Variation Browser

Download
Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
oprm_human 6 N-term A => V missense 0.0278 2345 84358 219 nan 0.01
oprm_human 7 N-term P => H missense 2.282e-05 2 87626 0 nan 0.996
oprm_human 9 N-term N => K missense 3.167e-05 3 94728 0 nan 0.875
oprm_human 9 N-term N => K missense 1.056e-05 1 94728 0 nan 0.875
oprm_human 10 N-term A => D missense 1.034e-05 1 96750 0 nan 0.535
oprm_human 13 N-term C => G missense 3.892e-05 4 102786 0 nan 0.999
oprm_human 15 N-term D => H missense 2.822e-05 3 106292 0 0.0 0.987
oprm_human 16 N-term A => T missense 9.292e-06 1 107616 0 nan 0.022
oprm_human 16 N-term A => G missense 9.252e-06 1 108080 0 nan 0.185
oprm_human 18 N-term A => T missense 9.062e-06 1 110348 0 nan 0.108
oprm_human 18 N-term A => V missense 5.418e-05 6 110746 0 0.04 0.115
oprm_human 18 N-term A => G missense 1.806e-05 2 110746 0 nan 0.753
oprm_human 21 N-term S => G missense 8.764e-06 1 114098 0 0.03 0.025
oprm_human 23 N-term S => P missense 1.728e-05 2 115760 0 0.07 0.054
oprm_human 23 N-term S => F missense 8.621e-06 1 115990 0 nan 0.817
oprm_human 25 N-term A => T missense 8.535e-06 1 117168 0 nan 0.155
oprm_human 27 N-term S => I missense 8.447e-06 1 118382 0 0.01 0.731
oprm_human 35 N-term S => Y missense 8.334e-06 1 119992 0 0.0 0.999
oprm_human 36 N-term H => Y missense 0.0001333 16 120048 0 0.15 0.583
oprm_human 38 N-term D => Y missense 4.16e-05 5 120182 0 0.03 0.964
oprm_human 40 N-term N => D missense 0.1856 22327 120298 2888 0.04 0.978
oprm_human 42 N-term S => T missense 0.002285 275 120364 4 0.07 0.709
oprm_human 42 N-term S => F missense 8.31e-06 1 120340 0 0.01 0.945
oprm_human 43 N-term D => V missense 8.31e-06 1 120334 0 0.02 0.974
oprm_human 46 N-term G => C missense 1.662e-05 2 120306 0 0.01 0.994
oprm_human 48 N-term N => K missense 1.663e-05 2 120286 0 0.02 0.977
oprm_human 51 N-term D => N missense 8.317e-06 1 120236 0 0.19 0.248
oprm_human 53 N-term G => S missense 8.318e-06 1 120224 0 0.08 0.646
oprm_human 54 N-term G => R missense 8.322e-06 1 120158 0 0.0 0.509
oprm_human 55 N-term R => I missense 8.324e-06 1 120134 0 0.04 0.395
oprm_human 58 N-term L => P missense 8.33e-06 1 120046 0 0.06 0.054
oprm_human 59 N-term C => Y missense 8.334e-06 1 119986 0 0.1 0.989
oprm_human 60 N-term P => S missense 8.338e-06 1 119926 0 0.05 0.219
oprm_human 62 N-term T => S missense 8.345e-06 1 119834 0 0.46 0.051
oprm_human 63 N-term G => V missense 4.174e-05 5 119796 0 0.0 0.991
oprm_human 66 N-term S => F missense 9.193e-05 11 119662 0 0.0 0.991
oprm_human 67 1.29x29 TM1 M => V missense 2.508e-05 3 119636 0 0.1 0.051
oprm_human 67 1.29x29 TM1 M => T missense 1.672e-05 2 119610 0 0.17 0.051
oprm_human 68 1.30x30 TM1 I => T missense 3.349e-05 4 119434 0 0.01 0.757
oprm_human 71 1.33x33 TM1 I => V missense 8.39e-06 1 119188 0 0.39 0.147
oprm_human 74 1.36x36 TM1 M => T missense 9.269e-05 11 118676 0 0.39 0.076
oprm_human 76 1.38x38 TM1 L => P missense 8.46e-06 1 118206 0 0.0 0.991
