Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
ssr4_human 8 N-term P => A missense 2.601e-05 1 38454 0 0.17 0.099
ssr4_human 8 N-term P => L missense 0.0003242 13 40094 0 0.14 0.329
ssr4_human 9 N-term P => A missense 2.316e-05 1 43176 0 0.06 0.017
ssr4_human 10 N-term G => W missense 0.01006 482 47892 6 0.08 0.009
ssr4_human 11 N-term G => S missense 1.924e-05 1 51978 0 0.86 0.225
ssr4_human 18 N-term A => T missense 1.301e-05 1 76876 0 0.46 0.0
ssr4_human 18 N-term A => V missense 1.278e-05 1 78272 0 0.12 0.001
ssr4_human 20 N-term P => A missense 1.2e-05 1 83312 0 0.13 0.006
ssr4_human 20 N-term P => R missense 1.179e-05 1 84820 0 0.08 0.048
ssr4_human 26 N-term S => N missense 1.036e-05 1 96538 0 0.05 0.932
ssr4_human 28 N-term A => S missense 1.015e-05 1 98474 0 0.39 0.001
ssr4_human 32 N-term A => T missense 9.921e-06 1 100796 0 0.66 0.003
ssr4_human 32 N-term A => G missense 9.909e-06 1 100918 0 0.54 0.0
ssr4_human 36 N-term V => M missense 1.941e-05 2 103028 0 0.22 0.001
ssr4_human 37 N-term A => V missense 9.752e-06 1 102542 0 0.33 0.0
ssr4_human 37 N-term A => E missense 9.752e-06 1 102542 0 0.47 0.001
ssr4_human 38 N-term G => R missense 0.000473 49 103596 1 0.04 0.001
ssr4_human 38 N-term G => R missense 9.653e-06 1 103596 0 0.04 0.001
ssr4_human 38 N-term G => E missense 9.64e-06 1 103734 0 0.07 0.035
ssr4_human 40 N-term G => W missense 4.795e-05 5 104274 0 0.08 0.648
ssr4_human 40 N-term G => R missense 9.59e-06 1 104274 0 0.62 0.004
ssr4_human 40 N-term G => E missense 9.554e-06 1 104672 0 0.89 0.003
ssr4_human 41 N-term D => E missense 9.504e-06 1 105216 0 1.0 0.0
ssr4_human 42 N-term A => T missense 9.506e-06 1 105196 0 0.59 0.001
ssr4_human 45 1.30x30 TM1 A => P missense 7.504e-05 8 106608 0 0.05 0.003
ssr4_human 46 1.31x31 TM1 G => R missense 4.655e-05 5 107408 0 0.45 0.759
ssr4_human 47 1.32x32 TM1 M => V missense 8.337e-05 9 107954 0 0.46 0.006
ssr4_human 50 1.35x35 TM1 I => L missense 9.185e-06 1 108878 0 0.09 0.012
ssr4_human 55 1.40x40 TM1 A => S missense 9.143e-06 1 109376 0 0.42 0.144
ssr4_human 55 1.40x40 TM1 A => V missense 1.828e-05 2 109384 0 0.3 0.377
ssr4_human 57 1.42x42 TM1 V => M missense 9.129e-06 1 109546 0 0.01 0.303
ssr4_human 82 2.39x39 TM2 T => I missense 1.804e-05 2 110844 0 0.0 1.0
ssr4_human 86 2.43x43 TM2 L => P missense 8.976e-06 1 111402 0 0.0 0.992
ssr4_human 91 2.48x48 TM2 V => I missense 8.933e-06 1 111946 0 0.99 0.005
ssr4_human 93 2.50x50 TM2 D => N missense 1.782e-05 2 112206 0 0.0 0.999
ssr4_human 99 2.56x56 TM2 S => T missense 1.773e-05 2 112812 0 0.0 0.999
ssr4_human 99 2.56x56 TM2 S => N missense 8.864e-06 1 112812 0 0.0 1.0
ssr4_human 101 2.58x58 TM2 P => T missense 8.862e-06 1 112846 0 0.0 1.0
ssr4_human 103 2.60x60 TM2 V => M missense 2.657e-05 3 112900 0 0.03 0.864
ssr4_human 108 2.65x65 TM2 A => T missense 1.774e-05 2 112738 0 0.05 0.117
