Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
gnrhr_human 319 7.49x49 TM7 D => H missense 8.253e-06 1 121174 0 0.0 0.962 SodiumPocket MicroSwitch
gnrhr_human 318 7.48x48 TM7 F => L missense 1.65e-05 2 121196 0 1.0 0.009
gnrhr_human 317 7.47x47 TM7 C => S missense 8.249e-06 1 121222 0 0.04 0.999
gnrhr_human 313 7.43x42 TM7 F => L missense 8.244e-06 1 121300 0 1.0 0.003
gnrhr_human 305 7.35x34 TM7 N => K missense 8.239e-06 1 121370 0 0.03 0.345
gnrhr_human 305 7.35x34 TM7 N => Y missense 8.239e-06 1 121376 0 0.06 0.038
gnrhr_human 296 ECL3 M => I missense 8.238e-06 1 121394 0 0.14 0.044
gnrhr_human 287 6.55x55 TM6 G => E missense 8.237e-06 1 121398 0 0.0 1.0
gnrhr_human 284 6.52x52 TM6 Y => C missense 8.237e-06 1 121398 0 0.0 0.974
gnrhr_human 279 6.47x47 TM6 C => Y missense 7.414e-05 9 121398 0 0.0 1.0
gnrhr_human 269 6.37x37 TM6 T => M missense 1.648e-05 2 121392 0 0.0 0.999 GP (contact)
gnrhr_human 268 6.36x36 TM6 M => T missense 2.471e-05 3 121396 0 0.0 0.997 GP (contact)
gnrhr_human 266 6.34x34 TM6 L => R missense 8.238e-06 1 121394 0 0.0 1.0 SodiumPocket MicroSwitch
gnrhr_human 262 6.30x30 TM6 R => Q missense 0.002035 247 121380 1 0.0 0.924 SodiumPocket MicroSwitch
gnrhr_human 251 ICL3 L => R missense 8.249e-06 1 121232 0 0.06 0.887
gnrhr_human 250 ICL3 Q => P missense 8.253e-06 1 121174 0 0.3 0.012
gnrhr_human 249 ICL3 L => R missense 8.254e-06 1 121152 0 0.21 0.114
gnrhr_human 246 5.73x73 TM5 P => L missense 1.658e-05 2 120660 0 0.11 0.111
gnrhr_human 243 5.70x70 TM5 H => R missense 8.277e-06 1 120820 0 0.81 0.001
gnrhr_human 241 5.68x68 TM5 V => A missense 8.271e-06 1 120906 0 0.34 0.338 GP (contact)
gnrhr_human 240 5.67x67 TM5 R => Q missense 0.0004382 53 120962 0 0.38 0.006 GP (contact)
gnrhr_human 237 5.64x64 TM5 T => I missense 8.252e-06 1 121182 0 0.02 0.309 GP (contact)
gnrhr_human 222 5.49x49 TM5 I => T missense 1.648e-05 2 121360 0 0.21 0.011
gnrhr_human 218 5.45x46 TM5 C => F missense 8.239e-06 1 121368 0 0.1 0.02
gnrhr_human 213 5.40x41 TM5 F => V missense 8.24e-06 1 121366 0 0.01 0.077
gnrhr_human 205 5.32x33 TM5 W => R missense 7.415e-05 9 121374 0 1.0 0.126
gnrhr_human 200 45.50x50 ECL2 C => Y missense 4.12e-05 5 121366 0 0.0 0.544
gnrhr_human 191 ECL2 K => E missense 1.648e-05 2 121332 0 1.0 0.0
gnrhr_human 188 ECL2 G => V missense 8.243e-06 1 121312 0 0.08 0.97
gnrhr_human 188 ECL2 G => A missense 8.243e-06 1 121312 0 0.45 0.827
gnrhr_human 187 ECL2 S => C missense 8.243e-06 1 121308 0 0.05 0.494
gnrhr_human 174 4.60x61 TM4 Q => L missense 9.791e-06 1 102134 0 0.02 0.399
gnrhr_human 172 4.58x59 TM4 G => R missense 1.897e-05 2 105442 0 0.03 0.998
gnrhr_human 171 4.57x57 TM4 A => T missense 9.343e-06 1 107034 0 0.0 0.982
gnrhr_human 166 4.52x52 TM4 L => F missense 8.952e-06 1 111702 0 0.04 0.646
gnrhr_human 156 4.42x42 TM4 G => E missense 8.549e-06 1 116968 0 0.15 0.009
gnrhr_human 156 4.42x42 TM4 G => R missense 3.416e-05 4 117080 0 0.1 0.015
gnrhr_human 155 4.41x41 TM4 V => L missense 1.698e-05 2 117776 0 0.39 0.002
gnrhr_human 154 4.40x40 TM4 K => Q missense 2.537e-05 3 118234 0 0.13 0.055
