Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
glp1r_human 5 N-term P => L missense 0.0003851 6 15580 0 nan 0.0
glp1r_human 7 N-term P => L missense 0.4573 14194 31042 2489 nan 0.0
glp1r_human 9 N-term R => C missense 7.266e-05 2 27524 0 nan 0.0
glp1r_human 17 N-term M => T missense 0.0001085 3 27656 0 nan 0.0
glp1r_human 20 N-term R => K missense 0.007527 202 26838 3 nan 0.0
glp1r_human 26 N-term Q => K missense 3.89e-05 1 25708 0 0.07 0.004
glp1r_human 33 N-term W => R missense 8.358e-06 1 119642 0 0.67 0.017
glp1r_human 35 N-term T => M missense 1.667e-05 2 119950 0 0.32 0.945
glp1r_human 40 N-term R => Q missense 5.827e-05 7 120130 0 0.08 0.046
glp1r_human 43 N-term R => Q missense 1.666e-05 2 120032 0 0.53 0.004
glp1r_human 44 N-term R => C missense 2.499e-05 3 120028 1 0.01 0.552
glp1r_human 44 N-term R => H missense 0.003695 443 119880 12 0.18 0.001
glp1r_human 45 N-term Q => H missense 8.344e-06 1 119840 0 0.0 0.578
glp1r_human 48 N-term R => C missense 8.368e-06 1 119510 0 0.02 0.29
glp1r_human 48 N-term R => H missense 5.021e-05 6 119508 0 0.64 0.001
glp1r_human 53 N-term D => V missense 8.442e-06 1 118458 0 0.28 0.002
glp1r_human 54 N-term P => S missense 3.399e-05 4 117680 0 0.01 0.747
glp1r_human 56 N-term P => L missense 2.552e-05 3 117558 0 0.06 0.005
glp1r_human 64 N-term R => Q missense 8.636e-06 1 115788 0 0.0 0.999
glp1r_human 67 N-term D => N missense 1.722e-05 2 116146 0 0.01 1.0
glp1r_human 70 N-term A => T missense 1.728e-05 2 115752 0 0.03 0.949
glp1r_human 80 N-term F => L missense 9.335e-06 1 107120 0 0.29 0.008
glp1r_human 81 N-term V => M missense 9.438e-06 1 105956 0 0.04 0.986
glp1r_human 87 N-term W => R missense 4.225e-05 4 94668 0 0.0 0.928
glp1r_human 101 N-term Y => C missense 3.91e-05 1 25578 0 0.01 0.919
glp1r_human 124 N-term S => L missense 4.909e-05 3 61114 0 0.02 0.57
glp1r_human 127 N-term E => K missense 1.452e-05 1 68872 0 0.07 0.081
glp1r_human 130 N-term K => T missense 1.337e-05 1 74768 0 0.31 0.011
glp1r_human 131 N-term R => Q missense 0.04483 3803 84832 294 0.46 0.0
glp1r_human 132 N-term G => W missense 0.0007085 61 86102 0 0.07 0.998
glp1r_human 132 N-term G => R missense 1.161e-05 1 86102 0 0.24 0.974
glp1r_human 132 N-term G => A missense 9.243e-05 8 86548 0 0.45 0.729
glp1r_human 137 N-term P => L missense 5.121e-05 6 117166 0 0.15 0.097
glp1r_human 141 1.36x36 TM1 L => F missense 8.358e-06 1 119640 0 0.57 0.056
glp1r_human 147 1.42x42 TM1 I => V missense 1.659e-05 2 120562 0 0.15 0.014
glp1r_human 149 1.44x44 TM1 T => M missense 8.283e-06 1 120724 0 0.0 0.976
glp1r_human 160 1.55x55 TM1 V => I missense 8.278e-06 1 120806 0 0.43 0.015
glp1r_human 161 1.56x56 TM1 I => F missense 8.281e-06 1 120754 0 0.01 0.702
glp1r_human 164 1.59x59 TM1 A => V missense 6.65e-05 8 120304 0 0.09 0.542
