Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
ssr3_human 418 C-term L => P missense 8.447e-06 1 118386 0 nan 0.998
ssr3_human 415 C-term I => V missense 8.432e-06 1 118594 0 nan 0.002
ssr3_human 415 C-term I => F missense 2.53e-05 3 118594 0 nan 0.265
ssr3_human 414 C-term R => H missense 0.002033 241 118520 5 1.0 0.0
ssr3_human 414 C-term R => C missense 0.0003032 36 118738 0 nan 0.394
ssr3_human 412 C-term T => M missense 5.881e-05 7 119030 0 nan 0.014
ssr3_human 412 C-term T => P missense 8.398e-06 1 119074 0 nan 0.001
ssr3_human 411 C-term S => T missense 0.01932 2302 119180 244 nan 0.103
ssr3_human 411 C-term S => I missense 8.391e-06 1 119180 0 nan 0.429
ssr3_human 401 C-term P => S missense 8.332e-06 1 120018 0 nan 0.999
ssr3_human 398 C-term Q => K missense 8.333e-06 1 120012 0 nan 0.001
ssr3_human 396 C-term E => K missense 8.329e-06 1 120066 0 nan 0.03
ssr3_human 394 C-term S => G missense 4.165e-05 5 120054 0 nan 0.0
ssr3_human 393 C-term A => D missense 2.499e-05 3 120068 0 nan 0.101
ssr3_human 390 C-term S => R missense 8.333e-06 1 120004 0 nan 0.209
ssr3_human 389 C-term P => L missense 8.331e-06 1 120036 0 nan 0.002
ssr3_human 388 C-term P => L missense 4.167e-05 5 119990 0 nan 0.006
ssr3_human 387 C-term R => Q missense 3.336e-05 4 119908 0 nan 0.003
ssr3_human 387 C-term R => W missense 5.005e-05 6 119892 0 nan 0.513
ssr3_human 386 C-term E => K missense 8.337e-06 1 119948 0 nan 0.075
ssr3_human 382 C-term T => N missense 8.342e-06 1 119870 0 0.74 0.002
ssr3_human 382 C-term T => I missense 8.342e-06 1 119870 0 0.18 0.096
ssr3_human 378 C-term T => M missense 0.0001169 14 119798 0 0.01 0.297
ssr3_human 373 C-term R => W missense 5.857e-05 7 119510 0 0.01 0.513
ssr3_human 369 C-term E => G missense 8.383e-06 1 119294 0 0.22 0.0
ssr3_human 366 C-term K => R missense 8.397e-06 1 119090 0 0.79 0.0
ssr3_human 363 C-term E => D missense 8.405e-06 1 118970 0 0.57 0.014
ssr3_human 363 C-term E => K missense 8.407e-06 1 118944 0 0.8 0.0
ssr3_human 356 C-term E => K missense 2.527e-05 3 118740 0 0.55 0.014
ssr3_human 355 C-term E => G missense 8.44e-06 1 118484 0 0.37 0.002
ssr3_human 355 C-term E => K missense 0.00027 32 118522 0 0.47 0.007
ssr3_human 352 C-term D => E missense 9.289e-05 11 118424 0 1.0 0.0
ssr3_human 352 C-term D => Y missense 1.688e-05 2 118480 0 0.01 0.17
ssr3_human 351 C-term E => K missense 8.445e-06 1 118416 0 0.45 0.019
ssr3_human 345 C-term P => L missense 0.0002886 34 117804 0 0.56 0.006
ssr3_human 341 C-term T => A missense 0.0002544 30 117946 0 1.0 0.0 PTM (Phosphorylation)
ssr3_human 337 C-term S => G missense 1.693e-05 2 118100 0 0.21 0.101 PTM (Phosphorylation)
