Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
mtr1b_human 3 N-term E => G missense 1.461e-05 1 68448 0 nan 0.007
mtr1b_human 5 N-term G => S missense 4.281e-05 3 70070 0 nan 0.02
mtr1b_human 7 N-term F => I missense 1.398e-05 1 71514 0 nan 0.012
mtr1b_human 11 N-term C => Y missense 2.663e-05 2 75114 0 0.0 0.971
mtr1b_human 13 N-term A => S missense 1.317e-05 1 75922 0 0.18 0.015
mtr1b_human 13 N-term A => V missense 0.003112 237 76146 2 0.21 0.003
mtr1b_human 13 N-term A => E missense 3.94e-05 3 76146 0 0.11 0.257
mtr1b_human 14 N-term G => D missense 1.301e-05 1 76874 0 0.12 0.039
mtr1b_human 15 N-term G => R missense 1.291e-05 1 77434 0 0.05 0.066
mtr1b_human 15 N-term G => W missense 1.291e-05 1 77434 0 0.0 0.991
mtr1b_human 24 N-term G => E missense 0.08563 7125 83204 293 0.17 0.009
mtr1b_human 28 N-term A => V missense 7.171e-05 6 83668 0 0.12 0.006
mtr1b_human 33 N-term T => I missense 1.135e-05 1 88116 0 0.15 0.003
mtr1b_human 52 1.44x44 TM1 A => V missense 3.707e-05 4 107894 0 1.0 0.067
mtr1b_human 54 1.46x46 TM1 D => V missense 9.188e-06 1 108842 0 0.0 1.0
mtr1b_human 60 1.52x52 TM1 L => R missense 0.0003826 42 109762 0 0.0 0.995
mtr1b_human 60 1.52x52 TM1 L => Q missense 4.555e-05 5 109762 0 0.01 0.995
mtr1b_human 64 1.56x56 TM1 S => Y missense 9.171e-06 1 109038 0 0.0 0.997
mtr1b_human 65 1.57x57 TM1 V => A missense 0.0002857 31 108488 0 0.0 0.997
mtr1b_human 71 12.50x50 ICL1 L => H missense 9.792e-06 1 102124 0 0.0 1.0
mtr1b_human 80 2.44x44 TM2 V => L missense 1.669e-05 2 119866 0 0.01 0.609
mtr1b_human 85 2.49x49 TM2 A => V missense 8.272e-06 1 120894 0 0.0 0.999
mtr1b_human 86 2.50x50 TM2 D => H missense 1.652e-05 2 121030 0 0.0 0.999
mtr1b_human 91 2.55x55 TM2 F => L missense 8.245e-06 1 121284 0 1.0 0.001
mtr1b_human 92 2.56x56 TM2 Y => D missense 8.243e-06 1 121316 0 0.0 0.908
mtr1b_human 95 2.59x59 TM2 P => L missense 4.12e-05 5 121372 0 0.04 0.998
mtr1b_human 98 2.62x62 TM2 L => P missense 8.238e-06 1 121396 0 0.03 0.874
mtr1b_human 99 2.63x63 TM2 V => M missense 2.471e-05 3 121402 0 0.26 0.046
mtr1b_human 103 2.67x67 TM2 Y => H missense 8.237e-06 1 121410 0 1.0 0.001
mtr1b_human 105 23.49x49 ECL1 G => S missense 2.471e-05 3 121410 0 0.03 0.382
mtr1b_human 105 23.49x49 ECL1 G => D missense 8.237e-06 1 121410 0 0.09 0.25
mtr1b_human 107 23.51x51 ECL1 A => T missense 8.237e-06 1 121410 0 0.74 0.023
mtr1b_human 109 3.21x21 TM3 G => E missense 8.237e-06 1 121408 0 0.01 0.949
mtr1b_human 111 3.23x23 TM3 E => G missense 8.237e-06 1 121408 0 0.07 0.0
mtr1b_human 117 3.29x29 TM3 A => T missense 2.471e-05 3 121412 0 0.05 0.053
mtr1b_human 118 3.30x30 TM3 F => L missense 1.647e-05 2 121412 0 0.11 0.521
mtr1b_human 118 3.30x30 TM3 F => S missense 8.237e-06 1 121410 0 0.0 0.988
mtr1b_human 120 3.32x32 TM3 M => I missense 5.766e-05 7 121408 0 0.05 0.082
mtr1b_human 123 3.35x35 TM3 S => G missense 8.236e-06 1 121412 0 0.02 0.718
mtr1b_human 124 3.36x36 TM3 V => I missense 0.0008072 98 121412 0 0.03 0.921
mtr1b_human 126 3.38x38 TM3 G => S missense 1.647e-05 2 121410 0 0.07 0.455
mtr1b_human 126 3.38x38 TM3 G => D missense 8.237e-06 1 121410 0 0.02 0.529
