Variation Browser

Download
Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
pf2r_human 8 N-term Q => L missense 0.005935 705 118786 7 0.17 0.005
pf2r_human 10 N-term V => A missense 0.0001923 23 119634 0 1.0 0.002
pf2r_human 11 N-term S => A missense 8.347e-06 1 119802 0 0.51 0.043
pf2r_human 14 N-term A => V missense 2.487e-05 3 120650 0 0.3 0.005
pf2r_human 25 1.31x31 TM1 E => G missense 8.247e-06 1 121256 0 0.04 0.096
pf2r_human 26 1.32x32 TM1 N => I missense 8.246e-06 1 121264 0 0.07 0.382
pf2r_human 27 1.33x33 TM1 R => W missense 8.246e-06 1 121264 0 0.03 0.003
pf2r_human 27 1.33x33 TM1 R => G missense 8.246e-06 1 121264 0 0.37 0.001
pf2r_human 27 1.33x33 TM1 R => Q missense 8.247e-06 1 121256 0 0.46 0.065
pf2r_human 30 1.36x36 TM1 V => E missense 8.244e-06 1 121296 0 0.01 0.972
pf2r_human 37 1.43x43 TM1 M => V missense 8.241e-06 1 121348 0 0.0 0.992
pf2r_human 41 1.47x47 TM1 I => L missense 8.24e-06 1 121366 0 0.01 0.891
pf2r_human 45 1.51x51 TM1 S => R missense 8.239e-06 1 121370 0 0.04 0.992
pf2r_human 47 1.53x53 TM1 A => V missense 1.648e-05 2 121380 0 0.0 1.0
pf2r_human 49 1.55x55 TM1 A => T missense 8.239e-06 1 121380 0 0.25 0.733
pf2r_human 54 1.60x60 TM1 A => P missense 2.471e-05 3 121404 1 0.0 0.997
pf2r_human 60 2.33x33 TM2 Q => R missense 8.237e-06 1 121404 0 1.0 0.012
pf2r_human 63 2.36x36 TM2 K => T missense 8.237e-06 1 121404 0 0.0 0.995
pf2r_human 64 2.37x37 TM2 A => T missense 8.237e-06 1 121404 0 0.0 0.933
pf2r_human 67 2.40x40 TM2 L => R missense 7.413e-05 9 121408 0 0.0 1.0
pf2r_human 70 2.43x43 TM2 A => T missense 1.647e-05 2 121408 0 0.0 1.0
pf2r_human 75 2.48x48 TM2 I => T missense 8.237e-06 1 121408 0 0.05 0.189
pf2r_human 78 2.51x51 TM2 F => S missense 8.237e-06 1 121408 0 0.02 0.723
pf2r_human 91 2.64x64 TM2 V => A missense 8.236e-06 1 121412 0 0.01 0.999
pf2r_human 100 23.52x52 ECL1 R => H missense 8.236e-06 1 121412 0 0.15 0.009
pf2r_human 104 3.21x21 TM3 S => L missense 2.471e-05 3 121410 0 0.17 0.314
pf2r_human 106 3.23x23 TM3 V => I missense 1.647e-05 2 121410 0 0.49 0.008
pf2r_human 109 3.26x26 TM3 S => G missense 8.237e-06 1 121410 0 0.19 0.867
pf2r_human 109 3.26x26 TM3 S => R missense 8.237e-06 1 121408 0 0.27 0.969
pf2r_human 110 3.27x27 TM3 I => V missense 8.237e-06 1 121410 0 0.34 0.012
pf2r_human 115 3.32x32 TM3 M => L missense 8.237e-06 1 121410 0 0.04 0.993
pf2r_human 130 3.47x47 TM3 A => T missense 8.236e-06 1 121412 0 0.0 1.0
pf2r_human 133 3.50x50 TM3 R => Q missense 8.236e-06 1 121412 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
pf2r_human 138 3.55x55 TM3 T => S missense 8.237e-06 1 121408 0 0.03 0.957 GP (contact)
pf2r_human 142 34.52x52 ICL2 F => C missense 1.647e-05 2 121408 0 0.0 1.0 GP (contact)
pf2r_human 145 34.55x55 ICL2 T => M missense 0.0002801 34 121402 0 0.06 0.993 GP (contact)
pf2r_human 147 34.57x57 ICL2 I => N missense 8.237e-06 1 121398 0 0.0 0.74 GP (contact)
pf2r_human 148 4.38x38 TM4 T => A missense 9.061e-05 11 121398 0 0.13 0.401
pf2r_human 149 4.39x39 TM4 S => P missense 8.238e-06 1 121396 0 0.03 0.953
pf2r_human 149 4.39x39 TM4 S => F missense 1.648e-05 2 121396 0 0.12 0.816