glp1r_human 167 1.62x62 TM1 L => F missense 8.329e-06 1 120066 0 0.01 0.133
glp1r_human 168 1.63x63 TM1 G => S missense 0.234 27986 119620 4045 0.31 0.036
glp1r_human 168 1.63x63 TM1 G => R missense 8.36e-06 1 119620 0 0.09 0.085
glp1r_human 171 12.49x49 ICL1 H => Q missense 8.363e-06 1 119574 0 0.07 0.984
glp1r_human 173 12.51x51 ICL1 H => R missense 4.163e-05 5 120094 0 0.22 0.059
glp1r_human 173 12.51x51 ICL1 H => P missense 8.327e-06 1 120094 0 0.0 0.921
glp1r_human 175 2.45x45 TM2 T => I missense 8.295e-06 1 120552 0 0.06 0.745
glp1r_human 176 2.46x46 TM2 R => W missense 1.652e-05 2 121080 0 0.0 1.0
glp1r_human 176 2.46x46 TM2 R => K missense 4.125e-05 5 121204 0 0.0 0.997
glp1r_human 180 2.50x50 TM2 H => Y missense 8.243e-06 1 121314 0 0.0 0.999
glp1r_human 190 2.60x60 TM2 R => Q missense 8.237e-06 1 121400 0 0.0 0.999
glp1r_human 194 2.64x64 TM2 V => I missense 0.0004778 58 121400 0 0.36 0.06
glp1r_human 194 2.64x64 TM2 V => A missense 3.295e-05 4 121402 0 0.0 0.672
glp1r_human 199 2.69x69 TM2 A => T missense 8.238e-06 1 121394 0 0.32 0.01
glp1r_human 209 ECL1 A => T missense 8.245e-05 10 121292 1 0.66 0.017
glp1r_human 216 ECL1 G => V missense 4.137e-05 5 120846 0 0.39 0.805
glp1r_human 225 3.28x28 TM3 S => G missense 8.253e-06 1 121164 0 1.0 0.001
glp1r_human 227 3.30x30 TM3 R => C missense 8.247e-06 1 121250 0 0.0 0.997
glp1r_human 227 3.30x30 TM3 R => H missense 8.245e-06 1 121284 0 0.0 0.998
glp1r_human 231 3.34x34 TM3 L => P missense 8.239e-06 1 121370 0 0.0 0.958
glp1r_human 232 3.35x35 TM3 L => F missense 8.239e-06 1 121374 0 0.78 0.609
glp1r_human 238 3.41x41 TM3 A => V missense 1.647e-05 2 121400 0 1.0 0.043
glp1r_human 239 3.42x42 TM3 A => T missense 0.0001565 19 121402 0 0.02 0.893
glp1r_human 244 3.47x47 TM3 L => F missense 8.237e-06 1 121408 0 0.09 0.959
glp1r_human 249 3.52x52 TM3 V => M missense 9.06e-05 11 121408 0 0.11 0.103
glp1r_human 254 3.57x57 TM3 L => M missense 8.237e-06 1 121408 0 0.0 1.0 GP (contact)
glp1r_human 257 3.60x60 TM3 F => I missense 8.237e-06 1 121408 0 0.28 0.11 GP (contact)
glp1r_human 258 ICL2 S => L missense 8.237e-06 1 121408 0 0.04 0.557
glp1r_human 259 ICL2 V => I missense 3.295e-05 4 121410 0 0.0 0.243
glp1r_human 260 ICL2 L => F missense 0.5638 68417 121358 19287 1.0 0.004
glp1r_human 261 ICL2 S => A missense 8.238e-06 1 121396 0 0.05 0.688
glp1r_human 264 4.40x41 TM4 W => R missense 8.238e-06 1 121392 0 0.62 0.0
glp1r_human 268 4.44x45 TM4 L => F missense 0.000239 29 121356 0 0.02 0.826
glp1r_human 268 4.44x45 TM4 L => I missense 8.24e-06 1 121356 0 0.27 0.093
glp1r_human 270 4.46x47 TM4 V => M missense 2.473e-05 3 121302 0 0.03 0.44
glp1r_human 272 4.48x49 TM4 I => T missense 8.248e-06 1 121236 0 0.01 0.016
glp1r_human 285 4.61x61 TM4 G => S missense 8.243e-06 1 121320 0 0.14 0.958
