Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
hcar2_human 350 C-term G => S missense 0.0001565 19 121394 0 nan 0.0
hcar2_human 350 C-term G => R missense 8.238e-06 1 121394 0 nan 0.001
hcar2_human 350 C-term G => C missense 8.238e-06 1 121394 0 nan 0.003
hcar2_human 329 C-term V => I missense 4.118e-05 5 121412 0 0.35 0.001
hcar2_human 325 C-term R => H missense 8.236e-06 1 121412 0 0.05 0.336
hcar2_human 319 C-term G => S missense 8.237e-06 1 121410 0 0.38 0.003
hcar2_human 264 ECL3 Q => H missense 4.14e-05 5 120764 0 0.14 0.002
hcar2_human 208 5.58x58 TM5 S => L missense 1.649e-05 2 121296 0 0.0 0.477 SodiumPocket MicroSwitch
hcar2_human 192 5.42x43 TM5 M => I missense 8.238e-06 1 121396 0 0.07 0.043
hcar2_human 191 5.41x42 TM5 A => V missense 8.237e-06 1 121398 0 0.75 0.088
hcar2_human 190 5.40x41 TM5 E => K missense 4.943e-05 6 121396 0 0.22 0.017
hcar2_human 187 5.37x38 TM5 Q => R missense 9.061e-05 11 121400 0 0.69 0.0
hcar2_human 187 5.37x38 TM5 Q => L missense 1.647e-05 2 121400 0 0.13 0.003
hcar2_human 186 5.36x37 TM5 F => L missense 8.237e-06 1 121400 0 0.7 0.012
hcar2_human 185 5.35x36 TM5 T => S missense 8.237e-06 1 121402 0 0.66 0.001
hcar2_human 185 5.35x36 TM5 T => I missense 1.647e-05 2 121402 0 0.13 0.003
hcar2_human 184 5.34x35 TM5 H => R missense 8.237e-06 1 121402 0 0.54 0.001
hcar2_human 183 5.33x34 TM5 C => W missense 8.237e-06 1 121402 0 0.02 0.463
hcar2_human 179 45.52x52 ECL2 S => R missense 8.237e-06 1 121400 0 0.0 0.992
hcar2_human 175 ECL2 N => S missense 8.237e-06 1 121402 0 0.29 0.002
hcar2_human 173 ECL2 G => A missense 0.001837 223 121404 0 0.1 0.001
hcar2_human 173 ECL2 G => S missense 0.001886 229 121400 0 0.17 0.003
hcar2_human 173 ECL2 G => C missense 2.471e-05 3 121400 0 0.01 0.706
hcar2_human 172 ECL2 G => A missense 8.237e-06 1 121406 0 0.6 0.016
hcar2_human 167 ECL2 M => I missense 8.237e-06 1 121410 0 0.18 0.024
hcar2_human 160 4.58x58 TM4 V => I missense 9.884e-05 12 121410 0 0.66 0.012
hcar2_human 159 4.57x57 TM4 T => R missense 8.237e-06 1 121410 0 0.0 0.53
hcar2_human 156 4.54x54 TM4 I => V missense 1.647e-05 2 121410 0 0.11 0.627
hcar2_human 155 4.53x53 TM4 T => I missense 2.471e-05 3 121410 0 0.72 0.124
hcar2_human 155 4.53x53 TM4 T => P missense 8.237e-06 1 121410 0 0.15 0.414
hcar2_human 151 4.49x49 TM4 L => M missense 4.118e-05 5 121408 0 0.05 0.968
hcar2_human 151 4.49x49 TM4 L => V missense 8.237e-06 1 121408 0 0.05 0.773
hcar2_human 144 4.42x42 TM4 A => P missense 1.647e-05 2 121410 0 0.0 0.999
hcar2_human 142 4.40x40 TM4 R => Q missense 8.237e-06 1 121410 0 0.19 0.041
hcar2_human 135 34.53x53 ICL2 A => T missense 0.0002142 26 121408 0 0.54 0.005 GP (contact)
