Variation Browser

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Receptor Position GPCRdb Segment Variant Mutation type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
Receptor Position GPCRdb Segment Variant Mutation Type Allele Frequency Allele Count Allele Number Homozygotes SIFT score PolyPhen score Functional annotation
v1ar_human 418 C-term T => I missense 2.475e-05 3 121200 0 nan 0.976
v1ar_human 413 C-term F => L missense 3.296e-05 4 121360 0 nan 0.686
v1ar_human 408 C-term S => F missense 8.237e-06 1 121398 0 0.0 0.985 PTM (Phosphorylation)
v1ar_human 405 C-term P => R missense 8.237e-06 1 121404 0 0.06 0.905
v1ar_human 398 C-term T => R missense 0.0008566 104 121410 0 0.19 0.831
v1ar_human 398 C-term T => M missense 3.295e-05 4 121410 0 0.12 0.131
v1ar_human 392 C-term R => G missense 1.647e-05 2 121410 0 0.09 0.969
v1ar_human 391 C-term N => S missense 8.237e-06 1 121410 0 0.56 0.012
v1ar_human 383 C-term R => G missense 1.647e-05 2 121410 0 0.02 0.983
v1ar_human 377 C-term D => V missense 2.471e-05 3 121410 0 0.18 0.915
v1ar_human 373 C-term F => I missense 0.003138 381 121410 7 0.2 0.033
v1ar_human 371 C-term E => G missense 8.237e-06 1 121408 0 0.39 0.002
v1ar_human 369 C-term M => I missense 8.237e-06 1 121408 0 0.4 0.001
v1ar_human 369 C-term M => V missense 8.237e-06 1 121408 0 0.51 0.001
v1ar_human 363 8.58x58 H8 F => L missense 8.237e-06 1 121406 0 0.64 0.011
v1ar_human 362 8.57x57 H8 S => R missense 8.237e-06 1 121406 0 0.42 0.751
v1ar_human 362 8.57x57 H8 S => C missense 8.237e-06 1 121406 0 0.26 0.018
v1ar_human 357 8.52x52 H8 Q => H missense 8.237e-06 1 121404 0 0.48 0.384
v1ar_human 356 8.51x51 H8 L => F missense 8.237e-06 1 121408 0 0.41 0.654 GP (contact)
v1ar_human 353 8.48x48 H8 G => A missense 1.647e-05 2 121408 0 0.01 0.994 GP (contact)
v1ar_human 350 7.55x55 TM7 F => V missense 8.237e-06 1 121408 0 0.11 0.131 GP (contact)
v1ar_human 350 7.55x55 TM7 F => L missense 8.237e-06 1 121408 0 0.37 0.045 GP (contact)
v1ar_human 349 7.54x54 TM7 M => V missense 8.237e-06 1 121410 0 0.0 0.944
v1ar_human 346 7.51x51 TM7 W => C missense 3.295e-05 4 121410 0 0.01 1.0
v1ar_human 337 7.42x41 TM7 G => C missense 8.237e-06 1 121406 0 0.0 0.759
v1ar_human 334 7.39x38 TM7 A => T missense 1.647e-05 2 121402 0 0.07 0.955
v1ar_human 330 7.35x34 TM7 I => V missense 1.648e-05 2 121362 0 0.45 0.002
v1ar_human 327 7.32x31 TM7 N => K missense 3.297e-05 4 121332 0 0.01 0.786
v1ar_human 325 7.30x29 TM7 S => L missense 1.65e-05 2 121204 0 0.01 0.959
v1ar_human 321 ECL3 V => F missense 8.326e-06 1 120106 0 0.01 0.099
