Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
s1pr1_human 3 N-term P => T missense 1.785e-05 2 112034 0 0.17 0.0
s1pr1_human 5 N-term S => G missense 8.763e-06 1 114122 0 0.13 0.0 PTM (O-GalNAc)
s1pr1_human 11 N-term A => D missense 0.00455 539 118470 11 0.23 0.019
s1pr1_human 13 N-term R => G missense 0.01404 1678 119544 17 0.39 0.001
s1pr1_human 13 N-term R => H missense 8.354e-06 1 119704 0 0.08 0.002
s1pr1_human 15 N-term S => L missense 1.661e-05 2 120408 0 0.33 0.001
s1pr1_human 15 N-term S => W missense 1.661e-05 2 120408 0 0.02 0.473
s1pr1_human 20 N-term V => F missense 8.255e-06 1 121134 0 0.66 0.001
s1pr1_human 27 N-term R => Q missense 8.239e-06 1 121370 0 0.51 0.001
s1pr1_human 38 N-term S => G missense 8.237e-06 1 121406 0 0.42 0.0
s1pr1_human 38 N-term S => R missense 8.237e-06 1 121406 0 0.74 0.001
s1pr1_human 39 N-term A => T missense 1.647e-05 2 121406 0 0.61 0.0
s1pr1_human 45 1.32x32 TM1 I => T missense 0.002001 243 121412 6 0.23 0.002
s1pr1_human 51 1.38x38 TM1 V => M missense 8.236e-06 1 121412 0 0.03 0.01
s1pr1_human 54 1.41x41 TM1 L => I missense 8.236e-06 1 121412 0 0.94 0.001
s1pr1_human 61 1.48x48 TM1 L => M missense 8.236e-06 1 121412 0 0.01 0.693
s1pr1_human 64 1.51x51 TM1 I => M missense 3.295e-05 4 121412 0 0.03 0.099
s1pr1_human 79 2.38x38 TM2 P => S missense 8.236e-06 1 121412 0 0.14 0.977
s1pr1_human 81 2.40x40 TM2 Y => C missense 8.236e-06 1 121412 0 0.0 0.998
s1pr1_human 115 3.23x23 TM3 A => T missense 8.238e-06 1 121396 0 0.82 0.013
s1pr1_human 123 3.31x31 TM3 S => C missense 8.237e-06 1 121410 0 0.03 0.275
s1pr1_human 123 3.31x31 TM3 S => R missense 8.237e-06 1 121410 0 0.0 0.908
s1pr1_human 137 3.45x45 TM3 A => S missense 8.237e-06 1 121398 0 0.0 0.999
s1pr1_human 153 34.54x54 ICL2 N => D missense 8.241e-06 1 121348 0 1.0 0.004 GP (contact)
s1pr1_human 157 4.39x39 TM4 N => K missense 8.241e-06 1 121338 0 1.0 0.002
s1pr1_human 166 4.48x48 TM4 A => T missense 8.242e-06 1 121326 0 0.25 0.05
s1pr1_human 172 4.54x54 TM4 L => F missense 8.242e-06 1 121332 0 0.28 0.052
s1pr1_human 180 4.62x62 TM4 M => I missense 8.242e-06 1 121334 0 0.11 0.068
s1pr1_human 185 ECL2 I => V missense 8.242e-06 1 121330 0 0.04 0.007
s1pr1_human 186 ECL2 S => I missense 8.242e-06 1 121328 0 0.05 0.094
s1pr1_human 190 ECL2 S => N missense 8.241e-06 1 121338 0 0.21 0.003
s1pr1_human 198 ECL2 Y => C missense 8.24e-06 1 121352 0 0.0 0.885
s1pr1_human 215 5.52x52 TM5 L => V missense 1.648e-05 2 121350 0 0.36 0.129
s1pr1_human 216 5.53x53 TM5 S => C missense 8.241e-06 1 121342 0 0.0 0.759
s1pr1_human 224 5.61x61 TM5 I => T missense 8.242e-06 1 121334 0 0.0 0.997 GP (contact)
s1pr1_human 224 5.61x61 TM5 I => N missense 8.242e-06 1 121334 0 0.0 0.999 GP (contact)
s1pr1_human 231 5.68x68 TM5 R => W missense 8.245e-06 1 121288 0 0.01 0.983 GP (contact)
s1pr1_human 231 5.68x68 TM5 R => Q missense 8.244e-06 1 121298 0 0.15 0.283 GP (contact)
s1pr1_human 238 ICL3 R => C missense 0.0001732 21 121280 0 0.01 0.93
s1pr1_human 239 ICL3 K => E missense 8.246e-06 1 121278 0 0.23 0.507