pf2r_human 151 4.41x41 TM4 H => D missense 8.238e-06 1 121396 0 0.0 0.924
pf2r_human 152 4.42x42 TM4 V => M missense 8.238e-06 1 121382 0 0.29 0.525
pf2r_human 155 4.45x45 TM4 M => I missense 0.003584 435 121384 1 0.59 0.002
pf2r_human 159 4.49x49 TM4 V => M missense 8.238e-06 1 121384 0 0.01 0.824
pf2r_human 159 4.49x49 TM4 V => A missense 1.648e-05 2 121388 0 0.05 0.02
pf2r_human 162 4.52x52 TM4 F => L missense 8.238e-06 1 121382 0 1.0 0.006
pf2r_human 163 4.53x53 TM4 A => D missense 1.648e-05 2 121374 0 0.0 0.995
pf2r_human 164 4.54x54 TM4 V => L missense 8.239e-06 1 121374 0 1.0 0.014
pf2r_human 166 4.56x56 TM4 I => T missense 8.239e-06 1 121368 0 0.0 0.392
pf2r_human 172 4.62x62 TM4 L => F missense 3.296e-05 4 121354 0 0.54 0.25
pf2r_human 174 4.64x64 TM4 H => Y missense 8.24e-06 1 121362 0 0.88 0.102
pf2r_human 175 ECL2 R => Q missense 8.24e-06 1 121358 0 0.28 0.783
pf2r_human 178 ECL2 K => T missense 8.24e-06 1 121354 0 0.65 0.013
pf2r_human 179 ECL2 I => V missense 3.296e-05 4 121354 0 0.85 0.272
pf2r_human 186 45.50x50 ECL2 C => R missense 8.241e-06 1 121340 0 0.0 1.0
pf2r_human 191 ECL2 E => V missense 8.243e-06 1 121318 0 0.26 0.868
pf2r_human 192 ECL2 D => N missense 5.77e-05 7 121314 0 0.6 0.002
pf2r_human 192 ECL2 D => G missense 1.649e-05 2 121320 0 0.46 0.002
pf2r_human 194 ECL2 K => E missense 8.244e-06 1 121300 0 1.0 0.006
pf2r_human 196 ECL2 W => R missense 8.245e-06 1 121280 0 0.35 1.0
pf2r_human 196 ECL2 W => L missense 8.246e-06 1 121274 0 0.14 1.0
pf2r_human 196 ECL2 W => C missense 8.246e-06 1 121272 0 0.04 1.0
pf2r_human 199 5.35x35 TM5 R => G missense 8.248e-06 1 121240 0 0.01 0.777
pf2r_human 218 5.54x54 TM5 L => S missense 0.001299 157 120824 2 0.03 0.038
pf2r_human 229 5.65x65 TM5 R => K missense 3.337e-05 4 119880 0 0.22 0.02 GP (contact)
pf2r_human 230 5.66x66 TM5 V => A missense 0.0002674 32 119680 0 1.0 0.07 GP (contact)
pf2r_human 235 5.71x71 TM5 Q => R missense 8.434e-06 1 118570 0 0.59 0.542 GP (contact)
pf2r_human 236 5.72x72 TM5 Q => R missense 8.461e-06 1 118190 0 0.5 0.02 GP (contact)
pf2r_human 243 6.29x29 TM6 H => R missense 8.622e-06 1 115978 0 0.05 0.919 GP (contact)
pf2r_human 248 6.34x34 TM6 V => G missense 1.752e-05 2 114170 0 0.0 0.901 SodiumPocket MicroSwitch
pf2r_human 253 6.39x39 TM6 A => V missense 6.277e-05 7 111518 0 0.03 0.411
pf2r_human 255 6.41x41 TM6 M => T missense 9.017e-06 1 110902 0 0.0 0.999
pf2r_human 267 6.53x53 TM6 V => I missense 8.542e-06 1 117072 0 0.68 0.004
pf2r_human 272 6.58x58 TM6 I => T missense 8.373e-06 1 119436 0 0.23 0.372
pf2r_human 279 ECL3 S => F missense 8.301e-06 1 120468 0 0.11 0.01
pf2r_human 288 7.37x36 TM7 F => S missense 1.655e-05 2 120872 0 0.02 0.186
pf2r_human 305 7.54x54 TM7 I => T missense 8.26e-06 1 121062 0 0.0 0.999
pf2r_human 308 8.47x47 H8 R => Q missense 2.478e-05 3 121064 0 0.0 0.999 GP (contact)
pf2r_human 309 8.48x48 H8 K => T missense 0.0001074 13 121066 0 0.01 0.886 GP (contact)
pf2r_human 310 8.49x49 H8 A => T missense 8.26e-06 1 121072 0 0.18 0.382 GP (contact)
pf2r_human 313 8.52x52 H8 K => R missense 0.0002643 32 121082 0 1.0 0.003
pf2r_human 314 8.53x53 H8 N => H missense 5.781e-05 7 121082 0 0.01 0.45
