Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
oprd_human 10 N-term E => K missense 0.0002279 1 4388 0 0.7 0.001
oprd_human 14 N-term P => L missense 0.0003863 3 7766 0 0.3 0.0
oprd_human 22 N-term A => T missense 0.0001888 2 10596 0 0.5 0.0
oprd_human 24 N-term P => A missense 0.0001817 2 11006 0 0.13 0.001
oprd_human 27 N-term C => F missense 0.9198 23407 25448 10722 0.72 0.0
oprd_human 44 1.27x27 TM1 S => L missense 2.23e-05 1 44836 0 0.23 0.012
oprd_human 45 1.28x28 TM1 S => T missense 2.112e-05 1 47358 0 0.15 0.483
oprd_human 48 1.31x31 TM1 L => Q missense 0.0001976 12 60728 0 0.08 0.902
oprd_human 48 1.31x31 TM1 L => P missense 1.647e-05 1 60728 0 0.1 0.902
oprd_human 52 1.35x35 TM1 I => V missense 0.00803 611 76086 24 0.05 0.141
oprd_human 55 1.38x38 TM1 L => F missense 1.185e-05 1 84388 0 0.01 0.86
oprd_human 61 1.44x44 TM1 A => S missense 1.085e-05 1 92160 0 0.06 0.03
oprd_human 65 1.48x48 TM1 L => V missense 1.064e-05 1 94008 0 1.0 0.01
oprd_human 68 1.51x51 TM1 V => L missense 6.415e-05 6 93532 0 0.45 0.003
oprd_human 71 1.54x54 TM1 M => T missense 1.099e-05 1 91000 0 0.0 0.365
oprd_human 72 1.55x55 TM1 F => L missense 1.115e-05 1 89678 0 0.0 0.403
oprd_human 73 1.56x56 TM1 G => V missense 1.141e-05 1 87680 0 1.0 0.011
oprd_human 76 1.59x59 TM1 R => W missense 1.199e-05 1 83418 0 0.0 0.944
oprd_human 79 12.49x49 ICL1 K => E missense 1.675e-05 2 119386 0 0.0 0.975
oprd_human 79 12.49x49 ICL1 K => R missense 8.371e-06 1 119454 0 0.0 0.888
oprd_human 83 2.38x38 TM2 A => P missense 8.333e-06 1 120010 0 0.01 0.45
oprd_human 95 2.50x50 TM2 D => N missense 8.28e-06 1 120774 0 0.0 0.995
oprd_human 96 2.51x51 TM2 A => V missense 8.277e-06 1 120822 0 0.19 0.372
oprd_human 96 2.51x51 TM2 A => G missense 8.277e-06 1 120822 0 0.0 0.72
oprd_human 100 2.55x55 TM2 S => T missense 8.268e-06 1 120954 0 0.48 0.023
oprd_human 100 2.55x55 TM2 S => R missense 8.267e-06 1 120958 0 0.03 0.778
oprd_human 101 2.56x56 TM2 T => M missense 8.267e-06 1 120968 0 0.0 0.877
oprd_human 106 2.61x61 TM2 S => G missense 1.652e-05 2 121096 0 0.33 0.115
oprd_human 107 2.62x62 TM2 A => V missense 8.257e-06 1 121104 0 0.34 0.116
oprd_human 113 23.49x49 ECL1 T => M missense 1.65e-05 2 121180 0 0.22 0.657
oprd_human 113 23.49x49 ECL1 T => R missense 1.65e-05 2 121180 0 0.43 0.932
oprd_human 117 3.21x21 TM3 G => S missense 1.65e-05 2 121236 0 0.04 0.945
oprd_human 118 3.22x22 TM3 E => K missense 3.299e-05 4 121254 0 0.38 0.03
oprd_human 120 3.24x24 TM3 L => I missense 2.474e-05 3 121280 0 0.11 0.18
oprd_human 121 3.25x25 TM3 C => R missense 1.649e-05 2 121288 0 0.0 0.989
oprd_human 122 3.26x26 TM3 K => E missense 8.244e-06 1 121296 0 0.0 0.985
oprd_human 122 3.26x26 TM3 K => R missense 8.244e-06 1 121300 0 0.49 0.889
oprd_human 127 3.31x31 TM3 I => V missense 8.241e-06 1 121342 0 0.49 0.116
oprd_human 129 3.33x33 TM3 Y => C missense 8.24e-06 1 121354 0 0.09 0.35 LB (polar (hydrogen bond))
oprd_human 132 3.36x36 TM3 M => I missense 8.24e-06 1 121362 0 0.0 0.533 LB (hydrophobic)
oprd_human 142 3.46x46 TM3 M => L missense 2.472e-05 3 121376 0 0.26 0.938
oprd_human 142 3.46x46 TM3 M => I missense 8.239e-06 1 121378 0 0.0 0.995
