MC2 receptor (acthr_bovin)

FAMILY

Class A (Rhodopsin) Peptide receptors Melanocortin receptors MC2 receptor

GENE

MC2R

ORGANISM

Bovine (Bos taurus)

ALT. NAMES

Adrenocorticotropic hormone receptor, ACTH receptor, ACTH-R, Adrenocorticotropin receptor, Melanocortin receptor 2, MC2-R

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
K
H
I
L
N
L
Y
E
N
10
                   
I
N
S
T
A
R
N
N
S
D
20
            TM1  
C
P
A
V
I
L
P
E
E
I
30
                   
F
F
T
V
S
I
V
G
V
L
40
                   
E
N
L
M
V
L
L
A
V
A
50
    ICL1 TM2  
K
N
K
S
L
Q
S
P
M
Y
60
                   
F
F
I
C
S
L
A
I
S
D
70
                   
M
L
G
S
L
Y
K
I
L
E
80
                   
N
V
L
I
M
F
K
N
M
G
90
ECL1   TM3    
Y
L
E
P
R
G
S
F
E
S
100
                   
T
A
D
D
V
V
D
S
L
F
110
                   
I
L
S
L
L
G
S
I
C
S
120
                   
L
S
V
I
A
A
D
R
Y
I
130
        ICL2    
T
I
F
H
A
L
Q
Y
H
R
140
    TM4          
I
M
T
P
H
R
A
L
V
I
150
                   
L
T
V
L
W
A
G
C
T
G
160
                   
S
G
I
T
I
V
T
F
S
H
170
TM5              
H
V
P
T
V
I
A
F
T
A
180
                   
L
F
P
L
M
L
A
F
I
L
190
                   
C
L
Y
V
H
M
F
L
L
A
200
                   
R
S
H
T
R
R
T
P
S
L
210
ICL3 TM6      
P
K
A
N
M
R
G
A
V
T
220
                   
L
T
V
L
L
G
V
F
I
F
230
                   
C
W
A
P
F
V
L
H
V
L
240
          ECL3 TM7
L
M
T
F
C
P
A
D
P
Y
250
               
C
A
C
Y
M
S
L
F
Q
V
260
                   
N
G
V
L
I
M
C
N
A
I
270
                   
I
D
P
F
I
Y
A
F
R
S
280
H8                
P
E
L
R
V
A
F
K
K
M
290
        C-term
V
I
C
N
C
Y
Q

LINKS

UniProt

DIAGRAMS

ICL1 K S L Q ICL1ECL1 Y L E P R ECL1ICL2 A L Q Y H R I M ICL2ECL2 H ECL2ICL3 S L P K A ICL3ECL3 P A ECL3N-term M K H I L N L Y E N I N S T A R N N S D C P A V I L N-termC-term C Y Q C-term P E E I F F T V S I V G V L E N L M V L L A V A K N S P M Y F F I C S L A I S D M L G S L Y K I L E N V L I M F K N M G G S F E S T A D D V V D S L F I L S L L G S I C S L S V I A A D R Y I T I F H T P H R A L V I L T V L W A G C T G S G I T I V T F S H V P T V I A F T A L F P L M L A F I L C L Y V H M F L L A R S H T R R T P N M R G A V T L T V L L G V F I F C W A P F V L H V L L M T F C D P Y C A C Y M S L F Q V N G V L I M C N A I I D P F I Y A F R S P E F K K N L R V A M V I C
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

L N E L V G V I S V T F F I E E P 1 C S L A I S D M L G S L Y K I L E N V L 2 V S L S C I S G L L S L I F L S D V V D 3 A L V I L T V L W A G C T G S G I T I V 4 Y L C L I F A L M L P F L A T F A I V T 5 T V L L G V F I F C W A P F V L H V L L 6 F P D I I A N C M I L V G N V Q F L S 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

ENDOGENOUS LIGANDS

No endogenous ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available