gnrhr_human 154 4.40x40 TM4 K => E missense 4.229e-05 5 118234 0 0.02 0.307
gnrhr_human 153 4.39x39 TM4 S => R missense 8.432e-06 1 118602 0 0.7 0.008
gnrhr_human 152 4.38x38 TM4 N => S missense 5.893e-05 7 118782 0 0.15 0.004
gnrhr_human 151 ICL2 S => C missense 8.378e-06 1 119358 0 0.01 0.882
gnrhr_human 146 34.50x50 ICL2 P => S missense 0.00132 159 120412 1 0.0 1.0 GP (contact)
gnrhr_human 144 3.55x55 TM3 T => M missense 8.288e-06 1 120658 0 0.02 1.0 GP (contact)
gnrhr_human 141 3.52x52 TM3 L => R missense 1.654e-05 2 120938 0 0.2 0.991
gnrhr_human 139 3.50x50 TM3 R => H missense 0.0001736 21 120978 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
gnrhr_human 135 3.46x46 TM3 I => V missense 8.256e-06 1 121124 0 0.02 0.997
gnrhr_human 134 3.45x45 TM3 V => G missense 8.255e-06 1 121136 0 0.0 0.905
gnrhr_human 132 3.43x43 TM3 M => V missense 1.651e-05 2 121162 0 0.52 0.005
gnrhr_human 129 3.40x40 TM3 A => D missense 8.251e-06 1 121198 0 0.0 1.0 SodiumPocket MicroSwitch
gnrhr_human 129 3.40x40 TM3 A => G missense 8.251e-06 1 121198 0 0.0 0.999 SodiumPocket MicroSwitch
gnrhr_human 129 3.40x40 TM3 A => T missense 8.251e-06 1 121200 0 0.0 1.0 SodiumPocket MicroSwitch
gnrhr_human 127 3.38x38 TM3 A => V missense 0.0001238 15 121194 0 0.01 0.043
gnrhr_human 126 3.37x37 TM3 Y => C missense 8.25e-06 1 121212 0 0.0 1.0
gnrhr_human 125 3.36x36 TM3 M => V missense 8.25e-06 1 121212 0 0.0 0.994
gnrhr_human 116 3.27x27 TM3 V => A missense 8.245e-06 1 121280 0 0.14 0.076
gnrhr_human 113 3.24x24 TM3 L => V missense 8.245e-06 1 121284 0 0.25 0.999
gnrhr_human 113 3.24x24 TM3 L => F missense 8.245e-06 1 121284 0 0.05 1.0
gnrhr_human 108 23.51x51 ECL1 Y => C missense 8.243e-06 1 121320 0 0.01 0.979
gnrhr_human 106 23.49x49 ECL1 Q => R missense 0.002522 306 121330 0 0.0 0.974
gnrhr_human 105 ECL1 V => I missense 8.242e-06 1 121332 0 0.05 0.44
gnrhr_human 96 2.59x58 TM2 P => S missense 8.24e-06 1 121366 0 0.0 1.0
gnrhr_human 94 2.57x56 TM2 V => A missense 0.0001401 17 121370 0 0.0 0.999
gnrhr_human 91 2.54x54 TM2 T => P missense 8.238e-06 1 121384 0 0.0 1.0
gnrhr_human 90 2.53x53 TM2 E => K missense 3.295e-05 4 121388 0 0.01 0.999
gnrhr_human 77 2.40x40 TM2 K => E missense 1.648e-05 2 121384 0 0.0 0.805
gnrhr_human 75 2.38x38 TM2 R => S missense 2.472e-05 3 121380 0 0.01 0.956
gnrhr_human 74 12.51x51 ICL1 S => P missense 2.471e-05 3 121384 0 0.04 0.185
gnrhr_human 70 ICL1 G => R missense 1.648e-05 2 121372 0 0.26 0.035
gnrhr_human 69 ICL1 K => T missense 8.239e-06 1 121370 0 0.04 0.759
gnrhr_human 68 ICL1 E => K missense 8.239e-06 1 121374 0 0.21 0.068
gnrhr_human 63 1.60x60 TM1 W => C missense 2.473e-05 3 121330 0 0.0 0.819
gnrhr_human 63 1.60x60 TM1 W => L missense 1.649e-05 2 121322 0 0.03 0.197
gnrhr_human 62 1.59x59 TM1 K => N missense 1.649e-05 2 121322 0 0.06 0.024
gnrhr_human 54 1.51x51 TM1 A => T missense 8.252e-06 1 121190 0 0.12 0.025
gnrhr_human 51 1.48x48 TM1 T => I missense 8.252e-06 1 121178 0 0.44 0.007
gnrhr_human 50 1.47x47 TM1 A => V missense 5.778e-05 7 121152 0 0.04 0.044
gnrhr_human 46 1.43x43 TM1 F => S missense 8.258e-06 1 121100 0 0.0 0.999
