TAAR4 (taar4_rat)

FAMILY

Class A (Rhodopsin) Orphan receptors Class A orphans TAAR4P

GENE

Taar4 (Ta2, Tar2, Trar2)

ORGANISM

Rat (Rattus norvegicus)

ALT. NAMES

Trace amine-associated receptor 4, TaR-4, Trace amine receptor 4, 2-phenylethylamine receptor, Trace amine receptor 2, TaR-2

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
N
S
P
D
L
W
Y
S
P
10
                   
E
T
Q
F
C
F
A
A
A
N
20
                   
N
S
C
P
R
K
A
R
P
A
30
TM1              
L
V
V
C
A
M
Y
L
V
M
40
                   
I
G
A
I
V
M
T
M
L
G
50
                   
N
M
V
V
I
I
S
I
A
H
60
  ICL1 TM2    
F
K
Q
L
H
S
P
T
N
F
70
                   
L
I
L
S
M
A
T
T
D
F
80
                   
L
L
S
C
V
V
M
P
F
S
90
                   
M
V
R
S
I
E
S
C
W
Y
100
ECL1 TM3      
F
G
D
L
F
C
K
V
H
S
110
                   
C
C
D
I
M
L
C
T
T
S
120
                   
I
F
H
L
C
F
I
S
V
D
130
                   
R
H
Y
A
V
C
D
P
L
H
140
ICL2   TM4    
Y
V
T
Q
I
T
V
G
V
V
150
                   
G
V
F
L
L
I
S
W
S
V
160
                   
P
I
L
F
A
F
G
L
V
F
170
ECL2            
S
E
L
N
L
I
G
A
E
D
180
                   
F
V
A
A
I
D
C
T
G
L
190
          TM5    
C
V
L
I
F
N
K
L
W
G
200
                   
V
L
A
S
F
I
A
F
F
L
210
                   
P
G
A
I
M
V
G
I
Y
I
220
                   
H
I
F
T
V
A
R
K
H
A
230
        ICL3    
R
K
I
G
P
G
P
R
T
K
240
            TM6  
R
A
L
S
E
S
K
M
K
A
250
                   
T
S
G
K
E
S
K
A
T
K
260
                   
T
L
S
I
V
M
G
V
F
V
270
                   
L
C
W
L
P
F
F
V
L
T
280
            ECL3
I
T
D
P
F
I
G
F
T
T
290
TM7              
P
E
D
L
Y
N
V
F
L
W
300
                   
L
G
Y
F
N
S
T
F
N
P
310
            H8    
I
I
Y
G
M
F
Y
P
W
F
320
                   
R
K
A
L
R
M
I
V
T
G
330
C-term        
T
I
F
R
S
D
S
S
T
S
340
             
S
L
H
P
A
H
P

LINKS

Guide To Pharmacology

UniProt

DIAGRAMS

ICL1 K Q L H ICL1ECL1 C W Y F ECL1ICL2 P L H Y V T Q I ICL2ECL2 S E L N L I G A E D F V A A I D C T G L C V L I F ECL2ICL3 P G P R T K R A L S E S ICL3ECL3 G F T T ECL3N-term M N S P D L W Y S P E T Q F C F A A A N N S C P R K A R P A N-termC-term T I F R S D S S T S S L H P A H P C-term L V V C A M Y L V M I G A I V M T M L G N M V V I I S I A H F S P T N F L I L S M A T T D F L L S C V V M P F S M V R S I E S G D L F C K V H S C C D I M L C T T S I F H L C F I S V D R H Y A V C D T V G V V G V F L L I S W S V P I L F A F G L V F N K L W G V L A S F I A F F L P G A I M V G I Y I H I F T V A R K H A R K I G K M K A T S G K E S K A T K T L S I V M G V F V L C W L P F F V L T I T D P F I P E D L Y N V F L W L G Y F N S T F N P I I Y G M F Y P W L R M F R K A I V T G
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

M N G L M T M V I A G I M V L Y M A C V 1 L S M A T T D F L L S V C V M P F S M V R 2 F C L H F I S T T C L M I D C C S H V K 3 V G V F L L I S W S V P I L F A F G L V 4 Y I G V M I A G P L F F A I F S A L V G W 5 S I V M G V F V L C W L P F F V L T I T 6 I P N F T S N F Y G L W L F V N Y L D 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

ENDOGENOUS LIGANDS

No endogenous ligands available

STRUCTURE MODELS

No structure models available. Check the Archive on Structure models for earlier releases.

STRUCTURES

No structures available