5-HT1A receptor homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive (Δ distance (Å): -1.81 docs)

VERSION

2018-04-06

MAIN TEMPLATE

D2 receptor (sequence similarity: 63%) PDB: 6CM4

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 74.3 12.8 12.8
Side-chains 29.3 50.0 20.7

Number of backbone templates: 5
Number of rotamer templates: 33

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4IAQ
6CM4
5WF6
3SN6
5TVN
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone Xtal Rotamer Xtal
N-term 27 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
N-term 28 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
N-term 29 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
N-term 30 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
N-term 31 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
TM1 32 1x28 5-HT1B receptor 4IAQ - -
TM1 33 1x29 5-HT1B receptor 4IAQ - -
TM1 34 1x30 5-HT1B receptor 4IAQ CB1 receptor 5TGZ
TM1 35 1x31 5-HT1B receptor 4IAQ OX2 receptor 5WS3
TM1 36 1x32 5-HT1B receptor 4IAQ A1 receptor 5UEN
TM1 37 1x33 D2 receptor 6CM4 P2Y12 receptor 4NTJ
TM1 38 1x34 D2 receptor 6CM4 κ receptor 4DJH
TM1 39 1x35 D2 receptor 6CM4 S1P1 receptor 3V2Y
TM1 40 1x36 D2 receptor 6CM4 S1P1 receptor 3V2Y
TM1 41 1x37 D2 receptor 6CM4 D3 receptor 3PBL
TM1 42 1x38 D2 receptor 6CM4 D2 receptor 6CM4
TM1 43 1x39 D2 receptor 6CM4 D2 receptor 6CM4
TM1 44 1x40 D2 receptor 6CM4 M3 receptor 4U15
TM1 45 1x41 D2 receptor 6CM4 H1 receptor 3RZE
TM1 46 1x42 D2 receptor 6CM4 D2 receptor 6CM4
TM1 47 1x43 D2 receptor 6CM4 D2 receptor 6CM4
TM1 48 1x44 D2 receptor 6CM4 P2Y12 receptor 4NTJ
TM1 49 1x45 D2 receptor 6CM4 - -
TM1 50 1x46 D2 receptor 6CM4 A2A receptor 3VG9
TM1 51 1x47 D2 receptor 6CM4 D2 receptor 6CM4
TM1 52 1x48 D2 receptor 6CM4 A2A receptor 3VG9
TM1 53 1x49 D2 receptor 6CM4 D2 receptor 6CM4
TM1 54 1x50 D2 receptor 6CM4 D2 receptor 6CM4
TM1 55 1x51 D2 receptor 6CM4 C5a1 receptor 5O9H
TM1 56 1x52 D2 receptor 6CM4 - -
TM1 57 1x53 D2 receptor 6CM4 D2 receptor 6CM4
TM1 58 1x54 D2 receptor 6CM4 CCR2 5T1A
TM1 59 1x55 D2 receptor 6CM4 5-HT1B receptor 4IAQ
TM1 60 1x56 D2 receptor 6CM4 D2 receptor 6CM4
TM1 61 1x57 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM1 62 1x58 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM1 63 1x59 D2 receptor 6CM4 A2A receptor 3VG9
TM1 64 1x60 D2 receptor 6CM4 D3 receptor 3PBL
ICL1 65 12x48 - - - -
ICL1 66 12x49 5-HT1B receptor 4IAQ CB1 receptor 5TGZ
ICL1 67 12x50 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
ICL1 68 12x51 - - - -
TM2 69 2x37 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM2 70 2x38 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM2 71 2x39 D2 receptor 6CM4 apelin receptor 5VBL
