Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
pe2r1_human 395 C-term R => Q missense 0.000139 12 86336 0 0.18 0.0
pe2r1_human 390 C-term S => W missense 3.412e-05 3 87936 0 0.0 0.0
pe2r1_human 390 C-term S => L missense 1.137e-05 1 87936 0 0.0 0.0
pe2r1_human 390 C-term S => T missense 4.535e-05 4 88206 0 0.0 0.0
pe2r1_human 388 C-term A => V missense 3.414e-05 3 87882 0 0.54 0.0
pe2r1_human 386 C-term W => C missense 2.274e-05 2 87948 0 0.0 0.0
pe2r1_human 385 C-term A => V missense 1.139e-05 1 87814 0 1.0 0.0
pe2r1_human 383 C-term P => Q missense 1.145e-05 1 87342 0 0.31 0.0
pe2r1_human 381 C-term L => P missense 1.146e-05 1 87276 0 0.1 0.0
pe2r1_human 376 C-term P => H missense 1.149e-05 1 87052 0 0.21 0.0
pe2r1_human 376 C-term P => L missense 1.149e-05 1 87052 0 0.18 0.0
pe2r1_human 371 C-term G => A missense 0.0001137 10 87962 0 0.09 0.0
pe2r1_human 368 C-term P => L missense 2.247e-05 2 89002 0 0.33 0.0
pe2r1_human 364 8.56x56 H8 R => C missense 3.291e-05 3 91164 0 0.08 0.0
pe2r1_human 362 8.54x54 H8 L => M missense 1.089e-05 1 91816 0 0.01 0.0
pe2r1_human 360 8.52x52 H8 R => H missense 1.095e-05 1 91356 0 0.06 0.0
pe2r1_human 359 8.51x51 H8 L => Q missense 1.093e-05 1 91500 0 0.0 0.0 GP (contact)
pe2r1_human 357 8.49x49 H8 A => D missense 2.21e-05 2 90502 0 0.0 0.0 GP (contact)
pe2r1_human 355 8.47x47 H8 R => H missense 2.234e-05 2 89510 0 0.0 0.0 GP (contact)
pe2r1_human 352 7.54x54 TM7 I => M missense 1.143e-05 1 87476 0 0.0 0.703
pe2r1_human 352 7.54x54 TM7 I => T missense 1.151e-05 1 86872 0 0.0 0.507
pe2r1_human 347 7.49x49 TM7 D => A missense 3.72e-05 3 80648 0 0.0 0.96 SodiumPocket MicroSwitch
pe2r1_human 346 7.48x48 TM7 L => P missense 1.266e-05 1 78970 0 0.0 0.973
pe2r1_human 338 7.40x39 TM7 R => H missense 1.613e-05 1 62010 0 0.02 0.954
pe2r1_human 338 7.40x39 TM7 R => S missense 3.331e-05 2 60050 0 0.0 0.913
pe2r1_human 336 7.38x37 TM7 A => D missense 1.773e-05 1 56392 0 0.0 0.975
pe2r1_human 332 7.34x33 TM7 P => S missense 2.696e-05 1 37096 0 0.41 0.046
pe2r1_human 331 7.33x32 TM7 R => P missense 8.319e-05 3 36064 0 0.04 0.357
pe2r1_human 331 7.33x32 TM7 R => Q missense 2.773e-05 1 36064 0 0.19 0.003
pe2r1_human 330 7.32x31 TM7 Q => R missense 3.006e-05 1 33272 0 0.33 0.728
pe2r1_human 321 6.59x59 TM6 V => F missense 5.412e-05 1 18478 0 0.09 0.289
pe2r1_human 320 6.58x58 TM6 A => T missense 5.55e-05 1 18018 0 0.07 0.945
pe2r1_human 313 6.51x51 TM6 M => V missense 0.00015 5 33334 0 0.05 0.0
pe2r1_human 308 6.46x46 TM6 I => V missense 2.379e-05 1 42028 0 0.1 0.006
pe2r1_human 296 6.34x34 TM6 V => M missense 2.016e-05 1 49608 0 0.0 0.992 SodiumPocket MicroSwitch
pe2r1_human 294 6.32x32 TM6 E => D missense 6.215e-05 3 48272 0 0.01 0.973 GP (contact)
pe2r1_human 293 6.31x31 TM6 V => G missense 2.114e-05 1 47302 0 0.0 0.981
pe2r1_human 292 6.30x30 TM6 D => V missense 2.157e-05 1 46364 0 0.0 0.983 SodiumPocket MicroSwitch
pe2r1_human 291 6.29x29 TM6 H => R missense 6.574e-05 3 45632 0 0.0 0.803 GP (contact)
pe2r1_human 290 6.28x28 TM6 A => S missense 2.235e-05 1 44740 0 1.0 0.954 GP (contact)
pe2r1_human 290 6.28x28 TM6 A => T missense 2.235e-05 1 44740 0 0.07 0.948 GP (contact)
pe2r1_human 275 ICL3 F => L missense 2.746e-05 1 36416 0 nan 0.0
pe2r1_human 274 ICL3 T => I missense 2.787e-05 1 35884 0 nan 0.02
pe2r1_human 274 ICL3 T => S missense 2.787e-05 1 35884 0 nan 0.006
pe2r1_human 266 ICL3 A => V missense 4.45e-05 1 22470 0 nan 0.052
pe2r1_human 259 ICL3 R => G missense 7.26e-05 1 13774 0 nan 0.913
pe2r1_human 256 ICL3 H => R missense 0.02256 266 11790 35 1.0 0.0
pe2r1_human 255 ICL3 A => V missense 0.0003029 3 9904 0 nan 0.021
pe2r1_human 252 ICL3 R => L missense 0.0001297 1 7712 0 nan 0.017
pe2r1_human 240 5.74x74 TM5 R => W missense 0.0001921 1 5206 0 0.0 0.579 GP (contact)
pe2r1_human 231 5.65x65 TM5 R => G missense 0.000153 1 6534 0 0.04 0.913 GP (contact)
pe2r1_human 189 45.51x51 ECL2 F => L missense 0.000105 1 9526 0 0.0 0.999
pe2r1_human 127 3.42x42 TM3 L => P missense 0.0001004 1 9964 0 0.0 0.999
pe2r1_human 126 3.41x41 TM3 L => P missense 0.0001971 2 10148 0 0.0 0.998
pe2r1_human 118 3.33x33 TM3 V => A missense 0.0002818 3 10644 0 0.0 0.928
pe2r1_human 108 3.23x23 TM3 G => R missense 9.372e-05 1 10670 0 0.53 0.067
pe2r1_human 105 23.51x51 ECL1 P => L missense 0.000375 4 10668 0 0.01 0.734
pe2r1_human 100 2.66x66 TM2 T => A missense 9.362e-05 1 10682 0 1.0 0.002
pe2r1_human 83 2.49x49 TM2 T => N missense 0.0007536 8 10616 0 0.0 0.974
pe2r1_human 41 1.41x41 TM1 F => I missense 9.915e-05 1 10086 0 0.67 0.235
pe2r1_human 40 1.40x40 TM1 I => V missense 9.889e-05 1 10112 0 0.32 0.118
pe2r1_human 20 N-term A => V missense 9.645e-05 1 10368 0 0.32 0.002
pe2r1_human 19 N-term A => V missense 9.63e-05 1 10384 0 0.12 0.004
pe2r1_human 6 N-term P => S missense 0.0001972 2 10140 0 nan 0.002
pe2r1_human 365 8.57x57 H8 L => SerfsTer17 frameshift 0.0005729 52 90770 0 None None
pe2r1_human 356 8.48x48 H8 Q => Ter stop gained 1.112e-05 1 89914 0 None None GP (contact)