v1ar_human 311 6.55x55 TM6 Q => H missense 8.266e-06 1 120984 0 0.01 1.0
v1ar_human 308 6.52x52 TM6 F => L missense 0.009781 1184 121050 9 0.02 0.858
v1ar_human 294 6.38x38 TM6 F => S missense 8.252e-06 1 121178 0 0.01 0.517
v1ar_human 288 6.32x32 TM6 R => L missense 8.251e-06 1 121198 0 0.0 0.997 GP (contact)
v1ar_human 286 6.30x30 TM6 K => R missense 8.25e-06 1 121206 0 0.01 0.86 SodiumPocket MicroSwitch
v1ar_human 285 6.29x29 TM6 A => V missense 4.125e-05 5 121214 0 0.0 1.0 GP (contact)
v1ar_human 284 6.28x28 TM6 R => Q missense 8.25e-06 1 121208 0 0.02 0.923 GP (contact)
v1ar_human 284 6.28x28 TM6 R => W missense 1.65e-05 2 121208 0 0.0 1.0 GP (contact)
v1ar_human 282 6.26x26 TM6 I => T missense 2.475e-05 3 121210 0 0.0 0.844 GP (contact)
v1ar_human 280 6.24x24 TM6 K => N missense 8.25e-06 1 121208 0 0.05 0.444
v1ar_human 275 ICL3 C => W missense 8.251e-06 1 121204 0 0.19 0.033
v1ar_human 274 ICL3 P => S missense 8.251e-06 1 121198 0 1.0 0.036
v1ar_human 273 ICL3 A => G missense 1.65e-05 2 121202 0 0.3 0.149
v1ar_human 270 ICL3 F => L missense 0.0004786 58 121196 0 1.0 0.001
v1ar_human 269 ICL3 G => V missense 8.252e-06 1 121180 0 0.0 0.924
v1ar_human 263 ICL3 G => D missense 1.651e-05 2 121124 0 0.07 0.371
v1ar_human 263 ICL3 G => V missense 1.651e-05 2 121124 0 0.05 0.03
v1ar_human 259 ICL3 A => T missense 8.261e-06 1 121056 0 0.25 0.008
v1ar_human 252 5.74x74 TM5 A => V missense 0.0002233 27 120922 1 0.2 0.009 GP (contact)
v1ar_human 252 5.74x74 TM5 A => T missense 8.271e-06 1 120906 0 0.31 0.008 GP (contact)
v1ar_human 246 5.68x68 TM5 N => K missense 8.283e-06 1 120736 0 0.0 0.539 GP (contact)
v1ar_human 235 5.57x57 TM5 C => S missense 1.66e-05 2 120494 0 0.0 0.733
v1ar_human 232 5.54x54 TM5 L => V missense 1.661e-05 2 120392 0 0.0 0.996
v1ar_human 223 5.45x46 TM5 G => C missense 8.326e-06 1 120108 0 0.08 0.547
v1ar_human 219 5.41x42 TM5 W => G missense 8.334e-06 1 119994 0 0.0 0.998
v1ar_human 214 5.36x37 TM5 R => G missense 5.009e-05 6 119786 0 0.0 0.898
v1ar_human 211 5.33x34 TM5 W => C missense 8.352e-06 1 119738 0 0.0 0.995
v1ar_human 209 ECL2 Q => L missense 8.354e-06 1 119702 0 0.62 0.013
v1ar_human 208 ECL2 I => T missense 2.506e-05 3 119704 0 0.09 0.11
v1ar_human 207 ECL2 F => V missense 8.357e-06 1 119664 0 0.0 0.994
v1ar_human 206 ECL2 T => I missense 8.359e-06 1 119638 0 0.03 0.515
v1ar_human 201 ECL2 R => C missense 8.363e-06 1 119576 0 0.01 0.001
v1ar_human 199 ECL2 K => R missense 0.0003428 41 119604 1 0.03 0.014
v1ar_human 196 ECL2 N => D missense 8.358e-06 1 119650 0 0.35 0.034
v1ar_human 193 ECL2 E => K missense 2.507e-05 3 119652 0 0.02 0.746