TM2 72 2x40 D2 receptor 6CM4 D2 receptor 6CM4
TM2 73 2x41 D2 receptor 6CM4 D2 receptor 6CM4
TM2 74 2x42 D2 receptor 6CM4 D2 receptor 6CM4
TM2 75 2x43 D2 receptor 6CM4 D2 receptor 6CM4
TM2 76 2x44 D2 receptor 6CM4 NTS1 receptor 4BUO
TM2 77 2x45 D2 receptor 6CM4 D2 receptor 6CM4
TM2 78 2x46 D2 receptor 6CM4 D2 receptor 6CM4
TM2 79 2x47 D2 receptor 6CM4 D2 receptor 6CM4
TM2 80 2x48 D2 receptor 6CM4 D2 receptor 6CM4
TM2 81 2x49 D2 receptor 6CM4 5-HT1B receptor 4IAQ
TM2 82 2x50 D2 receptor 6CM4 D2 receptor 6CM4
TM2 83 2x51 D2 receptor 6CM4 D2 receptor 6CM4
TM2 84 2x52 D2 receptor 6CM4 - -
TM2 85 2x53 D2 receptor 6CM4 D2 receptor 6CM4
TM2 86 2x54 D2 receptor 6CM4 CB1 receptor 5TGZ
TM2 87 2x55 D2 receptor 6CM4 M3 receptor 4U15
TM2 88 2x551 D2 receptor 6CM4 D2 receptor 6CM4
TM2 89 2x56 D2 receptor 6CM4 D2 receptor 6CM4
TM2 90 2x57 D2 receptor 6CM4 D4 receptor 5WIV
TM2 91 2x58 D2 receptor 6CM4 D2 receptor 6CM4
TM2 92 2x59 D2 receptor 6CM4 H1 receptor 3RZE
TM2 93 2x60 D2 receptor 6CM4 A2A receptor 3VG9
TM2 94 2x61 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM2 95 2x62 D2 receptor 6CM4 M2 receptor 3UON
TM2 96 2x63 D2 receptor 6CM4 M3 receptor 4U15
TM2 97 2x64 D2 receptor 6CM4 - -
TM2 98 2x65 D2 receptor 6CM4 D3 receptor 3PBL
TM2 99 2x66 D2 receptor 6CM4 NOP receptor 5DHG
TM2 100 2x67 D2 receptor 6CM4 κ receptor 4DJH
ECL1 101 23x49 - - - -
ECL1 102 23x50 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
ECL1 103 23x51 5-HT1B receptor 4IAQ β2-adrenoceptor 5JQH
ECL1 104 23x52 - - - -
TM3 105 3x21 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM3 106 3x22 D2 receptor 6CM4 OX2 receptor 5WS3
TM3 107 3x23 D2 receptor 6CM4 M2 receptor 3UON
TM3 108 3x24 D2 receptor 6CM4 A1 receptor 5UEN
TM3 109 3x25 D2 receptor 6CM4 D2 receptor 6CM4
TM3 110 3x26 D2 receptor 6CM4 D2 receptor 6CM4
TM3 111 3x27 D2 receptor 6CM4 M3 receptor 4U15
TM3 112 3x28 D2 receptor 6CM4 D2 receptor 6CM4
TM3 113 3x29 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM3 114 3x30 D2 receptor 6CM4 M2 receptor 3UON
TM3 115 3x31 D2 receptor 6CM4 D2 receptor 6CM4
TM3 116 3x32 D2 receptor 6CM4 D2 receptor 6CM4
TM3 117 3x33 D2 receptor 6CM4 D2 receptor 6CM4
TM3 118 3x34 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM3 119 3x35 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM3 120 3x36 D2 receptor 6CM4 D2 receptor 6CM4
TM3 121 3x37 D2 receptor 6CM4 D2 receptor 6CM4
TM3 122 3x38 D2 receptor 6CM4 A2A receptor 3VG9
TM3 123 3x39 D2 receptor 6CM4 D2 receptor 6CM4
TM3 124 3x40 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM3 125 3x41 D2 receptor 6CM4 D2 receptor 6CM4
TM3 126 3x42 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM3 127 3x43 D2 receptor 6CM4 D2 receptor 6CM4
