Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
pi2r_human 382 C-term A => S missense 9.127e-06 1 109560 0 nan 0.012
pi2r_human 382 C-term A => T missense 9.127e-06 1 109560 0 nan 0.122
pi2r_human 381 C-term V => I missense 9.127e-06 1 109560 0 nan 0.041
pi2r_human 374 C-term S => L missense 1.827e-05 2 109480 0 nan 0.0
pi2r_human 373 C-term T => M missense 9.137e-06 1 109450 0 0.08 0.015
pi2r_human 373 C-term T => R missense 9.137e-06 1 109450 0 0.0 0.138
pi2r_human 371 C-term V => M missense 0.0001372 15 109312 0 nan 0.015
pi2r_human 370 C-term A => T missense 8.229e-05 9 109372 0 1.0 0.0
pi2r_human 369 C-term S => R missense 0.0002838 31 109228 0 nan 0.273
pi2r_human 368 C-term G => S missense 9.14e-06 1 109414 0 nan 0.001
pi2r_human 358 C-term E => K missense 2.74e-05 3 109480 0 0.01 0.0
pi2r_human 355 C-term G => E missense 1.82e-05 2 109918 0 nan 0.013
pi2r_human 354 C-term E => K missense 1.82e-05 2 109896 0 nan 0.003
pi2r_human 353 C-term G => D missense 4.532e-05 5 110324 0 0.05 0.558
pi2r_human 352 C-term W => G missense 9.018e-06 1 110890 0 nan 0.005
pi2r_human 350 C-term S => L missense 5.376e-05 6 111606 0 0.0 0.122
pi2r_human 350 C-term S => P missense 8.939e-06 1 111872 0 nan 0.006
pi2r_human 348 C-term P => S missense 8.883e-06 1 112572 0 0.01 0.402
pi2r_human 347 C-term V => L missense 8.846e-06 1 113040 0 nan 0.217
pi2r_human 343 C-term E => K missense 3.465e-05 4 115442 0 nan 0.005
pi2r_human 340 C-term V => A missense 5.984e-05 7 116976 0 nan 0.001
pi2r_human 340 C-term V => M missense 1.708e-05 2 117094 0 0.14 0.073
pi2r_human 338 C-term A => V missense 1.699e-05 2 117716 0 0.05 0.015
pi2r_human 338 C-term A => S missense 8.489e-06 1 117800 0 nan 0.008
pi2r_human 335 C-term A => D missense 2.527e-05 3 118712 0 nan 0.068
pi2r_human 335 C-term A => T missense 1.685e-05 2 118702 0 nan 0.001
pi2r_human 332 C-term D => E missense 8.387e-06 1 119232 0 0.06 0.055
pi2r_human 330 C-term R => K missense 8.372e-06 1 119450 0 0.13 0.035
pi2r_human 329 C-term G => R missense 1.673e-05 2 119578 0 0.14 0.003
pi2r_human 324 C-term S => F missense 2.502e-05 3 119898 0 0.0 0.472
pi2r_human 322 C-term P => S missense 8.342e-06 1 119870 0 0.2 0.002
pi2r_human 319 C-term S => W missense 0.008438 1011 119814 41 0.03 0.712
pi2r_human 319 C-term S => L missense 8.346e-06 1 119814 0 0.4 0.002
pi2r_human 319 C-term S => P missense 8.346e-06 1 119824 0 0.22 0.002
pi2r_human 318 C-term D => N missense 8.345e-06 1 119828 0 0.17 0.002
pi2r_human 317 C-term G => R missense 5.009e-05 6 119796 0 0.07 0.002
pi2r_human 315 C-term A => V missense 8.353e-06 1 119716 0 0.19 0.003
pi2r_human 313 C-term G => R missense 0.0001003 12 119668 0 0.46 0.001
pi2r_human 313 C-term G => R missense 3.343e-05 4 119668 0 0.46 0.001
pi2r_human 312 C-term L => R missense 8.361e-06 1 119610 0 0.19 0.002
pi2r_human 311 C-term C => F missense 8.363e-06 1 119568 0 0.44 0.027 PTM (Palmitoylation)
pi2r_human 308 8.59x59 H8 C => F missense 1.674e-05 2 119456 0 0.0 0.21 PTM (Palmitoylation)
pi2r_human 302 8.53x53 H8 R => Q missense 2.52e-05 3 119070 0 0.03 0.01
