5X33_refined

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Cavia porcellus

STATE

Inactive (Δ distance (Å): 0.72 docs)

MAIN TEMPLATE

BLT1 receptor (sequence similarity: 100%) PDB: 5X33

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 79.7 14.9 5.4
Side-chains 77.4 12.2 10.5

Number of backbone templates: 4
Number of rotamer templates: 19

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5X33
4ZUD
3ODU
5VBL
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone Xtal Rotamer Xtal
N-term 12 - - - -
N-term 13 - - - -
N-term 14 - - - -
N-term 15 BLT1 receptor 5X33 BLT1 receptor 5X33
N-term 16 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 17 1x29 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 18 1x30 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 19 1x31 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 20 1x32 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 21 1x33 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 22 1x34 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 23 1x35 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 24 1x36 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 25 1x37 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 26 1x38 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 27 1x39 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 28 1x40 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 29 1x41 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 30 1x42 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 31 1x43 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 32 1x44 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 33 1x45 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 34 1x46 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 35 1x47 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 36 1x48 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 37 1x49 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 38 1x50 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 39 1x51 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 40 1x52 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 41 1x53 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 42 1x54 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 43 1x55 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 44 1x56 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 45 1x57 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 46 1x58 BLT1 receptor 5X33 BLT1 receptor 5X33
TM1 47 1x59 BLT1 receptor 5X33 OX2 receptor 5WS3
TM1 48 1x60 BLT1 receptor 5X33 US28 4XT1
ICL1 49 12x48 - - - -
ICL1 50 12x49 AT1 receptor 4ZUD β2-adrenoceptor 5JQH
ICL1 51 12x50 AT1 receptor 4ZUD - -
ICL1 52 12x51 - - - -
TM2 53 2x37 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 54 2x38 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 55 2x39 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 56 2x40 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 57 2x41 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 58 2x42 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 59 2x43 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 60 2x44 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 61 2x45 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 62 2x46 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 63 2x47 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 64 2x48 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 65 2x49 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 66 2x50 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 67 2x51 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 68 2x52 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 69 2x53 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 70 2x54 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 71 2x55 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 72 2x56 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 73 2x57 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 74 2x58 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 75 2x59 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 76 2x60 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 77 2x61 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 78 2x62 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 79 2x63 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 80 2x64 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 81 2x65 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 82 2x66 BLT1 receptor 5X33 BLT1 receptor 5X33
TM2 83 2x67 BLT1 receptor 5X33 C5a1 receptor 5O9H
ECL1 84 23x49 BLT1 receptor 5X33 BLT1 receptor 5X33
ECL1 85 23x50 BLT1 receptor 5X33 BLT1 receptor 5X33
ECL1 86 23x51 BLT1 receptor 5X33 BLT1 receptor 5X33
ECL1 87 23x52 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 88 3x21 BLT1 receptor 5X33 - -
