TAS2R46 (t2r46_human)

FAMILY

Class T (Taste 2) Sensory receptors Taste 2 receptors TAS2R46

GENE

TAS2R46

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Taste receptor type 2 member 46, T2R46, Taste receptor type 2 member 54, T2R54

SOURCE

SWISSPROT

SEQUENCE

N-term TM1  
M
I
T
F
L
P
I
I
F
S
10
                   
I
L
I
V
V
T
F
V
I
G
20
                   
N
F
A
N
G
F
I
A
L
V
30
                   
N
S
I
E
W
F
K
R
Q
K
40
ICL1 TM2      
I
S
F
A
D
Q
I
L
T
A
50
                   
L
A
V
S
R
V
G
L
L
W
60
                   
V
L
V
L
N
W
Y
A
T
E
70
    ECL1 TM3  
L
N
P
A
F
N
S
I
E
V
80
                   
R
I
T
A
Y
N
V
W
A
V
90
                   
I
N
H
F
S
N
W
L
A
T
100
                   
S
L
S
I
F
Y
L
L
K
I
110
  ICL2          
A
N
F
S
N
L
I
F
L
H
120
      TM4        
L
K
R
R
V
K
S
V
V
L
130
                   
V
I
L
L
G
P
L
L
F
L
140
                   
V
C
H
L
F
V
I
N
M
N
150
    ECL2        
Q
I
I
W
T
K
E
Y
E
G
160
                   
N
M
T
W
K
I
K
L
R
S
170
          TM5    
A
M
Y
L
S
N
T
T
V
T
180
                   
I
L
A
N
L
V
P
F
T
L
190
                   
T
L
I
S
F
L
L
L
I
C
200
                   
S
L
C
K
H
L
K
K
M
Q
210
      ICL3 TM6
L
H
G
K
G
S
Q
D
P
S
220
                   
M
K
V
H
I
K
A
L
Q
T
230
                   
V
T
S
F
L
L
L
C
A
I
240
                   
Y
F
L
S
I
I
M
S
V
W
250
        ECL3 TM7
S
F
E
S
L
E
N
K
P
V
260
                 
F
M
F
C
E
A
I
A
F
S
270
                   
Y
P
S
T
H
P
F
I
L
I
280
    H8            
W
G
N
K
K
L
K
Q
T
F
290
                   
L
S
V
L
W
H
V
R
Y
W
300
  C-term    
V
K
G
E
K
P
S
S
S

LINKS

BitterDB

Guide To Pharmacology

UniProt

DIAGRAMS

ICL1 K I ICL1ECL1 P A F N ECL1ICL2 N F S N L I F L H L K R ICL2ECL2 I W T K E Y E G N M T W K I K L R S A M Y L S ECL2ICL3 K G S Q ICL3ECL3 L E N ECL3N-term M N-termC-term K G E K P S S S C-term I T F L P I I F S I L I V V T F V I G N F A N G F I A L V N S I E W F K R Q S F A D Q I L T A L A V S R V G L L W V L V L N W Y A T E L N S I E V R I T A Y N V W A V I N H F S N W L A T S L S I F Y L L K I A R V K S V V L V I L L G P L L F L V C H L F V I N M N Q I N T T V T I L A N L V P F T L T L I S F L L L I C S L C K H L K K M Q L H G D P S M K V H I K A L Q T V T S F L L L C A I Y F L S I I M S V W S F E S K P V F M F C E A I A F S Y P S T H P F I L I W G N K K F L S V R Y L K Q T V L W H W V
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

G N A F N G I V F T V V I L I S F I I P 1 T A L A V S R V G L L W V L V L N W Y A 2 S T A L W N S F H N I V A W V N Y A T I 3 V L V I L L G P L L F L V C H L F V I N 4 F S I L T L T F P V L N A L I T V T T N 5 V T S F L L L C A I Y F L S I I M S V W 6 F P H T S P Y S F A I A E C F M F V P 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

ENDOGENOUS LIGANDS

No endogenous ligands available

STRUCTURE MODELS

t2r46_human inactive,

t2r46_human active

STRUCTURES

Found 3 structure(s) - view all details on the Structures page

PDBs: 7XP4, 7XP5, 7XP6