pi2r_human 302 8.53x53 H8 R => P missense 8.398e-06 1 119070 0 0.01 0.334
pi2r_human 296 8.47x47 H8 R => H missense 1.688e-05 2 118468 0 0.0 0.996 GP (contact)
pi2r_human 296 8.47x47 H8 R => C missense 8.45e-06 1 118350 0 0.0 0.998 GP (contact)
pi2r_human 293 7.54x54 TM7 I => N missense 6.775e-05 8 118086 0 0.0 0.984
pi2r_human 287 7.48x48 TM7 L => V missense 8.504e-06 1 117598 0 0.18 0.014
pi2r_human 284 7.45x45 TM7 N => S missense 8.517e-06 1 117414 0 0.0 0.998
pi2r_human 282 7.43x42 TM7 A => T missense 2.559e-05 3 117212 0 0.0 0.948
pi2r_human 279 7.40x39 TM7 R => H missense 2.564e-05 3 116990 0 0.0 0.999
pi2r_human 279 7.40x39 TM7 R => C missense 2.567e-05 3 116878 0 0.0 1.0
pi2r_human 274 7.35x34 TM7 D => G missense 8.587e-06 1 116458 0 0.0 0.99
pi2r_human 274 7.35x34 TM7 D => H missense 0.000103 12 116456 0 0.0 0.967
pi2r_human 274 7.35x34 TM7 D => N missense 1.717e-05 2 116456 0 0.1 0.893
pi2r_human 267 ECL3 D => N missense 0.0004071 47 115464 0 0.06 0.105
pi2r_human 265 6.61x61 TM6 A => T missense 3.474e-05 4 115146 0 0.17 0.009
pi2r_human 263 6.59x59 TM6 A => S missense 8.717e-06 1 114712 0 0.04 0.348
pi2r_human 258 6.54x54 TM6 R => H missense 1.777e-05 2 112546 0 0.03 0.082
pi2r_human 258 6.54x54 TM6 R => L missense 8.885e-06 1 112546 0 0.01 0.644
pi2r_human 258 6.54x54 TM6 R => C missense 7.128e-05 8 112226 0 0.04 0.082
pi2r_human 258 6.54x54 TM6 R => S missense 8.911e-06 1 112226 0 0.01 0.342
pi2r_human 256 6.52x52 TM6 T => M missense 0.0001733 4 23084 0 0.0 1.0
pi2r_human 249 6.45x45 TM6 A => G missense 3.606e-05 1 27732 0 0.0 0.39
pi2r_human 246 6.42x42 TM6 V => A missense 3.485e-05 1 28696 0 0.03 0.009
pi2r_human 231 6.27x27 TM6 G => R missense 0.003724 85 22822 1 0.39 0.133
pi2r_human 228 6.24x24 TM6 P => L missense 4.824e-05 1 20728 0 0.12 0.009
pi2r_human 227 6.23x23 TM6 R => W missense 4.957e-05 1 20174 0 0.01 0.8
pi2r_human 226 6.22x22 TM6 P => T missense 0.002776 55 19816 1 0.12 0.142
pi2r_human 215 5.68x68 TM5 R => C missense 0.0001739 3 17248 0 0.0 0.996 GP (contact)
pi2r_human 212 5.65x65 TM5 R => H missense 0.001793 30 16736 1 0.05 0.082 GP (contact)
pi2r_human 212 5.65x65 TM5 R => C missense 0.00572 95 16608 1 0.0 0.932 GP (contact)
pi2r_human 205 5.58x58 TM5 S => L missense 6.496e-05 1 15394 0 0.15 0.534 SodiumPocket MicroSwitch
pi2r_human 204 5.57x57 TM5 G => S missense 0.0003903 6 15374 0 0.38 0.283
pi2r_human 194 5.47x47 TM5 L => M missense 0.0006912 10 14468 0 0.02 0.979 SodiumPocket MicroSwitch
pi2r_human 189 5.42x42 TM5 A => G missense 0.0002844 4 14066 0 0.0 0.951
pi2r_human 185 5.38x38 TM5 S => L missense 0.0002078 3 14438 0 0.29 0.132
pi2r_human 183 5.36x36 TM5 A => P missense 7.238e-05 1 13816 0 0.03 0.997
pi2r_human 181 5.34x34 TM5 G => V missense 6.265e-05 1 15962 0 0.2 0.014
pi2r_human 179 5.32x32 TM5 P => S missense 5.749e-05 1 17394 0 0.43 0.026
pi2r_human 178 5.31x31 TM5 Q => E missense 5.375e-05 1 18604 0 1.0 0.002
pi2r_human 177 5.30x30 TM5 A => G missense 0.0001039 2 19252 0 0.3 0.006
pi2r_human 175 ECL2 R => H missense 0.000141 3 21276 0 0.07 0.884
pi2r_human 175 ECL2 R => C missense 8.928e-05 2 22402 0 0.01 0.964
