Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
ptafr_human 342 C-term N => D missense 8.625e-06 1 115944 0 nan 0.003
ptafr_human 338 C-term N => S missense 0.007644 899 117602 36 nan 0.001
ptafr_human 338 C-term N => D missense 2.546e-05 3 117840 0 nan 0.0
ptafr_human 337 C-term G => V missense 8.46e-06 1 118210 0 nan 0.0
ptafr_human 337 C-term G => S missense 8.436e-06 1 118534 0 nan 0.015
ptafr_human 333 C-term N => S missense 8.341e-06 1 119890 0 0.34 0.007
ptafr_human 328 C-term V => M missense 8.273e-06 1 120868 0 0.17 0.021
ptafr_human 327 C-term E => D missense 8.271e-06 1 120910 0 0.34 0.015
ptafr_human 326 C-term T => I missense 8.26e-06 1 121060 0 1.0 0.002
ptafr_human 326 C-term T => A missense 8.258e-06 1 121098 0 0.21 0.05
ptafr_human 323 C-term D => G missense 8.246e-06 1 121266 0 0.02 0.297
ptafr_human 323 C-term D => N missense 8.246e-06 1 121266 0 0.21 0.027
ptafr_human 322 C-term T => M missense 8.243e-06 1 121308 0 0.07 0.081
ptafr_human 321 C-term T => A missense 8.242e-05 10 121336 0 0.08 0.997
ptafr_human 317 C-term C => W missense 8.239e-06 1 121376 0 0.0 0.982
ptafr_human 317 C-term C => R missense 8.239e-06 1 121376 0 0.0 0.945
ptafr_human 315 C-term R => Q missense 4.119e-05 5 121386 0 0.14 0.045
ptafr_human 314 C-term S => R missense 1.648e-05 2 121394 0 0.08 0.776
ptafr_human 314 C-term S => G missense 8.238e-06 1 121394 0 0.48 0.025
ptafr_human 312 8.62x62 H8 R => L missense 8.238e-06 1 121396 0 0.03 0.436
ptafr_human 312 8.62x62 H8 R => C missense 8.237e-06 1 121398 0 0.01 0.891
ptafr_human 306 8.56x56 H8 E => K missense 8.237e-06 1 121406 0 0.15 0.118
ptafr_human 301 8.51x51 H8 R => L missense 8.237e-06 1 121404 0 0.0 0.866 GP (contact)
ptafr_human 301 8.51x51 H8 R => H missense 8.237e-06 1 121404 0 0.02 0.091 GP (contact)
ptafr_human 301 8.51x51 H8 R => C missense 8.237e-06 1 121398 0 0.0 0.939 GP (contact)
ptafr_human 299 7.59x59 TM7 K => N missense 2.471e-05 3 121396 0 0.06 0.662
ptafr_human 295 7.55x55 TM7 F => C missense 8.238e-06 1 121396 0 0.0 0.999 GP (contact)
ptafr_human 292 7.52x52 TM7 I => F missense 1.648e-05 2 121380 0 0.0 1.0
ptafr_human 291 7.51x51 TM7 V => I missense 8.239e-06 1 121376 0 0.9 0.011
ptafr_human 275 7.35x34 TM7 H => Y missense 1.651e-05 2 121112 0 0.0 1.0
ptafr_human 274 7.34x33 TM7 A => T missense 0.001215 147 121034 0 0.07 0.202
ptafr_human 267 7.27x26 TM7 F => L missense 8.27e-06 1 120918 0 0.72 0.009
ptafr_human 265 7.25x24 TM7 S => N missense 8.278e-06 1 120808 0 0.51 0.004
ptafr_human 264 7.24x23 TM7 D => E missense 8.275e-06 1 120848 0 0.41 0.077
ptafr_human 250 6.53x53 TM6 V => M missense 3.322e-05 4 120426 0 0.25 0.031
ptafr_human 249 6.52x52 TM6 H => Y missense 8.305e-06 1 120408 0 0.0 1.0
ptafr_human 249 6.52x52 TM6 H => D missense 8.305e-06 1 120408 0 0.0 1.0
ptafr_human 242 6.45x46 TM6 I => V missense 8.313e-06 1 120298 0 0.97 0.006
ptafr_human 239 6.42x43 TM6 A => V missense 4.161e-05 5 120162 0 0.12 0.026
ptafr_human 232 6.35x36 TM6 W => R missense 8.331e-06 1 120032 0 1.0 0.392 GP (contact)
ptafr_human 230 6.33x34 TM6 A => V missense 1.669e-05 2 119842 0 0.0 1.0 SodiumPocket MicroSwitch
ptafr_human 229 6.32x33 TM6 R => Q missense 0.000259 31 119696 0 0.13 0.672 GP (contact)