TM3 128 3x44 D2 receptor 6CM4 D2 receptor 6CM4
TM3 129 3x45 D2 receptor 6CM4 D2 receptor 6CM4
TM3 130 3x46 D2 receptor 6CM4 D2 receptor 6CM4
TM3 131 3x47 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM3 132 3x48 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM3 133 3x49 D2 receptor 6CM4 D2 receptor 6CM4
TM3 134 3x50 D2 receptor 6CM4 D2 receptor 6CM4
TM3 135 3x51 D2 receptor 6CM4 D2 receptor 6CM4
TM3 136 3x52 D2 receptor 6CM4 5-HT1B receptor 4IAQ
TM3 137 3x53 D2 receptor 6CM4 D2 receptor 6CM4
TM3 138 3x54 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM3 139 3x55 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM3 140 3x56 D2 receptor 6CM4 5-HT1B receptor 4IAQ
ICL2 141 34x50 - - - -
ICL2 142 34x51 5-HT1B receptor 4IAQ - -
ICL2 143 34x52 5-HT1B receptor 4IAQ - -
ICL2 144 34x53 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
ICL2 145 34x54 5-HT1B receptor 4IAQ - -
ICL2 146 34x55 5-HT1B receptor 4IAQ - -
ICL2 147 34x56 5-HT1B receptor 4IAQ M3 receptor 4U15
ICL2 148 34x57 - - - -
TM4 149 4x38 D2 receptor 6CM4 κ receptor 4DJH
TM4 150 4x39 D2 receptor 6CM4 M1 receptor 5CXV
TM4 151 4x40 D2 receptor 6CM4 D3 receptor 3PBL
TM4 152 4x41 D2 receptor 6CM4 D2 receptor 6CM4
TM4 153 4x42 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM4 154 4x43 D2 receptor 6CM4 D3 receptor 3PBL
TM4 155 4x44 D2 receptor 6CM4 H1 receptor 3RZE
TM4 156 4x45 D2 receptor 6CM4 D4 receptor 5WIV
TM4 157 4x46 D2 receptor 6CM4 D2 receptor 6CM4
TM4 158 4x47 D2 receptor 6CM4 D2 receptor 6CM4
TM4 159 4x48 D2 receptor 6CM4 M3 receptor 4U15
TM4 160 4x49 D2 receptor 6CM4 D4 receptor 5WIV
TM4 161 4x50 D2 receptor 6CM4 D2 receptor 6CM4
TM4 162 4x51 D2 receptor 6CM4 D4 receptor 5WIV
TM4 163 4x52 D2 receptor 6CM4 M3 receptor 4U15
TM4 164 4x53 D2 receptor 6CM4 - -
TM4 165 4x54 D2 receptor 6CM4 D2 receptor 6CM4
TM4 166 4x55 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM4 167 4x56 D2 receptor 6CM4 D2 receptor 6CM4
TM4 168 4x57 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
TM4 169 4x58 5-HT1B receptor 4IAQ κ receptor 4DJH
TM4 170 4x59 5-HT1B receptor 4IAQ 5-HT1B receptor 4IAQ
TM4 171 4x60 D2 receptor 6CM4 D2 receptor 6CM4
TM4 172 4x61 D2 receptor 6CM4 A2A receptor 3VG9
TM4 173 4x62 D2 receptor 6CM4 D2 receptor 6CM4
TM4 174 4x63 D2 receptor 6CM4 H1 receptor 3RZE
ECL2 175 - - - -
ECL2 176 A2A receptor 5WF6 - -
ECL2 177 A2A receptor 5WF6 - -
ECL2 178 A2A receptor 5WF6 - -
ECL2 179 - - - -
ECL2 180 - - - -
ECL2 181 - - - -
ECL2 182 - - - -
ECL2 183 - - - -
ECL2 184 - - - -
ECL2 185 - - - -
ECL2 186 - - - -
ECL2 187 45x50 D2 receptor 6CM4 D2 receptor 6CM4
ECL2 188 45x51 D2 receptor 6CM4 - -
ECL2 189 45x52 D2 receptor 6CM4 D2 receptor 6CM4
ECL2 190 - - - -
ECL2 191 - - - -