ssr4_human 110 ECL1 R => C missense 1.775e-05 2 112700 0 0.1 0.932
ssr4_human 110 ECL1 R => H missense 2.66e-05 3 112770 0 0.42 0.021
ssr4_human 110 ECL1 R => L missense 8.868e-06 1 112770 0 0.49 0.715
ssr4_human 115 3.21x21 TM3 G => R missense 1.774e-05 2 112740 0 0.01 1.0
ssr4_human 117 3.23x23 TM3 V => E missense 8.864e-06 1 112810 0 0.11 0.395
ssr4_human 120 3.26x26 TM3 R => H missense 8.848e-06 1 113022 0 0.02 0.477
ssr4_human 121 3.27x27 TM3 A => T missense 1.766e-05 2 113262 0 0.21 0.021
ssr4_human 125 3.31x31 TM3 V => I missense 8.755e-06 1 114224 0 0.03 0.74
ssr4_human 125 3.31x31 TM3 V => A missense 8.751e-06 1 114272 0 0.11 0.803
ssr4_human 125 3.31x31 TM3 V => D missense 8.751e-06 1 114272 0 0.0 0.982
ssr4_human 127 3.33x33 TM3 G => R missense 8.686e-06 1 115126 0 0.0 0.999
ssr4_human 127 3.33x33 TM3 G => S missense 8.686e-06 1 115126 0 0.33 0.992
ssr4_human 129 3.35x35 TM3 N => T missense 8.581e-06 1 116540 0 0.01 1.0
ssr4_human 130 3.36x36 TM3 M => L missense 8.56e-05 10 116816 0 0.08 0.628
ssr4_human 130 3.36x36 TM3 M => V missense 8.56e-06 1 116816 0 0.02 0.734
ssr4_human 134 3.40x40 TM3 V => I missense 8.494e-06 1 117736 0 1.0 0.386 SodiumPocket MicroSwitch
ssr4_human 135 3.41x41 TM3 F => L missense 8.478e-06 1 117952 0 0.0 0.93
ssr4_human 138 3.44x44 TM3 T => S missense 8.449e-06 1 118356 0 0.01 0.868
ssr4_human 144 3.50x50 TM3 R => C missense 5.062e-05 6 118540 0 0.03 0.344 SodiumPocket MicroSwitch GP (contact)
ssr4_human 145 3.51x51 TM3 Y => N missense 3.375e-05 4 118526 0 0.0 1.0
ssr4_human 150 3.56x56 TM3 H => N missense 8.471e-06 1 118056 0 0.0 1.0 GP (contact)
ssr4_human 153 34.52x52 ICL2 R => H missense 1.702e-05 2 117482 0 0.02 0.893 GP (contact)
ssr4_human 154 34.53x53 ICL2 A => V missense 2.558e-05 3 117274 0 0.02 0.176 GP (contact)
ssr4_human 155 34.54x54 ICL2 A => V missense 1.708e-05 2 117106 0 0.0 0.995 GP (contact)
ssr4_human 158 34.57x57 ICL2 R => Q missense 8.579e-06 1 116568 0 0.0 0.377 GP (contact)
ssr4_human 163 4.42x42 TM4 A => G missense 6.913e-05 8 115732 0 0.0 0.999
ssr4_human 168 4.47x47 TM4 L => R missense 8.676e-06 1 115264 0 0.15 0.721
ssr4_human 170 4.49x49 TM4 V => M missense 8.694e-06 1 115026 0 0.02 0.968
ssr4_human 170 4.49x49 TM4 V => A missense 8.692e-06 1 115052 0 0.03 0.896
ssr4_human 174 4.53x53 TM4 S => P missense 8.727e-06 1 114582 0 0.0 0.968
ssr4_human 178 4.57x57 TM4 T => N missense 3.509e-05 4 113988 0 0.15 0.864
ssr4_human 185 4.64x65 TM4 A => T missense 8.796e-06 1 113692 0 0.01 0.869
ssr4_human 188 ECL2 R => G missense 3.56e-05 4 112372 0 0.32 0.158
ssr4_human 196 ECL2 V => M missense 2.732e-05 3 109792 0 0.1 0.999
ssr4_human 197 ECL2 A => S missense 1.815e-05 2 110172 0 0.25 0.633
ssr4_human 198 45.50x50 ECL2 C => Y missense 9.046e-06 1 110552 0 0.01 0.998
ssr4_human 205 5.32x33 TM5 P => L missense 1.757e-05 2 113850 0 0.01 0.077
ssr4_human 208 5.35x36 TM5 S => L missense 8.655e-06 1 115544 0 0.52 0.021