ssr3_human 336 C-term R => H missense 8.47e-06 1 118062 0 0.08 0.006
ssr3_human 336 C-term R => C missense 0.003573 422 118120 0 0.06 0.614
ssr3_human 334 C-term R => H missense 5.924e-05 7 118158 0 0.03 0.988
ssr3_human 334 C-term R => C missense 5.079e-05 6 118142 0 0.01 0.994
ssr3_human 333 C-term R => C missense 0.000262 31 118330 0 0.02 0.98
ssr3_human 332 C-term S => F missense 8.446e-06 1 118400 0 0.02 0.979 PTM (Phosphorylation)
ssr3_human 331 C-term P => L missense 8.444e-06 1 118432 0 0.03 0.883
ssr3_human 330 C-term R => W missense 6.749e-05 8 118530 0 0.03 0.999
ssr3_human 325 8.55x55 H8 R => C missense 8.397e-06 1 119088 0 0.0 0.999
ssr3_human 319 8.49x49 H8 R => H missense 2.511e-05 3 119496 0 0.01 0.927 GP (contact)
ssr3_human 319 8.49x49 H8 R => C missense 8.364e-06 1 119554 0 0.0 0.962 GP (contact)
ssr3_human 307 7.47x47 TM7 C => W missense 1.662e-05 2 120372 0 0.0 1.0
ssr3_human 307 7.47x47 TM7 C => Y missense 8.306e-06 1 120388 0 0.0 1.0
ssr3_human 306 7.46x46 TM7 S => R missense 8.306e-06 1 120398 0 0.0 1.0
ssr3_human 302 7.42x41 TM7 P => L missense 8.302e-06 1 120456 0 0.04 0.978
ssr3_human 300 7.40x39 TM7 A => V missense 8.302e-06 1 120458 0 1.0 0.037
ssr3_human 300 7.40x39 TM7 A => E missense 8.302e-06 1 120458 0 0.0 0.969
ssr3_human 294 7.34x33 TM7 L => F missense 8.304e-06 1 120428 0 0.02 0.949
ssr3_human 289 7.29x28 TM7 P => R missense 8.308e-06 1 120364 0 0.05 1.0
ssr3_human 289 7.29x28 TM7 P => T missense 8.309e-06 1 120358 0 0.01 1.0
ssr3_human 287 ECL3 E => K missense 8.311e-06 1 120326 0 0.11 0.545
ssr3_human 281 6.59x59 TM6 V => G missense 8.314e-06 1 120282 0 0.0 0.868
ssr3_human 281 6.59x59 TM6 V => M missense 2.495e-05 3 120264 0 0.01 0.913
ssr3_human 275 6.53x53 TM6 V => M missense 7.491e-05 9 120152 0 0.12 0.507
ssr3_human 269 6.47x47 TM6 C => Y missense 8.341e-06 1 119896 0 0.0 1.0
ssr3_human 267 6.45x45 TM6 V => M missense 3.341e-05 4 119736 0 0.01 0.993
ssr3_human 264 6.42x42 TM6 A => E missense 3.359e-05 4 119072 0 0.02 0.95
ssr3_human 264 6.42x42 TM6 A => V missense 3.359e-05 4 119072 0 0.57 0.05
ssr3_human 264 6.42x42 TM6 A => T missense 8.398e-06 1 119074 0 0.19 0.284
ssr3_human 262 6.40x40 TM6 V => M missense 8.403e-06 1 119000 0 0.04 0.996 GP (contact)
ssr3_human 259 6.37x37 TM6 V => M missense 8.422e-06 1 118742 0 0.0 1.0 GP (contact)
ssr3_human 257 6.35x35 TM6 R => H missense 4.218e-05 5 118546 0 0.04 0.045
ssr3_human 257 6.35x35 TM6 R => L missense 6.748e-05 8 118546 0 0.0 0.699
ssr3_human 257 6.35x35 TM6 R => C missense 0.0001015 12 118210 0 0.0 0.103
ssr3_human 256 6.34x34 TM6 T => M missense 1.692e-05 2 118236 0 0.0 1.0 SodiumPocket MicroSwitch