glp1r_human 286 4.62x62 TM4 I => V missense 4.121e-05 5 121320 0 1.0 0.02
glp1r_human 287 4.63x63 TM4 V => D missense 8.242e-06 1 121326 0 0.0 0.988
glp1r_human 289 4.65x65 TM4 Y => C missense 8.242e-06 1 121326 0 0.34 1.0
glp1r_human 291 4.67x67 TM4 Y => C missense 8.242e-06 1 121324 0 0.0 0.959
glp1r_human 292 4.68x68 TM4 E => V missense 8.242e-06 1 121326 0 0.0 1.0
glp1r_human 293 ECL2 D => Y missense 1.648e-05 2 121328 0 0.0 0.998
glp1r_human 294 ECL2 E => K missense 9.066e-05 11 121332 0 0.89 0.979
glp1r_human 298 45.52x52 ECL2 T => A missense 1.648e-05 2 121384 0 0.15 0.519
glp1r_human 302 ECL2 N => Y missense 8.238e-06 1 121396 0 0.0 0.974
glp1r_human 310 5.40x40 TM5 R => W missense 8.237e-06 1 121406 0 0.0 0.984
glp1r_human 310 5.40x40 TM5 R => Q missense 8.237e-06 1 121408 0 0.0 0.438
glp1r_human 316 5.46x46 TM5 A => T missense 0.01048 1272 121410 16 0.01 0.977 SodiumPocket MicroSwitch
glp1r_human 317 5.47x47 TM5 I => T missense 5.766e-05 7 121410 0 0.0 0.745
glp1r_human 320 5.50x50 TM5 N => Y missense 8.237e-06 1 121406 0 0.0 0.983
glp1r_human 326 5.56x56 TM5 R => W missense 8.237e-06 1 121406 0 0.0 0.999
glp1r_human 330 5.60x60 TM5 I => V missense 8.237e-06 1 121404 0 0.13 0.02 GP (contact)
glp1r_human 331 5.61x61 TM5 V => M missense 1.647e-05 2 121404 0 0.0 0.894 GP (contact)
glp1r_human 333 5.63x63 TM5 S => T missense 8.237e-06 1 121400 0 0.04 0.068 GP (contact)
glp1r_human 333 5.63x63 TM5 S => C missense 4.119e-05 5 121400 0 0.0 0.914 GP (contact)
glp1r_human 341 ICL3 C => S missense 8.238e-06 1 121394 0 0.53 0.543 PTM (ADP-ribosylation)
glp1r_human 342 ICL3 K => Q missense 8.238e-06 1 121396 0 0.08 0.971
glp1r_human 344 6.33x33 TM6 D => E missense 0.0002719 33 121390 1 0.0 0.964 GP (contact)
glp1r_human 355 6.44x44 TM6 T => I missense 1.665e-05 2 120132 0 0.02 1.0 LB (polar (hydrogen bond))
glp1r_human 357 6.46x46 TM6 I => F missense 8.297e-06 1 120530 0 0.0 0.999
glp1r_human 361 6.50x50 TM6 G => R missense 8.26e-06 1 121060 0 0.02 1.0
glp1r_human 363 6.52x52 TM6 H => Y missense 1.651e-05 2 121152 0 0.0 0.999
glp1r_human 367 6.56x56 TM6 F => L missense 8.247e-06 1 121256 0 0.0 0.998
glp1r_human 375 ECL3 A => T missense 1.648e-05 2 121342 0 0.21 1.0
glp1r_human 376 ECL3 R => W missense 3.296e-05 4 121350 0 0.0 0.986
glp1r_human 376 ECL3 R => Q missense 0.0009971 121 121358 0 1.0 0.851
glp1r_human 376 ECL3 R => L missense 8.24e-06 1 121358 0 0.04 0.753
glp1r_human 380 7.35x34 TM7 R => C missense 8.239e-06 1 121376 0 0.0 1.0
glp1r_human 391 7.46x45 TM7 T => A missense 8.244e-06 1 121306 0 0.06 0.046
glp1r_human 401 7.56x56 TM7 L => I missense 8.293e-06 1 120582 0 0.0 0.996 LB (polar (hydrogen bond with backbone), hydrophobic)
glp1r_human 408 8.49x49 H8 E => G missense 1.665e-05 2 120104 0 0.0 0.543 GP (contact)