pf2r_human 314 8.53x53 H8 N => Y missense 8.259e-06 1 121082 0 0.0 0.547
pf2r_human 316 8.55x55 H8 Y => C missense 3.304e-05 4 121080 0 0.05 0.847
pf2r_human 316 8.55x55 H8 Y => S missense 8.259e-06 1 121080 0 0.0 0.649
pf2r_human 326 C-term H => Q missense 8.265e-06 1 120994 0 0.14 0.002
pf2r_human 328 C-term I => V missense 8.268e-06 1 120954 0 0.6 0.002
pf2r_human 331 C-term H => R missense 2.482e-05 3 120892 0 0.55 0.391
pf2r_human 338 C-term I => V missense 0.003772 455 120638 1 0.31 0.012
pf2r_human 338 C-term I => T missense 8.29e-06 1 120632 0 0.01 0.25
pf2r_human 339 C-term K => N missense 8.298e-06 1 120504 0 0.28 0.726
pf2r_human 340 C-term N => S missense 1.66e-05 2 120500 0 1.0 0.0
pf2r_human 343 C-term K => Q missense 1.663e-05 2 120296 0 0.07 0.728
pf2r_human 344 C-term V => F missense 8.319e-06 1 120208 0 0.05 0.157
pf2r_human 344 C-term V => G missense 2.498e-05 3 120074 0 0.41 0.002
pf2r_human 345 C-term A => T missense 8.329e-06 1 120062 0 0.05 0.804
pf2r_human 353 C-term A => S missense 8.421e-06 1 118748 0 0.66 0.001
pf2r_human 353 C-term A => V missense 8.446e-06 1 118404 0 0.42 0.001
pf2r_human 354 C-term E => K missense 8.447e-06 1 118384 0 nan 0.002
pf2r_human 355 C-term K => E missense 1.695e-05 2 118016 1 nan 0.165
pf2r_human 356 C-term S => A missense 1.7e-05 2 117652 0 nan 0.0
pf2r_human 356 C-term S => L missense 8.52e-06 1 117376 0 nan 0.0
pf2r_human 33 1.39x39 TM1 S => PhefsTer27 frameshift 2.473e-05 3 121292 0 None None
pf2r_human 83 2.56x56 TM2 I => SerfsTer14 frameshift 1.647e-05 2 121410 0 None None
pf2r_human 151 4.41x41 TM4 H => ArgfsTer27 frameshift 5.766e-05 7 121396 0 None None
pf2r_human 161 4.51x51 TM4 L => PhefsTer6 frameshift 8.238e-06 1 121386 0 None None
pf2r_human 292 7.41x40 TM7 M => Ter stop gained 8.495e-06 1 117718 0 None None
pf2r_human 274 6.60x60 TM6 I => AsnfsTer3 frameshift 8.373e-06 1 119436 0 None None
pf2r_human 291 7.40x39 TM7 R => Ter stop gained 3.309e-05 4 120894 0 None None


Residue

Diagrams

Q Y R F R ICL1ECL1 D K E W I R ECL1 P I F H S T K I ICL2ECL2 R D Y K I Q A S R T W C F Y N T E D I K D W E D ECL2ICL3 H R Q G R S ICL3ECL3 G N H S L E ECL3N-term M S M N N S K Q L V S P A A A L L S N T T C N-termC-term L A S Q C C G V H V I S L H I W E L S S I K N S L K V A A I S E S P V A E K S A S T C-term Q T E N R L S V F F S V I F M T V G I L S N S L A I A I L M K A Q K S K A S F L L L A S G L V I T D F F G H L I N G A I A V F V Y A S F D Q S N V L C S I F G I C M V F S G L C P L L L G S V M A I E R C I G V T K T S K H V K M M L S G V C L F A V F I A L L P I L G H R F Y L L L F S F L G L L A L G V S L L C N A I T G I T L L R V K F K S Q Q H H L E M V I Q L L A I M C V S C I C W S P F L V T M A N I G I N T C E T T L F A L R M A T W N Q I L D P W V Y I L L R K A L Y K V L K N
SnakePlot Download: PNG | SVG S N S L I G V T M F I V S F F V S L R N 1 S G L V I T D F F G H L I N G A I A V F 2 V S G L L L P C L G S F V M C I G F I S 3 V K M M L S G V C L F A V F I A L L P I 4 I A N C L L S V G L A L L G L F S F L L 5 L A I M C V S C I C W S P F L V T M A N 6 W P D L I Q N W T A M R L A F L T T E 7
HelixBox Download: PNG | SVG