ssr4_human 211 5.38x39 TM5 F => L missense 6.001e-05 7 116648 0 0.0 0.999
ssr4_human 212 5.39x40 TM5 V => M missense 8.552e-06 1 116932 0 0.11 0.627
ssr4_human 213 5.40x41 TM5 V => F missense 0.0001109 13 117192 0 0.15 0.853
ssr4_human 214 5.41x42 TM5 Y => F missense 5.96e-05 7 117448 0 0.01 0.973
ssr4_human 215 5.42x43 TM5 T => A missense 5.104e-05 6 117552 0 0.07 0.268
ssr4_human 216 5.43x44 TM5 F => S missense 8.495e-06 1 117710 0 0.99 0.189
ssr4_human 219 5.46x461 TM5 G => A missense 8.474e-06 1 118002 0 0.0 1.0
ssr4_human 220 5.47x47 TM5 F => L missense 8.471e-06 1 118044 0 0.0 0.999 SodiumPocket MicroSwitch
ssr4_human 224 5.51x51 TM5 V => L missense 0.000169 20 118372 0 1.0 0.547
ssr4_human 224 5.51x51 TM5 V => M missense 8.448e-06 1 118372 0 0.01 0.539
ssr4_human 226 5.53x53 TM5 A => G missense 8.439e-06 1 118500 0 0.0 0.999
ssr4_human 227 5.54x54 TM5 I => M missense 8.429e-06 1 118638 0 0.06 0.302
ssr4_human 232 5.59x59 TM5 L => M missense 1.682e-05 2 118884 0 0.0 0.913
ssr4_human 233 5.60x60 TM5 L => I missense 8.407e-06 1 118942 0 0.02 0.956
ssr4_human 237 5.64x64 TM5 K => N missense 8.383e-06 1 119292 0 0.0 0.969 GP (contact)
ssr4_human 239 5.66x66 TM5 R => H missense 1.675e-05 2 119402 0 0.0 0.988 GP (contact)
ssr4_human 240 5.67x67 TM5 A => V missense 7.531e-05 9 119510 0 0.08 0.557 GP (contact)
ssr4_human 241 5.68x68 TM5 V => M missense 2.507e-05 3 119652 0 0.09 0.979 GP (contact)
ssr4_human 242 ICL3 A => V missense 1.67e-05 2 119752 0 0.0 0.99
ssr4_human 244 ICL3 R => C missense 0.002935 352 119940 3 0.0 0.788
ssr4_human 244 ICL3 R => H missense 8.334e-06 1 119988 0 0.07 0.667
ssr4_human 245 ICL3 A => T missense 4.164e-05 5 120082 0 0.01 0.853
ssr4_human 245 ICL3 A => S missense 8.328e-06 1 120082 0 0.05 0.813
ssr4_human 245 ICL3 A => D missense 0.0009075 109 120110 0 0.0 0.918
ssr4_human 250 6.26x26 TM6 R => C missense 1.661e-05 2 120410 0 0.01 0.996 GP (contact)
ssr4_human 250 6.26x26 TM6 R => H missense 1.66e-05 2 120448 0 0.01 0.996 GP (contact)
ssr4_human 253 6.29x29 TM6 S => W missense 8.297e-06 1 120530 0 0.0 1.0 GP (contact)
ssr4_human 255 6.31x31 TM6 K => N missense 1.658e-05 2 120620 0 0.0 0.665
ssr4_human 263 6.39x39 TM6 M => R missense 8.284e-06 1 120716 0 0.03 0.008
ssr4_human 264 6.40x40 TM6 V => I missense 8.283e-06 1 120722 0 0.27 0.344 GP (contact)
ssr4_human 264 6.40x40 TM6 V => A missense 4.142e-05 5 120724 0 0.0 0.852 GP (contact)
ssr4_human 266 6.42x42 TM6 V => I missense 8.282e-06 1 120746 0 0.12 0.003
ssr4_human 266 6.42x42 TM6 V => F missense 8.282e-06 1 120746 0 0.04 0.013
ssr4_human 271 6.47x47 TM6 C => G missense 0.0003311 40 120820 0 0.0 0.976
ssr4_human 273 6.49x49 TM6 M => V missense 8.275e-06 1 120844 0 0.0 0.491
ssr4_human 274 6.50x50 TM6 P => S missense 1.655e-05 2 120850 0 0.0 1.0 SodiumPocket MicroSwitch
ssr4_human 278 6.54x54 TM6 V => M missense 8.27e-06 1 120912 0 0.03 0.883