oprm_human 79 1.41x41 TM1 I => T missense 8.524e-06 1 117320 0 0.01 0.951
oprm_human 80 1.42x42 TM1 V => L missense 1.711e-05 2 116880 0 0.0 0.999
oprm_human 81 1.43x43 TM1 C => R missense 8.562e-06 1 116790 0 0.0 1.0
oprm_human 85 1.47x47 TM1 L => I missense 8.702e-06 1 114922 0 0.0 0.999
oprm_human 92 1.54x54 TM1 M => R missense 1.785e-05 2 112024 0 0.0 0.998
oprm_human 93 1.55x55 TM1 Y => H missense 8.931e-06 1 111964 0 0.0 0.994
oprm_human 98 1.60x60 TM1 Y => C missense 8.71e-06 1 114816 0 0.0 1.0
oprm_human 99 12.48x48 ICL1 T => A missense 8.68e-06 1 115212 0 0.4 0.999
oprm_human 100 12.49x49 ICL1 K => T missense 8.623e-06 1 115966 0 0.0 1.0
oprm_human 104 2.38x38 TM2 A => D missense 0.0001275 15 117626 1 0.0 1.0
oprm_human 115 2.49x49 TM2 A => V missense 8.295e-06 1 120550 0 0.0 1.0
oprm_human 119 2.53x53 TM2 A => P missense 8.287e-06 1 120674 0 0.08 0.989
oprm_human 122 2.56x56 TM2 T => S missense 3.313e-05 4 120730 0 0.19 0.999
oprm_human 122 2.56x56 TM2 T => I missense 8.282e-06 1 120742 0 0.0 1.0
oprm_human 125 2.59x59 TM2 F => L missense 4.141e-05 5 120756 0 0.0 0.654
oprm_human 132 2.66x66 TM2 M => I missense 8.281e-06 1 120762 0 0.01 0.702
oprm_human 144 3.27x27 TM3 I => L missense 1.656e-05 2 120776 0 0.22 0.343
oprm_human 144 3.27x27 TM3 I => T missense 3.312e-05 4 120774 0 0.18 0.913
oprm_human 147 3.30x30 TM3 S => P missense 8.28e-06 1 120774 0 0.0 1.0 LB (polar (charge-charge))
oprm_human 147 3.30x30 TM3 S => A missense 8.28e-06 1 120774 0 0.22 0.998 LB (polar (charge-charge))
oprm_human 147 3.30x30 TM3 S => C missense 0.00462 558 120772 1 0.0 1.0 LB (polar (charge-charge))
oprm_human 148 3.31x31 TM3 I => V missense 1.656e-05 2 120774 0 0.33 0.998 LB (polar (hydrogen bond))
oprm_human 152 3.35x35 TM3 N => D missense 0.0007617 92 120782 0 0.0 1.0
oprm_human 153 3.36x36 TM3 M => V missense 1.656e-05 2 120780 0 0.0 0.996
oprm_human 155 3.38x38 TM3 T => I missense 0.0002236 27 120776 0 0.01 0.919
oprm_human 159 3.42x42 TM3 T => A missense 8.279e-06 1 120782 0 0.02 1.0
oprm_human 161 3.44x44 TM3 C => S missense 2.484e-05 3 120778 0 0.0 0.403
oprm_human 162 3.45x45 TM3 T => A missense 8.28e-06 1 120778 0 0.09 0.919
oprm_human 165 3.48x48 TM3 V => I missense 1.656e-05 2 120782 0 0.2 0.398
oprm_human 165 3.48x48 TM3 V => D missense 8.28e-06 1 120778 0 0.0 0.994
oprm_human 167 3.50x50 TM3 R => Q missense 8.279e-06 1 120782 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
oprm_human 171 3.54x54 TM3 V => A missense 8.279e-06 1 120784 0 0.0 1.0 GP (contact)
oprm_human 174 34.50x50 ICL2 P => A missense 4.14e-05 5 120778 0 0.0 1.0 GP (contact)
oprm_human 174 34.50x50 ICL2 P => S missense 8.28e-06 1 120778 0 0.0 1.0 GP (contact)
oprm_human 174 34.50x50 ICL2 P => R missense 8.28e-06 1 120778 0 0.0 1.0 GP (contact)
oprm_human 177 34.53x53 ICL2 A => S missense 8.28e-06 1 120766 0 0.13 0.999 GP (contact)
oprm_human 180 34.56x56 ICL2 F => S missense 1.656e-05 2 120762 0 0.0 0.996 GP (contact)
