => Y missense 1.751e-05 2 114236 0 nan 0.01
ada1d_human 529 C-term A => T missense 8.886e-06 1 112538 0 nan 0.003
ada1d_human 525 C-term G => A missense 0.002826 315 111484 1 nan 0.009
ada1d_human 523 C-term A => P missense 9.027e-06 1 110774 0 nan 0.302
ada1d_human 522 C-term R => H missense 9.05e-06 1 110498 0 nan 0.006
ada1d_human 522 C-term R => C missense 9.061e-06 1 110362 0 nan 0.61
ada1d_human 519 C-term H => L missense 4.59e-05 5 108926 0 0.0 0.033
ada1d_human 519 C-term H => R missense 1.836e-05 2 108926 0 0.01 0.022
ada1d_human 518 C-term S => W missense 2.769e-05 3 108326 0 0.0 0.998
ada1d_human 514 C-term V => A missense 0.0001239 13 104930 0 0.0 0.527
ada1d_human 513 C-term K => E missense 2.898e-05 3 103518 0 0.0 0.876
ada1d_human 508 C-term T => S missense 2.067e-05 2 96754 0 0.41 0.056
ada1d_human 507 C-term T => M missense 1.064e-05 1 94016 0 nan 0.781
ada1d_human 504 C-term R => Q missense 0.0001589 14 88110 0 0.92 0.002
ada1d_human 503 C-term F => L missense 0.0001635 14 85634 0 1.0 0.001
ada1d_human 502 C-term P => L missense 2.395e-05 2 83500 0 0.0 0.949
ada1d_human 501 C-term G => R missense 1.243e-05 1 80438 0 0.15 0.005
ada1d_human 500 C-term L => V missense 6.25e-05 5 79998 0 0.16 0.007
ada1d_human 497 C-term W => R missense 1.326e-05 1 75422 0 nan 0.98
ada1d_human 492 C-term S => R missense 1.493e-05 1 67000 0 0.43 0.001
ada1d_human 478 C-term P => R missense 9.565e-05 3 31364 0 nan 0.002
ada1d_human 478 C-term P => L missense 3.188e-05 1 31364 0 nan 0.036
ada1d_human 477 C-term T => A missense 3.474e-05 1 28788 0 nan 0.0
ada1d_human 460 C-term A => V missense 0.001376 4 2906 0 0.32 0.001
ada1d_human 441 C-term S => C missense 0.0001207 1 8282 0 0.0 0.436
ada1d_human 439 C-term R => W missense 0.0004399 4 9094 0 0.0 0.17
ada1d_human 433 C-term V => I missense 0.0005464 6 10980 0 0.29 0.0
ada1d_human 427 C-term R => H missense 7.757e-05 1 12892 0 0.08 0.001
ada1d_human 425 C-term R => Q missense 6.971e-05 1 14346 0 0.24 0.519
ada1d_human 420 C-term Q => R missense 0.000197 4 20300 0 0.17 0.005
ada1d_human 418 8.59x59 H8 R => C missense 8.372e-05 2 23890 1 0.09 0.61
ada1d_human 414 8.55x55 H8 L => F missense 0.0002738 9 32870 0 0.48 0.003
ada1d_human 412 8.53x53 H8 A => V missense 2.722e-05 1 36736 0 0.0 0.71
ada1d_human 411 8.52x52 H8 R => G missense 2.405e-05 1 41586 0 0.0 0.997
ada1d_human 407 8.48x48 H8 R => C missense 0.0002301 13 56492 0 0.0 0.586 GP (contact)
ada1d_human 406 8.47x47 H8 S => R missense 1.723e-05 1 58046 0 0.0 0.126 GP (contact)
ada1d_human 406 8.47x47 H8 S => R missense 1.615e-05 1 61908 0 0.0 0.126 GP (contact)
ada1d_human 401 7.52x52 TM7 I => V missense 5.88e-05 5 85032 0 0.0 0.896
ada1d_human 399 7.50x50 TM7 P => R missense 1.089e-05 1 91822 0 0.0 1.0 SodiumPocket MicroSwitch
ada1d_human 398 7.49x49 TM7 N => K missense 1.058e-05 1 94504 0 0.0 0.986 SodiumPocket MicroSwitch
ada1d_human 397 7.48x48 TM7 V => M missense 9.953e-06 1 100476 0 0.26 0.327
ada1d_human 396 7.47x47 TM7 C => R missense 9.56e-06 1 104604 0 0.0 0.953
ada1d_human 393 7.44x43 TM7 F => L missense 9.104e-06 1 109844 0 0.15 0.013 SodiumPocket MicroSwitch
ada1d_human 389 7.40x39 TM7 W => R missense 1.728e-05 2 115736 0 0.0 0.98
