Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
hrh3_human 439 C-term S => Y missense 3.026e-05 1 33052 0 0.01 0.747
hrh3_human 438 C-term S => I missense 2.874e-05 1 34796 0 0.49 0.012
hrh3_human 431 C-term K => N missense 1.945e-05 1 51410 0 0.0 0.876
hrh3_human 421 8.52x52 H8 R => Q missense 3.677e-05 3 81582 0 0.04 0.516
hrh3_human 421 8.52x52 H8 R => P missense 1.226e-05 1 81582 0 0.0 0.956
hrh3_human 421 8.52x52 H8 R => W missense 1.204e-05 1 83082 0 0.0 0.982
hrh3_human 420 8.51x51 H8 R => H missense 3.523e-05 3 85148 1 0.0 0.975 GP (contact)
hrh3_human 418 8.49x49 H8 S => T missense 1.076e-05 1 92974 0 0.01 0.883 GP (contact)
hrh3_human 407 7.48x48 TM7 V => I missense 1.816e-05 2 110132 0 1.0 0.124
hrh3_human 405 7.46x46 TM7 S => L missense 8.915e-06 1 112170 0 0.0 1.0
hrh3_human 403 7.44x43 TM7 A => V missense 8.813e-06 1 113470 0 0.71 0.01 SodiumPocket MicroSwitch
hrh3_human 389 ECL3 V => I missense 0.0003738 44 117704 0 0.67 0.014
hrh3_human 387 ECL3 H => Y missense 8.478e-06 1 117948 0 0.02 0.002
hrh3_human 385 ECL3 H => R missense 8.463e-06 1 118158 0 0.17 0.039
hrh3_human 383 6.60x60 TM6 A => S missense 8.459e-06 1 118212 0 0.0 0.713
hrh3_human 383 6.60x60 TM6 A => T missense 1.692e-05 2 118212 0 0.02 0.277
hrh3_human 381 6.58x58 TM6 R => Q missense 8.441e-06 1 118472 0 0.0 0.757
hrh3_human 381 6.58x58 TM6 R => W missense 8.44e-06 1 118478 0 0.0 0.994
hrh3_human 370 6.47x47 TM6 C => Y missense 8.457e-06 1 118252 0 0.0 0.999
hrh3_human 365 6.42x42 TM6 S => C missense 8.538e-06 1 117130 0 1.0 0.012
hrh3_human 362 6.39x39 TM6 V => I missense 0.0008549 99 115800 1 1.0 0.021
hrh3_human 349 6.26x26 TM6 R => W missense 1.863e-05 2 107336 0 0.0 0.989 GP (contact)
hrh3_human 347 6.24x24 TM6 R => C missense 2.86e-05 3 104900 0 0.03 0.502
hrh3_human 340 ICL3 V => L missense 1.005e-05 1 99488 0 0.13 0.017
hrh3_human 336 ICL3 R => H missense 1.079e-05 1 92666 0 0.01 0.112
hrh3_human 332 ICL3 S => L missense 1.542e-05 1 64848 0 0.07 0.49
hrh3_human 330 ICL3 S => L missense 1.832e-05 1 54596 0 0.1 0.227
hrh3_human 328 ICL3 A => S missense 2.192e-05 1 45620 0 0.63 0.01
hrh3_human 320 ICL3 L => I missense 0.0003515 8 22758 0 0.32 0.119
hrh3_human 311 ICL3 S => L missense 0.0001298 2 15404 0 0.55 0.102
hrh3_human 308 ICL3 G => S missense 7.279e-05 1 13738 0 0.77 0.007
hrh3_human 300 ICL3 V => M missense 8.699e-05 1 11496 0 0.24 0.002
hrh3_human 292 ICL3 G => R missense 0.0002085 3 14390 0 0.51 0.995
hrh3_human 292 ICL3 G => R missense 6.949e-05 1 14390 0 0.51 0.995
hrh3_human 290 ICL3 T => P missense 0.0001234 2 16210 0 0.39 0.006
hrh3_human 289 ICL3 A => V missense 0.0005746 10 17402 0 0.34 0.001
hrh3_human 287 ICL3 G => R missense 4.814e-05 1 20772 0 0.53 0.995
hrh3_human 285 ICL3 E => K missense 4.073e-05 1 24552 0 0.58 0.126
hrh3_human 284 ICL3 A => V missense 0.0001959 5 25524 0 0.17 0.014
hrh3_human 282 ICL3 V => I missense 9.949e-05 3 30154 0 0.23 0.017
hrh3_human 280 ICL3 A => V missense 5.424e-05 2 36876 0 0.31 0.003
hrh3_human 279 ICL3 E => K missense 2.392e-05 1 41814 0 0.55 0.085
hrh3_human 271 ICL3 P => L missense 0.0001156 7 60578 0 0.18 0.065
hrh3_human 271 ICL3 P => S missense 0.0001815 11 60598 0 0.29 0.009
hrh3_human 270 ICL3 M => T missense 1.581e-05 1 63258 0 0.73 0.007