ptafr_human 229 6.32x33 TM6 R => W missense 8.35e-06 1 119764 0 0.0 0.998 GP (contact)
ptafr_human 228 6.31x32 TM6 R => H missense 6.682e-05 8 119718 0 0.11 0.011 GP (contact)
ptafr_human 228 6.31x32 TM6 R => C missense 8.351e-06 1 119752 0 0.02 0.027 GP (contact)
ptafr_human 225 6.28x29 TM6 E => D missense 8.355e-06 1 119688 0 0.53 0.006 GP (contact)
ptafr_human 224 6.27x28 TM6 A => D missense 0.007462 892 119532 33 0.28 0.861 GP (contact)
ptafr_human 224 6.27x28 TM6 A => T missense 1.674e-05 2 119510 0 0.43 0.161 GP (contact)
ptafr_human 222 6.25x26 TM6 R => H missense 0.0001256 15 119384 0 0.08 0.004 GP (contact)
ptafr_human 222 6.25x26 TM6 R => C missense 8.375e-06 1 119396 0 0.05 0.002 GP (contact)
ptafr_human 217 ICL3 P => L missense 3.356e-05 4 119182 0 0.02 0.732
ptafr_human 215 5.67x67 TM5 M => T missense 8.387e-06 1 119232 0 0.56 0.001 GP (contact)
ptafr_human 211 5.63x63 TM5 R => C missense 1.682e-05 2 118910 0 0.02 0.937
ptafr_human 208 5.60x60 TM5 V => L missense 3.362e-05 4 118968 0 1.0 0.015
ptafr_human 206 5.58x58 TM5 N => Y missense 8.391e-06 1 119176 0 0.0 1.0 SodiumPocket MicroSwitch
ptafr_human 193 5.45x45 TM5 F => S missense 2.499e-05 3 120048 0 0.44 0.007
ptafr_human 192 5.44x44 TM5 V => M missense 5.826e-05 7 120156 0 0.01 0.839
ptafr_human 186 5.38x38 TM5 I => V missense 8.284e-06 1 120718 0 1.0 0.009
ptafr_human 184 5.36x36 TM5 V => I missense 8.273e-06 1 120882 0 0.12 0.186
ptafr_human 182 5.34x34 TM5 V => M missense 4.132e-05 5 120994 0 0.15 0.004
ptafr_human 178 ECL2 E => K missense 0.0001403 17 121198 0 0.05 0.269
ptafr_human 176 ECL2 H => R missense 8.246e-06 1 121276 0 0.28 0.015
ptafr_human 175 45.52x52 ECL2 E => Q missense 8.245e-06 1 121284 0 0.0 1.0
ptafr_human 172 ECL2 R => C missense 1.648e-05 2 121324 0 0.0 0.999
ptafr_human 171 ECL2 T => I missense 8.241e-06 1 121340 0 0.12 0.949
ptafr_human 170 ECL2 V => I missense 8.241e-06 1 121346 0 1.0 0.003
ptafr_human 165 ECL2 A => P missense 8.239e-06 1 121374 0 0.27 0.006
ptafr_human 163 ECL2 D => N missense 3.295e-05 4 121386 0 0.93 0.001
ptafr_human 162 ECL2 P => S missense 2.471e-05 3 121386 0 0.61 0.002
ptafr_human 161 ECL2 V => G missense 1.648e-05 2 121392 0 0.38 0.608
ptafr_human 156 ECL2 D => E missense 8.237e-06 1 121400 0 0.73 0.022
ptafr_human 155 4.63x63 TM4 L => P missense 8.237e-06 1 121404 0 0.36 0.226
ptafr_human 154 4.62x62 TM4 I => T missense 8.237e-06 1 121404 0 0.22 0.006
ptafr_human 145 4.53x53 TM4 I => F missense 6.589e-05 8 121408 0 0.01 0.829
ptafr_human 144 4.52x52 TM4 A => V missense 0.0001318 16 121410 0 1.0 0.003
ptafr_human 144 4.52x52 TM4 A => S missense 8.237e-06 1 121408 0 0.12 0.011
ptafr_human 133 4.41x41 TM4 R => H missense 8.237e-06 1 121410 0 0.0 1.0
ptafr_human 131 4.39x39 TM4 R => H missense 8.237e-06 1 121410 0 0.01 0.98
ptafr_human 131 4.39x39 TM4 R => C missense 8.237e-06 1 121408 0 0.0 0.986
ptafr_human 121 3.56x56 TM3 R => Q missense 9.06e-05 11 121410 0 0.24 0.006 GP (contact)
ptafr_human 114 3.49x49 TM3 N => S missense 0.002735 332 121410 2 0.03 0.999 SodiumPocket MicroSwitch
ptafr_human 110 3.45x45 TM3 V => I missense 1.647e-05 2 121410 0 0.05 0.21
ptafr_human 99 3.34x34 TM3 I => T missense 8.236e-06 1 121412 0 0.0 0.877