oprd_human 146 3.50x50 TM3 R => C missense 8.24e-06 1 121366 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
oprd_human 146 3.50x50 TM3 R => H missense 1.648e-05 2 121368 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
oprd_human 156 34.53x53 ICL2 A => S missense 8.245e-06 1 121286 0 0.16 0.426 GP (contact)
oprd_human 158 34.55x55 ICL2 D => E missense 8.25e-06 1 121210 0 0.06 0.316 GP (contact)
oprd_human 160 34.57x57 ICL2 R => C missense 8.253e-06 1 121162 0 0.02 1.0 GP (contact)
oprd_human 160 34.57x57 ICL2 R => H missense 8.255e-06 1 121146 0 0.0 0.999 GP (contact)
oprd_human 161 4.38x38 TM4 T => M missense 8.254e-06 1 121156 0 0.01 0.999
oprd_human 165 4.42x42 TM4 A => V missense 8.263e-06 1 121018 0 0.0 0.999
oprd_human 171 4.48x48 TM4 C => R missense 1.658e-05 2 120614 0 0.0 0.957
oprd_human 181 4.58x58 TM4 V => M missense 8.481e-06 1 117914 0 0.04 0.715
oprd_human 181 4.58x58 TM4 V => L missense 8.481e-06 1 117914 0 1.0 0.081
oprd_human 183 4.60x60 TM4 I => V missense 0.0001626 19 116816 0 0.58 0.076
oprd_human 186 4.63x63 TM4 M => V missense 8.755e-06 1 114218 0 0.02 0.275
oprd_human 186 4.63x63 TM4 M => K missense 1.758e-05 2 113762 0 0.0 0.864
oprd_human 190 ECL2 R => H missense 1.921e-05 2 104120 0 0.01 0.006
oprd_human 192 ECL2 R => W missense 9.898e-06 1 101028 0 0.0 0.663
oprd_human 192 ECL2 R => Q missense 2.988e-05 3 100392 0 0.25 0.013
oprd_human 194 ECL2 G => R missense 8.97e-06 1 111484 0 0.01 0.936
oprd_human 197 ECL2 V => M missense 8.82e-06 1 113374 0 0.25 0.073
oprd_human 208 5.33x34 TM5 Y => C missense 8.429e-06 1 118636 0 0.02 0.997
oprd_human 213 5.38x39 TM5 T => S missense 8.328e-06 1 120074 0 0.0 0.721 PTM (Phosphorylation)
oprd_human 218 5.43x44 TM5 F => L missense 8.288e-06 1 120658 0 0.0 0.972
oprd_human 220 5.45x46 TM5 F => L missense 1.656e-05 2 120740 0 0.4 0.156
oprd_human 221 5.46x461 TM5 A => S missense 8.281e-06 1 120756 0 0.36 0.712
oprd_human 229 5.54x54 TM5 I => T missense 8.286e-06 1 120692 0 0.0 0.993
oprd_human 231 5.56x56 TM5 V => L missense 8.29e-06 1 120630 0 0.66 0.48
oprd_human 236 5.61x61 TM5 M => V missense 8.305e-06 1 120404 0 0.02 0.421 GP (contact)
oprd_human 237 5.62x62 TM5 L => P missense 8.316e-06 1 120256 0 0.0 0.949
oprd_human 242 5.67x67 TM5 S => R missense 8.35e-06 1 119762 0 0.03 0.008 GP (contact)
oprd_human 246 ICL3 L => P missense 2.521e-05 3 119004 0 0.02 0.515
oprd_human 247 ICL3 S => W missense 8.425e-06 1 118696 0 0.0 0.999
oprd_human 250 6.24x24 TM6 K => E missense 2.547e-05 3 117774 0 0.01 0.845
oprd_human 250 6.24x24 TM6 K => R missense 0.0001698 20 117754 0 0.65 0.139
oprd_human 253 6.27x27 TM6 D => H missense 2.59e-05 3 115822 0 0.01 0.87
oprd_human 254 6.28x28 TM6 R => C missense 8.721e-06 1 114668 0 0.0 0.999 GP (contact)
oprd_human 261 6.35x35 TM6 R => L missense 0.0002822 31 109862 0 0.08 0.994
oprd_human 263 6.37x37 TM6 V => L missense 9.17e-06 1 109054 0 0.0 0.954 GP (contact)
oprd_human 265 6.39x39 TM6 V => M missense 9.267e-06 1 107906 0 0.21 0.978
oprd_human 269 6.43x43 TM6 A => S missense 1.905e-05 2 104976 0 0.0 0.928
oprd_human 271 6.45x45 TM6 V => L missense 3.847e-05 4 103968 0 0.02 0.854
