Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
pd2r2_human 346 C-term S => T missense 0.0004677 1 2138 0 0.28 0.124
pd2r2_human 343 C-term R => C missense 0.000528 1 1894 0 0.02 0.985
pd2r2_human 342 C-term R => H missense 0.0005423 2 3688 0 0.02 0.98
pd2r2_human 340 C-term R => H missense 0.0002431 1 4114 0 0.07 0.98
pd2r2_human 332 C-term E => Q missense 0.0007326 6 8190 0 0.05 0.439
pd2r2_human 327 C-term L => M missense 9.088e-05 1 11004 0 0.01 0.99
pd2r2_human 325 C-term S => T missense 8.57e-05 1 11668 0 0.21 0.011 PTM (Phosphorylation)
pd2r2_human 317 8.56x56 H8 R => C missense 0.0006481 9 13886 0 0.0 0.719
pd2r2_human 313 8.52x52 H8 R => C missense 6.707e-05 1 14910 0 0.06 0.517
pd2r2_human 299 7.48x48 TM7 A => V missense 6.193e-05 1 16146 0 0.41 0.002
pd2r2_human 297 7.46x46 TM7 S => T missense 6.191e-05 1 16152 0 0.02 0.761
pd2r2_human 288 7.37x36 TM7 F => L missense 6.808e-05 1 14688 0 0.52 0.007
pd2r2_human 279 7.28x27 TM7 R => Q missense 8.42e-05 1 11876 0 0.54 0.205
pd2r2_human 275 ECL3 N => K missense 9.365e-05 1 10678 0 0.4 0.007
pd2r2_human 275 ECL3 N => T missense 9.353e-05 1 10692 0 0.43 0.012
pd2r2_human 271 6.60x60 TM6 R => Q missense 0.0001065 1 9386 0 0.63 0.08
pd2r2_human 254 6.43x43 TM6 A => D missense 0.0002971 1 3366 0 0.0 0.955
pd2r2_human 246 6.35x35 TM6 R => G missense 0.0005405 1 1850 0 0.0 0.588
pd2r2_human 243 6.32x32 TM6 R => C missense 0.0005 1 2000 0 0.0 0.986 GP (contact)
pd2r2_human 242 6.31x31 TM6 G => V missense 0.0004888 1 2046 0 0.5 0.075
pd2r2_human 236 5.68x68 TM5 R => C missense 0.000471 2 4246 0 0.0 1.0 GP (contact)
pd2r2_human 232 5.64x64 TM5 R => L missense 0.0001244 1 8038 0 0.08 0.04 GP (contact)
pd2r2_human 225 5.57x57 TM5 S => N missense 0.0001933 4 20688 0 0.02 0.988
pd2r2_human 221 5.53x53 TM5 I => T missense 3.229e-05 1 30970 0 0.02 0.125
pd2r2_human 208 5.40x41 TM5 V => I missense 1.483e-05 1 67436 0 1.0 0.007
pd2r2_human 204 5.36x37 TM5 V => A missense 0.996 112410 112860 55985 0.9 0.001
pd2r2_human 204 5.36x37 TM5 V => L missense 8.876e-06 1 112662 0 0.4 0.001
pd2r2_human 202 5.34x35 TM5 R => Q missense 8.803e-06 1 113596 0 0.01 0.997
pd2r2_human 192 ECL2 G => R missense 1.734e-05 2 115348 0 0.12 0.88
pd2r2_human 191 ECL2 P => L missense 1.732e-05 2 115492 0 0.0 0.732
pd2r2_human 190 ECL2 N => K missense 8.643e-06 1 115696 0 0.24 0.124
pd2r2_human 185 ECL2 N => Y missense 8.593e-06 1 116380 0 0.0 0.994
pd2r2_human 184 45.52x52 ECL2 Y => F missense 0.0004383 51 116370 1 0.11 0.989
pd2r2_human 183 45.51x51 ECL2 Y => S missense 8.592e-06 1 116386 0 0.0 0.999
pd2r2_human 183 45.51x51 ECL2 Y => H missense 8.589e-06 1 116430 0 0.0 1.0
pd2r2_human 181 ECL2 M => V missense 3.438e-05 4 116348 0 0.1 0.312
pd2r2_human 179 ECL2 R => S missense 8.614e-06 1 116090 0 0.01 0.995
pd2r2_human 175 ECL2 R => Q missense 8.611e-06 1 116128 0 0.09 0.91
pd2r2_human 167 4.61x62 TM4 F => L missense 0.0001834 21 114508 0 0.01 0.644
pd2r2_human 167 4.61x62 TM4 F => S missense 8.737e-06 1 114462 0 0.07 0.815
pd2r2_human 160 4.54x54 TM4 V => M missense 1.791e-05 2 111642 0 0.01 0.398
pd2r2_human 159 4.53x53 TM4 A => P missense 8.978e-06 1 111384 0 0.0 0.998
pd2r2_human 155 4.49x49 TM4 L => I missense 1.83e-05 2 109302 0 1.0 0.078
pd2r2_human 152 4.46x46 TM4 C => G missense 0.0002434 26 106806 0 0.01 0.99
pd2r2_human 151 4.45x45 TM4 V => A missense 9.453e-06 1 105784 0 0.0 0.23
pd2r2_human 148 4.42x42 TM4 A => V missense 3.895e-05 4 102694 0 0.15 0.79
pd2r2_human 147 4.41x41 TM4 A => V missense 5.909e-05 6 101532 0 0.24 0.016
pd2r2_human 143 34.57x57 ICL2 R => H missense 1.016e-05 1 98438 0 0.0 1.0 GP (contact)
pd2r2_human 143 34.57x57 ICL2 R => C missense 2.038e-05 2 98140 0 0.0 1.0 GP (contact)
pd2r2_human 136 34.50x50 ICL2 P => L missense 3.332e-05 3 90032 0 0.0 1.0 GP (contact)
pd2r2_human 135 3.56x56 TM3 R => P missense 0.000124 11 88728 0 0.04 0.899 GP (contact)
pd2r2_human 135 3.56x56 TM3 R => Q missense 4.508e-05 4 88728 0 0.12 0.73 GP (contact)
pd2r2_human 135 3.56x56 TM3 R => W missense 1.149e-05 1 87024 0 0.22 0.912 GP (contact)
pd2r2_human 134 3.55x55 TM3 V => M missense 0.0006352 55 86592 0 0.03 0.526 GP (contact)
pd2r2_human 114 3.35x35 TM3 N => H missense 2.044e-05 1 48914 0 0.0 1.0
pd2r2_human 104 3.25x25 TM3 C => Y missense 2.75e-05 1 36362 0 0.0 1.0
pd2r2_human 85 2.58x58 TM2 P => S missense 3.82e-05 1 26178 0 0.0 1.0
pd2r2_human 82 2.55x55 TM2 A => V missense 3.887e-05 1 25730 0 0.69 0.315
pd2r2_human 74 2.47x47 TM2 A => E missense 4.259e-05 1 23482 0 0.0 1.0
pd2r2_human 72 2.45x45 TM2 H => N missense 0.0008166 19 23266 0 1.0 0.14
pd2r2_human 62 ICL1 R => H missense 4.513e-05 1 22156 0 0.0 0.06
pd2r2_human 62 ICL1 R => S missense 4.544e-05 1 22008 0 0.04 0.287
pd2r2_human 62 ICL1 R => C missense 4.544e-05 1 22008 0 0.0 0.94
pd2r2_human 60 1.60x60 TM1 R => P missense 4.555e-05 1 21952 0 0.0 0.945
pd2r2_human 58 1.58x58 TM1 G => D missense 4.577e-05 1 21850 0 0.0 1.0
pd2r2_human 44 1.44x44 TM1 L => P missense 4.604e-05 1 21720 0 0.1 0.401
pd2r2_human 34 1.34x34 TM1 A => V missense 4.558e-05 1 21940 0 0.82 0.001
pd2r2_human 34 1.34x34 TM1 A => G missense 4.558e-05 1 21940 0 0.15 0.009
pd2r2_human 30 N-term Y => H missense 4.53e-05 1 22074 0 0.16 0.771
pd2r2_human 29 N-term R => S missense 9.107e-05 2 21962 0 0.02 0.806
pd2r2_human 29 N-term R => C missense 4.553e-05 1 21962 0 0.0 0.877
pd2r2_human 24 N-term S => N missense 4.542e-05 1 22018 0 0.38 0.009
pd2r2_human 19 N-term R => P missense 0.0001365 3 21986 0 0.14 0.161
pd2r2_human 5 N-term A => D missense 5.174e-05 1 19326 0 0.3 0.0
pd2r2_human 308 8.47x47 H8 C => Ter stop gained 0.0001279 2 15632 0 None None GP (contact)
pd2r2_human 150 4.44x44 TM4 K => SerfsTer44 frameshift 0.001046 110 105194 0 None None