ssr3_human 253 6.31x31 TM6 R => H missense 1.71e-05 2 116952 0 0.0 0.99
ssr3_human 253 6.31x31 TM6 R => C missense 4.273e-05 5 117006 0 0.03 0.479
ssr3_human 253 6.31x31 TM6 R => S missense 8.547e-06 1 117006 0 0.0 0.977
ssr3_human 250 6.28x28 TM6 R => C missense 8.777e-06 1 113930 0 0.01 0.009 GP (contact)
ssr3_human 248 6.26x26 TM6 R => W missense 8.614e-05 10 116094 0 0.0 0.993 GP (contact)
ssr3_human 247 6.25x25 TM6 R => Q missense 2.584e-05 3 116108 0 0.11 0.686 GP (contact)
ssr3_human 247 6.25x25 TM6 R => W missense 0.0001723 20 116056 0 0.03 0.984 GP (contact)
ssr3_human 244 ICL3 S => L missense 2.584e-05 3 116080 0 0.0 0.686
ssr3_human 243 ICL3 P => R missense 8.613e-06 1 116106 0 0.02 0.555
ssr3_human 242 ICL3 A => P missense 0.0002502 29 115912 0 0.01 0.939
ssr3_human 239 5.71x71 TM5 R => Q missense 0.0005006 58 115856 0 0.0 0.109 GP (contact)
ssr3_human 238 5.70x70 TM5 R => H missense 1.726e-05 2 115906 0 0.04 0.996
ssr3_human 238 5.70x70 TM5 R => C missense 0.0001036 12 115868 1 0.08 0.998
ssr3_human 237 5.69x69 TM5 G => R missense 8.624e-06 1 115962 0 0.01 0.93 GP (contact)
ssr3_human 234 5.66x66 TM5 R => H missense 0.0002842 33 116124 0 0.0 0.998 GP (contact)
ssr3_human 230 5.62x62 TM5 V => M missense 5.161e-05 6 116250 0 0.0 0.861
ssr3_human 224 5.56x56 TM5 L => F missense 8.615e-06 1 116076 0 0.01 0.576
ssr3_human 222 5.54x54 TM5 I => N missense 8.627e-06 1 115918 0 0.0 0.967
ssr3_human 217 5.49x49 TM5 G => R missense 1.74e-05 2 114916 0 0.15 0.994
ssr3_human 214 5.46x461 TM5 G => D missense 1.75e-05 2 114296 0 0.0 1.0
ssr3_human 214 5.46x461 TM5 G => A missense 8.749e-06 1 114296 0 0.0 1.0
ssr3_human 210 5.42x43 TM5 T => M missense 7.048e-05 8 113510 0 0.0 0.939
ssr3_human 210 5.42x43 TM5 T => S missense 8.818e-06 1 113410 0 0.0 0.856
ssr3_human 206 5.38x39 TM5 F => L missense 8.948e-06 1 111752 0 0.02 0.099
ssr3_human 205 5.37x38 TM5 G => S missense 4.529e-05 5 110388 0 0.17 0.159
ssr3_human 200 5.32x33 TM5 A => V missense 4.639e-05 5 107776 0 0.26 0.276
ssr3_human 199 5.31x32 TM5 A => V missense 2.843e-05 3 105510 0 0.41 0.172
ssr3_human 197 ECL2 E => K missense 0.0003118 33 105842 1 0.02 0.144
ssr3_human 189 ECL2 S => T missense 2.922e-05 3 102682 0 0.34 0.201
ssr3_human 188 ECL2 M => I missense 1.935e-05 2 103354 0 0.41 0.244
ssr3_human 188 ECL2 M => R missense 2.905e-05 3 103268 0 0.37 0.143
ssr3_human 187 ECL2 G => S missense 9.673e-06 1 103376 0 0.05 0.083
ssr3_human 186 ECL2 R => H missense 0.0005801 60 103434 2 0.21 0.022
ssr3_human 186 ECL2 R => P missense 9.668e-06 1 103434 0 0.19 0.763
ssr3_human 186 ECL2 R => C missense 9.647e-06 1 103654 0 0.02 0.846