TM5 192 5x36 5-HT1B receptor 4IAQ D4 receptor 5WIV
TM5 193 5x37 5-HT1B receptor 4IAQ - -
TM5 194 5x38 D2 receptor 6CM4 apelin receptor 5VBL
TM5 195 5x39 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM5 196 5x40 D2 receptor 6CM4 M3 receptor 4U15
TM5 197 5x41 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM5 198 5x42 D2 receptor 6CM4 D2 receptor 6CM4
TM5 199 5x43 D2 receptor 6CM4 D2 receptor 6CM4
TM5 200 5x44 D2 receptor 6CM4 NTS1 receptor 4BUO
TM5 201 5x45 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM5 202 5x46 D2 receptor 6CM4 5-HT1B receptor 4IAQ
TM5 203 5x461 D2 receptor 6CM4 M3 receptor 4U15
TM5 204 5x47 D2 receptor 6CM4 D2 receptor 6CM4
TM5 205 5x48 D2 receptor 6CM4 D2 receptor 6CM4
TM5 206 5x49 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM5 207 5x50 D2 receptor 6CM4 D2 receptor 6CM4
TM5 208 5x51 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM5 209 5x52 D2 receptor 6CM4 H1 receptor 3RZE
TM5 210 5x53 D2 receptor 6CM4 H1 receptor 3RZE
TM5 211 5x54 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM5 212 5x55 D2 receptor 6CM4 D2 receptor 6CM4
TM5 213 5x56 D2 receptor 6CM4 M2 receptor 3UON
TM5 214 5x57 D2 receptor 6CM4 M3 receptor 4U15
TM5 215 5x58 D2 receptor 6CM4 D2 receptor 6CM4
TM5 216 5x59 D2 receptor 6CM4 δ receptor 4N6H
TM5 217 5x60 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM5 218 5x61 D2 receptor 6CM4 D2 receptor 6CM4
TM5 219 5x62 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM5 220 5x63 D2 receptor 6CM4 M2 receptor 3UON
TM5 221 5x64 D2 receptor 6CM4 M2 receptor 3UON
TM5 222 5x65 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM5 223 5x66 D2 receptor 6CM4 5-HT2C receptor 6BQH
TM5 224 5x67 D2 receptor 6CM4 - -
TM5 225 5x68 D2 receptor 6CM4 D2 receptor 6CM4
TM5 226 5x69 D2 receptor 6CM4 5-HT1B receptor 4IAR
TM5 227 5x70 D2 receptor 6CM4 - -
TM5 228 5x71 D2 receptor 6CM4 β2-adrenoceptor 3SN6
TM5 229 5x72 β2-adrenoceptor 3SN6 P2Y12 receptor 4NTJ
TM5 230 5x73 β2-adrenoceptor 3SN6 - -
TM5 231 5x74 β2-adrenoceptor 3SN6 β2-adrenoceptor 3SN6
TM5 232 5x75 β2-adrenoceptor 3SN6 - -
TM5 233 5x76 β2-adrenoceptor 3SN6 - -
ICL3 234 - - - -
ICL3 235 - - - -
ICL3 236 - - - -
ICL3 237 - - - -
ICL3 238 - - - -
ICL3 329 - - - -
ICL3 330 - - - -
ICL3 331 - - - -
ICL3 332 - - - -
ICL3 333 - - - -
TM6 334 6x24 5-HT2B receptor 5TVN δ receptor 4RWD
TM6 335 6x25 5-HT2B receptor 5TVN - -
TM6 336 6x26 5-HT2B receptor 5TVN 5-HT2C receptor 6BQH
TM6 337 6x27 5-HT2B receptor 5TVN M1 receptor 5CXV
TM6 338 6x28 5-HT2B receptor 5TVN 5-HT1B receptor 4IAQ
TM6 339 6x29 5-HT2B receptor 5TVN D3 receptor 3PBL
TM6 340 6x30 D2 receptor 6CM4 D2 receptor 6CM4
TM6 341 6x31 D2 receptor 6CM4 H1 receptor 3RZE
TM6 342 6x32 D2 receptor 6CM4 β2-adrenoceptor 2RH1