ada1d_human 388 7.39x38 TM7 F => L missense 8.613e-06 1 116110 0 0.01 0.03
ada1d_human 375 ECL3 P => R missense 8.525e-06 1 117298 0 0.02 0.593
ada1d_human 371 6.58x58 TM6 G => V missense 1.703e-05 2 117436 0 0.02 0.101
ada1d_human 371 6.58x58 TM6 G => A missense 8.515e-06 1 117436 0 0.03 0.058
ada1d_human 371 6.58x58 TM6 G => R missense 1.853e-05 1 53956 0 0.03 0.262
ada1d_human 366 6.53x53 TM6 F => S missense 1.572e-05 1 63612 0 0.0 0.739
ada1d_human 365 6.52x52 TM6 F => L missense 1.537e-05 1 65064 0 0.0 1.0
ada1d_human 358 6.45x45 TM6 V => L missense 1.386e-05 1 72132 0 0.06 0.555
ada1d_human 355 6.42x42 TM6 G => R missense 1.373e-05 1 72818 0 0.0 1.0
ada1d_human 346 6.33x33 TM6 A => V missense 1.498e-05 1 66756 0 0.02 0.957 GP (contact)
ada1d_human 344 6.31x31 TM6 K => N missense 4.571e-05 3 65632 0 0.0 0.823
ada1d_human 342 6.29x29 TM6 R => C missense 1.603e-05 1 62396 0 0.0 0.997 GP (contact)
ada1d_human 336 ICL3 R => H missense 1.889e-05 1 52946 0 0.03 0.985
ada1d_human 333 ICL3 L => F missense 4.428e-05 2 45172 0 0.23 0.033
ada1d_human 332 ICL3 S => L missense 2.264e-05 1 44178 0 0.0 0.389
ada1d_human 332 ICL3 S => W missense 2.264e-05 1 44178 0 0.0 0.987
ada1d_human 317 ICL3 G => E missense 0.0004675 10 21390 0 0.33 0.006
ada1d_human 317 ICL3 G => R missense 4.679e-05 1 21370 0 0.24 0.004
ada1d_human 313 ICL3 T => R missense 0.0002634 5 18982 0 0.29 0.231
ada1d_human 309 ICL3 R => P missense 0.0001218 2 16420 0 0.0 0.408
ada1d_human 309 ICL3 R => G missense 0.0005112 8 15650 0 0.09 0.055
ada1d_human 308 ICL3 C => S missense 6.424e-05 1 15566 0 0.19 0.089
ada1d_human 298 ICL3 K => N missense 7.274e-05 1 13748 0 0.44 0.115
ada1d_human 282 5.66x66 TM5 R => H missense 0.0003606 7 19410 0 0.04 0.581 GP (contact)
ada1d_human 282 5.66x66 TM5 R => G missense 0.000102 2 19604 0 0.01 0.959 GP (contact)
ada1d_human 281 5.65x65 TM5 A => V missense 0.0008009 16 19978 0 0.02 0.932 GP (contact)
ada1d_human 275 5.59x59 TM5 C => F missense 8.546e-05 2 23402 0 0.41 0.006
ada1d_human 271 5.55x55 TM5 V => M missense 3.9e-05 1 25642 0 0.02 0.508
ada1d_human 268 5.52x52 TM5 A => V missense 3.611e-05 1 27696 0 0.39 0.03
ada1d_human 266 5.50x50 TM5 P => S missense 3.377e-05 1 29612 0 0.0 1.0 SodiumPocket MicroSwitch
ada1d_human 266 5.50x50 TM5 P => T missense 3.377e-05 1 29612 0 0.0 1.0 SodiumPocket MicroSwitch
ada1d_human 265 5.49x49 TM5 L => P missense 3.322e-05 1 30102 0 0.0 0.99
ada1d_human 264 5.48x48 TM5 Y => C missense 3.248e-05 1 30784 0 0.0 0.992
ada1d_human 256 5.40x41 TM5 V => I missense 2.806e-05 1 35644 0 0.35 0.009
ada1d_human 252 5.36x37 TM5 A => V missense 5.023e-05 2 39816 0 0.3 0.005
ada1d_human 247 45.51x51 ECL2 G => S missense 0.0001483 7 47190 0 0.81 0.009
ada1d_human 247 45.51x51 ECL2 G => R missense 4.238e-05 2 47190 0 0.65 0.016
ada1d_human 245 ECL2 F => L missense 3.94e-05 2 50756 0 0.66 0.034
ada1d_human 244 ECL2 R => L missense 3.9e-05 2 51280 0 0.3 0.048
ada1d_human 243 ECL2 E => K missense 3.726e-05 2 53680 0 0.01 0.108
ada1d_human 242 ECL2 D => V missense 1.811e-05 1 55220 0 0.0 0.968
ada1d_human 241 ECL2 P => L missense 0.0002296 13 56626 0 0.04 0.005
ada1d_human 241 ECL2 P => R missense 8.83e-05 5 56626 0 0.05 0.027
