Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
ada2b_human 445 C-term T => M missense 0.0005522 58 105032 0 nan 0.185
ada2b_human 445 C-term T => K missense 4.76e-05 5 105032 0 nan 0.769
ada2b_human 441 C-term P => L missense 2.705e-05 3 110922 0 nan 0.032
ada2b_human 440 C-term R => H missense 8.947e-06 1 111774 0 nan 0.846
ada2b_human 440 C-term R => C missense 4.451e-05 5 112338 0 nan 0.918
ada2b_human 435 8.55x55 H8 R => Q missense 5.22e-05 6 114950 0 nan 0.493
ada2b_human 435 8.55x55 H8 R => W missense 6.074e-05 7 115236 0 nan 0.764
ada2b_human 433 8.53x53 H8 A => P missense 8.637e-06 1 115784 0 nan 0.956
ada2b_human 433 8.53x53 H8 A => T missense 1.727e-05 2 115784 0 nan 0.511
ada2b_human 432 8.52x52 H8 R => H missense 8.627e-06 1 115916 0 nan 0.099
ada2b_human 432 8.52x52 H8 R => C missense 4.308e-05 5 116068 0 nan 0.78
ada2b_human 431 8.51x51 H8 R => H missense 8.61e-06 1 116138 0 nan 0.336 GP (contact)
ada2b_human 431 8.51x51 H8 R => C missense 4.3e-05 5 116272 0 nan 0.992 GP (contact)
ada2b_human 429 8.49x49 H8 D => H missense 8.57e-06 1 116688 0 nan 0.967 GP (contact)
ada2b_human 420 7.50x50 TM7 P => S missense 8.53e-06 1 117236 0 nan 1.0 SodiumPocket MicroSwitch
ada2b_human 417 7.47x47 TM7 S => L missense 8.54e-06 1 117098 0 nan 0.02
ada2b_human 415 7.45x45 TM7 N => H missense 8.586e-06 1 116474 0 nan 0.999
ada2b_human 413 7.43x42 TM7 Y => C missense 3.393e-05 4 117902 0 nan 1.0
ada2b_human 412 7.42x41 TM7 G => S missense 4.246e-05 5 117750 0 nan 1.0
ada2b_human 411 7.41x40 TM7 I => V missense 9.339e-05 11 117780 0 nan 0.316
ada2b_human 409 7.39x38 TM7 F => S missense 1.7e-05 2 117670 0 nan 0.971
ada2b_human 399 ECL3 K => R missense 5.986e-05 7 116946 0 nan 0.008
ada2b_human 395 ECL3 P => L missense 1.718e-05 2 116388 0 nan 0.884
ada2b_human 394 6.61x61 TM6 C => G missense 8.564e-06 1 116768 0 nan 0.996
ada2b_human 389 6.56x56 TM6 S => R missense 1.726e-05 2 115876 0 nan 0.984
ada2b_human 383 6.50x50 TM6 P => A missense 8.657e-06 1 115510 0 nan 1.0 SodiumPocket MicroSwitch
ada2b_human 382 6.49x49 TM6 F => L missense 1.73e-05 2 115590 0 nan 0.042
ada2b_human 380 6.47x47 TM6 C => Y missense 5.193e-05 6 115550 0 nan 0.998
ada2b_human 376 6.43x43 TM6 V => G missense 0.0001471 17 115602 0 nan 0.786
ada2b_human 376 6.43x43 TM6 V => I missense 0.002181 252 115550 0 nan 0.771
ada2b_human 374 6.41x41 TM6 I => T missense 8.647e-06 1 115644 0 nan 0.196
ada2b_human 374 6.41x41 TM6 I => S missense 8.647e-06 1 115644 0 nan 0.802
ada2b_human 369 6.36x36 TM6 V => L missense 8.686e-06 1 115126 0 nan 0.902 GP (contact)
ada2b_human 367 6.34x34 TM6 T => I missense 1.745e-05 2 114624 0 nan 0.985 SodiumPocket MicroSwitch
ada2b_human 366 6.33x33 TM6 F => C missense 8.748e-06 1 114308 0 nan 0.991 GP (contact)
ada2b_human 365 6.32x32 TM6 R => C missense 1.762e-05 2 113510 0 nan 1.0 GP (contact)
ada2b_human 362 6.29x29 TM6 R => Q missense 1.778e-05 2 112474 0 nan 0.992 GP (contact)