hrh3_human 267 ICL3 G => R missense 0.0003705 25 67478 0 0.37 0.008
hrh3_human 267 ICL3 G => R missense 2.964e-05 2 67478 0 0.37 0.008
hrh3_human 266 ICL3 H => Y missense 1.442e-05 1 69372 0 0.04 0.06
hrh3_human 265 ICL3 G => R missense 1.406e-05 1 71104 0 0.51 0.196
hrh3_human 264 ICL3 K => R missense 1.391e-05 1 71910 0 0.38 0.005
hrh3_human 262 ICL3 W => C missense 1.371e-05 1 72918 0 0.15 0.875
hrh3_human 258 ICL3 C => F missense 1.292e-05 1 77384 0 0.27 0.477
hrh3_human 257 ICL3 G => A missense 5.124e-05 4 78070 0 0.25 0.023
hrh3_human 255 ICL3 P => L missense 1.266e-05 1 78960 0 0.19 0.0
hrh3_human 254 ICL3 P => S missense 2.488e-05 2 80374 0 0.51 0.006
hrh3_human 253 ICL3 P => L missense 1.232e-05 1 81176 0 0.22 0.059
hrh3_human 251 ICL3 S => L missense 1.207e-05 1 82838 0 0.07 0.419
hrh3_human 248 ICL3 A => V missense 1.164e-05 1 85920 0 0.29 0.015
hrh3_human 247 ICL3 E => K missense 5.728e-05 5 87294 0 0.43 0.146
hrh3_human 246 ICL3 P => R missense 1.112e-05 1 89962 0 0.62 0.187
hrh3_human 243 ICL3 E => K missense 2.126e-05 2 94054 0 0.23 0.09
hrh3_human 242 ICL3 P => L missense 1.034e-05 1 96690 0 0.33 0.016
hrh3_human 241 ICL3 G => R missense 1.007e-05 1 99288 0 0.37 0.232
hrh3_human 237 ICL3 R => Q missense 0.000176 19 107944 0 0.6 0.007
hrh3_human 237 ICL3 R => P missense 9.264e-06 1 107944 0 0.26 0.446
hrh3_human 237 ICL3 R => G missense 9.165e-06 1 109106 0 0.38 0.165
hrh3_human 236 ICL3 A => S missense 2.711e-05 3 110664 0 0.43 0.093
hrh3_human 234 5.74x74 TM5 D => H missense 8.833e-06 1 113212 0 0.19 0.983 GP (contact)
hrh3_human 230 5.70x70 TM5 R => H missense 8.633e-06 1 115834 0 0.01 0.938
hrh3_human 230 5.70x70 TM5 R => C missense 2.576e-05 3 116440 0 0.03 0.938
hrh3_human 230 5.70x70 TM5 R => S missense 8.588e-05 10 116440 0 0.26 0.668
hrh3_human 228 5.68x68 TM5 R => H missense 8.511e-06 1 117492 0 0.08 0.999 GP (contact)
hrh3_human 228 5.68x68 TM5 R => C missense 8.493e-06 1 117740 0 0.0 0.999 GP (contact)
hrh3_human 214 5.54x54 TM5 V => I missense 7.511e-05 9 119826 0 0.0 0.995
hrh3_human 214 5.54x54 TM5 V => F missense 8.345e-06 1 119826 0 0.0 0.999
hrh3_human 208 5.48x48 TM5 F => L missense 8.331e-06 1 120032 0 0.03 0.992
hrh3_human 201 5.41x42 TM5 T => M missense 6.665e-05 8 120024 0 0.14 0.845
hrh3_human 198 5.38x39 TM5 F => Y missense 8.332e-06 1 120022 0 0.0 0.995
hrh3_human 186 ECL2 G => D missense 2.504e-05 3 119788 0 0.5 0.959
hrh3_human 185 ECL2 E => K missense 1.67e-05 2 119744 0 0.33 0.362
hrh3_human 183 ECL2 I => T missense 8.351e-06 1 119748 0 0.08 0.998
hrh3_human 179 ECL2 G => R missense 1.672e-05 2 119616 0 0.04 1.0
hrh3_human 164 4.54x54 TM4 F => C missense 8.404e-06 1 118996 0 0.0 0.999
hrh3_human 159 4.49x49 TM4 V => L missense 8.458e-06 1 118228 0 0.01 0.994
hrh3_human 156 4.46x46 TM4 M => T missense 8.512e-06 1 117484 0 0.01 0.985
hrh3_human 154 4.44x44 TM4 R => Q missense 1.723e-05 2 116094 0 0.16 0.002
hrh3_human 154 4.44x44 TM4 R => W missense 8.617e-06 1 116054 0 0.07 0.003
hrh3_human 152 4.42x42 TM4 A => P missense 8.697e-06 1 114982 0 0.34 0.999
hrh3_human 151 4.41x41 TM4 R => Q missense 8.728e-06 1 114574 0 0.43 0.019
hrh3_human 151 4.41x41 TM4 R => W missense 1.746e-05 2 114538 0 0.0 0.877