ada1d_human 241 ECL2 P => T missense 1.747e-05 1 57246 0 0.1 0.016
ada1d_human 232 4.61x61 TM4 L => P missense 1.414e-05 1 70744 0 0.0 0.997
ada1d_human 230 4.59x59 TM4 G => R missense 4.171e-05 3 71928 0 0.0 0.993
ada1d_human 229 4.58x58 TM4 V => A missense 2.765e-05 2 72342 0 0.02 0.07
ada1d_human 227 4.56x56 TM4 V => L missense 2.731e-05 2 73220 0 0.0 0.45
ada1d_human 223 4.52x52 TM4 V => I missense 1.348e-05 1 74184 0 0.22 0.091
ada1d_human 222 4.51x51 TM4 V => I missense 1.337e-05 1 74768 0 0.44 0.038
ada1d_human 218 4.47x47 TM4 A => V missense 1.332e-05 1 75092 0 0.93 0.241
ada1d_human 211 4.40x40 TM4 R => C missense 1.334e-05 1 74948 0 0.04 0.747
ada1d_human 211 4.40x40 TM4 R => G missense 1.334e-05 1 74948 0 0.06 0.708
ada1d_human 210 4.39x39 TM4 E => Q missense 1.328e-05 1 75302 0 0.1 0.378
ada1d_human 206 34.55x55 ICL2 A => D missense 1.303e-05 1 76724 0 0.01 0.148 GP (contact)
ada1d_human 205 34.54x54 ICL2 P => L missense 1.298e-05 1 77022 0 0.0 0.901 GP (contact)
ada1d_human 203 34.52x52 ICL2 K => E missense 1.282e-05 1 77988 0 0.01 0.18 GP (contact)
ada1d_human 201 34.50x50 ICL2 S => L missense 8.926e-05 7 78426 0 0.08 0.811 PTM (Phosphorylation) GP (contact)
ada1d_human 199 3.55x55 TM3 R => C missense 2.531e-05 2 79006 0 0.0 0.964 GP (contact)
ada1d_human 195 3.51x51 TM3 Y => H missense 1.215e-05 1 82296 0 0.0 0.999
ada1d_human 193 3.49x49 TM3 D => E missense 3.599e-05 3 83368 0 0.02 1.0 SodiumPocket MicroSwitch
ada1d_human 192 3.48x48 TM3 V => M missense 1.186e-05 1 84348 0 0.02 0.913
ada1d_human 187 3.43x43 TM3 L => F missense 1.153e-05 1 86728 0 0.0 1.0
ada1d_human 186 3.42x42 TM3 S => G missense 1.147e-05 1 87200 0 0.03 0.306
ada1d_human 185 3.41x41 TM3 L => F missense 0.0001374 12 87318 0 0.04 0.733
ada1d_human 177 3.33x33 TM3 V => M missense 2.159e-05 2 92630 0 0.0 0.999
ada1d_human 176 3.32x32 TM3 D => G missense 1.072e-05 1 93246 0 0.0 1.0
ada1d_human 172 3.28x28 TM3 W => R missense 1.031e-05 1 96994 0 0.0 0.996
ada1d_human 170 3.26x26 TM3 D => E missense 1.023e-05 1 97764 0 0.03 0.5
ada1d_human 168 3.24x24 TM3 F => L missense 2.005e-05 2 99746 0 0.09 0.071
ada1d_human 166 3.22x22 TM3 R => G missense 2.96e-05 3 101360 0 0.0 0.593
ada1d_human 161 23.49x49 ECL1 F => L missense 9.397e-06 1 106416 0 0.18 0.009
ada1d_human 154 2.62x61 TM2 A => S missense 9.036e-06 1 110664 0 0.0 0.967
ada1d_human 153 2.61x60 TM2 S => L missense 8.971e-06 1 111466 0 0.0 0.984
ada1d_human 150 2.58x57 TM2 L => P missense 8.825e-06 1 113312 0 0.0 0.999
ada1d_human 149 2.57x56 TM2 V => I missense 8.798e-06 1 113660 0 0.0 0.972
ada1d_human 144 2.52x52 TM2 L => R missense 8.68e-06 1 115204 0 0.0 0.998
ada1d_human 135 2.43x43 TM2 I => T missense 8.582e-06 1 116528 0 0.0 0.992
ada1d_human 133 2.41x41 TM2 Y => C missense 8.587e-06 1 116450 0 0.0 0.549
ada1d_human 132 2.40x40 TM2 N => S missense 8.597e-06 1 116326 0 0.0 0.996
ada1d_human 131 2.39x39 TM2 T => A missense 8.611e-06 1 116130 0 0.0 0.987
ada1d_human 130 2.38x38 TM2 V => I missense 8.622e-06 1 115982 0 0.04 0.786
ada1d_human 126 12.49x49 ICL1 H => Q missense 8.674e-06 1 115286 0 0.07 0.115
ada1d_human 124 1.60x60 TM1 N => S missense 8.716e-06 1 114734 0 0.04 0.349