ada2b_human 362 6.29x29 TM6 R => W missense 0.0002316 26 112276 1 nan 0.999 GP (contact)
ada2b_human 361 6.28x28 TM6 T => S missense 8.93e-06 1 111982 0 nan 0.004 GP (contact)
ada2b_human 357 6.24x24 TM6 R => Q missense 8.376e-05 9 107446 0 nan 0.814
ada2b_human 357 6.24x24 TM6 R => W missense 9.336e-06 1 107110 0 nan 0.198
ada2b_human 355 ICL3 R => H missense 0.0005806 61 105062 0 nan 0.954
ada2b_human 355 ICL3 R => P missense 1.904e-05 2 105062 0 nan 0.964
ada2b_human 355 ICL3 R => C missense 8.667e-05 9 103840 0 nan 0.302
ada2b_human 354 ICL3 W => C missense 1.947e-05 2 102736 0 nan 0.99
ada2b_human 351 ICL3 G => R missense 1.016e-05 1 98406 0 nan 0.107
ada2b_human 346 ICL3 V => M missense 0.0001881 17 90362 0 nan 0.016
ada2b_human 337 ICL3 R => H missense 2.934e-05 2 68168 0 nan 0.063
ada2b_human 337 ICL3 R => C missense 5.908e-05 4 67704 0 nan 0.944
ada2b_human 331 ICL3 R => L missense 2.017e-05 1 49588 0 nan 0.313
ada2b_human 331 ICL3 R => Q missense 2.017e-05 1 49588 0 nan 0.013
ada2b_human 331 ICL3 R => W missense 2.052e-05 1 48730 0 nan 0.828
ada2b_human 323 ICL3 P => R missense 2.887e-05 1 34634 0 nan 0.022
ada2b_human 323 ICL3 P => T missense 8.635e-05 3 34744 0 nan 0.012
ada2b_human 316 ICL3 P => L missense 3.238e-05 1 30888 0 nan 0.031
ada2b_human 312 ICL3 V => M missense 0.0005292 15 28344 0 nan 0.009
ada2b_human 309 ICL3 P => S missense 0.0003346 8 23910 0 nan 0.098
ada2b_human 290 ICL3 G => E missense 2.213e-05 1 45190 0 nan 0.011
ada2b_human 284 ICL3 Q => H missense 1.908e-05 1 52406 0 nan 0.019
ada2b_human 281 ICL3 G => V missense 3.313e-05 2 60362 0 nan 0.047
ada2b_human 277 ICL3 L => F missense 1.375e-05 1 72746 0 nan 0.012
ada2b_human 269 ICL3 A => S missense 9.976e-06 1 100240 0 nan 0.007
ada2b_human 268 ICL3 R => W missense 4.849e-05 5 103122 0 nan 0.005
ada2b_human 266 ICL3 G => E missense 3.769e-05 4 106138 0 nan 0.007
ada2b_human 263 ICL3 E => K missense 0.0002105 23 109250 0 nan 0.03
ada2b_human 253 ICL3 T => A missense 8.753e-05 10 114242 0 nan 0.002
ada2b_human 252 ICL3 S => T missense 8.735e-06 1 114486 0 nan 0.003
ada2b_human 250 ICL3 S => L missense 6.957e-05 8 114994 0 nan 0.008
ada2b_human 244 ICL3 R => I missense 1.723e-05 2 116088 0 nan 0.023
ada2b_human 244 ICL3 R => G missense 1.723e-05 2 116108 0 nan 0.0
ada2b_human 239 ICL3 S => F missense 8.563e-06 1 116776 0 nan 0.031
ada2b_human 236 ICL3 A => V missense 8.543e-06 1 117054 0 nan 0.038
ada2b_human 236 ICL3 A => D missense 1.709e-05 2 117054 0 nan 0.006
ada2b_human 230 ICL3 A => P missense 8.502e-06 1 117622 0 nan 0.012
ada2b_human 229 ICL3 L => S missense 4.248e-05 5 117710 0 nan 0.001
ada2b_human 226 ICL3 G => V missense 2.545e-05 3 117882 0 nan 0.005
ada2b_human 224 ICL3 D => E missense 8.475e-06 1 117988 0 nan 0.002
ada2b_human 224 ICL3 D => N missense 8.476e-06 1 117984 0 nan 0.001