ptafr_human 95 3.30x30 TM3 C => Y missense 8.236e-06 1 121412 0 0.21 0.125
ptafr_human 92 3.27x27 TM3 V => M missense 2.471e-05 3 121412 0 0.07 0.261
ptafr_human 87 3.22x22 TM3 K => R missense 2.471e-05 3 121410 0 0.1 0.011
ptafr_human 87 3.22x22 TM3 K => T missense 8.237e-06 1 121410 0 0.12 0.011
ptafr_human 79 2.66x66 TM2 N => K missense 8.237e-06 1 121404 0 0.67 0.529
ptafr_human 78 2.65x65 TM2 Q => E missense 8.237e-06 1 121400 0 0.24 0.021
ptafr_human 60 2.47x47 TM2 T => N missense 8.24e-06 1 121360 0 0.0 0.983
ptafr_human 50 2.37x37 TM2 N => S missense 5.771e-05 7 121300 0 0.29 0.095
ptafr_human 46 ICL1 C => R missense 8.246e-06 1 121274 0 0.09 0.001
ptafr_human 42 1.59x59 TM1 R => H missense 8.252e-06 1 121186 0 0.17 0.002
ptafr_human 36 1.53x53 TM1 V => M missense 8.256e-06 1 121130 0 0.0 1.0
ptafr_human 35 1.52x52 TM1 Y => C missense 8.256e-06 1 121128 0 0.0 1.0
ptafr_human 29 1.46x46 TM1 G => R missense 8.271e-06 1 120902 0 0.0 1.0
ptafr_human 28 1.45x45 TM1 L => F missense 0.0007617 92 120780 1 0.03 0.079
ptafr_human 24 1.41x41 TM1 I => T missense 8.318e-06 1 120224 0 0.0 0.548
ptafr_human 21 1.38x38 TM1 V => I missense 8.422e-06 1 118734 0 0.36 0.002
ptafr_human 14 1.31x31 TM1 R => Q missense 1.728e-05 2 115740 0 0.0 0.999
ptafr_human 9 N-term M => L missense 8.792e-06 1 113746 0 0.95 0.0
ptafr_human 8 N-term H => R missense 8.816e-06 1 113432 0 0.48 0.0
ptafr_human 6 N-term S => F missense 8.902e-06 1 112336 0 0.04 0.002
ptafr_human 3 N-term P => T missense 9.026e-06 1 110796 0 nan 0.001
ptafr_human 330 C-term V => GlyfsTer20 frameshift 8.304e-06 1 120424 0 None None
ptafr_human 323 C-term D => ValfsTer27 frameshift 8.247e-06 1 121260 0 None None
ptafr_human 252 6.55x55 TM6 Q => Ter stop gained 8.299e-06 1 120500 0 None None LB (polar (hydrogen bond))
ptafr_human 230 6.33x34 TM6 A => GlyfsTer30 frameshift 8.344e-06 1 119842 0 None None SodiumPocket MicroSwitch
ptafr_human 177 ECL2 Y => Ter stop gained 1.65e-05 2 121226 0 None None
ptafr_human 70 2.57x57 TM2 L => CysfsTer50 frameshift 1.648e-05 2 121392 0 None None


Residue

Diagrams

ICL1 P C K K ICL1ECL1 G N W I L ECL1 P I K T A Q A N ICL2ECL2 D S T N T V P D S A G S G N V T R C F E H Y E K G ECL2ICL3 P V Q Q ICL3ECL3 F Q ECL3N-term M E P H D S S H M N-termC-term S R K C S R A T T D T V T E V V V P F N Q I P G N S L K N C-term D S E F R Y T L F P I V Y S I I F V L G V I A N G Y V L W V F A R L Y F N E I K I F M V N L T M A D M L F L I T L P L W I V Y Y Q N Q P K F L C N V A G C L F F I N T Y C S V A F L G V I T Y N R F Q A V T R T R K R G I S L S L V I W V A I V G A A S Y F L I L S V P V L I I H I F I V F S F F L V F L I I L F C N L V I I R T L L M Q Q R N A E V K R R A L W M V C T V L A V F I I C F V P H H V V Q L P W T L A E L G D S K F H Q A I N D A H Q V T L C L L S T N C V L D P V I Y C F L T K K F R K K F Y H L T E S M R S
SnakePlot Download: PNG | SVG G N A I V G L V F I I S Y V I P F L T Y 1 V N L T M A D M L F L I T L P L W I V Y 2 V G L F A V S C Y T N I F F L C G A V N 3 G I S L S L V I W V A I V G A A S Y F L 4 N C F L I I L F V L F F S F V I F I H I 5 V C T V L A V F I I C F V P H H V V Q L P 6 V P D L V C N T S L L C L T V Q H A D 7
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