TM3 89 3x22 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 90 3x23 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 91 3x24 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 92 3x25 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 93 3x26 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 94 3x27 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 95 3x28 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 96 3x29 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 97 3x30 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 98 3x31 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 99 3x32 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 100 3x33 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 101 3x34 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 102 3x35 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 103 3x36 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 104 3x37 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 105 3x38 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 106 3x39 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 107 3x40 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 108 3x41 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 109 3x42 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 110 3x43 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 111 3x44 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 112 3x45 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 113 3x46 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 114 3x47 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 115 3x48 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 116 3x49 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 117 3x50 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 118 3x51 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 119 3x52 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 120 3x53 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 121 3x54 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 122 3x55 BLT1 receptor 5X33 BLT1 receptor 5X33
TM3 123 3x56 BLT1 receptor 5X33 BLT1 receptor 5X33
ICL2 124 34x50 BLT1 receptor 5X33 BLT1 receptor 5X33
ICL2 125 34x51 BLT1 receptor 5X33 BLT1 receptor 5X33
ICL2 126 34x52 BLT1 receptor 5X33 BLT1 receptor 5X33
ICL2 127 34x53 BLT1 receptor 5X33 BLT1 receptor 5X33
ICL2 128 34x54 BLT1 receptor 5X33 BLT1 receptor 5X33
ICL2 129 34x55 BLT1 receptor 5X33 BLT1 receptor 5X33
ICL2 130 34x56 BLT1 receptor 5X33 BLT1 receptor 5X33
ICL2 131 34x57 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 132 4x38 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 133 4x39 BLT1 receptor 5X33 β2-adrenoceptor 2RH1
TM4 134 4x40 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 135 4x41 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 136 4x42 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 137 4x43 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 138 4x44 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 139 4x45 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 140 4x46 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 141 4x47 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 142 4x48 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 143 4x49 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 144 4x50 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 145 4x51 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 146 4x52 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 147 4x53 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 148 4x54 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 149 4x55 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 150 4x56 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 151 4x57 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 152 4x59 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 153 4x60 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 154 4x61 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 155 4x62 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 156 4x63 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 157 4x64 BLT1 receptor 5X33 BLT1 receptor 5X33
TM4 158 4x65 BLT1 receptor 5X33 BLT1 receptor 5X33
ECL2 159 BLT1 receptor 5X33 BLT1 receptor 5X33
ECL2 160 BLT1 receptor 5X33 BLT1 receptor 5X33
ECL2 161 BLT1 receptor 5X33 BLT1 receptor 5X33
ECL2 162 BLT1 receptor 5X33 BLT1 receptor 5X33
ECL2 163 BLT1 receptor 5X33 BLT1 receptor 5X33
ECL2 164 BLT1 receptor 5X33 BLT1 receptor 5X33
ECL2 165 BLT1 receptor 5X33 BLT1 receptor 5X33
ECL2 166 BLT1 receptor 5X33 BLT1 receptor 5X33
ECL2 167 BLT1 receptor 5X33 BLT1 receptor 5X33
ECL2 168 BLT1 receptor 5X33 BLT1 receptor 5X33
ECL2 169 BLT1 receptor 5X33 BLT1 receptor 5X33
ECL2 170 45x50 BLT1 receptor 5X33 BLT1 receptor 5X33
ECL2 171 45x51 BLT1 receptor 5X33 BLT1 receptor 5X33
ECL2 172 45x52 BLT1 receptor 5X33 BLT1 receptor 5X33
ECL2 173 BLT1 receptor 5X33 BLT1 receptor 5X33
ECL2 174 BLT1 receptor 5X33 BLT1 receptor 5X33
ECL2 175 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 176 5x32 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 177 5x33 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 178 5x34 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 179 5x35 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 180 5x36 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 181 5x37 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 182 5x38 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 183 5x39 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 184 5x40 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 185 5x41 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 186 5x42 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 187 5x43 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 188 5x44 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 189 5x45 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 190 5x46 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 