Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
oprk_human 380 C-term V => L missense 0.0001098 13 118400 0 nan 0.985
oprk_human 376 C-term M => I missense 8.357e-06 1 119654 0 nan 0.0
oprk_human 376 C-term M => T missense 1.669e-05 2 119818 0 1.0 0.0
oprk_human 374 C-term D => G missense 8.301e-06 1 120472 0 0.06 0.0
oprk_human 374 C-term D => N missense 0.006347 765 120524 16 0.04 0.177
oprk_human 374 C-term D => H missense 8.297e-06 1 120524 0 0.04 0.022
oprk_human 372 C-term D => H missense 1.653e-05 2 120990 0 0.12 0.004
oprk_human 366 C-term D => H missense 8.243e-06 1 121310 0 0.08 0.255
oprk_human 361 C-term R => Q missense 2.472e-05 3 121340 0 0.05 0.003
oprk_human 354 C-term R => P missense 8.24e-06 1 121362 0 0.19 0.222
oprk_human 354 C-term R => W missense 2.472e-05 3 121360 0 0.01 0.329
oprk_human 352 C-term M => I missense 8.24e-06 1 121364 0 0.34 0.003
oprk_human 343 8.56x56 H8 D => N missense 4.944e-05 6 121352 0 0.51 0.94
oprk_human 342 8.55x55 H8 R => Q missense 1.648e-05 2 121338 0 0.44 0.073
oprk_human 342 8.55x55 H8 R => W missense 3.296e-05 4 121346 0 0.0 0.76
oprk_human 339 8.52x52 H8 R => Q missense 8.242e-06 1 121330 0 0.06 0.997
oprk_human 339 8.52x52 H8 R => P missense 1.648e-05 2 121330 0 0.0 0.999
oprk_human 339 8.52x52 H8 R => W missense 8.242e-06 1 121334 0 0.0 0.999
oprk_human 333 7.56x56 TM7 L => P missense 1.648e-05 2 121328 0 0.0 0.956 GP (contact)
oprk_human 331 7.54x54 TM7 A => T missense 2.473e-05 3 121316 0 0.0 0.74
oprk_human 318 7.41x40 TM7 L => F missense 8.246e-06 1 121276 0 0.0 1.0
oprk_human 317 7.40x39 TM7 A => T missense 1.649e-05 2 121270 0 0.02 1.0
oprk_human 306 7.29x28 TM7 T => P missense 8.246e-05 10 121270 0 0.53 0.093
oprk_human 305 7.28x27 TM7 S => G missense 8.246e-06 1 121278 0 0.04 0.001
oprk_human 302 ECL3 T => N missense 8.246e-06 1 121268 0 0.13 0.112
oprk_human 296 6.57x57 TM6 V => A missense 8.245e-06 1 121288 0 0.09 0.999
oprk_human 294 6.55x55 TM6 I => T missense 8.244e-06 1 121300 0 0.07 0.542 LB (hydrophobic)
oprk_human 293 6.54x54 TM6 F => L missense 1.649e-05 2 121300 0 0.09 0.998
oprk_human 291 6.52x52 TM6 H => N missense 7.42e-05 9 121298 1 0.0 0.999
oprk_human 290 6.51x51 TM6 I => V missense 4.122e-05 5 121308 0 0.13 0.997 LB (hydrophobic)
oprk_human 288 6.49x49 TM6 T => I missense 8.244e-06 1 121294 0 0.1 1.0
oprk_human 287 6.48x48 TM6 W => C missense 8.244e-06 1 121298 0 0.0 1.0 SodiumPocket MicroSwitch
oprk_human 286 6.47x47 TM6 C => R missense 2.473e-05 3 121298 0 0.0 0.186
oprk_human 285 6.46x46 TM6 V => I missense 1.649e-05 2 121284 0 0.68 0.023
oprk_human 284 6.45x45 TM6 V => I missense 6.596e-05 8 121290 0 0.63 0.007
oprk_human 281 6.42x42 TM6 A => V missense 1.649e-05 2 121288 0 0.09 1.0
oprk_human 281 6.42x42 TM6 A => S missense 8.245e-06 1 121288 0 0.0 0.999
oprk_human 280 6.41x41 TM6 V => M missense 8.244e-06 1 121300 0 0.0 1.0
oprk_human 274 6.35x35 TM6 R => K missense 8.243e-06 1 121314 0 0.02 0.057