Residue

Diagrams

ICL1 M R Q ICL1ECL1 G H S W E L ECL1 P V W A Q N H R ICL2ECL2 D T I S R L D G R I M C Y Y N V L L L N P G P D R D A ECL2ICL3 G R R R ICL3ECL3 H A N P G L ECL3N-term M S A N A T L K P L C P I L E Q M S R L Q S H S N T S I R Y I D N-termC-term L E S V L V D D S E L G G A G S S R R R R T S S T A R S A S P L A L C S R P E E P R G P A R L L G W L L G S C A A S P Q T G P L N R A L S S T S S C-term H A A V L L H G L A S L L G L V E N G V I L F V V G C R T V V T T W V L H L A L S D L L A S A S L P F F T Y F L A V G T T F C K L H S S I F F L N M F A S G F L L S A I S L D R C L Q V V R T V A A A H K V C L V L W A L A V L N T V P Y F V F R T C N S R Q V A L A V S K F L L A F L V P L A I I A S S H A A V S L R L Q H R P G R F V R L V A A V V A A F A L C W G P Y H V F S L L E A R A R P L V W R G L P F V T S L A F F N S V A N P V L Y V L T C P D L R R V M L R K S L R T
SnakePlot Download: PNG | SVG G N E V L G L L S A L G H L L V A A H 1 L H L A L S D L L A S A S L P F F T Y F 2 A S L L F G S A F M N L F F I S S H L K 3 A H K V C L V L W A L A V L N T V P Y 4 H S S A I I A L P V L F A L L F K S V A L 5 A A V V A A F A L C W G P Y H V F S L L 6 V P N A V S N F F A L S T V F P L G R 7
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