Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
ntr2_human 409 C-term R => Q missense 6.918e-05 8 115642 0 nan 0.001
ntr2_human 406 C-term P => T missense 2.547e-05 3 117804 0 0.12 0.001
ntr2_human 405 C-term P => A missense 8.457e-06 1 118242 0 0.04 0.098
ntr2_human 404 C-term D => N missense 8.432e-06 1 118600 0 0.36 0.0
ntr2_human 398 C-term T => I missense 1.658e-05 2 120654 0 0.02 0.001
ntr2_human 394 C-term T => I missense 8.259e-06 1 121084 0 0.09 0.009
ntr2_human 391 C-term Q => P missense 1.65e-05 2 121240 0 0.37 0.0
ntr2_human 388 C-term P => L missense 0.0265 3215 121336 439 0.47 0.0
ntr2_human 387 C-term P => L missense 5.768e-05 7 121360 1 0.0 0.003
ntr2_human 387 C-term P => H missense 8.24e-06 1 121360 0 0.05 0.514
ntr2_human 387 C-term P => T missense 8.24e-06 1 121360 0 0.09 0.002
ntr2_human 387 C-term P => S missense 4.12e-05 5 121360 0 0.07 0.003
ntr2_human 386 C-term L => S missense 8.24e-06 1 121366 0 0.46 0.001
ntr2_human 385 C-term R => Q missense 9.063e-05 11 121366 0 0.57 0.012
ntr2_human 385 C-term R => W missense 1.648e-05 2 121372 0 0.02 0.153
ntr2_human 382 C-term P => T missense 0.000552 67 121386 0 0.06 0.003
ntr2_human 381 C-term H => Y missense 2.471e-05 3 121390 0 0.11 0.243
ntr2_human 379 C-term E => G missense 8.238e-06 1 121392 0 0.19 0.003
ntr2_human 374 C-term S => N missense 8.238e-06 1 121396 0 0.2 0.079
ntr2_human 374 C-term S => G missense 8.237e-06 1 121400 0 0.51 0.001
ntr2_human 373 8.58x58 H8 V => I missense 4.943e-05 6 121396 0 0.03 0.008
ntr2_human 367 8.52x52 H8 K => E missense 8.237e-06 1 121400 0 0.03 0.354
ntr2_human 363 8.48x48 H8 S => F missense 8.237e-06 1 121400 0 0.0 0.937 GP (contact)
ntr2_human 361 7.56x56 TM7 V => M missense 3.295e-05 4 121404 0 0.11 0.011 GP (contact)
ntr2_human 360 7.55x55 TM7 A => T missense 1.647e-05 2 121406 0 0.21 0.004 GP (contact)
ntr2_human 353 7.48x48 TM7 V => M missense 2.471e-05 3 121408 0 0.0 1.0
ntr2_human 349 7.44x43 TM7 V => I missense 4.942e-05 6 121408 0 0.08 0.025 SodiumPocket MicroSwitch
ntr2_human 345 7.40x39 TM7 T => I missense 1.647e-05 2 121400 0 0.06 0.385
ntr2_human 341 7.36x35 TM7 M => R missense 0.0002389 29 121370 0 0.0 0.756
ntr2_human 341 7.36x35 TM7 M => V missense 8.239e-06 1 121370 0 0.06 0.025
ntr2_human 338 7.33x32 TM7 Y => C missense 8.241e-06 1 121348 0 0.0 0.566
ntr2_human 338 7.33x32 TM7 Y => S missense 8.241e-06 1 121348 0 0.01 0.204
ntr2_human 335 7.30x29 TM7 F => S missense 8.247e-06 1 121258 0 0.06 0.999
ntr2_human 333 7.28x27 TM7 Y => C missense 8.26e-06 1 121070 0 0.01 0.983
ntr2_human 331 7.26x25 TM7 P => S missense 8.275e-06 1 120846 0 0.73 0.013
ntr2_human 330 7.25x24 TM7 D => E missense 1.655e-05 2 120836 0 0.56 0.015
ntr2_human 329 7.24x23 TM7 T => A missense 1.655e-05 2 120882 0 0.0 0.656
ntr2_human 327 ECL3 A => V missense 0.0001985 24 120896 0 0.28 0.016