191 5x461 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 192 5x47 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 193 5x48 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 194 5x49 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 195 5x50 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 196 5x51 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 197 5x52 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 198 5x53 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 199 5x54 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 200 5x55 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 201 5x56 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 202 5x57 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 203 5x58 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 204 5x59 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 205 5x60 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 206 5x61 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 207 5x62 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 208 5x63 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 209 5x64 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 210 5x65 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 211 5x66 BLT1 receptor 5X33 δ receptor 4N6H
TM5 212 5x67 BLT1 receptor 5X33 BLT1 receptor 5X33
TM5 213 5x68 BLT1 receptor 5X33 BLT1 receptor 5X33
ICL3 214 - - - -
ICL3 215 - - - -
ICL3 216 - - - -
ICL3 217 - - - -
TM6 218 6x30 CXCR4 3ODU CCR5 5UIW
TM6 219 6x31 CXCR4 3ODU CXCR4 3ODU
TM6 220 6x32 CXCR4 3ODU apelin receptor 5VBL
TM6 221 6x33 CXCR4 3ODU OX2 receptor 5WS3
TM6 222 6x34 CXCR4 3ODU - -
TM6 223 6x35 CXCR4 3ODU κ receptor 4DJH
TM6 224 6x36 CXCR4 3ODU κ receptor 4DJH
TM6 225 6x37 CXCR4 3ODU κ receptor 4DJH
TM6 226 6x38 CXCR4 3ODU CXCR4 3ODU
TM6 227 6x39 BLT1 receptor 5X33 BLT1 receptor 5X33
TM6 228 6x40 BLT1 receptor 5X33 BLT1 receptor 5X33
TM6 229 6x41 BLT1 receptor 5X33 BLT1 receptor 5X33
TM6 230 6x42 BLT1 receptor 5X33 BLT1 receptor 5X33
TM6 231 6x43 BLT1 receptor 5X33 BLT1 receptor 5X33
TM6 232 6x44 BLT1 receptor 5X33 BLT1 receptor 5X33
TM6 233 6x45 BLT1 receptor 5X33 BLT1 receptor 5X33
TM6 234 6x46 BLT1 receptor 5X33 BLT1 receptor 5X33
TM6 235 6x47 BLT1 receptor 5X33 BLT1 receptor 5X33
TM6 236 6x48 BLT1 receptor 5X33 BLT1 receptor 5X33
TM6 237 6x49 BLT1 receptor 5X33 BLT1 receptor 5X33
TM6 238 6x50 BLT1 receptor 5X33 BLT1 receptor 5X33
TM6 239 6x51 BLT1 receptor 5X33 BLT1 receptor 5X33
TM6 240 6x52 BLT1 receptor 5X33 BLT1 receptor 5X33
TM6 241 6x53 BLT1 receptor 5X33 BLT1 receptor 5X33
TM6 242 6x54 BLT1 receptor 5X33 BLT1 receptor 5X33
TM6 243 6x55 BLT1 receptor 5X33 BLT1 receptor 5X33
TM6 244 6x56 BLT1 receptor 5X33 BLT1 receptor 5X33
TM6 245 6x57 BLT1 receptor 5X33 BLT1 receptor 5X33
TM6 246 6x58 BLT1 receptor 5X33 BLT1 receptor 5X33
TM6 247 6x59 BLT1 receptor 5X33 BLT1 receptor 5X33
TM6 248 6x60 BLT1 receptor 5X33 BLT1 receptor 5X33
TM6 249 6x61 BLT1 receptor 5X33 BLT1 receptor 5X33
TM6 250 6x62 CXCR4 3ODU - -
TM6 251 6x63 CXCR4 3ODU CXCR4 3ODU
TM6 252 6x64 CXCR4 3ODU CCR9 5LWE
ECL3 253 - - - -
ECL3 254 - - - -
TM7 255 7x23 CXCR4 3ODU - -
TM7 256 7x24 CXCR4 3ODU - -
TM7 257 7x25 CXCR4 3ODU - -
TM7 258 7x26 CXCR4 3ODU CCR5 5UIW
TM7 259 7x27 CXCR4 3ODU - -
TM7 260 7x28 CXCR4 3ODU - -
TM7 261 7x29 BLT1 receptor 5X33 BLT1 receptor 5X33
TM7 262 7x30 BLT1 receptor 5X33 BLT1 receptor 5X33
TM7 263 7x31 BLT1 receptor 5X33 BLT1 receptor 5X33
TM7 264 7x32 BLT1 receptor 5X33 apelin receptor 5VBL
TM7 265 7x33 BLT1 receptor 5X33 BLT1 receptor 5X33
TM7 266 7x34 BLT1 receptor 5X33 BLT1 receptor 5X33
TM7 267 7x35 BLT1 receptor 5X33 BLT1 receptor 5X33
TM7 268 7x36 BLT1 receptor 5X33 BLT1 receptor 5X33
TM7 269 7x37 BLT1 receptor 5X33 BLT1 receptor 5X33
TM7 270 7x38 BLT1 receptor 5X33 BLT1 receptor 5X33
TM7 271 7x39 BLT1 receptor 5X33 BLT1 receptor 5X33
TM7 272 7x40 BLT1 receptor 5X33 BLT1 receptor 5X33
TM7 273 7x41 BLT1 receptor 5X33 BLT1 receptor 5X33
TM7 274 7x42 BLT1 receptor 5X33 BLT1 receptor 5X33
TM7 275 7x43 BLT1 receptor 5X33 BLT1 receptor 5X33
TM7 276 7x45 BLT1 receptor 5X33 BLT1 receptor 5X33
TM7 277 7x46 BLT1 receptor 5X33 BLT1 receptor 5X33
TM7 278 7x47 BLT1 receptor 5X33 BLT1 receptor 5X33
TM7 279 7x48 apelin receptor 5VBL D2 receptor 6CM4
TM7 280 7x49 apelin receptor 5VBL apelin receptor 5VBL
TM7 281 7x50 apelin receptor 5VBL apelin receptor 5VBL
TM7 282 7x51 apelin receptor 5VBL AT1 receptor 4ZUD
TM7 283 7x52 apelin receptor 5VBL apelin receptor 5VBL
TM7 284 7x53 apelin receptor 5VBL apelin receptor 5VBL
TM7 285 7x54 apelin receptor 5VBL apelin receptor 5VBL
TM7 286 7x55 apelin receptor 5VBL - -
TM7 287 7x56 apelin receptor 5VBL C5a1 receptor 5O9H
H8 288 8x47 apelin receptor 5VBL CCR5 5UIW
H8 289 8x48 apelin receptor 5VBL OX2 receptor 5WS3
H8 290 8x49 apelin receptor 5VBL - -
H8 291 8x50 apelin receptor 5VBL CB1 receptor 5TGZ
H8 292 8x51 apelin receptor 5VBL C5a1 receptor 5O9H
H8 293 8x52 apelin receptor 5VBL κ receptor 4DJH
H8 294 8x53 apelin receptor 5VBL P2Y12 receptor 4NTJ
H8 295 8x54 apelin receptor 5VBL PAR2 5NDD
H8 296 8x55 apelin receptor 5VBL 5-HT2B receptor 4IB4
H8 297 8x56 apelin receptor 5VBL CCR2 5T1A
H8 298 8x57 apelin receptor 5VBL - -
H8 299 8x58 apelin receptor 5VBL CCR5 5UIW
H8 300 8x59 apelin receptor 5VBL - -
H8 301 8x60 apelin receptor 5VBL - -
H8 302 8x61 apelin receptor 5VBL - -
C-term 303 - - - -
C-term 304 - - - -
C-term 305 - - - -
C-term 306 - - - -
C-term 307 - - - -