hcar2_human 135 34.53x53 ICL2 A => S missense 1.647e-05 2 121408 0 0.56 0.027 GP (contact)
hcar2_human 133 34.51x51 ICL2 H => P missense 1.647e-05 2 121408 0 0.01 0.997 GP (contact)
hcar2_human 128 3.53x53 TM3 R => Q missense 1.647e-05 2 121408 0 0.01 0.977 GP (contact)
hcar2_human 128 3.53x53 TM3 R => W missense 2.471e-05 3 121402 0 0.0 0.999 GP (contact)
hcar2_human 125 3.50x50 TM3 R => G missense 8.237e-06 1 121408 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
hcar2_human 119 3.44x44 TM3 T => M missense 8.237e-06 1 121408 0 0.15 0.987
hcar2_human 118 3.43x43 TM3 L => P missense 8.237e-06 1 121408 0 0.0 0.999
hcar2_human 111 3.36x36 TM3 R => H missense 1.647e-05 2 121402 0 0.0 0.975
hcar2_human 111 3.36x36 TM3 R => C missense 2.471e-05 3 121398 0 0.0 1.0
hcar2_human 109 3.34x34 TM3 M => T missense 7.413e-05 9 121404 0 0.09 0.241
hcar2_human 103 3.28x28 TM3 M => V missense 3.295e-05 4 121396 0 1.0 0.001
hcar2_human 101 3.26x26 TM3 R => Q missense 8.238e-06 1 121392 0 0.0 0.903
hcar2_human 101 3.26x26 TM3 R => W missense 8.238e-06 1 121392 0 0.0 0.857
hcar2_human 97 3.22x22 TM3 D => A missense 3.295e-05 4 121398 0 0.0 0.259
hcar2_human 93 23.50x50 ECL1 W => S missense 6.59e-05 8 121396 0 0.0 1.0
hcar2_human 90 2.67x67 TM2 R => H missense 4.119e-05 5 121394 0 0.38 0.009
hcar2_human 90 2.67x67 TM2 R => L missense 8.238e-06 1 121394 0 0.09 0.231
hcar2_human 90 2.67x67 TM2 R => C missense 2.471e-05 3 121396 0 0.03 0.773
hcar2_human 86 2.63x63 TM2 N => K missense 8.238e-06 1 121394 0 0.22 0.345
hcar2_human 85 2.62x62 TM2 D => E missense 8.238e-06 1 121396 0 0.01 0.997
hcar2_human 82 2.59x59 TM2 F => L missense 8.238e-06 1 121394 0 0.1 0.601
hcar2_human 79 2.56x56 TM2 C => G missense 1.647e-05 2 121398 0 0.02 0.444
hcar2_human 78 2.55x55 TM2 I => F missense 1.647e-05 2 121398 0 0.52 0.073
hcar2_human 68 2.45x45 TM2 N => S missense 0.0001153 14 121396 0 0.06 0.774
hcar2_human 64 2.41x41 TM2 I => T missense 1.648e-05 2 121392 0 0.0 0.491
hcar2_human 63 2.40x40 TM2 R => Q missense 7.414e-05 9 121392 0 0.04 0.283
hcar2_human 63 2.40x40 TM2 R => L missense 1.648e-05 2 121392 0 0.04 0.408
hcar2_human 63 2.40x40 TM2 R => W missense 8.238e-06 1 121392 0 0.02 0.098
hcar2_human 44 1.49x49 TM1 G => D missense 8.238e-06 1 121392 0 0.0 0.989
hcar2_human 44 1.49x49 TM1 G => C missense 8.238e-06 1 121392 0 0.0 1.0
hcar2_human 37 1.42x42 TM1 E => A missense 2.471e-05 3 121394 0 0.39 0.562
hcar2_human 36 1.41x41 TM1 L => P missense 8.238e-06 1 121394 0 0.02 0.713
hcar2_human 33 1.38x38 TM1 V => A missense 8.238e-06 1 121396 0 0.0 0.403
hcar2_human 32 1.37x37 TM1 P => L missense 1.647e-05 2 121400 0 0.0 0.698
hcar2_human 31 1.36x36 TM1 P => S missense 8.237e-06 1 121402 0 0.01 0.616