s1pr1_human 241 ICL3 I => V missense 2.474e-05 3 121254 0 0.68 0.001
s1pr1_human 243 ICL3 K => R missense 1.65e-05 2 121232 0 0.64 0.005
s1pr1_human 245 6.24x24 TM6 S => G missense 8.249e-06 1 121234 0 0.18 0.099
s1pr1_human 245 6.24x24 TM6 S => N missense 3.3e-05 4 121228 0 0.29 0.005
s1pr1_human 267 6.46x46 TM6 A => T missense 8.264e-06 1 121012 0 0.07 0.432
s1pr1_human 270 6.49x49 TM6 A => V missense 8.266e-06 1 120984 0 0.15 0.043
s1pr1_human 276 6.55x55 TM6 L => F missense 8.269e-06 1 120932 0 0.21 0.866 LB (hydrophobic)
s1pr1_human 293 7.35x34 TM7 A => T missense 8.282e-06 1 120742 0 0.04 0.092
s1pr1_human 307 7.49x49 TM7 N => D missense 8.286e-06 1 120692 0 0.0 1.0 SodiumPocket MicroSwitch
s1pr1_human 309 7.51x51 TM7 I => L missense 8.286e-06 1 120684 0 0.27 0.047
s1pr1_human 314 7.56x56 TM7 T => S missense 0.0002238 27 120650 0 0.4 0.001 GP (contact)
s1pr1_human 323 8.55x55 H8 I => L missense 8.303e-06 1 120440 0 1.0 0.0
s1pr1_human 324 8.56x56 H8 R => Q missense 8.307e-06 1 120384 0 0.01 0.078
s1pr1_human 326 8.58x58 H8 M => T missense 8.312e-06 1 120302 0 0.0 0.005
s1pr1_human 332 C-term P => A missense 8.344e-06 1 119846 0 0.55 0.0
s1pr1_human 332 C-term P => R missense 5.009e-05 6 119778 0 0.39 0.001
s1pr1_human 332 C-term P => Q missense 8.349e-06 1 119778 0 0.33 0.063
s1pr1_human 334 C-term G => R missense 4.181e-05 5 119578 0 0.46 0.001
s1pr1_human 342 C-term R => Q missense 8.426e-06 1 118676 0 0.44 0.006
s1pr1_human 344 C-term I => M missense 8.478e-06 1 117950 0 0.23 0.615
s1pr1_human 346 C-term A => S missense 8.486e-06 1 117842 0 0.83 0.002
s1pr1_human 352 C-term R => G missense 2.569e-05 3 116782 0 0.35 0.023
s1pr1_human 352 C-term R => C missense 8.563e-06 1 116782 0 0.12 0.032
s1pr1_human 358 C-term S => C missense 8.604e-06 1 116220 0 0.01 0.96 PTM (Phosphorylation)
s1pr1_human 365 C-term E => K missense 8.62e-06 1 116014 0 0.24 0.001
s1pr1_human 367 C-term D => G missense 1.724e-05 2 115996 0 0.17 0.002
s1pr1_human 374 C-term S => F missense 8.629e-06 1 115894 0 0.0 0.839
s1pr1_human 378 C-term V => I missense 8.634e-06 1 115818 0 0.69 0.001
s1pr1_human 380 C-term S => Y missense 1.729e-05 2 115664 0 0.02 0.825
s1pr1_human 283 ECL3 K => Ter stop gained 8.276e-06 1 120838 0 None None


Residue

Diagrams

K K F H ICL1ECL1 S G A T T Y K L ECL1 M K L H N G S ICL2ECL2 W N C I S A L S S C S T V L P L Y ECL2ICL3 F R K N I S K A ICL3ECL3 K V K T C ECL3N-term M G P T S V P L V K A H R S S V S D Y V N Y D I I V R H Y N Y T G K L N I S A D K N-termC-term C C K C P S G D S A G K F K R P I I A G M E F S R S K S D N S S H P Q K D E G D N P E T I M S S G N V N S S S C-term E N S I K L T S V V F I L I C C F I I L E N I F V L L T I W K T R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K N N F R L F L L I S A C W V I S L I L G G L P I M G H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T S R S S E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E F I R M R R A I M S
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