oprk_human 270 6.31x31 TM6 R => H missense 1.649e-05 2 121300 0 0.0 1.0
oprk_human 270 6.31x31 TM6 R => C missense 2.473e-05 3 121314 0 0.0 1.0
oprk_human 269 6.30x30 TM6 L => P missense 1.649e-05 2 121304 0 0.01 1.0 SodiumPocket MicroSwitch
oprk_human 268 6.29x29 TM6 N => K missense 8.243e-06 1 121310 0 0.0 1.0 GP (contact)
oprk_human 257 ICL3 R => Q missense 3.297e-05 4 121336 0 0.01 0.999
oprk_human 257 ICL3 R => W missense 1.648e-05 2 121332 0 0.0 1.0
oprk_human 256 5.68x68 TM5 V => I missense 6.593e-05 8 121334 0 0.0 0.999 GP (contact)
oprk_human 252 5.64x64 TM5 R => C missense 1.648e-05 2 121334 0 0.0 1.0 GP (contact)
oprk_human 250 5.62x62 TM5 I => V missense 8.242e-06 1 121334 0 0.46 0.136
oprk_human 244 5.56x56 TM5 V => I missense 3.298e-05 4 121296 0 0.46 0.023
oprk_human 237 5.49x49 TM5 I => V missense 1.652e-05 2 121102 0 1.0 0.009
oprk_human 237 5.49x49 TM5 I => F missense 8.258e-06 1 121102 0 0.04 0.487
oprk_human 236 5.48x48 TM5 V => M missense 3.305e-05 4 121018 0 0.09 0.798
oprk_human 235 5.47x47 TM5 F => L missense 6.619e-05 8 120872 0 0.0 0.998 SodiumPocket MicroSwitch
oprk_human 232 5.44x45 TM5 I => V missense 8.327e-06 1 120088 0 0.54 0.001
oprk_human 230 5.42x43 TM5 V => I missense 5.861e-05 7 119440 0 0.1 0.999 LB (hydrophobic)
oprk_human 228 5.40x41 TM5 I => S missense 8.41e-06 1 118900 0 0.0 0.565
oprk_human 213 ECL2 Q => R missense 8.741e-06 1 114400 0 0.41 0.998
oprk_human 211 45.51x51 ECL2 S => Y missense 8.781e-06 1 113886 0 0.02 0.958
oprk_human 210 45.50x50 ECL2 C => Y missense 8.831e-06 1 113238 0 0.0 1.0
oprk_human 206 ECL2 D => N missense 3.624e-05 4 110366 0 0.64 0.221
oprk_human 205 ECL2 V => I missense 9.13e-06 1 109526 0 0.42 0.002
oprk_human 204 ECL2 D => N missense 8.377e-06 1 119380 0 0.32 0.575
oprk_human 204 ECL2 D => H missense 3.351e-05 4 119380 0 0.05 0.923
oprk_human 201 ECL2 V => L missense 8.308e-06 1 120370 0 0.4 0.232
oprk_human 200 ECL2 K => N missense 8.299e-06 1 120502 0 0.18 0.014
oprk_human 200 ECL2 K => E missense 0.0004479 54 120574 0 0.38 0.16
oprk_human 186 4.53x53 TM4 S => L missense 5.768e-05 7 121364 0 0.0 0.749
oprk_human 180 4.47x47 TM4 I => M missense 8.237e-06 1 121400 0 0.02 0.917
oprk_human 179 4.46x46 TM4 N => S missense 8.237e-06 1 121400 0 0.07 0.581
oprk_human 177 4.44x44 TM4 I => F missense 1.647e-05 2 121402 0 0.01 0.009
oprk_human 176 4.43x43 TM4 K => N missense 8.237e-06 1 121402 0 0.0 0.966
oprk_human 175 4.42x42 TM4 A => S missense 8.237e-06 1 121404 0 0.0 0.97
oprk_human 170 34.57x57 ICL2 R => C missense 5.766e-05 7 121402 0 0.0 0.994 GP (contact)
oprk_human 169 34.56x56 ICL2 F => S missense 8.237e-06 1 121404 0 0.0 0.999 GP (contact)
oprk_human 164 34.51x51 ICL2 V => M missense 1.648e-05 2 121382 0 0.02 0.991 GP (contact)
oprk_human 160 3.54x54 TM3 V => M missense 2.471e-05 3 121386 0 0.0 1.0 GP (contact)
oprk_human 157 3.51x51 TM3 Y => S missense 8.238e-06 1 121384 0 0.0 1.0