ada2b_human 223 ICL3 P => R missense 8.462e-06 1 118174 0 nan 0.003
ada2b_human 223 ICL3 P => L missense 8.462e-06 1 118174 0 nan 0.003
ada2b_human 222 ICL3 R => Q missense 8.459e-06 1 118214 0 nan 0.003
ada2b_human 222 ICL3 R => P missense 8.459e-06 1 118214 0 nan 0.003
ada2b_human 221 ICL3 P => S missense 8.435e-06 1 118556 0 nan 0.008
ada2b_human 220 ICL3 Q => H missense 8.434e-06 1 118570 0 nan 0.669
ada2b_human 217 ICL3 E => K missense 3.367e-05 4 118808 0 nan 0.003
ada2b_human 217 ICL3 E => Q missense 8.417e-06 1 118808 0 nan 0.02
ada2b_human 212 ICL3 G => A missense 8.405e-06 1 118974 0 nan 0.005
ada2b_human 212 ICL3 G => V missense 8.405e-06 1 118974 0 nan 0.008
ada2b_human 211 ICL3 G => A missense 0.03618 4312 119196 102 nan 0.003
ada2b_human 211 ICL3 G => V missense 8.39e-06 1 119196 0 nan 0.088
ada2b_human 210 ICL3 K => N missense 1.677e-05 2 119268 0 nan 0.012
ada2b_human 210 ICL3 K => M missense 1.677e-05 2 119246 0 nan 0.126
ada2b_human 210 ICL3 K => E missense 1.676e-05 2 119300 0 nan 0.038
ada2b_human 206 5.72x72 TM5 G => D missense 8.37e-06 1 119478 0 nan 0.438 GP (contact)
ada2b_human 205 5.71x71 TM5 R => T missense 8.37e-06 1 119480 0 nan 0.096 GP (contact)
ada2b_human 205 5.71x71 TM5 R => I missense 8.37e-06 1 119480 0 nan 0.096 GP (contact)
ada2b_human 203 5.69x69 TM5 N => K missense 8.36e-06 1 119616 0 nan 0.001 GP (contact)
ada2b_human 197 5.63x63 TM5 L => Q missense 8.346e-06 1 119820 0 nan 0.209
ada2b_human 194 5.60x60 TM5 R => H missense 1.668e-05 2 119886 0 nan 0.993
ada2b_human 194 5.60x60 TM5 R => S missense 8.341e-06 1 119896 0 nan 0.903
ada2b_human 190 5.56x56 TM5 L => F missense 1.667e-05 2 119978 0 nan 0.71
ada2b_human 188 5.54x54 TM5 M => L missense 8.333e-06 1 120004 0 nan 0.645
ada2b_human 187 5.53x53 TM5 I => M missense 0.0001333 16 120002 0 nan 0.997
ada2b_human 186 5.52x52 TM5 L => F missense 8.333e-06 1 120012 0 nan 0.274
ada2b_human 179 5.45x46 TM5 G => V missense 8.339e-06 1 119920 0 nan 0.628
ada2b_human 179 5.45x46 TM5 G => R missense 8.34e-06 1 119908 0 nan 0.961
ada2b_human 178 5.44x45 TM5 I => V missense 8.34e-06 1 119910 0 nan 0.012
ada2b_human 171 5.37x38 TM5 W => C missense 3.341e-05 4 119718 0 nan 0.991
ada2b_human 170 5.36x37 TM5 A => V missense 0.0002173 26 119648 0 nan 0.042
ada2b_human 164 45.50x50 ECL2 C => Y missense 8.381e-06 1 119316 0 nan 1.0
ada2b_human 164 45.50x50 ECL2 C => R missense 1.677e-05 2 119288 0 nan 1.0
ada2b_human 160 ECL2 G => E missense 8.402e-06 1 119024 0 nan 0.037
ada2b_human 160 ECL2 G => R missense 6.727e-05 8 118930 0 nan 0.656
ada2b_human 159 ECL2 R => L missense 2.523e-05 3 118924 0 nan 0.005
ada2b_human 159 ECL2 R => C missense 1.683e-05 2 118866 0 nan 0.017
ada2b_human 158 ECL2 P => L missense 8.412e-06 1 118872 0 nan 0.03
ada2b_human 155 ECL2 G => S missense 8.429e-06 1 118636 0 nan 0.008
ada2b_human 153 ECL2 D => Y missense 8.437e-06 1 118520 0 nan 0.737