ntr2_human 327 ECL3 A => T missense 4.136e-05 5 120896 0 0.56 0.048
ntr2_human 326 ECL3 D => E missense 8.272e-06 1 120890 0 0.42 0.167
ntr2_human 323 6.61x61 TM6 V => I missense 9.098e-05 11 120902 0 0.65 0.027
ntr2_human 319 6.57x57 TM6 M => I missense 1.655e-05 2 120868 0 0.0 0.947
ntr2_human 318 6.56x56 TM6 L => F missense 8.275e-06 1 120850 0 0.0 0.986
ntr2_human 317 6.55x55 TM6 R => T missense 8.275e-06 1 120840 0 0.02 0.972
ntr2_human 316 6.54x54 TM6 R => H missense 0.0002317 28 120826 0 0.0 0.971
ntr2_human 316 6.54x54 TM6 R => C missense 4.139e-05 5 120806 0 0.0 0.986
ntr2_human 312 6.50x50 TM6 P => L missense 5.8e-05 7 120698 0 0.05 0.378 SodiumPocket MicroSwitch
ntr2_human 311 6.49x49 TM6 L => M missense 2.486e-05 3 120652 0 0.13 0.176
ntr2_human 307 6.45x45 TM6 V => G missense 3.319e-05 4 120536 0 0.02 0.965
ntr2_human 305 6.43x43 TM6 M => R missense 8.302e-06 1 120448 0 0.01 0.119
ntr2_human 304 6.42x42 TM6 V => A missense 0.0008138 98 120422 0 0.48 0.0
ntr2_human 303 6.41x41 TM6 V => M missense 1.661e-05 2 120384 0 0.04 0.434
ntr2_human 299 6.37x37 TM6 L => F missense 8.954e-06 1 111688 0 0.02 0.949 GP (contact)
ntr2_human 296 6.34x34 TM6 V => I missense 0.000284 32 112672 0 0.5 0.007 SodiumPocket MicroSwitch
ntr2_human 294 6.32x32 TM6 R => H missense 2.639e-05 3 113670 0 1.0 0.003 GP (contact)
ntr2_human 294 6.32x32 TM6 R => C missense 4.382e-05 5 114106 0 0.0 0.816 GP (contact)
ntr2_human 293 6.31x31 TM6 Q => R missense 1.746e-05 2 114580 0 0.63 0.062
ntr2_human 290 6.28x28 TM6 R => H missense 1.725e-05 2 115960 0 0.12 0.128 GP (contact)
ntr2_human 289 6.27x27 TM6 I => M missense 1.713e-05 2 116728 0 0.05 0.79
ntr2_human 288 6.26x26 TM6 R => W missense 3.4e-05 4 117648 0 0.0 0.787 GP (contact)
ntr2_human 287 6.25x25 TM6 R => H missense 4.234e-05 5 118080 0 0.34 0.009 GP (contact)
ntr2_human 287 6.25x25 TM6 R => C missense 0.0002618 31 118430 0 0.11 0.402 GP (contact)
ntr2_human 284 ICL3 K => T missense 8.357e-06 1 119664 0 0.27 0.782
ntr2_human 282 ICL3 R => K missense 0.007983 958 120010 45 0.08 0.996
ntr2_human 279 ICL3 S => R missense 8.307e-06 1 120380 0 0.1 0.603
ntr2_human 275 ICL3 G => E missense 0.0001906 23 120650 0 0.1 0.085
ntr2_human 265 ICL3 F => L missense 8.295e-06 1 120556 0 0.13 0.119
ntr2_human 264 ICL3 S => R missense 8.295e-06 1 120554 0 0.48 0.005
ntr2_human 262 ICL3 L => F missense 2.491e-05 3 120444 0 0.21 0.999
ntr2_human 253 ICL3 R => H missense 7.525e-05 9 119608 0 0.44 0.011
ntr2_human 253 ICL3 R => S missense 0.0006779 81 119480 1 0.23 0.473
ntr2_human 253 ICL3 R => C missense 8.37e-06 1 119480 0 0.04 0.026
ntr2_human 252 ICL3 S => T missense 8.37e-06 1 119472 0 0.12 0.833
ntr2_human 246 ICL3 P => L missense 1.692e-05 2 118226 0 0.21 0.006
ntr2_human 246 ICL3 P => R missense 8.458e-06 1 118226 0 0.19 0.346
ntr2_human 245 ICL3 T => N missense 8.475e-06 1 118000 0 0.06 0.136