v1ar_human 191 ECL2 M => R missense 8.355e-06 1 119688 0 0.01 0.024
v1ar_human 183 4.58x59 TM4 T => A missense 8.356e-06 1 119676 0 0.49 0.062
v1ar_human 168 4.43x43 TM4 R => H missense 8.39e-06 1 119188 0 0.32 0.006
v1ar_human 168 4.43x43 TM4 R => S missense 1.678e-05 2 119208 0 0.2 0.526
v1ar_human 166 4.41x41 TM4 R => L missense 8.387e-06 1 119234 0 0.01 0.886
v1ar_human 166 4.41x41 TM4 R => S missense 8.386e-06 1 119248 0 0.42 0.758
v1ar_human 156 34.50x50 ICL2 P => Q missense 8.384e-06 1 119276 0 0.0 1.0 GP (contact)
v1ar_human 155 3.56x56 TM3 H => Y missense 8.386e-06 1 119244 0 0.01 0.775 GP (contact)
v1ar_human 153 3.54x54 TM3 V => M missense 8.386e-06 1 119244 0 0.0 0.909 GP (contact)
v1ar_human 145 3.46x46 TM3 M => T missense 0.0001176 14 119096 0 0.0 0.587
v1ar_human 143 3.44x44 TM3 V => I missense 1.68e-05 2 119058 0 0.29 0.393
v1ar_human 140 3.41x41 TM3 Y => S missense 8.41e-06 1 118900 0 0.0 0.998
v1ar_human 139 3.40x40 TM3 A => P missense 8.419e-06 1 118782 0 0.02 0.049 SodiumPocket MicroSwitch
v1ar_human 136 3.37x37 TM3 F => L missense 8.453e-06 1 118296 0 0.0 0.986
v1ar_human 136 3.37x37 TM3 F => C missense 8.497e-06 1 117690 0 0.0 0.999
v1ar_human 135 3.36x36 TM3 M => V missense 2.55e-05 3 117634 0 0.0 0.968
v1ar_human 134 3.35x35 TM3 G => S missense 2.559e-05 3 117230 0 0.5 0.221
v1ar_human 129 3.30x30 TM3 H => Q missense 2.567e-05 3 116866 0 0.0 0.968
v1ar_human 129 3.30x30 TM3 H => Y missense 8.574e-06 1 116636 0 1.0 0.02
v1ar_human 123 3.24x24 TM3 L => V missense 8.629e-06 1 115884 0 0.03 0.836
v1ar_human 121 3.22x22 TM3 D => E missense 8.61e-06 1 116144 0 0.0 0.927
v1ar_human 115 23.50x50 ECL1 Y => C missense 6.892e-05 8 116074 0 0.0 0.928
v1ar_human 112 2.65x65 TM2 D => H missense 8.622e-06 1 115988 0 0.0 0.991
v1ar_human 108 2.61x61 TM2 Q => H missense 8.622e-06 1 115986 0 0.0 1.0
v1ar_human 107 2.60x60 TM2 P => L missense 8.651e-06 1 115600 0 0.0 0.999
v1ar_human 103 2.56x56 TM2 F => S missense 8.626e-06 1 115928 0 0.0 0.991
v1ar_human 93 2.46x46 TM2 L => F missense 8.577e-06 1 116586 0 0.0 1.0
v1ar_human 88 2.41x41 TM2 L => V missense 8.558e-06 1 116850 0 0.01 0.596
v1ar_human 84 2.37x37 TM2 S => F missense 8.634e-06 1 115822 0 0.0 0.996
v1ar_human 83 12.51x51 ICL1 T => M missense 3.465e-05 4 115454 0 0.22 0.028
v1ar_human 81 12.49x49 ICL1 R => H missense 3.479e-05 4 114972 0 0.41 0.142
v1ar_human 81 12.49x49 ICL1 R => G missense 8.714e-05 10 114752 0 0.0 0.869
v1ar_human 78 1.59x59 TM1 R => W missense 8.682e-06 1 115176 0 0.02 0.133
v1ar_human 77 1.58x58 TM1 H => Y missense 0.0005285 61 115430 0 0.99 0.004