ada1d_human 124 1.60x60 TM1 N => H missense 0.0001398 16 114454 0 0.24 0.241
ada1d_human 122 1.58x58 TM1 A => S missense 8.773e-06 1 113982 0 0.03 0.262
ada1d_human 119 1.55x55 TM1 L => I missense 8.889e-06 1 112494 0 0.02 0.579
ada1d_human 113 1.49x49 TM1 G => D missense 9.401e-06 1 106374 0 0.0 1.0
ada1d_human 111 1.47x47 TM1 V => M missense 2.855e-05 3 105092 0 0.0 0.868
ada1d_human 108 1.44x44 TM1 L => F missense 1.005e-05 1 99488 0 0.05 0.17
ada1d_human 101 1.37x37 TM1 V => I missense 1.448e-05 1 69078 0 0.26 0.003
ada1d_human 101 1.37x37 TM1 V => L missense 1.448e-05 1 69078 0 0.5 0.01
ada1d_human 91 1.27x27 TM1 V => M missense 2.317e-05 1 43158 0 0.03 0.131
ada1d_human 90 1.26x26 TM1 L => Q missense 2.4e-05 1 41658 0 0.01 0.514
ada1d_human 84 N-term T => M missense 3.43e-05 1 29158 0 0.0 0.416
ada1d_human 80 N-term D => E missense 4.866e-05 1 20552 0 1.0 0.0
ada1d_human 77 N-term A => E missense 0.007858 116 14762 0 0.25 0.003
ada1d_human 74 N-term S => R missense 9.901e-05 1 10100 0 nan 0.123
ada1d_human 31 N-term S => G missense 0.3125 30 96 3 1.0 0.0
ada1d_human 16 N-term P => R missense 0.002295 15 6536 0 nan 0.093
ada1d_human 540 C-term E => Ter stop gained 8.634e-06 1 115820 0 None None
ada1d_human 535 C-term Q => Ter stop gained 1.741e-05 2 114852 0 None None
ada1d_human 513 C-term K => SerfsTer75 frameshift 9.583e-06 1 104350 0 None None
ada1d_human 507 C-term T => LysfsTer32 frameshift 9.66e-06 1 103518 0 None None
ada1d_human 488 C-term R => Ter stop gained 1.906e-05 1 52478 0 None None
ada1d_human 431 C-term W => Ter stop gained 8.823e-05 1 11334 0 None None
ada1d_human 385 7.36x35 TM7 K => ArgfsTer13 frameshift 8.577e-06 1 116596 0 None None
ada1d_human 235 4.64x64 TM4 W => Ter stop gained 1.499e-05 1 66726 0 None None
ada1d_human 202 34.51x51 ICL2 L => SerfsTer6 frameshift 1.284e-05 1 77908 0 None None GP (contact)


Residue

Diagrams

R H L Q ICL1ECL1 G F W A F ECL1 S L K Y P A I M ICL2ECL2 K E P V P P D E R F C G I T E ECL2ICL3 G V K R E R G K A S E V V L R I H C R G A A T G A D G A H G M R S A K G H T F R S S L S V R ICL3ECL3 P Q L K P ECL3N-term M T F R D L L S V S F E G P R P D S S A G G S S A G G G G G S A G G A A P S E G P A V G G V P G G A G G G G G V V G A G S G E D N R S S A G E P G S A G A G G D V N G T A A V G N-termC-term C Q C R R R R R R R P L W R V Y G H H W R A S T S G L R Q D C A P S S G D A P P G A P L A L T A L P D P D P E P P G T P E M Q A P V A S R R K P P S A F R E W R L L G P F R R P T T Q L R A K V S S L S H K I R A G G A Q R A E A A C A Q R S E V E A V S L G V P H E V A E G A T C Q A Y E L A D Y S N L R E T D I C-term G L V V S A Q G V G V G V F L A A F I L M A V A G N L L V I L S V A C N T V T N Y F I V N L A V A D L L L S A T V L P F S A T M E V L G R A F C D V W A A V D V L C C T A S I L S L C T I S V D R Y V G V R H T E R K A A A I L A L L W V V A L V V S V G P L L G W E A G Y A V F S S V C S F Y L P M A V I V V M Y C R V Y V V A R S T T R S L E A L L K F S R E K K A A K T L A I V V G V F V L C W F P F F F V L P L G S L F S E G V F K V I F W L G Y F N S C V N P L I Y P C S S R E F L R F K R A L L R
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