ada2b_human 146 4.59x59 TM4 P => Q missense 8.463e-06 1 118162 0 nan 0.999
ada2b_human 135 4.48x48 TM4 T => I missense 8.484e-06 1 117874 0 nan 0.008
ada2b_human 133 4.46x46 TM4 I => N missense 8.482e-06 1 117902 0 nan 0.999
ada2b_human 128 4.41x41 TM4 R => P missense 8.523e-06 1 117336 0 nan 0.999
ada2b_human 128 4.41x41 TM4 R => S missense 0.0001704 20 117382 1 nan 0.998
ada2b_human 128 4.41x41 TM4 R => C missense 4.26e-05 5 117382 0 nan 1.0
ada2b_human 126 4.39x39 TM4 P => L missense 8.531e-06 1 117216 0 nan 0.716
ada2b_human 121 34.54x54 ICL2 N => S missense 8.541e-06 1 117084 0 nan 0.049 GP (contact)
ada2b_human 118 34.51x51 ICL2 L => V missense 2.566e-05 3 116906 0 nan 0.036 GP (contact)
ada2b_human 116 3.56x56 TM3 R => L missense 8.563e-06 1 116776 0 nan 0.66 GP (contact)
ada2b_human 116 3.56x56 TM3 R => H missense 8.563e-06 1 116776 0 nan 0.422 GP (contact)
ada2b_human 114 3.54x54 TM3 V => M missense 4.286e-05 5 116670 0 nan 0.998 GP (contact)
ada2b_human 112 3.52x52 TM3 W => R missense 8.559e-06 1 116838 0 nan 0.885
ada2b_human 111 3.51x51 TM3 Y => C missense 8.558e-06 1 116852 0 nan 0.994
ada2b_human 110 3.50x50 TM3 R => P missense 8.57e-06 1 116680 0 nan 1.0 SodiumPocket MicroSwitch GP (contact)
ada2b_human 110 3.50x50 TM3 R => C missense 8.569e-06 1 116696 0 nan 1.0 SodiumPocket MicroSwitch GP (contact)
ada2b_human 105 3.45x45 TM3 A => T missense 0.0002918 34 116524 1 nan 0.996
ada2b_human 105 3.45x45 TM3 A => S missense 8.582e-06 1 116524 0 nan 0.997
ada2b_human 88 3.28x28 TM3 Y => H missense 8.612e-06 1 116114 0 nan 0.8
ada2b_human 86 3.26x26 TM3 E => D missense 8.619e-06 1 116022 0 nan 0.047
ada2b_human 86 3.26x26 TM3 E => K missense 8.624e-06 1 115962 0 nan 0.027
ada2b_human 83 3.23x23 TM3 T => M missense 8.609e-06 1 116156 0 nan 0.063
ada2b_human 81 3.21x21 TM3 R => Q missense 8.594e-06 1 116354 0 nan 0.022
ada2b_human 81 3.21x21 TM3 R => P missense 8.594e-06 1 116354 0 nan 0.65
ada2b_human 72 2.64x63 TM2 N => K missense 8.543e-06 1 117054 0 nan 0.933
ada2b_human 68 2.60x59 TM2 F => I missense 0.0001107 13 117446 0 nan 0.924
ada2b_human 59 2.51x51 TM2 I => S missense 0.0001539 18 116936 0 nan 0.952
ada2b_human 58 2.50x50 TM2 D => G missense 8.577e-06 1 116596 0 nan 0.999
ada2b_human 56 2.48x48 TM2 A => T missense 2.577e-05 3 116402 0 nan 0.967
ada2b_human 50 2.42x42 TM2 F => L missense 8.606e-06 1 116192 0 nan 0.8
ada2b_human 46 2.38x38 TM2 P => A missense 8.683e-06 1 115162 0 nan 0.922
ada2b_human 45 2.37x37 TM2 A => V missense 8.698e-06 1 114974 0 nan 0.86
ada2b_human 44 12.51x51 ICL1 R => C missense 8.75e-05 10 114288 0 nan 0.927
ada2b_human 42 12.49x49 ICL1 S => P missense 8.79e-06 1 113772 0 nan 0.067
ada2b_human 32 1.52x52 TM1 L => V missense 9.143e-06 1 109370 0 nan 0.996
ada2b_human 31 1.51x51 TM1 A => G missense 9.145e-06 1 109348 0 nan 0.034
ada2b_human 29 1.49x49 TM1 G => C missense 9.257e-06 1 108030 0 nan 1.0
