Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
pe2r2_human 3 N-term N => S missense 1.897e-05 2 105416 0 nan 0.008
pe2r2_human 11 N-term E => G missense 9.484e-06 1 105440 0 0.12 0.002
pe2r2_human 12 N-term D => N missense 1.897e-05 2 105420 0 0.65 0.002
pe2r2_human 17 N-term Q => H missense 9.493e-06 1 105340 0 0.26 0.003
pe2r2_human 18 1.29x29 TM1 W => R missense 9.496e-06 1 105312 0 0.39 0.096
pe2r2_human 22 1.33x33 TM1 G => S missense 9.531e-06 1 104926 0 0.15 0.064
pe2r2_human 23 1.34x34 TM1 E => D missense 9.535e-06 1 104882 0 0.2 0.006
pe2r2_human 26 1.37x37 TM1 A => G missense 9.529e-06 1 104942 0 0.22 0.608
pe2r2_human 33 1.44x44 TM1 S => L missense 1.904e-05 2 105062 0 0.2 0.202 PTM (Phosphorylation)
pe2r2_human 40 1.51x51 TM1 L => F missense 1.899e-05 2 105304 0 0.03 0.983
pe2r2_human 42 1.53x53 TM1 A => V missense 1.899e-05 2 105326 0 0.0 1.0
pe2r2_human 43 1.54x54 TM1 L => V missense 9.535e-06 1 104878 0 0.0 0.999
pe2r2_human 44 1.55x55 TM1 A => E missense 1.905e-05 2 104998 0 0.02 0.763
pe2r2_human 47 1.58x58 TM1 A => T missense 9.549e-06 1 104718 0 0.6 0.075
pe2r2_human 48 1.59x59 TM1 R => H missense 9.572e-06 1 104472 0 0.54 0.005
pe2r2_human 51 ICL1 R => L missense 3.852e-05 4 103838 0 0.03 0.009
pe2r2_human 51 ICL1 R => Q missense 2.889e-05 3 103838 0 0.06 0.066
pe2r2_human 53 ICL1 D => N missense 9.584e-06 1 104340 0 0.15 0.22
pe2r2_human 59 12.51x51 ICL1 G => R missense 9.391e-06 1 106482 0 0.57 0.029
pe2r2_human 60 2.32x32 TM2 R => H missense 3.733e-05 4 107158 0 0.15 0.027
pe2r2_human 61 2.33x33 TM2 R => S missense 9.255e-06 1 108044 0 0.05 0.043
pe2r2_human 62 2.34x34 TM2 S => R missense 9.217e-06 1 108490 0 0.65 0.001 PTM (Phosphorylation)
pe2r2_human 71 2.43x43 TM2 V => L missense 8.853e-06 1 112962 0 0.01 0.649
pe2r2_human 71 2.43x43 TM2 V => M missense 8.853e-06 1 112962 0 0.0 0.995
pe2r2_human 73 2.45x45 TM2 E => K missense 2.633e-05 3 113934 0 0.84 0.617
pe2r2_human 73 2.45x45 TM2 E => Q missense 8.777e-06 1 113934 0 0.53 0.925
pe2r2_human 78 2.50x50 TM2 D => N missense 8.658e-06 1 115498 0 0.0 1.0
pe2r2_human 81 2.53x53 TM2 G => R missense 8.616e-06 1 116062 0 0.0 1.0
pe2r2_human 83 2.55x55 TM2 C => G missense 0.005392 628 116464 6 0.0 0.999
pe2r2_human 88 2.60x59 TM2 V => L missense 8.567e-06 1 116726 0 0.63 0.268
pe2r2_human 89 2.61x60 TM2 V => I missense 8.568e-06 1 116718 0 0.0 1.0
pe2r2_human 104 3.20x20 TM3 P => L missense 1.712e-05 2 116824 0 0.15 0.875
pe2r2_human 105 3.21x21 TM3 E => K missense 8.558e-06 1 116846 0 0.69 0.003
pe2r2_human 109 3.25x25 TM3 C => R missense 8.556e-06 1 116874 0 0.0 1.0
pe2r2_human 116 3.32x32 TM3 M => V missense 8.55e-06 1 116958 0 0.0 0.999
pe2r2_human 116 3.32x32 TM3 M => T missense 8.55e-06 1 116958 0 0.0 1.0
pe2r2_human 123 3.39x39 TM3 T => A missense 8.543e-06 1 117052 0 0.06 0.986
pe2r2_human 126 3.42x42 TM3 M => V missense 8.538e-06 1 117130 0 0.33 0.027
pe2r2_human 128 3.44x44 TM3 F => L missense 8.538e-06 1 117118 0 0.24 0.116
pe2r2_human 129 3.45x45 TM3 A => S missense 8.538e-06 1 117126 0 0.09 0.773
pe2r2_human 130 3.46x46 TM3 M => I missense 8.531e-06 1 117216 0 0.0 0.992
pe2r2_human 136 3.52x52 TM3 L => V missense 0.0001192 14 117430 0 0.02 0.11
pe2r2_human 143 34.52x52 ICL2 F => S missense 8.481e-06 1 117908 0 0.0 0.846 GP (contact)