hrh3_human 149 4.39x39 TM4 T => K missense 1.764e-05 2 113398 0 0.0 0.959
hrh3_human 149 4.39x39 TM4 T => M missense 8.818e-06 1 113398 0 0.08 0.989
hrh3_human 149 4.39x39 TM4 T => A missense 8.817e-06 1 113412 0 0.01 0.754
hrh3_human 147 34.58x58 ICL2 G => R missense 8.946e-06 1 111778 0 0.02 0.969
hrh3_human 145 34.56x56 ICL2 Q => R missense 9.027e-06 1 110774 0 0.06 0.992 GP (contact)
hrh3_human 144 34.55x55 ICL2 A => V missense 9.099e-06 1 109904 0 0.05 0.644 GP (contact)
hrh3_human 143 34.54x54 ICL2 R => W missense 7.373e-05 8 108498 0 0.0 1.0 GP (contact)
hrh3_human 139 34.50x50 ICL2 A => V missense 9.579e-06 1 104390 0 0.02 0.688 GP (contact)
hrh3_human 138 3.56x56 TM3 R => Q missense 9.447e-06 1 105850 0 0.06 0.781 GP (contact)
hrh3_human 131 3.49x49 TM3 D => N missense 8.941e-06 1 111842 0 0.02 0.807 SodiumPocket MicroSwitch
hrh3_human 129 3.47x47 TM3 S => G missense 8.846e-06 1 113044 0 0.0 0.668
hrh3_human 126 3.44x44 TM3 V => M missense 8.781e-06 1 113876 0 0.0 0.955
hrh3_human 126 3.44x44 TM3 V => L missense 3.513e-05 4 113876 0 0.0 0.639
hrh3_human 125 3.43x43 TM3 I => L missense 8.755e-06 1 114224 0 0.0 0.376
hrh3_human 120 3.38x38 TM3 S => T missense 8.7e-06 1 114940 0 0.07 0.11
hrh3_human 104 3.22x22 TM3 R => Q missense 0.0001639 19 115956 0 0.01 0.738
hrh3_human 104 3.22x22 TM3 R => W missense 8.613e-06 1 116104 0 0.0 0.983
hrh3_human 103 3.21x21 TM3 G => S missense 0.0003274 38 116064 0 0.0 1.0
hrh3_human 99 23.49x49 ECL1 R => H missense 8.626e-06 1 115924 0 0.01 0.938
hrh3_human 99 23.49x49 ECL1 R => C missense 8.625e-06 1 115940 0 0.0 0.938
hrh3_human 85 2.55x55 TM2 A => T missense 8.757e-06 1 114192 0 0.01 0.807
hrh3_human 69 2.39x39 TM2 N => H missense 8.431e-06 1 118612 0 0.03 0.998
hrh3_human 59 1.57x57 TM1 F => L missense 8.515e-06 1 117436 0 0.0 0.98
hrh3_human 48 1.46x46 TM1 T => M missense 9.018e-06 1 110890 0 0.0 0.968
hrh3_human 41 1.39x39 TM1 M => L missense 1.049e-05 1 95304 0 0.02 0.14
hrh3_human 39 1.37x37 TM1 A => V missense 2.213e-05 2 90356 0 1.0 0.499
hrh3_human 36 1.34x34 TM1 V => M missense 1.269e-05 1 78798 0 0.01 0.934
hrh3_human 237 ICL3 R => Ter stop gained 9.165e-06 1 109106 0 None None
hrh3_human 191 ECL2 E => Ter stop gained 1.668e-05 2 119906 0 None None


Residue

Diagrams

S S L R ICL1ECL1 G R W T F ECL1 A V S Y R A Q Q G ICL2ECL2 W E Y L S G G S S I P E G H C Y A E F F Y ECL2ICL3 A R E A A G P E P P P E A Q P S P P P P P G C W G C W Q K G H G E A M P L H R Y G V G E A A V G A E A G E A T L G G G G G G G S V A S P T S S S G S S S R G T E R P R S L K R G S K P S A S S A S L E K R M K M V S Q S F T Q ICL3ECL3 H G H C V ECL3N-term M E R A P P D G P L N A S G A L A G E A A A A G G A R G F S A A W T A N-termC-term P Q K L K I Q P H S S L E H C W K C-term V L A A L M A L L I V A T V L G N A L V M L A F V A D T Q N N F F L L N L A I S D F L V G A F C I P L Y V P Y V L T G R G L C K L W L V V D Y L L C T S S A F N I V L I S Y D R F L S V T R D T R R A V R K M L L V W V L A F L L Y G P A I L S N W Y F L I T A S T L E F F T P F L S V T F F N L S I Y L N I Q R R T R L R L D G R F R L S R D R K V A K S L A V I V S I F G L C W A P Y T L L M I I R A A C P D Y W Y E T S F W L L W A N S A V N P V L Y P L C H H S F T K F R R A L L C
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