Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
hrh2_human 4 N-term N => S missense 8.29e-06 1 120620 0 0.05 0.008
hrh2_human 15 1.29x29 TM1 T => S missense 8.24e-06 1 121354 0 0.58 0.016
hrh2_human 16 1.30x30 TM1 A => T missense 2.472e-05 3 121366 0 0.29 0.005
hrh2_human 17 1.31x31 TM1 C => R missense 8.239e-06 1 121380 0 0.35 0.014
hrh2_human 20 1.34x34 TM1 T => A missense 1.648e-05 2 121390 0 0.45 0.006
hrh2_human 23 1.37x37 TM1 V => M missense 1.647e-05 2 121412 0 0.07 0.021
hrh2_human 26 1.40x40 TM1 A => V missense 1.647e-05 2 121412 0 0.65 0.0
hrh2_human 26 1.40x40 TM1 A => E missense 8.236e-06 1 121412 0 0.28 0.036
hrh2_human 33 1.47x47 TM1 V => I missense 0.0001647 20 121412 0 1.0 0.002
hrh2_human 34 1.48x48 TM1 A => G missense 4.118e-05 5 121412 0 0.49 0.652
hrh2_human 38 1.52x52 TM1 V => L missense 8.236e-06 1 121412 0 1.0 0.173
hrh2_human 39 1.53x53 TM1 V => I missense 8.236e-06 1 121412 0 0.0 0.999
hrh2_human 42 1.56x56 TM1 A => V missense 8.236e-06 1 121412 0 0.02 0.951
hrh2_human 47 12.48x48 ICL1 R => C missense 8.237e-06 1 121410 0 0.0 0.998
hrh2_human 48 12.49x49 ICL1 R => Q missense 8.237e-06 1 121410 0 0.05 0.499
hrh2_human 50 12.51x51 ICL1 R => H missense 8.237e-06 1 121410 0 0.01 1.0
hrh2_human 58 2.44x44 TM2 V => M missense 9.06e-05 11 121408 0 0.03 0.73
hrh2_human 77 2.63x62 TM2 I => V missense 8.237e-06 1 121406 0 0.4 0.023
hrh2_human 85 23.51x51 ECL1 S => N missense 8.237e-06 1 121406 0 0.16 0.035
hrh2_human 92 3.26x26 TM3 N => S missense 1.647e-05 2 121406 0 0.0 0.262
hrh2_human 108 3.42x42 TM3 N => T missense 8.237e-06 1 121406 0 0.28 0.437
hrh2_human 116 3.50x50 TM3 R => W missense 8.237e-06 1 121400 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
hrh2_human 121 3.55x55 TM3 M => T missense 8.237e-06 1 121398 0 1.0 0.0 GP (contact)
hrh2_human 125 34.52x52 ICL2 R => W missense 8.237e-06 1 121398 0 0.0 0.999 GP (contact)
hrh2_human 125 34.52x52 ICL2 R => Q missense 8.238e-06 1 121390 0 0.04 0.985 GP (contact)
hrh2_human 136 4.43x43 TM4 A => T missense 8.239e-06 1 121372 0 0.26 0.081
hrh2_human 137 4.44x44 TM4 I => V missense 8.238e-06 1 121386 0 0.86 0.009
hrh2_human 144 4.51x51 TM4 V => F missense 8.238e-06 1 121388 0 0.05 0.913
hrh2_human 154 4.61x61 TM4 I => T missense 8.238e-06 1 121392 0 0.0 1.0
hrh2_human 155 4.62x62 TM4 H => N missense 8.238e-06 1 121392 0 0.03 0.992
hrh2_human 157 4.64x64 TM4 G => E missense 8.238e-06 1 121392 0 0.07 0.558
hrh2_human 162 ECL2 N => H missense 3.295e-05 4 121402 0 0.04 0.078
hrh2_human 172 ECL2 S => F missense 1.647e-05 2 121400 0 0.05 0.005
hrh2_human 200 5.56x56 TM5 I => V missense 1.648e-05 2 121384 0 0.94 0.006
hrh2_human 204 5.60x60 TM5 R => C missense 8.239e-06 1 121378 0 0.1 1.0
hrh2_human 204 5.60x60 TM5 R => H missense 8.239e-06 1 121370 0 0.01 0.998
hrh2_human 229 6.30x30 TM6 E => K missense 8.24e-06 1 121354 0 0.0 0.895 SodiumPocket MicroSwitch
hrh2_human 238 6.39x39 TM6 A => T missense 1.648e-05 2 121356 0 0.15 0.477
hrh2_human 238 6.39x39 TM6 A => V missense 8.24e-06 1 121356 0 0.47 0.107
hrh2_human 239 6.40x40 TM6 V => I missense 2.472e-05 3 121338 0 0.04 0.982 GP (contact)
hrh2_human 253 6.54x54 TM6 A => T missense 1.648e-05 2 121374 0 0.09 0.011