ssr3_human 182 4.64x65 TM4 S => L missense 4.796e-05 5 104262 0 0.0 0.984
ssr3_human 181 4.63x64 TM4 F => L missense 8.556e-05 9 105186 0 0.0 0.999
ssr3_human 179 4.61x62 TM4 V => L missense 9.48e-05 10 105486 0 0.17 0.047
ssr3_human 177 4.59x60 TM4 P => S missense 9.419e-06 1 106164 0 0.02 0.999
ssr3_human 173 4.55x55 TM4 V => M missense 0.001199 128 106750 0 0.02 0.967
ssr3_human 172 4.54x54 TM4 A => V missense 3.735e-05 4 107082 0 0.21 0.808
ssr3_human 168 4.50x50 TM4 W => R missense 9.254e-06 1 108056 0 0.0 1.0
ssr3_human 167 4.49x49 TM4 V => A missense 3.695e-05 4 108262 0 0.02 0.927
ssr3_human 165 4.47x47 TM4 A => V missense 0.0003853 42 109014 0 0.28 0.045
ssr3_human 165 4.47x47 TM4 A => T missense 0.0001559 17 109068 0 0.13 0.184
ssr3_human 162 4.44x44 TM4 T => M missense 6.353e-05 7 110192 0 0.21 0.067
ssr3_human 161 4.43x43 TM4 R => H missense 9.067e-06 1 110290 0 0.0 0.977
ssr3_human 161 4.43x43 TM4 R => C missense 8.13e-05 9 110706 0 0.0 0.977
ssr3_human 155 34.57x57 ICL2 R => H missense 8.858e-06 1 112888 0 0.0 1.0 GP (contact)
ssr3_human 155 34.57x57 ICL2 R => C missense 4.42e-05 5 113120 0 0.0 1.0 GP (contact)
ssr3_human 153 34.55x55 ICL2 R => H missense 3.522e-05 4 113582 0 0.01 0.969 GP (contact)
ssr3_human 153 34.55x55 ICL2 R => C missense 2.632e-05 3 113994 0 0.0 0.969 GP (contact)
ssr3_human 151 34.53x53 ICL2 S => L missense 2.573e-05 3 116576 0 0.0 0.995 GP (contact)
ssr3_human 150 34.52x52 ICL2 R => L missense 8.568e-06 1 116712 0 0.01 0.545 GP (contact)
ssr3_human 150 34.52x52 ICL2 R => C missense 2.564e-05 3 116994 0 0.02 0.077 GP (contact)
ssr3_human 145 3.54x54 TM3 V => M missense 8.471e-06 1 118052 0 0.0 1.0 GP (contact)
ssr3_human 142 3.51x51 TM3 Y => H missense 1.685e-05 2 118698 0 0.0 1.0 PTM (Phosphorylation)
ssr3_human 141 3.50x50 TM3 R => H missense 1.685e-05 2 118720 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
ssr3_human 141 3.50x50 TM3 R => L missense 8.423e-06 1 118720 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
ssr3_human 141 3.50x50 TM3 R => C missense 6.727e-05 8 118924 0 0.0 1.0 SodiumPocket MicroSwitch GP (contact)
ssr3_human 139 3.48x48 TM3 V => M missense 1.677e-05 2 119230 0 0.08 0.994
ssr3_human 138 3.47x47 TM3 S => T missense 1.675e-05 2 119414 0 0.0 0.999
ssr3_human 138 3.47x47 TM3 S => C missense 8.37e-06 1 119480 0 0.0 1.0
ssr3_human 137 3.46x46 TM3 M => T missense 1.672e-05 2 119616 0 0.0 0.964
ssr3_human 134 3.43x43 TM3 L => P missense 8.336e-06 1 119956 0 0.0 1.0
ssr3_human 125 3.34x34 TM3 I => T missense 8.3e-06 1 120478 0 0.01 0.247
ssr3_human 121 3.30x30 TM3 A => V missense 1.659e-05 2 120572 0 0.0 0.952