mtr1b_human 130 3.42x42 TM3 N => S missense 0.0001647 20 121406 0 0.05 0.458
mtr1b_human 135 3.47x47 TM3 A => T missense 1.647e-05 2 121402 0 0.01 0.573
mtr1b_human 138 3.50x50 TM3 R => C missense 0.001087 132 121398 0 0.07 0.672 SodiumPocket MicroSwitch GP (contact)
mtr1b_human 138 3.50x50 TM3 R => H missense 4.118e-05 5 121404 0 0.03 0.825 SodiumPocket MicroSwitch GP (contact)
mtr1b_human 140 3.52x52 TM3 C => F missense 8.237e-06 1 121398 0 0.02 0.461
mtr1b_human 141 3.53x53 TM3 Y => H missense 8.237e-06 1 121400 0 0.0 0.93 GP (contact)
mtr1b_human 141 3.53x53 TM3 Y => C missense 1.647e-05 2 121402 0 0.1 0.073 GP (contact)
mtr1b_human 142 3.54x54 TM3 I => F missense 8.237e-06 1 121404 0 0.0 0.99 GP (contact)
mtr1b_human 142 3.54x54 TM3 I => V missense 8.237e-06 1 121404 0 0.1 0.533 GP (contact)
mtr1b_human 142 3.54x54 TM3 I => M missense 8.237e-06 1 121402 0 0.01 0.954 GP (contact)
mtr1b_human 150 34.55x55 ICL2 R => Q missense 2.471e-05 3 121404 0 0.1 0.087 GP (contact)
mtr1b_human 153 4.38x38 TM4 R => W missense 4.118e-05 5 121406 0 0.07 0.009
mtr1b_human 153 4.38x38 TM4 R => Q missense 8.237e-06 1 121404 0 0.06 0.009
mtr1b_human 154 4.39x39 TM4 R => C missense 5.766e-05 7 121398 0 0.18 0.009
mtr1b_human 154 4.39x39 TM4 R => H missense 8.237e-06 1 121398 0 0.59 0.005
mtr1b_human 157 4.42x42 TM4 T => A missense 8.238e-06 1 121388 0 0.17 0.042
mtr1b_human 160 4.45x45 TM4 H => R missense 8.237e-06 1 121400 0 0.03 0.009
mtr1b_human 165 4.50x50 TM4 W => C missense 1.648e-05 2 121388 0 0.01 0.982
mtr1b_human 166 4.51x51 TM4 L => I missense 0.0001071 13 121394 0 0.39 0.119
mtr1b_human 167 4.52x52 TM4 L => F missense 8.238e-06 1 121394 0 0.04 0.656
mtr1b_human 169 4.54x54 TM4 V => M missense 4.119e-05 5 121382 0 0.05 0.426
mtr1b_human 170 4.55x55 TM4 V => M missense 0.0006508 79 121388 3 0.02 0.597
mtr1b_human 175 4.60x61 TM4 N => S missense 1.648e-05 2 121390 0 0.04 0.461
mtr1b_human 175 4.60x61 TM4 N => K missense 8.238e-06 1 121386 0 0.0 0.934
mtr1b_human 176 4.61x62 TM4 F => L missense 8.238e-06 1 121384 0 0.51 0.023
mtr1b_human 178 4.63x64 TM4 V => G missense 1.648e-05 2 121380 0 0.06 0.673
mtr1b_human 182 ECL2 E => D missense 0.0001236 15 121376 0 0.07 0.033
mtr1b_human 184 ECL2 D => E missense 8.239e-06 1 121376 0 0.0 0.995
mtr1b_human 188 ECL2 Y => C missense 1.648e-05 2 121378 0 0.01 0.634
mtr1b_human 189 ECL2 S => F missense 8.239e-06 1 121374 0 0.01 0.992
mtr1b_human 192 45.52x52 ECL2 F => S missense 1.648e-05 2 121372 0 0.0 0.955
mtr1b_human 196 ECL2 A => T missense 1.648e-05 2 121358 0 0.54 0.052
mtr1b_human 198 5.36x37 TM5 T => N missense 0.0004614 56 121368 1 0.02 0.281
mtr1b_human 200 5.38x39 TM5 Y => D missense 2.472e-05 3 121368 0 0.01 0.928
mtr1b_human 201 5.39x40 TM5 T => M missense 8.24e-06 1 121354 0 0.0 0.939
mtr1b_human 202 5.40x41 TM5 A => V missense 1.648e-05 2 121352 0 0.69 0.004
mtr1b_human 203 5.41x42 TM5 A => T missense 0.0001483 18 121354 0 0.52 0.192
mtr1b_human 208 5.46x461 TM5 H => N missense 8.241e-06 1 121338 0 0.0 0.955
mtr1b_human 214 5.52x52 TM5 A => S missense 8.244e-06 1 121306 0 0.57 0.062