oprk_human 156 3.50x50 TM3 R => H missense 8.24e-06 1 121356 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
oprk_human 156 3.50x50 TM3 R => C missense 7.416e-05 9 121356 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
oprk_human 154 3.48x48 TM3 V => M missense 8.239e-06 1 121372 0 0.06 1.0
oprk_human 153 3.47x47 TM3 S => R missense 8.239e-06 1 121368 0 0.0 1.0
oprk_human 152 3.46x46 TM3 M => I missense 8.239e-06 1 121368 0 0.0 0.996
oprk_human 152 3.46x46 TM3 M => R missense 8.239e-06 1 121370 0 0.0 0.998
oprk_human 148 3.42x42 TM3 T => N missense 1.648e-05 2 121364 0 0.01 1.0
oprk_human 144 3.38x38 TM3 T => S missense 8.239e-06 1 121374 0 0.01 0.97
oprk_human 142 3.36x36 TM3 M => K missense 8.239e-06 1 121380 0 0.0 0.998 LB (hydrophobic)
oprk_human 134 3.28x28 TM3 V => I missense 8.238e-06 1 121390 0 0.11 0.015 LB (hydrophobic)
oprk_human 133 3.27x27 TM3 I => T missense 0.0001977 24 121396 0 0.23 0.414
oprk_human 133 3.27x27 TM3 I => L missense 0.0001318 16 121396 0 0.36 0.107
oprk_human 129 3.23x23 TM3 V => L missense 8.237e-06 1 121408 0 0.61 0.204
oprk_human 127 3.21x21 TM3 G => R missense 1.647e-05 2 121406 0 0.0 1.0
oprk_human 126 23.52x52 ECL1 F => S missense 8.237e-06 1 121406 0 0.0 0.999
oprk_human 125 23.51x51 ECL1 P => R missense 8.237e-06 1 121406 0 0.0 1.0
oprk_human 121 2.66x66 TM2 M => L missense 8.237e-06 1 121406 0 1.0 0.01
oprk_human 119 2.64x64 TM2 Y => F missense 8.237e-06 1 121406 0 0.08 0.198
oprk_human 117 2.62x62 TM2 T => M missense 8.237e-06 1 121402 0 0.1 0.942
oprk_human 112 2.57x57 TM2 M => T missense 8.24e-06 1 121362 0 0.0 0.997
oprk_human 112 2.57x57 TM2 M => V missense 8.24e-06 1 121362 0 0.12 0.994
oprk_human 105 2.50x50 TM2 D => N missense 8.254e-06 1 121152 0 0.0 1.0
oprk_human 100 2.45x45 TM2 N => S missense 8.27e-06 1 120918 0 0.01 0.999
oprk_human 98 2.43x43 TM2 I => M missense 3.311e-05 4 120822 0 0.0 1.0
oprk_human 94 2.39x39 TM2 T => P missense 2.492e-05 3 120398 0 0.0 1.0
oprk_human 93 2.38x38 TM2 A => V missense 2.494e-05 3 120292 0 0.21 0.7
oprk_human 92 2.37x37 TM2 T => I missense 2.498e-05 3 120104 0 0.0 1.0
oprk_human 84 1.57x57 TM1 I => V missense 8.701e-06 1 114932 0 nan 0.978
oprk_human 83 1.56x56 TM1 V => M missense 2.598e-05 3 115474 0 nan 0.999
oprk_human 83 1.56x56 TM1 V => L missense 8.66e-06 1 115474 0 nan 0.995
oprk_human 72 1.45x45 TM1 V => L missense 8.483e-06 1 117876 0 0.05 0.995
oprk_human 72 1.45x45 TM1 V => L missense 1.697e-05 2 117876 0 0.05 0.995
oprk_human 71 1.44x44 TM1 V => A missense 8.492e-06 1 117762 0 nan 0.819
oprk_human 70 1.43x43 TM1 F => L missense 8.493e-06 1 117750 0 0.01 0.993
oprk_human 65 1.38x38 TM1 V => I missense 8.518e-06 1 117398 0 nan 0.99
oprk_human 63 1.36x36 TM1 T => M missense 5.969e-05 7 117278 0 nan 0.999
oprk_human 61 1.34x34 TM1 I => F missense 8.568e-06 1 116716 0 nan 0.998
oprk_human 57 1.30x30 TM1 A => T missense 8.652e-06 1 115584 0 nan 0.621
oprk_human 56 N-term P => Q missense 1.736e-05 2 115176 0 nan 0.948