gnrhr_human 45 1.42x42 TM1 L => F missense 8.258e-06 1 121100 0 0.05 1.0
gnrhr_human 43 1.40x40 TM1 F => L missense 8.262e-06 1 121040 0 0.11 0.891
gnrhr_human 40 1.37x37 TM1 T => M missense 2.48e-05 3 120950 0 0.08 0.22
gnrhr_human 34 N-term S => P missense 8.276e-06 1 120836 0 0.0 0.999
gnrhr_human 33 N-term L => S missense 8.276e-06 1 120832 0 0.11 0.8
gnrhr_human 30 N-term T => S missense 8.278e-06 1 120802 0 0.03 0.495
gnrhr_human 27 N-term N => T missense 8.282e-06 1 120748 0 0.18 0.005
gnrhr_human 26 N-term G => D missense 8.284e-06 1 120718 0 0.08 0.03
gnrhr_human 25 N-term Q => R missense 8.285e-06 1 120696 0 0.09 0.197
gnrhr_human 25 N-term Q => E missense 8.286e-06 1 120680 0 0.49 0.007
gnrhr_human 25 N-term Q => K missense 8.286e-06 1 120680 0 0.18 0.023
gnrhr_human 23 N-term L => V missense 8.291e-06 1 120610 0 0.27 0.024
gnrhr_human 18 N-term N => S missense 0.0001495 18 120386 0 0.08 0.999
gnrhr_human 11 N-term Q => K missense 0.0001751 21 119924 0 0.51 0.023
gnrhr_human 10 N-term N => K missense 0.0001752 21 119892 0 0.15 0.037
gnrhr_human 5 N-term A => V missense 8.373e-06 1 119426 0 0.12 0.024
gnrhr_human 5 N-term A => T missense 8.375e-06 1 119396 0 0.18 0.043
gnrhr_human 4 N-term S => R missense 8.377e-05 10 119374 0 0.14 0.017
gnrhr_human 4 N-term S => N missense 8.377e-06 1 119378 0 0.31 0.006
gnrhr_human 2 N-term A => T missense 8.392e-06 1 119162 0 0.01 0.53
gnrhr_human 325 7.55x55 TM7 Y => Ter stop gained 8.264e-06 1 121008 0 None None GP (contact)
gnrhr_human 283 6.51x51 TM6 Y => Ter stop gained 8.238e-06 1 121396 0 None None
gnrhr_human 217 5.44x45 TM5 S => Ter stop gained 8.239e-06 1 121368 0 None None
gnrhr_human 248 ICL3 E => ProfsTer47 frameshift 8.301e-06 1 120472 0 None None
gnrhr_human 205 5.32x33 TM5 W => Ter stop gained 2.489e-05 3 120536 0 None None
gnrhr_human 74 12.51x51 ICL1 S => Ter stop gained 8.238e-06 1 121382 0 None None
gnrhr_human 38 1.35x35 TM1 R => Ter stop gained 1.655e-05 2 120878 0 None None


Residue

Diagrams

K T Q K K E K G K L S ICL1ECL1 T V Q W Y A ECL1 P L A L K S ICL2ECL2 R M I H L A D S S G Q T K V F S Q C V T H C S F ECL2ICL3 E L Q L N ICL3ECL3 P E M L ECL3N-term M A N S A S P E Q N Q N H C S A I N N S I P L M Q G N L P T L T L S G N-termC-term S L C-term K I R V T V T F F L F L L S A T F N A S F L L K L Q K W R M K L L L K H L T L A N L L E T L I V M P L D G M W N I G E L L C K V L S Y L K L F S M Y A P A F M M V V I S L D R S L A I T R N S K V G Q S M V G L A W I L S S V F A G P Q L Y I F S Q W W H Q A F Y N F F T F S C L F I I P L F I M L I C N A K I I F T L T R V L H Q D P H Q S K N N I P R A R L K T L K M T V A F A T S F T V C W T P Y Y V L G I W Y W F D N R L S D P V N H F F F L F A F L N P C F D P L I Y G Y F
SnakePlot Download: PNG | SVG A N F T A S L L F L F F T V T V R I K 1 K H L T L A N L L E T I L V M P L D G M W 2 V V M M F A P A Y M S F L K L Y S L V K 3 G Q S M V G L A W I L S S V F A G P Q 4 N C I L M I F L P I I F L C S F T F F N Y 5 V A F A T S F T V C W T P Y Y V L G I W 6 L P D F C P N L F A F L F F F H N V P 7
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