pe2r2_human 146 34.55x55 ICL2 R => H missense 8.468e-06 1 118088 0 0.0 0.957 GP (contact)
pe2r2_human 147 34.56x56 ICL2 R => C missense 8.466e-06 1 118126 0 0.08 0.013 GP (contact)
pe2r2_human 150 4.39x39 TM4 R => C missense 8.453e-06 1 118302 0 0.13 0.015
pe2r2_human 161 4.50x50 TM4 Y => F missense 5.858e-05 7 119496 0 0.18 0.717
pe2r2_human 164 4.53x53 TM4 S => P missense 8.36e-06 1 119624 0 0.06 0.972
pe2r2_human 165 4.54x54 TM4 L => M missense 2.507e-05 3 119676 0 0.1 0.944
pe2r2_human 172 4.61x61 TM4 L => Q missense 2.503e-05 3 119844 0 0.05 0.996
pe2r2_human 178 ECL2 Y => C missense 8.341e-06 1 119894 0 0.0 0.999
pe2r2_human 180 ECL2 Q => R missense 8.335e-06 1 119970 0 0.0 0.984
pe2r2_human 180 ECL2 Q => H missense 5.837e-05 7 119918 0 0.0 0.994
pe2r2_human 187 45.50x50 ECL2 C => W missense 8.291e-06 1 120616 0 0.0 1.0
pe2r2_human 190 ECL2 R => W missense 8.285e-06 1 120694 0 0.03 0.013
pe2r2_human 190 ECL2 R => Q missense 8.284e-06 1 120710 0 0.78 0.004
pe2r2_human 192 ECL2 G => A missense 8.28e-06 1 120778 0 0.22 0.063
pe2r2_human 195 5.36x36 TM5 A => S missense 2.483e-05 3 120838 0 0.21 0.055
pe2r2_human 197 5.38x38 TM5 L => P missense 8.273e-06 1 120870 0 0.32 0.962
pe2r2_human 204 5.45x45 TM5 L => P missense 1.654e-05 2 120894 0 0.0 0.998
pe2r2_human 210 5.51x51 TM5 S => P missense 3.311e-05 4 120792 0 0.01 0.529
pe2r2_human 216 5.57x57 TM5 F => C missense 4.145e-05 5 120620 0 0.05 0.014
pe2r2_human 221 5.62x62 TM5 N => Y missense 8.306e-06 1 120400 0 0.0 0.493
pe2r2_human 221 5.62x62 TM5 N => S missense 8.311e-06 1 120326 0 0.51 0.038
pe2r2_human 223 5.64x64 TM5 I => L missense 3.327e-05 4 120238 0 0.31 0.002 GP (contact)
pe2r2_human 230 5.71x71 TM5 R => Q missense 8.396e-06 1 119100 0 0.62 0.023 GP (contact)
pe2r2_human 233 5.74x74 TM5 R => H missense 8.384e-06 1 119274 0 0.0 0.982 GP (contact)
pe2r2_human 235 5.76x76 TM5 G => R missense 8.389e-06 1 119198 0 0.05 0.777
pe2r2_human 242 ICL3 R => W missense 1.686e-05 2 118626 0 0.0 0.806
pe2r2_human 242 ICL3 R => G missense 8.43e-06 1 118626 0 0.05 0.011
pe2r2_human 242 ICL3 R => Q missense 7.589e-05 9 118596 0 0.09 0.019
pe2r2_human 242 ICL3 R => P missense 8.432e-06 1 118596 0 0.07 0.019
pe2r2_human 247 ICL3 A => V missense 8.425e-06 1 118696 0 0.39 0.021
pe2r2_human 247 ICL3 A => D missense 8.425e-06 1 118696 0 0.6 0.094
pe2r2_human 248 ICL3 R => H missense 8.42e-06 1 118758 0 0.06 0.015
pe2r2_human 249 ICL3 R => K missense 1.681e-05 2 118980 0 0.29 0.012
pe2r2_human 249 ICL3 R => S missense 8.401e-06 1 119030 0 0.1 0.063
pe2r2_human 252 ICL3 E => Q missense 0.0001006 12 119230 0 0.28 0.533
pe2r2_human 252 ICL3 E => K missense 2.516e-05 3 119230 0 0.14 0.038
pe2r2_human 262 6.33x33 TM6 H => Q missense 8.354e-06 1 119708 0 0.0 0.972 GP (contact)
pe2r2_human 263 6.34x34 TM6 L => F missense 8.353e-06 1 119716 0 0.0 0.998 SodiumPocket MicroSwitch
pe2r2_human 264 6.35x35 TM6 I => T missense 5.012e-05 6 119720 0 0.0 0.629
pe2r2_human 265 6.36x36 TM6 L => P missense 8.352e-06 1 119736 0 0.0 0.942 GP (contact)
pe2r2_human 268 6.39x39 TM6 I => V missense 8.358e-06 1 119648 0 0.2 0.026
pe2r2_human 271 6.42x42 TM6 I => V missense 8.368e-06 1 119502 0 0.26 0.37
pe2r2_human 271 6.42x42 TM6 I => T missense 8.371e-06 1 119466 0 0.02 0.961
pe2r2_human 274 6.45x45 TM6 A => D missense 8.389e-06 1 119206 0 0.0 0.925