oprk_human 54 N-term I => N missense 1.747e-05 2 114464 0 nan 0.858
oprk_human 54 N-term I => V missense 1.749e-05 2 114362 0 nan 0.022
oprk_human 51 N-term P => S missense 8.925e-06 1 112044 0 nan 0.019
oprk_human 48 N-term Q => K missense 1.826e-05 2 109540 0 0.72 0.15
oprk_human 43 N-term G => R missense 9.55e-06 1 104716 0 0.17 0.799
oprk_human 40 N-term G => S missense 9.559e-06 1 104618 0 nan 0.021
oprk_human 40 N-term G => C missense 9.559e-06 1 104618 0 nan 0.878
oprk_human 38 N-term S => N missense 9.725e-06 1 102824 0 0.45 0.011
oprk_human 38 N-term S => G missense 1.944e-05 2 102898 1 0.46 0.003
oprk_human 37 N-term D => Y missense 9.83e-06 1 101730 0 nan 0.95
oprk_human 35 N-term E => K missense 2.022e-05 2 98910 0 nan 0.848
oprk_human 34 N-term A => V missense 2.028e-05 2 98600 0 nan 0.111
oprk_human 31 N-term P => L missense 2.101e-05 2 95208 0 0.09 0.73
oprk_human 28 N-term A => D missense 3.298e-05 3 90958 0 nan 0.004
oprk_human 28 N-term A => S missense 4.436e-05 4 90170 0 nan 0.006
oprk_human 27 N-term S => R missense 5.61e-05 5 89134 0 0.07 0.444
oprk_human 25 N-term N => K missense 1.16e-05 1 86238 0 nan 0.91 PTM (N-linked Glycosylation)
oprk_human 24 N-term P => R missense 0.000157 13 82822 0 0.07 0.148
oprk_human 24 N-term P => A missense 1.246e-05 1 80288 0 0.26 0.819
oprk_human 19 N-term S => R missense 0.0002353 16 67988 0 nan 0.105
oprk_human 9 N-term R => H missense 2.278e-05 1 43900 0 nan 0.998
oprk_human 9 N-term R => C missense 6.957e-05 3 43120 0 nan 0.998
oprk_human 5 N-term I => M missense 9.785e-05 4 40880 0 nan 0.563
oprk_human 5 N-term I => N missense 2.458e-05 1 40690 0 nan 0.656
oprk_human 369 C-term Y => Ter stop gained 8.254e-06 1 121152 0 None None
oprk_human 361 C-term R => Ter stop gained 8.241e-06 1 121344 0 None None
oprk_human 263 6.24x24 TM6 R => Ter stop gained 0.000305 37 121324 0 None None
oprk_human 140 3.34x34 TM3 Y => ThrfsTer10 frameshift 8.239e-06 1 121372 0 None None
oprk_human 74 1.47x47 TM1 L => PhefsTer27 frameshift 8.492e-06 1 117760 0 None None


Residue

Diagrams

T K M K ICL1ECL1 N S W P F ECL1 P V K A L D F R ICL2ECL2 G T K V R E D V D V I E C S L Q F P D D ECL2ICL3 R L L S G ICL3ECL3 S T S H ECL3N-term M D S P I Q I F R G E P G P T C A P S A C L P P N S S A W F P G W A E P D S N G S A G S E D A Q L E P A H I S P N-termC-term P L K M R M E R Q S T S R V R N T V Q D P A Y L R D I D G M N K P V C-term A I P V I I T A V Y S V V F V V G L V G N S L V M F V I I R Y T A T N I Y I F N L A L A D A L V T T T M P F Q S T V Y L M G D V L C K I V I S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P L K A K I I N I C I W L L S S S V G I S A I V L G D Y S W W D L F M K I C V F I F A F V I P V L I I I V C Y T L M I L R L K S V S R E K D R N L R R I T R L V L V V V A V F V V C W T P I H I F I L V E A L G S T A A L S S Y Y F C I A L G Y T N S S L N P I L Y A F L D E N F R D F K R C F C F
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