v1ar_human 75 1.56x56 TM1 A => V missense 8.646e-06 1 115656 0 0.01 0.629
v1ar_human 75 1.56x56 TM1 A => P missense 8.651e-06 1 115594 0 0.0 0.992
v1ar_human 70 1.51x51 TM1 S => N missense 2.588e-05 3 115940 0 0.08 0.392
v1ar_human 68 1.49x49 TM1 G => R missense 8.636e-06 1 115796 0 0.0 0.999
v1ar_human 68 1.49x49 TM1 G => S missense 1.727e-05 2 115796 0 0.02 0.979
v1ar_human 66 1.47x47 TM1 V => M missense 5.192e-05 6 115552 0 0.04 0.158
v1ar_human 63 1.44x44 TM1 A => T missense 0.000199 23 115570 0 0.01 0.0
v1ar_human 61 1.42x42 TM1 T => A missense 0.0001989 23 115632 0 0.14 0.006
v1ar_human 59 1.40x40 TM1 A => T missense 8.63e-06 1 115880 0 0.03 0.21
v1ar_human 57 1.38x38 TM1 V => L missense 8.635e-06 1 115814 0 0.03 0.372
v1ar_human 55 1.36x36 TM1 I => F missense 2.592e-05 3 115756 0 0.0 0.933
v1ar_human 51 1.32x32 TM1 A => D missense 8.653e-06 1 115568 0 0.0 0.995
v1ar_human 48 N-term E => D missense 8.668e-06 1 115366 0 0.0 0.882
v1ar_human 48 N-term E => Q missense 0.0002603 30 115230 0 0.01 0.933
v1ar_human 47 N-term N => D missense 8.681e-06 1 115198 0 0.64 0.009
v1ar_human 45 N-term V => L missense 8.708e-06 1 114832 0 0.32 0.001
v1ar_human 44 N-term D => E missense 1.744e-05 2 114704 0 0.28 0.074
v1ar_human 43 N-term R => K missense 1.746e-05 2 114542 0 0.93 0.001
v1ar_human 43 N-term R => T missense 8.73e-06 1 114542 0 0.57 0.002
v1ar_human 42 N-term P => Q missense 8.739e-06 1 114434 0 0.67 0.004
v1ar_human 40 N-term G => S missense 8.782e-06 1 113868 0 0.58 0.001
v1ar_human 40 N-term G => R missense 1.756e-05 2 113868 0 0.18 0.019
v1ar_human 35 N-term L => V missense 2.66e-05 3 112762 0 0.74 0.002
v1ar_human 34 N-term A => T missense 0.0002223 25 112466 0 0.58 0.002
v1ar_human 30 N-term R => W missense 1.8e-05 2 111136 0 0.06 0.002
v1ar_human 26 N-term G => S missense 9.155e-06 1 109226 0 0.3 0.001
v1ar_human 25 N-term A => T missense 0.0002395 26 108566 0 0.38 0.003
v1ar_human 25 N-term A => S missense 1.842e-05 2 108566 0 0.5 0.001
v1ar_human 24 N-term G => S missense 9.241e-06 1 108214 0 0.59 0.0
v1ar_human 18 N-term W => R missense 1.903e-05 2 105110 0 0.09 0.001
v1ar_human 18 N-term W => R missense 9.514e-06 1 105110 0 0.09 0.001
v1ar_human 15 N-term S => Y missense 9.785e-06 1 102194 0 0.01 0.219
v1ar_human 14 N-term N => S missense 9.833e-06 1 101698 0 0.02 0.015
v1ar_human 10 N-term G => E missense 1.044e-05 1 95802 0 nan 0.002
v1ar_human 10 N-term G => V missense 1.044e-05 1 95802 0 nan 0.002
v1ar_human 8 N-term D => N missense 1.138e-05 1 87874 0 nan 0.001
v1ar_human 8 N-term D => Y missense 1.138e-05 1 87874 0 nan 0.002