oprm_human 181 34.57x57 ICL2 R => C missense 0.001673 202 120762 0 0.0 1.0 GP (contact)
oprm_human 181 34.57x57 ICL2 R => H missense 3.313e-05 4 120748 0 0.0 1.0 GP (contact)
oprm_human 183 4.39x39 TM4 P => A missense 8.281e-06 1 120762 0 0.01 1.0
oprm_human 184 4.40x40 TM4 R => Q missense 2.484e-05 3 120752 0 0.09 0.459
oprm_human 190 4.46x46 TM4 N => K missense 0.0002817 34 120708 0 0.0 1.0
oprm_human 191 4.47x47 TM4 V => I missense 8.285e-06 1 120704 0 0.34 0.065
oprm_human 192 4.48x48 TM4 C => F missense 0.005328 643 120688 5 0.01 0.996
oprm_human 193 4.49x49 TM4 N => D missense 8.287e-06 1 120676 0 0.0 0.987
oprm_human 194 4.50x50 TM4 W => S missense 8.29e-06 1 120632 0 0.0 1.0
oprm_human 195 4.51x51 TM4 I => V missense 8.291e-06 1 120612 0 0.63 0.628
oprm_human 199 4.55x55 TM4 A => T missense 1.662e-05 2 120352 0 0.07 0.871
oprm_human 201 4.57x57 TM4 G => V missense 8.326e-06 1 120106 0 0.03 1.0
oprm_human 205 4.61x61 TM4 M => T missense 0.0001761 21 119238 0 0.03 0.155
oprm_human 209 ECL2 T => K missense 8.471e-06 1 118050 0 0.33 0.845
oprm_human 210 ECL2 T => A missense 8.471e-06 1 118054 0 0.18 0.615
oprm_human 215 ECL2 G => C missense 8.582e-06 1 116524 0 0.0 0.993
oprm_human 215 ECL2 G => S missense 4.291e-05 5 116524 0 0.02 0.749
oprm_human 215 ECL2 G => V missense 8.52e-06 1 117376 0 0.0 0.981
oprm_human 217 ECL2 I => V missense 8.453e-06 1 118302 0 0.15 0.321
oprm_human 219 45.50x50 ECL2 C => F missense 1.679e-05 2 119134 0 0.0 1.0
oprm_human 222 ECL2 T => I missense 8.347e-06 1 119808 0 0.22 0.007
oprm_human 223 ECL2 F => S missense 1.667e-05 2 120004 0 0.0 1.0
oprm_human 224 ECL2 S => C missense 2.497e-05 3 120142 0 0.0 0.967
oprm_human 225 ECL2 H => Y missense 8.319e-06 1 120204 0 0.0 0.977
oprm_human 227 5.31x32 TM5 T => A missense 4.981e-05 6 120458 0 0.28 0.826
oprm_human 234 5.38x39 TM5 L => P missense 1.657e-05 2 120694 0 0.0 0.985
oprm_human 235 5.39x40 TM5 K => M missense 8.284e-06 1 120710 0 0.07 0.998
oprm_human 235 5.39x40 TM5 K => N missense 8.284e-06 1 120708 0 0.01 0.86
oprm_human 237 5.41x42 TM5 C => Y missense 8.283e-05 10 120724 0 0.37 1.0
oprm_human 238 5.42x43 TM5 V => I missense 8.283e-06 1 120726 0 0.09 1.0
oprm_human 240 5.44x45 TM5 I => M missense 1.656e-05 2 120740 0 0.01 1.0
oprm_human 242 5.46x461 TM5 A => T missense 8.282e-06 1 120740 0 0.0 1.0
oprm_human 244 5.48x48 TM5 I => V missense 2.485e-05 3 120748 0 0.57 0.432
oprm_human 244 5.48x48 TM5 I => F missense 8.282e-06 1 120748 0 0.24 0.945
oprm_human 245 5.49x49 TM5 M => V missense 8.282e-06 1 120748 0 0.06 0.823
oprm_human 247 5.51x51 TM5 V => M missense 1.656e-05 2 120746 0 0.01 0.979
oprm_human 249 5.53x53 TM5 I => V missense 8.282e-06 1 120740 0 0.49 0.412
oprm_human 249 5.53x53 TM5 I => N missense 4.141e-05 5 120738 0 0.0 0.986
oprm_human 251 5.55x55 TM5 T => A missense 8.282e-06 1 120744 0 0.05 0.885
oprm_human 252 5.56x56 TM5 V => M missense 2.485e-05 3 120744 0 0.04 0.984