ssr3_human 117 3.26x26 TM3 R => H missense 2.487e-05 3 120626 0 0.01 1.0
ssr3_human 117 3.26x26 TM3 R => L missense 8.29e-06 1 120626 0 0.0 1.0
ssr3_human 117 3.26x26 TM3 R => C missense 3.315e-05 4 120650 0 0.0 1.0
ssr3_human 112 3.21x21 TM3 G => S missense 1.657e-05 2 120682 0 0.0 1.0
ssr3_human 111 23.52x52 ECL1 F => L missense 8.286e-06 1 120686 0 0.0 0.999
ssr3_human 102 2.62x62 TM2 A => T missense 4.145e-05 5 120638 0 1.0 0.801
ssr3_human 96 2.56x56 TM2 G => W missense 1.658e-05 2 120644 0 0.0 1.0
ssr3_human 91 2.51x51 TM2 E => K missense 8.291e-06 1 120606 0 0.04 0.992
ssr3_human 86 2.46x46 TM2 L => V missense 3.317e-05 4 120604 0 0.0 0.999
ssr3_human 81 2.41x41 TM2 V => L missense 8.298e-06 1 120518 0 0.05 0.096
ssr3_human 81 2.41x41 TM2 V => I missense 1.66e-05 2 120518 0 1.0 0.034
ssr3_human 79 2.39x39 TM2 T => N missense 8.306e-06 1 120398 0 0.0 0.99
ssr3_human 79 2.39x39 TM2 T => P missense 2.492e-05 3 120388 0 0.0 0.986
ssr3_human 79 2.39x39 TM2 T => S missense 1.661e-05 2 120388 0 0.0 0.936
ssr3_human 75 12.50x50 ICL1 S => G missense 8.347e-06 1 119800 0 0.16 0.008
ssr3_human 73 12.48x48 ICL1 T => M missense 2.512e-05 3 119404 0 0.0 0.969
ssr3_human 72 1.60x60 TM1 H => Q missense 8.378e-06 1 119366 0 0.03 0.035
ssr3_human 71 1.59x59 TM1 R => Q missense 6.719e-05 8 119070 0 0.01 0.509 PTM (Methylation)
ssr3_human 69 1.57x57 TM1 V => F missense 1.686e-05 2 118648 0 0.0 0.962
ssr3_human 63 1.51x51 TM1 S => L missense 3.415e-05 4 117124 0 0.0 0.967
ssr3_human 57 1.45x45 TM1 V => L missense 1.736e-05 2 115238 0 0.04 0.016
ssr3_human 56 1.44x44 TM1 V => M missense 0.0001304 15 115038 2 0.02 0.987
ssr3_human 55 1.43x43 TM1 C => W missense 2.609e-05 3 114996 0 0.01 0.999
ssr3_human 55 1.43x43 TM1 C => Y missense 8.701e-06 1 114924 0 0.02 0.999
ssr3_human 46 1.34x34 TM1 L => V missense 8.86e-06 1 112864 0 0.49 0.916
ssr3_human 45 1.33x33 TM1 V => I missense 0.0003108 35 112622 0 0.43 0.01
ssr3_human 42 1.30x30 TM1 V => I missense 8.042e-05 9 111914 0 0.29 0.005
ssr3_human 38 N-term A => V missense 9.006e-06 1 111036 0 0.51 0.002
ssr3_human 37 N-term P => L missense 0.001397 155 110978 0 0.41 0.0
ssr3_human 37 N-term P => T missense 9.015e-06 1 110930 0 0.32 0.001
ssr3_human 36 N-term S => R missense 9.028e-06 1 110764 0 0.14 0.265
ssr3_human 33 N-term A => V missense 0.06833 7538 110322 384 0.4 0.002
ssr3_human 32 N-term S => L missense 5.451e-05 6 110078 1 0.04 0.564
ssr3_human 31 N-term V => E missense 5.456e-05 6 109964 0 1.0 0.021
ssr3_human 31 N-term V => M missense 9.1e-06 1 109896 0 0.15 0.075
ssr3_human 29 N-term G => D missense 9.117e-06 1 109680 0 0.25 0.367