mtr1b_human 214 5.52x52 TM5 A => T missense 8.244e-06 1 121306 0 0.97 0.021
mtr1b_human 215 5.53x53 TM5 V => F missense 8.243e-06 1 121322 0 0.0 0.905
mtr1b_human 216 5.54x54 TM5 V => M missense 3.297e-05 4 121312 0 0.02 0.647
mtr1b_human 222 5.60x60 TM5 R => C missense 4.944e-05 6 121352 0 0.12 0.262
mtr1b_human 222 5.60x60 TM5 R => H missense 8.24e-06 1 121354 0 0.03 0.431
mtr1b_human 231 5.69x69 TM5 R => C missense 2.472e-05 3 121358 0 0.04 0.4 GP (contact)
mtr1b_human 231 5.69x69 TM5 R => H missense 0.003848 467 121354 1 0.05 0.104 GP (contact)
mtr1b_human 233 5.71x71 TM5 K => T missense 8.239e-06 1 121372 0 0.01 0.314 GP (contact)
mtr1b_human 234 5.72x72 TM5 A => T missense 0.0002884 35 121372 0 0.03 0.297 GP (contact)
mtr1b_human 234 5.72x72 TM5 A => D missense 8.239e-06 1 121368 0 0.0 0.653 GP (contact)
mtr1b_human 235 ICL3 K => Q missense 4.943e-05 6 121380 0 0.0 0.905
mtr1b_human 235 ICL3 K => R missense 1.648e-05 2 121376 0 0.23 0.12
mtr1b_human 240 6.24x24 TM6 L => R missense 1.648e-05 2 121392 0 0.4 0.051
mtr1b_human 241 6.25x25 TM6 C => S missense 8.238e-06 1 121392 0 0.05 0.012 GP (contact)
mtr1b_human 243 6.27x27 TM6 K => R missense 0.04214 5116 121392 324 0.59 0.012
mtr1b_human 245 6.29x29 TM6 S => N missense 8.237e-06 1 121400 0 0.09 0.081 GP (contact)
mtr1b_human 248 6.32x32 TM6 R => Q missense 1.647e-05 2 121410 0 0.1 0.581 GP (contact)
mtr1b_human 253 6.37x37 TM6 M => T missense 1.647e-05 2 121412 0 0.08 0.461 GP (contact)
mtr1b_human 256 6.40x40 TM6 V => A missense 8.236e-06 1 121412 0 0.02 0.987 GP (contact)
mtr1b_human 262 6.46x46 TM6 I => F missense 8.237e-06 1 121410 0 0.19 0.031
mtr1b_human 265 6.49x49 TM6 A => V missense 4.942e-05 6 121410 0 0.0 0.965
mtr1b_human 266 6.50x50 TM6 P => L missense 8.236e-06 1 121412 0 0.05 0.965 SodiumPocket MicroSwitch
mtr1b_human 270 6.54x54 TM6 I => V missense 8.236e-06 1 121412 0 0.0 0.966
mtr1b_human 271 6.55x55 TM6 G => S missense 1.647e-05 2 121412 0 0.01 0.958
mtr1b_human 273 6.57x57 TM6 A => T missense 2.471e-05 3 121412 0 0.07 0.159
mtr1b_human 273 6.57x57 TM6 A => S missense 8.236e-06 1 121412 0 0.0 0.863
mtr1b_human 275 6.59x59 TM6 A => V missense 2.471e-05 3 121412 0 0.02 0.517
mtr1b_human 278 ECL3 P => A missense 3.295e-05 4 121410 0 0.0 0.991
mtr1b_human 284 7.29x28 TM7 Q => E missense 8.236e-06 1 121412 0 0.11 0.232
mtr1b_human 285 7.30x29 TM7 I => L missense 8.237e-06 1 121410 0 0.02 0.053
mtr1b_human 286 7.31x30 TM7 P => T missense 1.647e-05 2 121410 0 0.01 0.831
mtr1b_human 293 7.38x37 TM7 S => T missense 8.237e-06 1 121408 0 0.0 0.897
mtr1b_human 304 7.49x49 TM7 N => S missense 1.648e-05 2 121392 0 0.03 0.912 SodiumPocket MicroSwitch
mtr1b_human 306 7.51x51 TM7 I => V missense 2.471e-05 3 121392 0 0.83 0.086
mtr1b_human 308 7.53x53 TM7 Y => C missense 8.239e-06 1 121378 0 0.02 0.999 SodiumPocket MicroSwitch
mtr1b_human 309 7.54x54 TM7 G => E missense 8.239e-06 1 121372 0 0.0 0.991
mtr1b_human 310 7.55x55 TM7 L => F missense 2.472e-05 3 121362 0 0.06 0.016 GP (contact)
mtr1b_human 310 7.55x55 TM7 L => I missense 8.24e-06 1 121362 0 0.11 0.175 GP (contact)