pe2r2_human 277 6.48x48 TM6 S => C missense 8.399e-06 1 119060 0 0.0 0.995 SodiumPocket MicroSwitch
pe2r2_human 281 6.52x52 TM6 T => M missense 4.217e-05 5 118568 0 0.0 0.896
pe2r2_human 285 6.56x56 TM6 Y => C missense 0.001669 199 119248 3 0.0 0.566
pe2r2_human 287 6.58x58 TM6 N => S missense 2.505e-05 3 119768 0 0.06 0.191
pe2r2_human 292 ECL3 R => Q missense 1.661e-05 2 120438 0 0.45 0.009
pe2r2_human 293 ECL3 K => E missense 2.489e-05 3 120522 0 0.86 0.004
pe2r2_human 299 7.37x36 TM7 Q => H missense 1.655e-05 2 120818 0 0.12 0.617
pe2r2_human 300 7.38x37 TM7 A => V missense 8.275e-06 1 120840 0 0.04 0.458
pe2r2_human 306 7.44x43 TM7 I => V missense 0.0001157 14 121034 0 0.5 0.008 SodiumPocket MicroSwitch
pe2r2_human 312 7.50x50 TM7 P => L missense 8.249e-06 1 121228 0 0.0 0.997 SodiumPocket MicroSwitch
pe2r2_human 313 7.51x51 TM7 W => L missense 8.248e-06 1 121242 0 0.02 0.651
pe2r2_human 327 8.55x55 H8 R => C missense 8.24e-06 1 121364 0 0.01 0.891
pe2r2_human 327 8.55x55 H8 R => H missense 8.24e-06 1 121366 0 0.04 0.891
pe2r2_human 331 C-term C => S missense 1.648e-05 2 121372 0 0.05 0.965
pe2r2_human 333 C-term R => W missense 8.239e-06 1 121368 0 0.0 0.724
pe2r2_human 338 C-term T => S missense 1.648e-05 2 121352 0 0.52 0.003
pe2r2_human 342 C-term T => I missense 8.242e-06 1 121326 0 0.28 0.001
pe2r2_human 345 C-term S => F missense 8.245e-06 1 121292 0 0.05 0.59
pe2r2_human 346 C-term C => Y missense 0.0001319 16 121280 0 0.23 0.248
pe2r2_human 357 C-term D => E missense 3.318e-05 4 120542 0 0.19 0.004
pe2r2_human 53 ICL1 D => ThrfsTer19 frameshift 9.631e-06 1 103836 0 None None
pe2r2_human 93 2.65x64 TM2 Y => Ter stop gained 8.566e-06 1 116740 0 None None
pe2r2_human 153 4.42x42 TM4 G => AlafsTer117 frameshift 8.448e-06 1 118374 0 None None
pe2r2_human 232 5.73x73 TM5 S => ArgfsTer40 frameshift 8.396e-06 1 119100 0 None None
pe2r2_human 273 6.44x44 TM6 F => SerfsTer16 frameshift 8.367e-06 1 119512 0 None None SodiumPocket MicroSwitch
pe2r2_human 292 ECL3 R => Ter stop gained 6.645e-05 8 120388 0 None None
pe2r2_human 349 C-term Q => Ter stop gained 1.65e-05 2 121226 0 None None


Residue

Diagrams

C W R G D V G S A G ICL1ECL1 Q T L V A ECL1 P Y F Y Q R R V ICL2ECL2 G Q Y V Q Y C P G T W C F I R H G R ECL2ICL3 P S L G S G R G G P G A R R R G E ICL3ECL3 S R K E ECL3N-term M G N A S N D S Q S E D C E T R Q N-termC-term C C R I S L R T Q D A T Q T S C S T Q S D A S K Q A D L C-term W L P P G E S P A I S S V M F S A G V L G N L I A L A L L A R R R R S S L S L F H V L V T E L V F T D L L G T C L I S P V V L A S Y A R N L A P E S R A C T Y F A F A M T F F S L A T M L M L F A M A L E R Y L S I G H S R S G G L A V L P V I Y A V S L L F C S L P L L D Y T A Y L Q L Y A T L L L L L I V S V L A C N F S V I L N L I R M H R R S R R S R C G R V S M A E E T D H L I L L A I M T I T F A V C S L P F T I F A Y M N E T S K W D L Q A L R F L S I N S I I D P W V F A I L R P P M R S V L R L V L
SnakePlot Download: PNG | SVG L N G L V G A S F M V S S I A P S E G P 1 T E L V F T D L L G T L C I S P V V L A S 2 A F L M L M T A L S F F T M A F A F Y T 3 G L A V L P V I Y A V S L L F C S L P L 4 S F N C A L V S V I L L L L L T A Y L Q 5 A I M T I T F A V C S L P F T I F A Y M 6 W P D I I S N I S L F R L A Q L D W K 7
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