oprm_human 252 5.56x56 TM5 V => L missense 8.282e-06 1 120744 0 0.15 0.828
oprm_human 253 5.57x57 TM5 C => S missense 8.282e-06 1 120750 0 0.01 1.0
oprm_human 254 5.58x58 TM5 Y => C missense 8.282e-06 1 120748 0 0.0 1.0 SodiumPocket MicroSwitch
oprm_human 256 5.60x60 TM5 L => P missense 1.656e-05 2 120756 0 0.0 0.997
oprm_human 257 5.61x61 TM5 M => I missense 4.141e-05 5 120754 0 nan 0.999 GP (contact)
oprm_human 257 5.61x61 TM5 M => I missense 8.281e-06 1 120754 0 nan 0.999 GP (contact)
oprm_human 260 5.64x64 TM5 R => C missense 0.0001491 18 120756 0 0.0 1.0 GP (contact)
oprm_human 260 5.64x64 TM5 R => S missense 8.281e-06 1 120756 0 0.0 1.0 GP (contact)
oprm_human 260 5.64x64 TM5 R => H missense 0.0006211 75 120752 1 0.0 1.0 GP (contact)
oprm_human 262 5.66x66 TM5 K => R missense 8.281e-06 1 120760 0 0.46 0.649 GP (contact)
oprm_human 265 ICL3 R => C missense 0.0003396 41 120742 0 0.0 1.0
oprm_human 265 ICL3 R => H missense 8.282e-05 10 120750 0 0.0 1.0
oprm_human 265 ICL3 R => L missense 2.484e-05 3 120750 0 0.01 1.0
oprm_human 267 ICL3 L => H missense 1.656e-05 2 120764 1 0.0 0.999
oprm_human 268 ICL3 S => P missense 0.0002236 27 120760 0 0.01 1.0 PTM (Phosphorylation)
oprm_human 274 6.27x27 TM6 D => N missense 0.0001408 17 120750 0 0.01 1.0
oprm_human 275 6.28x28 TM6 R => G missense 8.282e-06 1 120750 0 0.0 0.994 GP (contact)
oprm_human 277 6.30x30 TM6 L => P missense 2.484e-05 3 120762 0 0.01 1.0 SodiumPocket MicroSwitch
oprm_human 278 6.31x31 TM6 R => Q missense 6.625e-05 8 120748 0 0.0 1.0
oprm_human 282 6.35x35 TM6 R => M missense 8.282e-06 1 120738 0 0.0 0.997
oprm_human 290 6.43x43 TM6 V => M missense 3.312e-05 4 120790 0 0.01 0.997
oprm_human 293 6.46x46 TM6 V => I missense 0.0008527 103 120786 0 nan 0.107 LB (hydrophobic)
oprm_human 302 6.55x55 TM6 V => I missense 9.935e-05 12 120782 0 nan 0.999
oprm_human 303 6.56x56 TM6 I => V missense 8.279e-06 1 120788 0 nan 0.998
oprm_human 313 7.28x27 TM7 T => I missense 1.656e-05 2 120760 0 0.01 0.886
oprm_human 314 7.29x28 TM7 T => M missense 0.0002402 29 120756 0 0.07 0.909
oprm_human 314 7.29x28 TM7 T => R missense 1.656e-05 2 120756 0 0.26 0.19
oprm_human 319 7.34x33 TM7 S => Y missense 8.282e-06 1 120744 0 0.08 0.956
oprm_human 327 7.42x41 TM7 G => C missense 1.656e-05 2 120746 0 0.0 1.0
oprm_human 330 7.45x45 TM7 N => K missense 1.656e-05 2 120738 0 0.0 1.0
oprm_human 331 7.46x46 TM7 S => R missense 0.0001077 13 120746 0 0.0 0.903
oprm_human 334 7.49x49 TM7 N => D missense 8.282e-06 1 120742 0 0.0 1.0 SodiumPocket MicroSwitch
oprm_human 334 7.49x49 TM7 N => K missense 8.281e-06 1 120754 0 0.0 1.0 SodiumPocket MicroSwitch
oprm_human 338 7.53x53 TM7 Y => C missense 4.141e-05 5 120730 0 0.0 1.0 SodiumPocket MicroSwitch PTM (Phosphorylation)
oprm_human 342 8.47x47 H8 D => E missense 8.287e-06 1 120674 0 0.0 0.999 GP (contact)
oprm_human 343 8.48x48 H8 E => D missense 1.658e-05 2 120642 0 0.26 0.986 GP (contact)
oprm_human 346 8.51x51 H8 K => E missense 2.488e-05 3 120572 0 0.0 0.999 GP (contact)