pi2r_human 173 ECL2 R => C missense 3.873e-05 1 25820 0 0.01 0.959
pi2r_human 170 45.50x50 ECL2 C => Y missense 3.391e-05 1 29490 0 0.0 1.0
pi2r_human 167 ECL2 G => S missense 5.626e-05 2 35552 0 0.0 1.0
pi2r_human 162 ECL2 Q => R missense 2.115e-05 1 47282 0 0.55 0.007
pi2r_human 157 4.63x63 TM4 G => C missense 1.658e-05 1 60310 0 0.0 0.999
pi2r_human 152 4.58x58 TM4 A => V missense 0.0001134 8 70530 0 0.18 0.312
pi2r_human 152 4.58x58 TM4 A => S missense 1.401e-05 1 71360 0 0.47 0.043
pi2r_human 152 4.58x58 TM4 A => T missense 1.401e-05 1 71360 0 0.2 0.531
pi2r_human 148 4.54x54 TM4 V => I missense 1.267e-05 1 78934 0 0.35 0.004
pi2r_human 145 4.51x51 TM4 A => T missense 3.581e-05 3 83766 0 0.31 0.041
pi2r_human 143 4.49x49 TM4 I => T missense 1.171e-05 1 85422 0 0.01 0.772
pi2r_human 143 4.49x49 TM4 I => V missense 1.168e-05 1 85634 0 0.22 0.042
pi2r_human 137 4.43x43 TM4 R => H missense 3.483e-05 3 86122 0 0.29 0.142
pi2r_human 137 4.43x43 TM4 R => C missense 2.325e-05 2 86024 0 0.07 0.935
pi2r_human 136 4.42x42 TM4 A => S missense 3.484e-05 3 86104 0 0.01 0.989
pi2r_human 135 4.41x41 TM4 C => G missense 1.153e-05 1 86718 0 0.54 0.19
pi2r_human 134 4.40x40 TM4 R => H missense 0.0002196 19 86536 0 0.03 0.12
pi2r_human 134 4.40x40 TM4 R => G missense 1.148e-05 1 87082 0 0.04 0.193
pi2r_human 134 4.40x40 TM4 R => S missense 1.148e-05 1 87082 0 0.1 0.239
pi2r_human 128 34.54x54 ICL2 A => V missense 8.98e-05 8 89084 0 0.05 0.331 GP (contact)
pi2r_human 128 34.54x54 ICL2 A => T missense 3.359e-05 3 89320 0 0.14 0.014 GP (contact)
pi2r_human 124 34.50x50 ICL2 P => R missense 1.121e-05 1 89242 0 0.0 1.0 GP (contact)
pi2r_human 124 34.50x50 ICL2 P => S missense 1.119e-05 1 89364 0 0.0 1.0 GP (contact)
pi2r_human 123 3.56x56 TM3 H => Q missense 1.12e-05 1 89312 0 0.04 0.943 GP (contact)
pi2r_human 117 3.50x50 TM3 R => C missense 2.273e-05 2 88000 0 0.0 0.999 SodiumPocket MicroSwitch GP (contact)
pi2r_human 116 3.49x49 TM3 E => K missense 1.14e-05 1 87694 0 0.0 0.999 SodiumPocket MicroSwitch
pi2r_human 115 3.48x48 TM3 V => L missense 2.301e-05 2 86918 0 0.79 0.473
pi2r_human 115 3.48x48 TM3 V => M missense 1.151e-05 1 86918 0 0.01 0.985
pi2r_human 114 3.47x47 TM3 A => G missense 1.155e-05 1 86588 0 0.0 0.999
pi2r_human 113 3.46x46 TM3 M => T missense 3.497e-05 3 85798 0 0.06 0.995
pi2r_human 112 3.45x45 TM3 A => V missense 2.372e-05 2 84332 0 0.0 0.983
pi2r_human 109 3.42x42 TM3 I => F missense 1.279e-05 1 78178 0 0.01 0.836
pi2r_human 107 3.40x40 TM3 M => T missense 5.381e-05 4 74342 0 0.37 0.007 SodiumPocket MicroSwitch
pi2r_human 107 3.40x40 TM3 M => V missense 2.722e-05 2 73474 0 0.01 0.217 SodiumPocket MicroSwitch
pi2r_human 105 3.38x38 TM3 A => V missense 0.0003085 21 68076 0 0.02 0.999
pi2r_human 104 3.37x37 TM3 L => R missense 1.532e-05 1 65256 0 0.0 0.997
pi2r_human 100 3.33x33 TM3 T => I missense 1.671e-05 1 59858 0 0.02 0.877
pi2r_human 97 3.30x30 TM3 F => L missense 1.913e-05 1 52280 0 0.02 0.997
pi2r_human 97 3.30x30 TM3 F => V missense 1.924e-05 1 51964 0 0.08 0.999
pi2r_human 90 3.23x23 TM3 A => P missense 0.0001625 6 36930 0 0.14 0.026