hcar2_human 29 1.34x34 TM1 V => A missense 8.237e-06 1 121406 0 0.01 0.465
hcar2_human 28 1.33x33 TM1 K => Q missense 2.471e-05 3 121406 0 1.0 0.001
hcar2_human 26 1.31x31 TM1 I => L missense 8.237e-06 1 121404 0 0.67 0.002
hcar2_human 24 N-term D => E missense 1.647e-05 2 121402 0 0.51 0.001
hcar2_human 24 N-term D => E missense 8.237e-06 1 121402 0 0.51 0.001
hcar2_human 22 N-term R => Q missense 1.647e-05 2 121402 0 0.26 0.004
hcar2_human 15 N-term K => E missense 8.238e-06 1 121384 0 0.15 0.0
hcar2_human 12 N-term E => K missense 3.296e-05 4 121368 0 nan 0.002
hcar2_human 11 N-term L => P missense 8.24e-06 1 121364 0 nan 0.736
hcar2_human 5 N-term H => Q missense 1.651e-05 2 121136 0 nan 0.0
hcar2_human 5 N-term H => P missense 1.651e-05 2 121138 0 nan 0.011
hcar2_human 3 N-term R => Q missense 7.434e-05 9 121058 0 nan 0.0
hcar2_human 3 N-term R => L missense 2.478e-05 3 121058 0 nan 0.0
hcar2_human 3 N-term R => W missense 8.262e-06 1 121036 0 nan 0.109
hcar2_human 355 C-term P => LeufsTer35 frameshift 1.647e-05 2 121400 0 None None
hcar2_human 353 C-term W => Ter stop gained 8.237e-06 1 121406 0 None None
hcar2_human 101 3.26x26 TM3 R => Ter frameshift 8.237e-06 1 121398 0 None None
hcar2_human 93 23.50x50 ECL1 W => Ter stop gained 8.238e-06 1 121396 0 None None
hcar2_human 70 2.47x47 TM2 A => GlnfsTer7 frameshift 8.238e-06 1 121394 0 None None
hcar2_human 22 N-term R => Ter stop gained 4.119e-05 5 121400 0 None None


Residue

Diagrams

ICL1 L K S W ICL1ECL1 W D W K F ECL1 P H H A L N K I ICL2ECL2 M P I Q N G G A N L C S S ECL2ICL3 R Q M D ICL3ECL3 S G T Q ECL3N-term M N R H H L Q D H F L E I D K K N C C V F R D D N-termC-term R C L Q R K M T G E P D N N R S T S V E L T G D P N K T R G A P E A L M A N S G E P W S P S Y L G P T S P C-term F I V K V L P P V L G L E F I F G L L G N G L A L W I F C F H K S S R I F L F N L A V A D F L L I I C L P F L M D N Y V R R G D I P C R L M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H S N R T A A I I S C L L W G I T I G L T V H L L K K K F S I C H T F Q W H E A M F L L E F F L P L G I I L F C S A R I I W S L R Q R H A K I K R A I T F I M V V A I V F V I C F L P S V V V R I R I F W L L H T N C E V Y R S V D L A F F I T L S F T Y M N S M L D P V V Y Y F S S P S F S T F P N F L I N
SnakePlot Download: PNG | SVG G N G L L G F I F E L G L V P P L V K V 1 F N L A V A D F L L I I C L P F L M D N 2 V T L F I I S G Q R N M A L M F L M L R 3 A A I I S C L L W G I T I G L T V H L L 4 S C F L I I G L P L F F E L L F M A E H W 5 M V V A I V F V I C F L P S V V V R I R 6 V P D L M S N M Y T F S L T I F F A L 7
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