Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
ednra_human 3 N-term T => I missense 8.826e-06 1 113302 0 nan 0.51
ednra_human 4 N-term L => V missense 1.759e-05 2 113724 0 nan 0.234
ednra_human 9 N-term S => Y missense 8.609e-06 1 116158 0 nan 0.067
ednra_human 16 N-term G => E missense 8.393e-06 1 119142 0 nan 1.0
ednra_human 20 N-term S => I missense 8.32e-06 1 120198 0 nan 0.865
ednra_human 28 N-term T => R missense 2.474e-05 3 121252 0 nan 0.907
ednra_human 33 N-term H => R missense 8.242e-06 1 121328 0 nan 0.005
ednra_human 38 N-term T => I missense 8.24e-06 1 121362 0 0.02 0.892
ednra_human 41 N-term R => C missense 2.472e-05 3 121364 0 nan 0.764
ednra_human 41 N-term R => H missense 4.944e-05 6 121368 0 nan 0.002
ednra_human 46 N-term S => R missense 8.238e-06 1 121382 0 nan 0.087
ednra_human 49 N-term V => I missense 8.238e-06 1 121388 0 nan 0.966
ednra_human 52 N-term H => R missense 8.238e-06 1 121388 0 0.56 0.976
ednra_human 58 N-term V => I missense 8.238e-06 1 121386 0 nan 0.167
ednra_human 60 N-term P => S missense 8.238e-06 1 121388 0 0.15 0.996
ednra_human 60 N-term P => H missense 8.238e-06 1 121392 0 0.0 0.999
ednra_human 65 N-term M => V missense 8.237e-06 1 121398 0 nan 0.002
ednra_human 70 1.22x22 TM1 P => L missense 8.237e-06 1 121406 0 0.36 0.997
ednra_human 86 1.38x38 TM1 I => V missense 0.00196 238 121412 2 0.8 0.902
ednra_human 86 1.38x38 TM1 I => L missense 4.118e-05 5 121412 0 0.47 0.902
ednra_human 86 1.38x38 TM1 I => M missense 8.236e-06 1 121412 0 0.02 0.993
ednra_human 92 1.44x44 TM1 I => V missense 8.237e-06 1 121410 0 0.27 0.902
ednra_human 94 1.46x46 TM1 G => A missense 8.236e-06 1 121412 0 0.0 1.0
ednra_human 96 1.48x48 TM1 V => M missense 4.118e-05 5 121412 0 0.0 0.997
ednra_human 103 1.55x55 TM1 R => M missense 1.647e-05 2 121406 0 0.0 0.999
ednra_human 108 1.60x60 TM1 N => K missense 8.237e-06 1 121398 0 0.0 0.999
ednra_human 117 2.41x41 TM2 A => T missense 1.65e-05 2 121220 0 0.09 0.999
ednra_human 117 2.41x41 TM2 A => V missense 3.3e-05 4 121206 0 0.24 0.999
ednra_human 145 23.49x49 ECL1 R => C missense 8.242e-06 1 121324 0 0.01 0.857
ednra_human 145 23.49x49 ECL1 R => H missense 3.297e-05 4 121322 0 0.11 0.016
ednra_human 150 3.17x17 TM3 H => Y missense 8.239e-06 1 121378 0 0.79 0.005
ednra_human 155 3.22x22 TM3 V => I missense 3.295e-05 4 121390 0 0.09 0.006
ednra_human 178 3.45x45 TM3 A => T missense 1.649e-05 2 121312 0 0.0 0.999
ednra_human 209 4.49x49 TM4 I => V missense 8.237e-06 1 121408 0 0.08 0.309
ednra_human 220 4.60x61 TM4 E => K missense 8.237e-06 1 121404 0 0.01 0.986
ednra_human 222 4.62x63 TM4 I => V missense 8.237e-06 1 121400 0 0.63 0.037
ednra_human 225 ECL2 V => I missense 1.648e-05 2 121394 0 0.01 0.265
ednra_human 233 ECL2 G => D missense 8.242e-06 1 121334 0 0.21 0.023
ednra_human 243 ECL2 A => P missense 8.254e-06 1 121152 0 1.0 0.004
ednra_human 248 5.31x32 TM5 M => V missense 3.306e-05 4 120990 0 0.03 0.068
ednra_human 250 5.33x34 TM5 F => Y missense 8.238e-06 1 121396 0 0.04 0.352
ednra_human 259 5.42x43 TM5 L => F missense 8.236e-06 1 121412 0 0.02 0.656
ednra_human 287 5.70x70 TM5 N => D missense 8.237e-06 1 121402 0 0.07 0.077
ednra_human 290 ICL3 L => W missense 4.942e-05 6 121398 0 0.0 1.0
ednra_human 297 6.26x26 TM6 H => R missense 2.472e-05 3 121378 0 0.05 0.919 GP (contact)
ednra_human 301 6.30x30 TM6 R => H missense 8.335e-06 1 119982 0 0.0 0.985 SodiumPocket MicroSwitch
ednra_human 302 6.31x31 TM6 R => Q missense 8.313e-06 1 120288 0 0.01 0.915
ednra_human 308 6.37x37 TM6 V => I missense 8.256e-06 1 121128 0 0.0 0.621 GP (contact)
ednra_human 316 6.45x45 TM6 A => D missense 8.242e-06 1 121330 0 0.0 0.979
ednra_human 317 6.46x46 TM6 L => V missense 1.648e-05 2 121336 0 0.11 0.999
ednra_human 335 ECL3 E => K missense 8.241e-06 1 121340 0 0.04 0.81
ednra_human 336 ECL3 M => T missense 1.653e-05 2 120962 0 0.57 0.402
ednra_human 354 7.38x37 TM7 G => S missense 1.688e-05 2 118454 0 0.22 0.972
ednra_human 356 7.40x39 TM7 N => D missense 9.256e-05 11 118842 0 0.0 0.984
ednra_human 363 7.47x47 TM7 C => S missense 8.423e-06 1 118718 0 0.0 0.995
ednra_human 368 7.52x52 TM7 A => T missense 8.508e-06 1 117542 0 0.03 0.908
ednra_human 370 7.54x54 TM7 Y => H missense 8.606e-06 1 116196 0 0.0 0.998
ednra_human 375 8.49x49 H8 K => E missense 9.169e-06 1 109066 0 0.0 0.998 GP (contact)
ednra_human 391 C-term S => C missense 1.648e-05 2 121344 1 0.02 0.843 PTM (Phosphorylation)
ednra_human 396 C-term T => N missense 8.241e-06 1 121350 0 0.22 0.607 PTM (Phosphorylation)
ednra_human 397 C-term S => L missense 6.593e-05 8 121348 0 0.43 0.519 PTM (Phosphorylation)
ednra_human 402 C-term G => A missense 8.242e-06 1 121326 0 0.06 0.899
ednra_human 419 C-term R => W missense 1.654e-05 2 120920 0 nan 0.835
ednra_human 419 C-term R => Q missense 2.481e-05 3 120910 0 nan 0.417
ednra_human 422 C-term H => R missense 8.257e-06 1 121116 0 0.69 0.402
ednra_human 251 5.34x35 TM5 Y => SerfsTer30 frameshift 8.238e-06 1 121394 0 None None
ednra_human 420 C-term S => AlafsTer7 frameshift 8.271e-06 1 120900 0 None None PTM (Phosphorylation)