pi2r_human 90 3.23x23 TM3 A => T missense 5.416e-05 2 36930 0 0.35 0.028
pi2r_human 83 ECL1 G => S missense 4.269e-05 1 23422 0 0.08 0.665
pi2r_human 77 2.67x66 TM2 R => H missense 0.0007731 13 16816 0 0.12 0.198
pi2r_human 77 2.67x66 TM2 R => C missense 0.000355 6 16902 0 0.04 0.973
pi2r_human 76 2.66x65 TM2 A => V missense 6.212e-05 1 16098 0 0.0 0.988
pi2r_human 72 2.62x61 TM2 F => L missense 0.0001525 2 13114 1 0.93 0.997
pi2r_human 71 2.61x60 TM2 V => M missense 8.135e-05 1 12292 0 0.0 1.0
pi2r_human 49 2.39x39 TM2 F => L missense 0.000242 3 12396 0 0.0 1.0
pi2r_human 42 ICL1 R => Q missense 0.0004148 5 12054 0 0.1 0.718
pi2r_human 32 1.51x51 TM1 G => R missense 8.61e-05 1 11614 0 0.02 0.99
pi2r_human 30 1.49x49 TM1 G => S missense 8.803e-05 1 11360 0 0.0 1.0
pi2r_human 25 1.44x44 TM1 V => M missense 0.007009 65 9274 4 0.06 0.624
pi2r_human 21 1.40x40 TM1 T => N missense 0.0001232 1 8114 0 0.02 0.691
pi2r_human 17 1.36x36 TM1 P => L missense 0.0001681 1 5950 0 0.02 0.799
pi2r_human 15 1.34x34 TM1 V => A missense 0.01513 76 5024 3 0.7 0.023
pi2r_human 15 1.34x34 TM1 V => L missense 0.0002103 1 4754 0 0.29 0.295
pi2r_human 13 N-term G => D missense 0.0002275 1 4396 0 0.72 0.006
pi2r_human 11 N-term V => L missense 0.0005005 2 3996 0 0.62 0.195
pi2r_human 2 N-term A => T missense 0.001759 5 2842 0 0.07 0.435
pi2r_human 364 C-term Q => Ter stop gained 9.134e-06 1 109486 0 None None
pi2r_human 343 C-term E => AlafsTer47 frameshift 8.754e-06 1 114236 0 None None
pi2r_human 337 C-term S => LeufsTer55 frameshift 2.535e-05 3 118326 0 None None PTM (Phosphorylation)
pi2r_human 323 C-term L => PhefsTer69 frameshift 8.342e-06 1 119870 0 None None
pi2r_human 304 8.55x55 H8 K => GlnfsTer282 frameshift 8.388e-06 1 119214 0 None None
pi2r_human 302 8.53x53 H8 R => Ter stop gained 2.52e-05 3 119048 0 None None
pi2r_human 290 7.51x51 TM7 W => Ter stop gained 8.489e-06 1 117804 0 None None
pi2r_human 163 ECL2 Q => Ter stop gained 0.0001103 5 45312 0 None None
pi2r_human 129 34.55x55 ICL2 Q => Ter stop gained 1.127e-05 1 88768 0 None None GP (contact)
pi2r_human 100 3.33x33 TM3 T => IlefsTer166 frameshift 3.198e-05 2 62532 0 None None


Residue

Diagrams

ICL1 R P A R P ICL1ECL1 N S S L L G L ECL1 P Y L Y A Q L D ICL2ECL2 G Q H Q Q Y C P G S W C F L R M R W ECL2ICL3 Q G S L G ICL3ECL3 P D S S ECL3N-term M A D S C R N L T Y V R G N-termC-term C L G P A H G D S Q T P L S Q L A S G R R D P R A P S A P V G K E G S C V P L S A W G E G Q V E P L P P T Q Q S S G S A V G T S S K A E A S V A C S L C C-term S V G P A T S T L M F V A G V V G N G L A L G I L S A R S A F A V L V T G L A A T D L L G T S F L S P A V F V A Y A R A R G G P A L C D A F A F A M T F F G L A S M L I L F A M A V E R C L A L S H G P R C A R L A L P A I Y A F C V L F C A L P L L G L A Q P G G A A F S L A Y A G L V A L L V A A I F L C N G S V T L S L C R M Y R Q Q K R H P R P R T G E D E V D H L I L L A L M T V V M A V C S L P L T I R C F T Q A V A S E M G D L L A F R F Y A F N P I L D P W V F I L F R K A L K L L V F Q R W V C C
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