glp1r_human 414 8.55x55 H8 R => W missense 1.648e-05 2 121330 0 0.12 0.027
glp1r_human 414 8.55x55 H8 R => Q missense 1.648e-05 2 121336 0 0.43 0.019
glp1r_human 417 8.58x58 H8 W => G missense 8.241e-06 1 121350 0 0.01 0.697
glp1r_human 417 8.58x58 H8 W => L missense 1.648e-05 2 121356 0 0.04 0.543
glp1r_human 419 8.60x60 H8 R => H missense 8.239e-06 1 121374 0 0.01 0.912
glp1r_human 421 8.62x62 H8 R => W missense 0.0003872 47 121378 0 0.0 0.863
glp1r_human 421 8.62x62 H8 R => Q missense 0.002027 246 121378 2 0.25 0.042
glp1r_human 421 8.62x62 H8 R => P missense 1.648e-05 2 121378 0 0.0 0.847
glp1r_human 425 8.66x66 H8 L => S missense 8.238e-06 1 121394 0 0.21 0.063
glp1r_human 427 8.68x68 H8 I => N missense 8.238e-06 1 121396 0 0.49 0.002
glp1r_human 429 8.70x70 H8 R => K missense 8.237e-06 1 121398 0 0.15 0.383
glp1r_human 430 8.71x71 H8 D => E missense 8.238e-06 1 121396 0 0.38 0.057
glp1r_human 434 C-term K => T missense 8.238e-06 1 121386 0 0.13 0.588
glp1r_human 435 C-term P => L missense 8.238e-06 1 121382 0 0.01 0.543
glp1r_human 440 C-term T => A missense 7.415e-05 9 121370 0 0.41 0.001
glp1r_human 443 C-term L => P missense 1.648e-05 2 121336 0 0.27 0.746
glp1r_human 445 C-term S => T missense 0.002045 248 121262 1 0.14 0.312
glp1r_human 449 C-term A => E missense 1.651e-05 2 121156 0 0.96 0.36
glp1r_human 449 C-term A => V missense 1.651e-05 2 121156 0 0.57 0.001
glp1r_human 450 C-term G => A missense 8.258e-06 1 121088 0 0.07 0.417
glp1r_human 453 C-term M => T missense 8.263e-06 1 121024 0 0.73 0.009
glp1r_human 26 N-term Q => ArgfsTer25 frameshift 3.899e-05 1 25648 0 None None
glp1r_human 40 N-term R => Ter stop gained 2.498e-05 3 120108 0 None None
glp1r_human 131 N-term R => Ter stop gained 1.215e-05 1 82316 0 None None
glp1r_human 152 1.47x47 TM1 Y => Ter stop gained 8.274e-06 1 120858 0 None None
glp1r_human 190 2.60x60 TM2 R => Ter stop gained 8.237e-06 1 121400 0 None None
glp1r_human 241 3.44x44 TM3 Y => Ter stop gained 8.237e-06 1 121404 0 None None SodiumPocket MicroSwitch
glp1r_human 243 3.46x46 TM3 W => Ter stop gained 8.237e-06 1 121406 0 None None
glp1r_human 269 4.45x46 TM4 Y => Ter stop gained 8.243e-06 1 121312 0 None None
glp1r_human 315 5.45x45 TM5 F => LeufsTer5 frameshift 8.237e-06 1 121410 0 None None
glp1r_human 446 C-term G => GlufsTer76 frameshift 8.247e-06 1 121256 0 None None


Residue

Diagrams

R H L H ICL1ECL1 K W M Y S T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L S ICL2ECL2 D E G C W T R N S N M N ECL2ICL3 N L M C K T ICL3ECL3 V M D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A D I K C R L A K S T L T L I P L L G T H E V I F A F G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
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