Residue

Diagrams

G A R L R ICL1ECL1 A G R A P A ECL1 P L L H A A R V ICL2ECL2 V G R Y E L Q Y P G T W C F I G L G P P G G W R Q A ECL2ICL3 P P P A S G P D S R R R W G A H G P R S A S A S S A S S I A S A S T F F G G S R S S G S A ICL3ECL3 W S S T S ECL3N-term M S P C G P L N L S L A G E A T T C A A P W V P N T S N-termC-term P R A G A K G G P A G L G L T P S A W E A S S L R S S R H S G L S H F C-term A V P P S G A S P A L P I F S M T L G A V S N L L A L A L L A Q A R R R S A A T F L L F V A S L L A T D L A G H V I P G A L V L R L Y T G G A C H F L G G C M V F F G L C P L L L G C G M A V E R C V G V T R S V A R A R L A L A A V A A V A L A V A L L P L A R L L A G L F A S L G L V A L L A A L V C N T L S G L A L L R A R W R R R S R R R R A R A H D V E M V G Q L V G I M V V S C I C W S P M L V L V A L A V G G L Q R P L F L A V R L A S W N Q I L D P W V Y I L L R Q A L L R V L R Q L L P
SnakePlot Download: PNG | SVG L N S V A G L T M S F I P L A P S A G S 1 A S L L A T D L A G H V I P G A L V L R 2 G C G L L L P C L G F F V M C G G L F H 3 A R L A L A A V A A V A L A V A L L P L 4 L T N C V L A A L L A V L G L S A F L G 5 V G I M V V S C I C W S P M L V L V A L 6 W P D L I Q N W S A L R V A L F L P R 7
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