ntr2_human 242 5.74x74 TM5 S => P missense 8.54e-06 1 117090 0 0.07 0.846 GP (contact)
ntr2_human 239 5.71x71 TM5 Q => P missense 8.595e-06 1 116350 0 0.0 0.999 GP (contact)
ntr2_human 235 5.67x67 TM5 A => T missense 8.713e-06 1 114774 0 0.17 0.887 GP (contact)
ntr2_human 229 5.61x61 TM5 T => A missense 1.779e-05 2 112442 0 0.26 0.243 GP (contact)
ntr2_human 228 5.60x60 TM5 V => I missense 0.000679 76 111936 0 0.58 0.129
ntr2_human 223 5.55x55 TM5 A => T missense 9.106e-06 1 109818 0 0.03 0.361
ntr2_human 221 5.53x53 TM5 L => P missense 9.127e-06 1 109568 0 0.0 1.0
ntr2_human 220 5.52x52 TM5 A => V missense 1.835e-05 2 108994 0 0.85 0.999
ntr2_human 219 5.51x51 TM5 L => F missense 9.194e-06 1 108770 0 0.01 1.0
ntr2_human 218 5.50x50 TM5 P => S missense 2.781e-05 3 107860 0 0.01 1.0 SodiumPocket MicroSwitch
ntr2_human 217 5.49x49 TM5 L => F missense 9.27e-06 1 107870 0 0.44 1.0
ntr2_human 216 5.48x48 TM5 V => M missense 8.379e-05 9 107408 0 0.02 0.87
ntr2_human 214 5.46x461 TM5 S => F missense 9.333e-06 1 107152 0 0.0 0.985
ntr2_human 211 5.43x44 TM5 V => M missense 9.379e-06 1 106620 0 0.01 1.0
ntr2_human 202 5.34x35 TM5 A => P missense 1.087e-05 1 91990 0 0.0 0.703
ntr2_human 202 5.34x35 TM5 A => T missense 1.087e-05 1 91990 0 1.0 0.005
ntr2_human 201 5.33x34 TM5 T => N missense 1.083e-05 1 92318 0 0.04 0.184
ntr2_human 200 5.32x33 TM5 R => H missense 2.164e-05 2 92434 0 0.17 0.027
ntr2_human 200 5.32x33 TM5 R => C missense 1.079e-05 1 92668 0 0.03 0.946
ntr2_human 200 5.32x33 TM5 R => G missense 1.079e-05 1 92668 0 0.21 0.819
ntr2_human 200 5.32x33 TM5 R => S missense 1.079e-05 1 92668 0 0.47 0.768
ntr2_human 197 ECL2 L => V missense 3.244e-05 3 92484 0 0.38 0.043
ntr2_human 192 ECL2 R => L missense 1.135e-05 1 88130 0 0.95 0.031
ntr2_human 192 ECL2 R => Q missense 0.0002723 24 88130 0 0.28 0.459
ntr2_human 190 ECL2 A => T missense 1.193e-05 1 83836 0 0.07 0.233
ntr2_human 188 ECL2 E => G missense 2.421e-05 2 82614 0 0.07 0.045
ntr2_human 183 ECL2 A => V missense 1.335e-05 1 74884 0 0.21 0.011
ntr2_human 182 ECL2 T => M missense 2.681e-05 2 74594 0 0.05 0.123
ntr2_human 174 4.64x65 TM4 M => T missense 3.238e-05 2 61760 0 0.03 0.018
ntr2_human 166 4.56x56 TM4 L => P missense 2.908e-05 1 34382 0 0.0 0.925
ntr2_human 163 4.53x53 TM4 S => L missense 3.293e-05 1 30370 0 0.0 0.887
ntr2_human 160 4.50x50 TM4 W => C missense 7.962e-05 2 25120 0 0.0 1.0
ntr2_human 159 4.49x49 TM4 S => L missense 0.0001271 3 23604 0 0.15 0.0
ntr2_human 154 4.44x44 TM4 W => R missense 5.461e-05 1 18310 0 0.72 0.0
ntr2_human 150 4.40x40 TM4 R => G missense 6.456e-05 1 15490 0 0.09 0.878
ntr2_human 141 34.51x51 ICL2 L => P missense 0.0001561 2 12816 0 0.04 0.034 GP (contact)
ntr2_human 133 3.50x50 TM3 R => G missense 8.243e-05 1 12132 0 0.0 0.918 SodiumPocket MicroSwitch GP (contact)
ntr2_human 128 3.45x45 TM3 G => D missense 7.961e-05 1 12562 0 0.0 0.171