v1ar_human 6 N-term G => S missense 0.01693 1432 84596 123 nan 0.003
v1ar_human 5 N-term A => P missense 1.237e-05 1 80858 0 nan 0.0
v1ar_human 3 N-term L => V missense 1.313e-05 1 76156 0 nan 0.0
v1ar_human 401 C-term W => Ter stop gained 8.237e-06 1 121406 0 None None
v1ar_human 392 C-term R => Ter stop gained 2.471e-05 3 121410 0 None None
v1ar_human 315 6.59x59 TM6 V => GlyfsTer24 frameshift 8.282e-06 1 120744 0 None None
v1ar_human 316 6.60x60 TM6 W => Ter stop gained 8.28e-06 1 120778 0 None None
v1ar_human 303 6.47x47 TM6 C => AlafsTer37 frameshift 8.256e-06 1 121130 0 None None
v1ar_human 266 ICL3 F => SerfsTer14 frameshift 8.253e-06 1 121164 0 None None
v1ar_human 244 5.66x66 TM5 W => CysfsTer36 frameshift 8.287e-06 1 120668 0 None None GP (contact)
v1ar_human 235 5.57x57 TM5 C => Ter stop gained 8.298e-06 1 120504 0 None None
v1ar_human 184 4.59x60 TM4 P => ArgfsTer8 frameshift 8.356e-06 1 119668 0 None None
v1ar_human 161 34.55x55 ICL2 Q => CysfsTer11 frameshift 8.384e-06 1 119278 0 None None GP (contact)
v1ar_human 131 3.32x32 TM3 Q => Ter stop gained 2.565e-05 3 116962 0 None None
v1ar_human 91 2.44x44 TM2 R => Ter stop gained 8.569e-06 1 116702 0 None None
v1ar_human 29 N-term S => AlafsTer32 frameshift 9.01e-06 1 110990 0 None None


Residue

Diagrams

P R K T ICL1ECL1 T Y R F ECL1 P L K T L Q Q ICL2ECL2 S M I E V N N V T K A R D C W A T F I Q P ECL2ICL3 Q S K G A E Q A G V A F Q K G F L L A P C V S S V ICL3ECL3 P M S V W ECL3N-term M R L S A G P D A G P S G N S S P W W P L A T G A G N T S R E A E A L G E G N G P P R D V R N E E N-termC-term P C C Q N M K E K F N K E D T D S M S R R Q T F Y S N N R S P T N S T G M W K D S P K S S K S I K F I P V S T C-term L A K L E I A V L A V T F A V A V L G N S S V L L A L H R T S R M H L F I R H L S L A D L A V A F F Q V L P Q M C W D I R G P D W L C R V V K H L Q V F G M F A S A Y M L V V M T A D R Y I A V C H P A R R S R L M I A A A W V L S F V L S T P Q Y F V F W G S R A Y V T W M T G G I F V A P V V I L G T C Y G F I C Y N I W C N V R G K T A S R K S I S R A K I R T V K M T F V I V T A Y I V C W A P F F I I Q M W S V W D T E S E N P T I T I T A L L G S L N S C C N P W I Y M F F S G H C V Q L L Q D S F
SnakePlot Download: PNG | SVG S N G L V A V A F T V A L V A I E L K A 1 R H L S L A D L A V A F F Q V L P Q M C 2 V V L M Y A S A F M G F V Q L H K V V R 3 S R L M I A A A W V L S F V L S T P Q 4 Y C T G L I V V P A V F I G G T M W T V Y 5 F V I V T A Y I V C W A P F F I I Q M W 6 W P N C C S N L S G L L A T I T I T P 7
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