Residue

Diagrams

K C M R N ICL1ECL1 G R W P F ECL1 W S R V Q G I G ICL2ECL2 V M V P F E Y R G E Q H K T C M L N A T ECL2ICL3 L R I A L ICL3ECL3 N E M D K N ECL3N-term M E T L C L R A S F W L A L V G C V I S D N P E R Y S T N L S N H V D D F T T F R G T E L S F L V T T H Q P T N L V L P S N G S M H N Y C N-termC-term C C Y Q S K S L M T S V P M N G T S I Q W K N H D Q N N H N T D R S S H K D S M N C-term P Q Q T K I T S A F K Y I N T V I S C T I F I V G M V G N A T L L R I I Y Q N G P N A L I A S L A L G D L I Y V V I D L P I N V F K L L A D H N D F G V F L C K L F P F L Q K S S V G I T V L N L C A L S V D R Y R A V A S I P L V T A I E I V S I W I L S F I L A I P E A I G F S K F M E F Y Q D V K D W W L F G F Y F C M P L V C T A I F Y T L M T C E M L N R R N G S S E H L K Q R R E V A K T V F C L V V I F A L C W F P L H L S R I L K K T V Y R C E L L S F L L L M D Y I G I N L A T M N S C I N P I A L Y F V S K K F Q S F K N C C L C C
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