hrh2_human 253 6.54x54 TM6 A => V missense 8.239e-06 1 121376 0 1.0 0.006
hrh2_human 257 6.58x58 TM6 R => C missense 8.238e-06 1 121390 0 0.11 0.993
hrh2_human 260 6.61x61 TM6 R => K missense 8.237e-06 1 121398 0 0.95 0.004
hrh2_human 266 7.31x30 TM7 N => S missense 0.003171 385 121402 3 0.59 0.068
hrh2_human 284 7.49x49 TM7 N => K missense 8.237e-06 1 121400 0 0.0 0.998 SodiumPocket MicroSwitch
hrh2_human 286 7.51x51 TM7 I => T missense 8.237e-06 1 121404 0 0.0 0.899
hrh2_human 288 7.53x53 TM7 Y => C missense 8.237e-06 1 121406 0 0.0 1.0 SodiumPocket MicroSwitch
hrh2_human 290 7.55x55 TM7 A => V missense 8.237e-06 1 121406 0 0.07 0.221 GP (contact)
hrh2_human 296 8.51x51 H8 R => H missense 8.238e-06 1 121394 0 0.0 0.999 GP (contact)
hrh2_human 297 8.52x52 H8 T => A missense 8.238e-06 1 121394 0 0.53 0.016
hrh2_human 298 8.53x53 H8 G => R missense 8.238e-06 1 121390 0 0.0 0.251
hrh2_human 309 C-term N => S missense 1.648e-05 2 121394 0 0.82 0.0
hrh2_human 310 C-term R => C missense 4.943e-05 6 121394 0 0.18 0.003
hrh2_human 310 C-term R => H missense 2.471e-05 3 121394 0 0.58 0.001
hrh2_human 311 C-term N => S missense 8.238e-06 1 121394 0 0.34 0.003
hrh2_human 314 C-term K => R missense 8.238e-06 1 121392 0 0.53 0.001
hrh2_human 315 C-term T => N missense 8.238e-06 1 121390 0 0.07 0.081
hrh2_human 317 C-term L => R missense 8.239e-06 1 121378 0 0.19 0.048
hrh2_human 317 C-term L => P missense 8.239e-06 1 121378 0 0.15 0.041
hrh2_human 321 C-term A => T missense 5.768e-05 7 121356 0 0.57 0.003
hrh2_human 326 C-term R => M missense 8.243e-06 1 121308 0 0.03 0.935
hrh2_human 328 C-term Q => E missense 1.649e-05 2 121286 0 0.29 0.004
hrh2_human 330 C-term R => Q missense 3.299e-05 4 121244 0 0.84 0.001
hrh2_human 339 C-term P => H missense 8.265e-06 1 120998 0 0.04 0.838
hrh2_human 341 C-term K => N missense 8.268e-06 1 120950 0 0.14 0.007
hrh2_human 343 C-term Q => H missense 8.272e-06 1 120888 0 0.1 0.017
hrh2_human 350 C-term V => I missense 8.31e-06 1 120344 0 0.2 0.003
hrh2_human 351 C-term T => M missense 9.16e-05 11 120090 0 0.08 0.032
hrh2_human 354 C-term Q => K missense 8.362e-06 1 119588 0 0.17 0.033
hrh2_human 354 C-term Q => H missense 8.36e-06 1 119612 0 0.02 0.45
hrh2_human 354 C-term Q => ArgfsTer19 frameshift 8.333e-06 1 120000 0 None None


Residue

Diagrams

R R L R ICL1ECL1 C K W S F ECL1 P L R Y P V L V ICL2ECL2 W N S R N E T S K G N H T T S K C K V Q V ECL2ICL3 H I S ICL3ECL3 G D D A I ECL3N-term M A P N G T A S S F N-termC-term C R L A N R N S H K T S L R S N A S Q L S R T Q S R E P R Q Q E E K P L K L Q V W S G T E V T A P Q G A T D R C-term C L D S T A C K I T I T V V L A V L I L I T V A G N V V V C L A V G L N N L T N C F I V S L A I T D L L L G L L V L P F S A I Y Q L S G K V F C N I Y T S L D V M L C T A S I L N L F M I S L D R Y C A V M D T P V R V A I S L V L I W V I S I T L S F L S I H L G N E V Y G L V D G L V T F Y L P L L I M C I T Y Y R I F K V A R D Q A K R I N S W K A A T I R E H K A T V T L A A V M G A F I I C W F P Y F T A F V Y R G L R N E V L E A I V L W L G Y A N S A L N P I L Y A A L N R D Y Q Q F R T G L F C
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