oprd_human 271 6.45x45 TM6 V => L missense 1.924e-05 2 103968 0 0.02 0.854
oprd_human 275 6.49x49 TM6 A => T missense 9.745e-06 1 102620 0 1.0 0.008
oprd_human 275 6.49x49 TM6 A => V missense 2.943e-05 3 101926 0 0.05 0.264
oprd_human 275 6.49x49 TM6 A => G missense 9.811e-06 1 101926 0 0.01 0.664
oprd_human 282 6.56x56 TM6 I => T missense 2.962e-05 3 101286 0 0.0 0.906
oprd_human 292 ECL3 R => C missense 3.04e-05 3 98690 0 0.05 0.608
oprd_human 294 7.29x28 TM7 P => Q missense 1.011e-05 1 98954 0 0.11 0.128
oprd_human 296 7.31x30 TM7 V => M missense 2.017e-05 2 99172 0 0.07 0.491
oprd_human 296 7.31x30 TM7 V => L missense 1.008e-05 1 99172 0 0.28 0.042
oprd_human 309 7.44x43 TM7 A => T missense 0.01309 1353 103352 52 0.93 0.1 SodiumPocket MicroSwitch
oprd_human 310 7.45x45 TM7 N => H missense 9.656e-06 1 103558 0 0.0 1.0
oprd_human 310 7.45x45 TM7 N => S missense 9.661e-06 1 103514 0 0.0 1.0
oprd_human 324 8.49x49 H8 N => S missense 1.063e-05 1 94090 0 0.02 0.906 GP (contact)
oprd_human 330 8.55x55 H8 R => C missense 1.175e-05 1 85086 0 0.0 0.947
oprd_human 334 8.59x59 H8 R => L missense 1.31e-05 1 76332 0 1.0 0.003
oprd_human 339 C-term R => C missense 2.933e-05 2 68196 0 0.04 0.339
oprd_human 340 C-term P => S missense 6.024e-05 4 66402 0 0.73 0.001
oprd_human 343 C-term S => G missense 1.663e-05 1 60124 0 0.44 0.0
oprd_human 346 C-term S => T missense 1.929e-05 1 51838 0 0.29 0.001
oprd_human 347 C-term R => C missense 0.0001369 7 51118 0 0.01 0.008
oprd_human 347 C-term R => H missense 7.908e-05 4 50582 0 0.02 0.781
oprd_human 349 C-term R => H missense 2.146e-05 1 46592 0 0.02 0.011
oprd_human 361 C-term T => N missense 0.0001526 4 26218 0 0.28 0.016 PTM (Phosphorylation)
oprd_human 365 C-term G => D missense 0.0003023 4 13230 0 0.03 0.001
oprd_human 366 C-term P => L missense 0.0002922 3 10268 0 0.2 0.004
oprd_human 367 C-term G => S missense 0.0002143 2 9334 0 0.44 0.062
oprd_human 209 5.34x35 TM5 W => Ter stop gained 5.047e-05 6 118884 0 None None
oprd_human 251 6.25x25 TM6 E => ArgfsTer227 frameshift 8.492e-06 1 117754 0 None None GP (contact)
oprd_human 337 C-term C => Ter stop gained 4.254e-05 3 70520 0 None None
oprd_human 356 C-term R => ProfsTer119 frameshift 2.775e-05 1 36042 0 None None


Residue

Diagrams

T K M K ICL1ECL1 E T W P F ECL1 P V K A L D F R ICL2ECL2 V T R P R D G A V V C M L Q F P S P ECL2ICL3 R L L S G ICL3ECL3 D I D R R ECL3N-term M E P A P S A G A E L Q P P L F A N A S D A Y P S A C P S A G A N A S G P P N-termC-term P C G R P D P S S F S R A R E A T A R E R V T A C T P S D G P G G G A A A C-term G A R S A S S L A L A I A I T A L Y S A V C A V G L L G N V L V M F G I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S A K Y L M G E L L C K A V L S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P A K A K L I N I C I W V L A S G V G V P I M V M A S W Y W D T V T K I C V F L F A F V V P I L I I T V C Y G L M L L R L R S V S K E K D R S L R R I T R M V L V V V G A F V V C W A P I H I F V I V W T L V D P L V V A A L H L C I A L G Y A N S S L N P V L Y A F L D E N F R Q F K R C L C R K
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