mtr1b_human 313 8.48x48 H8 Q => E missense 3.297e-05 4 121316 0 0.26 0.103 GP (contact)
mtr1b_human 313 8.48x48 H8 Q => R missense 4.946e-05 6 121320 0 0.16 0.005 GP (contact)
mtr1b_human 315 8.50x50 H8 F => L missense 8.244e-06 1 121304 0 0.0 0.927
mtr1b_human 316 8.51x51 H8 R => C missense 6.595e-05 8 121298 0 0.04 0.337 GP (contact)
mtr1b_human 316 8.51x51 H8 R => L missense 1.649e-05 2 121292 0 0.03 0.278 GP (contact)
mtr1b_human 316 8.51x51 H8 R => H missense 8.245e-06 1 121292 0 0.03 0.337 GP (contact)
mtr1b_human 322 8.57x57 H8 I => T missense 8.248e-06 1 121238 0 0.03 0.347
mtr1b_human 325 C-term A => V missense 0.0003466 42 121188 0 0.05 0.006
mtr1b_human 330 C-term R => W missense 1.651e-05 2 121114 0 0.2 0.022
mtr1b_human 330 C-term R => G missense 8.257e-06 1 121114 0 0.23 0.01
mtr1b_human 330 C-term R => Q missense 0.0007927 96 121100 1 0.16 0.024
mtr1b_human 332 C-term C => Y missense 1.652e-05 2 121062 0 0.26 0.194
mtr1b_human 336 C-term A => T missense 1.655e-05 2 120868 0 0.72 0.002
mtr1b_human 336 C-term A => V missense 8.273e-06 1 120868 0 0.26 0.003
mtr1b_human 338 C-term K => N missense 8.286e-06 1 120688 0 0.35 0.019
mtr1b_human 339 C-term G => S missense 0.0004309 52 120690 0 0.18 0.015
mtr1b_human 339 C-term G => V missense 8.295e-06 1 120558 0 0.03 0.288
mtr1b_human 340 C-term S => N missense 1.66e-05 2 120516 0 0.14 0.015
mtr1b_human 341 C-term H => R missense 8.298e-06 1 120506 0 0.58 0.0
mtr1b_human 342 C-term A => P missense 8.3e-06 1 120476 0 0.09 0.266
mtr1b_human 342 C-term A => V missense 0.0001245 15 120440 0 0.23 0.004
mtr1b_human 342 C-term A => E missense 1.661e-05 2 120440 0 0.42 0.002
mtr1b_human 353 C-term I => T missense 0.0004777 57 119320 0 0.48 0.0
mtr1b_human 362 C-term L => F missense 8.64e-06 1 115740 0 nan 0.558
mtr1b_human 30 N-term P => LeufsTer46 frameshift 1.181e-05 1 84690 0 None None
mtr1b_human 13 N-term A => Ter stop gained 1.156e-05 1 86524 0 None None
mtr1b_human 106 23.50x50 ECL1 W => Ter stop gained 8.237e-06 1 121410 0 None None
mtr1b_human 110 3.22x22 TM3 E => Ter stop gained 8.237e-06 1 121408 0 None None
mtr1b_human 356 C-term Q => Ter stop gained 8.454e-06 1 118284 0 None None
mtr1b_human 108 23.52x52 ECL1 L => ProfsTer8 frameshift 0.001327 14 10548 0 None None


Residue

Diagrams

R K L R ICL1ECL1 G W A L ECL1 S M A Y H R I Y ICL2ECL2 S L E Y D P R I Y S C T F I Q T A ECL2ICL3 K P E S R ICL3ECL3 P Q E M A ECL3N-term M S E N G S F A N C C E A G G W A V R P G W S G A G S A R P S R T P R P P W N-termC-term L A L W N P R H C I Q D A S K G S H A E G L Q S P A P P I I G V Q H Q A D A L C-term V A P A L S A V L I V T T A V D V V G N L L V I L S V L R N N A G N L F L V S L A L A D L V V A F Y P Y P L I L V A I F Y D G E E H C K A S A F V M G L S V I G S V F N I T A I A I N R Y C Y I C H R R W H T P L H I C L I W L L T V V A L L P N F F V G S T Q Y T A A V V V I H F L L P I A V V S F C Y L R I W V L V L Q A R R K A L C L K P S D L R S F L T M F V V F V I F A I C W A P L N C I G L A V A I N P Q I P E G L F V T S Y L L A Y F N S C L N A I V Y G L L N Q N Y K R F R R E I L
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