ssr3_human 27 N-term T => N missense 9.129e-06 1 109538 0 0.18 0.05
ssr3_human 23 N-term P => S missense 9.154e-06 1 109238 0 0.3 0.003
ssr3_human 21 N-term A => T missense 1.833e-05 2 109134 0 0.37 0.002
ssr3_human 20 N-term S => L missense 6.416e-05 7 109110 0 0.36 0.002
ssr3_human 19 N-term S => C missense 9.167e-06 1 109092 0 0.0 0.728
ssr3_human 11 N-term T => M missense 3.69e-05 4 108404 0 0.19 0.009
ssr3_human 8 N-term S => L missense 3.714e-05 4 107710 0 nan 0.001
ssr3_human 5 N-term H => Y missense 9.361e-06 1 106830 0 1.0 0.0
ssr3_human 4 N-term L => F missense 9.423e-06 1 106128 0 nan 0.03
ssr3_human 3 N-term M => T missense 1.889e-05 2 105896 0 nan 0.0
ssr3_human 405 C-term S => ProfsTer48 frameshift 8.346e-06 1 119816 0 None None
ssr3_human 402 C-term Q => Ter stop gained 8.335e-06 1 119980 0 None None
ssr3_human 361 C-term S => GlufsTer89 frameshift 1.682e-05 2 118902 0 None None
ssr3_human 322 8.52x52 H8 Q => Ter stop gained 8.38e-06 1 119328 0 None None
ssr3_human 274 6.52x52 TM6 Y => Ter stop gained 8.32e-06 1 120194 0 None None
ssr3_human 135 3.44x44 TM3 T => SerfsTer2 frameshift 8.354e-06 1 119704 0 None None
ssr3_human 68 1.56x56 TM1 V => GlyfsTer281 frameshift 8.428e-06 1 118648 0 None None
ssr3_human 27 N-term T => HisfsTer36 frameshift 1.826e-05 2 109502 0 None None


Residue

Diagrams

T A S P ICL1ECL1 S Y W P F ECL1 P T R S A R W R ICL2ECL2 G V P R G M S T C H M Q W P E ECL2ICL3 W A P S C ICL3ECL3 P L P E ECL3N-term M D M L H P S S V S T T S E P E N A S S A W P P D A T L G N V S A G P S P A G L A N-termC-term R P S R R V R S Q E P T V G P P E K T E E E D E E E E D G E E S R E G G K G K E M N G R V S Q I T Q P G T S G Q E R P P S R V A S K E Q Q L L P Q E A S T G E K S S T M R I S Y L C-term V S G V L I P L V Y L V V C V V G L L G N S L V I Y V V L R H S V T N V Y I L N L A L A D E L F M L G L P F L A A Q N A L G S L M C R L V M A V D G I N Q F T S I F C L T V M S V D R Y L A V V H T A P V A R T V S A A V W V A S A V V V L P V V V F S P A A A W R A G F I I Y T A A L G F F G P L L V I C L C Y L L I V V K V R S A G R R V Q R R R R S E R R V T R M V V A V V A L F V L C W M P F Y V L N I V N V V C E P A F F G L Y F L V V A L P Y A N S C A N P I L Y G F L S Y R F R R F K Q G V L L
SnakePlot Download: PNG | SVG S N G L L G V V C V V L Y V L P I L V G 1 L N L A L A D E L F M L G L P F L A A Q 2 V T L C F I S T F Q N I G D V A M V L R 3 A R T V S A A V W V A S A V V V L P V 4 Y C L C I V L L P G F F G L A A T Y I I F 5 V A V V A L F V L C W M P F Y V L N I V 6 I P N A C S N A Y P L A V V L F Y L G 7
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