ntr2_human 121 3.38x38 TM3 A => V missense 0.0004267 6 14060 0 0.0 0.516
ntr2_human 98 ECL1 H => R missense 0.0002051 7 34138 0 0.04 0.128
ntr2_human 96 2.67x66 TM2 W => C missense 0.0001132 4 35326 0 0.0 0.985
ntr2_human 95 2.66x65 TM2 V => M missense 2.729e-05 1 36638 0 0.0 1.0
ntr2_human 91 2.62x61 TM2 L => F missense 2.538e-05 1 39400 0 0.0 1.0
ntr2_human 88 2.59x58 TM2 P => S missense 7.402e-05 3 40528 0 0.0 1.0
ntr2_human 86 2.57x56 TM2 G => R missense 2.412e-05 1 41452 0 0.04 0.826
ntr2_human 78 2.49x49 TM2 A => V missense 2.805e-05 1 35654 0 0.05 0.217
ntr2_human 71 2.42x42 TM2 H => L missense 3.755e-05 1 26634 0 0.0 0.722
ntr2_human 65 ICL1 A => T missense 7.659e-05 1 13056 0 0.2 0.335
ntr2_human 63 ICL1 G => W missense 0.0001975 2 10126 0 0.09 0.998
ntr2_human 60 1.60x60 TM1 A => E missense 0.0001108 1 9022 0 0.45 0.01
ntr2_human 55 1.55x55 TM1 H => R missense 0.0001178 1 8486 0 0.24 0.022
ntr2_human 54 1.54x54 TM1 A => V missense 0.9965 9959 9994 4962 1.0 0.0
ntr2_human 42 1.42x42 TM1 I => T missense 0.0001198 1 8344 0 0.1 0.024
ntr2_human 405 C-term P => SerfsTer13 frameshift 1.691e-05 2 118242 0 None None
ntr2_human 369 8.54x54 H8 F => ProfsTer48 frameshift 8.237e-06 1 121398 0 None None
ntr2_human 367 8.52x52 H8 K => AsnfsTer17 frameshift 8.237e-06 1 121398 0 None None
ntr2_human 348 7.43x42 TM7 Y => Ter stop gained 1.647e-05 2 121406 0 None None
ntr2_human 346 7.41x40 TM7 L => PhefsTer8 frameshift 9.061e-05 11 121400 0 None None
ntr2_human 333 7.28x27 TM7 Y => Ter stop gained 9.08e-05 11 121148 0 None None
ntr2_human 300 6.38x38 TM6 R => LysfsTer43 frameshift 3.326e-05 4 120280 1 None None
ntr2_human 179 ECL2 E => Ter stop gained 0.0001878 13 69236 0 None None
ntr2_human 96 2.67x66 TM2 W => Ter stop gained 2.81e-05 1 35590 0 None None
ntr2_human 43 1.43x43 TM1 W => Ter stop gained 0.0001198 1 8348 0 None None
ntr2_human 30 1.30x30 TM1 W => Ter stop gained 0.0002788 2 7174 0 None None


Residue

Diagrams

ICL1 R A G R A ICL1ECL1 H Y P W V F ECL1 P L R A R S L L ICL2ECL2 G Q K H E L E T A D G E P E P A S R V C T V L V S ECL2ICL3 T S T P G S S T P S R L E L L S E E G L L S F I V W K K T F I Q G G Q V S L V R H K D ICL3ECL3 P D D A W ECL3N-term M E T S S P R P P R P S S N P G L S L D A R L G V D T R N-termC-term S S L C G E H H P M K R L P P K P Q S P T L M D T A S G F G D P P E T R T C-term L W A K V L F T A L Y A L I W A L G A A G N A L S A H V V L K A G R L R H H V L S L A L A G L L L L L V G V P V E L Y S F V W F G D L G C R G Y Y F V H E L C A Y A T V L S V A G L S A E R C L A V C Q T P R R T R W L V A L S W A A S L G L A L P M A V I M R T A L Q V F I Q V N V L V S F V L P L A L T A F L N G V T V S H L L A L C S Q V P S V R R I R S L Q R S V Q V L R A I V V M Y V I C W L P Y H A R R L M Y C Y V T D P L Y N F Y H Y F Y M V T N T L F Y V S S A V T P L L Y N A V S S S F L E F R K L A V
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