ssr4_human 280 6.56x56 TM6 L => V missense 8.268e-06 1 120944 0 0.14 0.999
ssr4_human 284 6.60x60 TM6 F => V missense 0.3488 42231 121066 7701 0.42 0.731
ssr4_human 285 6.61x61 TM6 V => M missense 1.652e-05 2 121078 0 0.04 0.072
ssr4_human 285 6.61x61 TM6 V => L missense 8.259e-06 1 121078 0 0.24 0.011
ssr4_human 287 ECL3 S => N missense 8.258e-06 1 121096 0 0.48 0.21
ssr4_human 290 7.32x31 TM7 A => V missense 8.257e-06 1 121104 0 0.18 0.103
ssr4_human 292 7.34x33 TM7 V => I missense 6.606e-05 8 121110 0 0.8 0.012
ssr4_human 294 7.36x35 TM7 H => D missense 8.256e-06 1 121130 0 0.23 0.403
ssr4_human 297 7.39x38 TM7 L => I missense 1.651e-05 2 121144 0 0.04 0.119
ssr4_human 300 7.42x41 TM7 S => R missense 8.253e-06 1 121166 0 0.01 0.995
ssr4_human 303 7.45x45 TM7 N => S missense 8.254e-06 1 121160 0 0.0 0.999
ssr4_human 308 7.50x50 TM7 P => T missense 8.254e-06 1 121152 0 0.0 1.0 SodiumPocket MicroSwitch
ssr4_human 314 7.56x56 TM7 L => P missense 8.267e-06 1 120964 0 0.01 0.971 GP (contact)
ssr4_human 318 8.50x50 H8 F => L missense 8.278e-06 1 120804 0 0.01 0.998
ssr4_human 319 8.51x51 H8 R => C missense 8.278e-06 1 120804 0 0.0 0.88 GP (contact)
ssr4_human 320 8.52x52 H8 R => L missense 1.656e-05 2 120746 0 0.0 0.491
ssr4_human 321 8.53x53 H8 F => S missense 0.4833 58347 120722 14360 1.0 0.0
ssr4_human 321 8.53x53 H8 F => Y missense 3.313e-05 4 120722 0 0.0 0.001
ssr4_human 324 8.56x56 H8 R => Q missense 8.314e-06 1 120272 0 0.05 0.765
ssr4_human 325 8.57x57 H8 V => I missense 1.663e-05 2 120270 0 0.16 0.047
ssr4_human 325 8.57x57 H8 V => A missense 8.313e-06 1 120290 0 0.24 0.047
ssr4_human 329 C-term R => C missense 8.325e-06 1 120118 0 0.13 0.003
ssr4_human 329 C-term R => L missense 8.323e-06 1 120148 0 0.02 0.166
ssr4_human 329 C-term R => H missense 8.323e-06 1 120148 0 0.1 0.433
ssr4_human 335 C-term G => S missense 1.667e-05 2 119986 0 0.6 0.004
ssr4_human 338 C-term G => V missense 8.339e-06 1 119922 0 0.33 0.104
ssr4_human 339 C-term A => S missense 8.34e-06 1 119908 0 0.62 0.09
ssr4_human 340 C-term E => Q missense 8.343e-06 1 119868 0 0.16 0.067
ssr4_human 341 C-term E => K missense 8.345e-06 1 119830 0 0.2 0.41
ssr4_human 342 C-term E => G missense 1.671e-05 2 119708 0 0.03 0.844
ssr4_human 343 C-term P => L missense 1.672e-05 2 119594 0 0.01 0.616
ssr4_human 344 C-term L => Q missense 1.674e-05 2 119510 0 0.12 0.905
ssr4_human 346 C-term Y => H missense 8.375e-06 1 119396 0 0.16 0.999
ssr4_human 347 C-term Y => C missense 1.677e-05 2 119234 0 0.2 0.003
ssr4_human 349 C-term T => S missense 1.682e-05 2 118916 0 0.13 0.354
ssr4_human 350 C-term A => T missense 8.429e-06 1 118640 0 0.13 0.005
ssr4_human 353 C-term S => T missense 1.698e-05 2 117780 0 0.1 0.14
ssr4_human 355 C-term G => S missense 8.555e-06 1 116894 0 0.06 0.066
ssr4_human 355 C-term G => D missense 6.844e-05 8 116890 0 0.12 0.097