ada2b_human 21 1.41x41 TM1 F => V missense 9.631e-06 1 103834 0 nan 0.971
ada2b_human 19 1.39x39 TM1 I => N missense 9.77e-06 1 102354 0 nan 0.671
ada2b_human 18 1.38x38 TM1 A => T missense 9.783e-06 1 102220 0 nan 0.007
ada2b_human 12 1.32x32 TM1 T => K missense 3.094e-05 3 96964 0 nan 0.784
ada2b_human 8 N-term S => Y missense 1.088e-05 1 91874 0 nan 0.974
ada2b_human 8 N-term S => F missense 1.088e-05 1 91874 0 nan 0.974
ada2b_human 6 N-term P => T missense 1.148e-05 1 87126 0 nan 0.926
ada2b_human 2 N-term D => N missense 2.424e-05 2 82508 0 nan 0.401
ada2b_human 442 C-term W => Ter stop gained 3.663e-05 4 109206 0 None None
ada2b_human 427 8.47x47 H8 N => ThrfsTer140 frameshift 8.564e-06 1 116772 0 None None GP (contact)
ada2b_human 379 6.46x46 TM6 L => ProfsTer40 frameshift 8.652e-06 1 115576 0 None None
ada2b_human 378 6.45x45 TM6 V => GlyfsTer41 frameshift 8.659e-06 1 115492 0 None None
ada2b_human 376 6.43x43 TM6 V => SerfsTer165 frameshift 8.654e-06 1 115550 0 None None
ada2b_human 366 6.33x33 TM6 F => ArgfsTer172 frameshift 8.696e-06 1 115000 0 None None GP (contact)
ada2b_human 356 ICL3 R => Ter stop gained 3.77e-05 4 106108 0 None None
ada2b_human 348 ICL3 A => Ter frameshift 1.062e-05 1 94204 0 None None
ada2b_human 297 ICL3 A => GlyfsTer11 frameshift 0.0001124 5 44486 0 None None
ada2b_human 295 ICL3 D => GlufsTer54 frameshift 8.111e-05 4 49316 0 None None
ada2b_human 220 ICL3 Q => Ter stop gained 1.686e-05 2 118612 0 None None
ada2b_human 208 5.74x74 TM5 R => GlyfsTer142 frameshift 1.676e-05 2 119360 0 None None GP (contact)
ada2b_human 157 ECL2 Q => Ter stop gained 8.423e-06 1 118728 0 None None
ada2b_human 104 3.44x44 TM3 C => Ter stop gained 8.599e-06 1 116286 0 None None
ada2b_human 98 3.38x38 TM3 S => Ter stop gained 0.0001117 13 116390 1 None None
ada2b_human 65 2.57x56 TM2 I => SerfsTer50 frameshift 8.515e-06 1 117434 0 None None


Residue

Diagrams

R S L R ICL1ECL1 Y W Y F ECL1 A L E Y N S K R ICL2ECL2 Y K G D Q G P Q P R G R P Q C K L N Q ECL2ICL3 K G G P G Q G E S K Q P R P D H G G A L A S A K L P A L A S V A S A R E V N G H S K S T G E K E E G E T P E D T G T R A L P P S W A A L P N S G Q G Q K E G V C G A S P E D E A E E E E E E E E E C E P Q A V P V S P A S A C S P P L Q Q P Q G S R V L A T L R G Q V L L G R G V G A I G G Q W W R R ICL3ECL3 P K H C K V ECL3N-term M D H Q D P Y S N-termC-term R P W T Q T A W C-term V Q A T A A I A A A I T F L I L F T I F G N A L V I L A V L T S A P Q N L F L V S L A A A D I L V A T L I I P F S L A N E L L G R R T W C E V Y L A L D V L F C T S S I V H L C A I S L D R Y W A V S R T P R R I K C I I L T V W L I A A V I S L P P L I E A W Y I L A S S I G S F F A P C L I M I L V Y L R I Y L I A K R S N R R G P R A R A Q L T R E K R F T F V L A V V I G V F V L C W F P F F F S Y S L G A I C P H G L F Q F F F W I G Y C N S S L N P V I Y T I F N Q D F R R F R R A I L C
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