oprm_human 347 8.52x52 H8 R => Q missense 5.809e-05 7 120506 0 0.0 0.996
oprm_human 348 8.53x53 H8 C => R missense 8.299e-05 10 120496 0 0.0 1.0
oprm_human 348 8.53x53 H8 C => F missense 8.302e-06 1 120460 0 0.0 1.0
oprm_human 350 8.55x55 H8 R => G missense 1.661e-05 2 120384 0 0.0 0.982
oprm_human 355 C-term P => S missense 8.344e-06 1 119842 0 0.07 1.0
oprm_human 356 C-term T => A missense 8.344e-06 1 119846 0 0.49 0.055 PTM (Phosphorylation)
oprm_human 358 C-term S => F missense 0.0003676 44 119702 0 0.34 0.399 PTM (Phosphorylation)
oprm_human 360 C-term I => T missense 5.855e-05 7 119550 0 0.17 0.273
oprm_human 363 C-term Q => K missense 8.386e-06 1 119242 0 0.13 0.889
oprm_human 367 C-term R => Q missense 7.61e-05 9 118264 0 0.03 0.999
oprm_human 369 C-term R => H missense 9.32e-05 11 118030 0 0.0 0.969
oprm_human 373 C-term R => K missense 8.524e-06 1 117312 0 0.21 0.851
oprm_human 376 C-term P => S missense 0.0001801 21 116630 0 0.1 0.036
oprm_human 378 C-term T => M missense 0.0005157 60 116348 0 0.05 0.954 PTM (Phosphorylation)
oprm_human 380 C-term N => S missense 1.728e-05 2 115718 0 0.18 0.077
oprm_human 381 C-term T => I missense 8.651e-06 1 115600 0 0.06 0.962
oprm_human 382 C-term V => E missense 8.669e-06 1 115356 0 0.04 0.848
oprm_human 383 C-term D => N missense 8.677e-06 1 115244 0 0.03 0.967
oprm_human 384 C-term R => K missense 8.701e-06 1 114930 0 0.08 0.997
oprm_human 386 C-term N => K missense 8.782e-06 1 113864 0 0.03 0.139
oprm_human 57 N-term S => Ter stop gained 0.0123 242 19678 8 None None
oprm_human 89 1.51x51 TM1 F => ArgfsTer42 frameshift 2.231e-05 1 44828 0 None None
oprm_human 99 12.48x48 ICL1 T => ValfsTer10 frameshift 1.218e-05 1 82120 0 None None
oprm_human 101 12.50x50 ICL1 M => HisfsTer8 frameshift 0.0001705 14 82120 0 None None
oprm_human 114 2.48x48 TM2 L => ValfsTer17 frameshift 1.766e-05 2 113266 0 None None
oprm_human 191 4.47x47 TM4 V => Ter stop gained 8.7e-06 1 114946 0 None None
oprm_human 277 6.30x30 TM6 L => Ter stop gained 0.0001408 17 120754 0 None None SodiumPocket MicroSwitch
oprm_human 307 6.60x60 TM6 L => Ter stop gained 8.567e-06 1 116732 0 None None
oprm_human 321 7.36x35 TM7 H => Ter stop gained 8.294e-06 1 120574 0 None None
oprm_human 137 23.52x52 ECL1 F => Ter stop gained 8.281e-06 1 120754 0 None None
oprm_human 160 3.43x43 TM3 L => Ter stop gained 9.939e-05 12 120736 0 None None
oprm_human 378 C-term T => AlafsTer21 frameshift 1.656e-05 2 120780 0 None None PTM (Phosphorylation)
oprm_human 396 C-term T => LeufsTer2 frameshift 5.047e-05 1 19814 0 None None PTM (Phosphorylation)
oprm_human 398 C-term P => Ter stop gained 5.205e-05 1 19212 0 None None


Residue

Diagrams

T K M K ICL1ECL1 G T W P F ECL1 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H P ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
SnakePlot Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7
HelixBox Download: PNG | SVG