ssr4_human 359 C-term C => F missense 3.462e-05 4 115554 0 0.47 0.019
ssr4_human 362 C-term P => S missense 8.769e-06 1 114038 0 0.19 0.001
ssr4_human 363 C-term P => L missense 8.81e-06 1 113502 0 0.04 0.031
ssr4_human 363 C-term P => Q missense 8.81e-06 1 113502 0 0.08 0.011
ssr4_human 367 C-term Q => P missense 0.0001608 18 111906 0 0.13 0.001
ssr4_human 371 C-term L => P missense 9.054e-06 1 110444 0 0.08 0.091
ssr4_human 371 C-term L => Q missense 9.054e-06 1 110444 0 0.12 0.068
ssr4_human 377 C-term R => G missense 9.367e-06 1 106760 0 nan 0.0
ssr4_human 377 C-term R => C missense 1.873e-05 2 106760 0 nan 0.0
ssr4_human 377 C-term R => H missense 9.381e-06 1 106600 0 nan 0.0
ssr4_human 379 C-term R => C missense 5.65e-05 6 106198 0 nan 0.153
ssr4_human 379 C-term R => P missense 2.828e-05 3 106076 0 nan 0.0
ssr4_human 379 C-term R => H missense 1.885e-05 2 106076 0 nan 0.0
ssr4_human 19 N-term W => Ter stop gained 1.213e-05 1 82428 0 None None
ssr4_human 54 1.39x39 TM1 Y => Ter stop gained 6.406e-05 7 109276 0 None None
ssr4_human 114 23.52x52 ECL1 F => SerfsTer149 frameshift 8.867e-06 1 112772 0 None None
ssr4_human 159 4.38x38 TM4 R => GlyfsTer104 frameshift 2.572e-05 3 116632 0 None None
ssr4_human 202 ECL2 W => Ter stop gained 8.893e-06 1 112452 0 None None
ssr4_human 207 5.34x35 TM5 W => Ter stop gained 8.67e-06 1 115340 0 None None
ssr4_human 253 6.29x29 TM6 S => Ter stop gained 8.297e-06 1 120530 0 None None GP (contact)
ssr4_human 262 6.38x38 TM6 L => HisfsTer27 frameshift 8.285e-06 1 120698 0 None None
ssr4_human 316 8.48x48 H8 D => AlafsTer? frameshift 8.274e-06 1 120864 0 None None GP (contact)
ssr4_human 320 8.52x52 H8 R => Ter stop gained 4.969e-05 6 120760 0 None None
ssr4_human 359 C-term C => AlafsTer? frameshift 8.597e-06 1 116316 0 None None
ssr4_human 376 C-term G => AlafsTer? frameshift 9.256e-06 1 108036 0 None None
ssr4_human 388 C-term F => SerfsTer? frameshift 9.53e-06 1 104934 0 None None


Residue

Diagrams

A K M K ICL1ECL1 R H W P F ECL1 P L R A A T Y R ICL2ECL2 D T R P A R G G Q A V A C N L Q W ECL2ICL3 A L R A G ICL3ECL3 T S L D ECL3N-term M S A P S T L P P G G E E G L G T A W P S A A N A S S A P A E A E E A V A G P G D A R A N-termC-term L R C C L L E G A G G A E E E P L D Y Y A T A L K S K G G A G C M C P P L P C Q Q E A L Q P E P G R K R I P L T R T T T F C-term A G M V A I Q C I Y A L V C L V G L V G N A L V I F V I L R Y T A T N I Y L L N L A V A D E L F M L S V P F V A S S A A L G S V L C R A V L S V D G L N M F T S V F C L T V L S V D R Y V A V V H R P S V A K L I N L G V W L A S L L V T L P I A I F A P H P A W S A V F V V Y T F L L G F L L P V L A I G L C Y L L I V G K M R A V W Q Q R R R S E K K I T R L V L M V V V V F V L C W M P F Y V V Q L L N L F V A T V N H V S L I L S Y A N S C A N P I L Y G F L S D N F Q R F R R F V L C
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