TM6 343 6x33 D2 receptor 6CM4 OX2 receptor 5WS3
TM6 344 6x34 D2 receptor 6CM4 NTS1 receptor 4BUO
TM6 345 6x35 D2 receptor 6CM4 β2-adrenoceptor 2RH1
TM6 346 6x36 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM6 347 6x37 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM6 348 6x38 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM6 349 6x39 D2 receptor 6CM4 D2 receptor 6CM4
TM6 350 6x40 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM6 351 6x41 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM6 352 6x42 D2 receptor 6CM4 D2 receptor 6CM4
TM6 353 6x43 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM6 354 6x44 D2 receptor 6CM4 D2 receptor 6CM4
TM6 355 6x45 D2 receptor 6CM4 D2 receptor 6CM4
TM6 356 6x46 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM6 357 6x47 D2 receptor 6CM4 D2 receptor 6CM4
TM6 358 6x48 D2 receptor 6CM4 D2 receptor 6CM4
TM6 359 6x49 D2 receptor 6CM4 D2 receptor 6CM4
TM6 360 6x50 D2 receptor 6CM4 D2 receptor 6CM4
TM6 361 6x51 D2 receptor 6CM4 D2 receptor 6CM4
TM6 362 6x52 D2 receptor 6CM4 D2 receptor 6CM4
TM6 363 6x53 D2 receptor 6CM4 D2 receptor 6CM4
TM6 364 6x54 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM6 365 6x55 D2 receptor 6CM4 Rhodopsin 1GZM
TM6 366 6x56 D2 receptor 6CM4 M3 receptor 4U15
TM6 367 6x57 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM6 368 6x58 D2 receptor 6CM4 5-HT2B receptor 4IB4
TM6 369 6x59 D2 receptor 6CM4 5-HT1B receptor 4IAQ
TM6 370 6x60 D2 receptor 6CM4 M3 receptor 4U15
ECL3 371 - - - -
ECL3 372 - - - -
ECL3 373 - - - -
ECL3 374 - - - -
ECL3 375 - - - -
ECL3 376 - - - -
ECL3 377 - - - -
TM7 378 7x30 D2 receptor 6CM4 D2 receptor 6CM4
TM7 379 7x31 D2 receptor 6CM4 μ receptor 4DKL
TM7 380 7x32 D2 receptor 6CM4 AT2 receptor 5UNG
TM7 381 7x33 D2 receptor 6CM4 D3 receptor 3PBL
TM7 382 7x34 D2 receptor 6CM4 - -
TM7 383 7x35 D2 receptor 6CM4 CB1 receptor 5TGZ
TM7 384 7x36 D2 receptor 6CM4 M2 receptor 3UON
TM7 385 7x37 D2 receptor 6CM4 - -
TM7 386 7x38 D2 receptor 6CM4 β2-adrenoceptor 5JQH
TM7 387 7x39 D2 receptor 6CM4 D2 receptor 6CM4
TM7 388 7x40 D2 receptor 6CM4 D2 receptor 6CM4
TM7 389 7x41 D2 receptor 6CM4 D2 receptor 6CM4
TM7 390 7x42 D2 receptor 6CM4 D2 receptor 6CM4
TM7 391 7x43 D2 receptor 6CM4 Rhodopsin 4ZWJ
TM7 392 7x45 D2 receptor 6CM4 D2 receptor 6CM4
TM7 393 7x46 D2 receptor 6CM4 D2 receptor 6CM4
TM7 394 7x47 D2 receptor 6CM4 5-HT1B receptor 4IAQ
TM7 395 7x48 D2 receptor 6CM4 D3 receptor 3PBL
TM7 396 7x49 D2 receptor 6CM4 D2 receptor 6CM4
TM7 397 7x50 D2 receptor 6CM4 D2 receptor 6CM4
TM7 398 7x51 D2 receptor 6CM4 D3 receptor 3PBL
TM7 399 7x52 D2 receptor 6CM4 D2 receptor 6CM4
TM7 400 7x53 D2 receptor 6CM4 D2 receptor 6CM4
TM7 401 7x54 D2 receptor 6CM4 M3 receptor 4U15
TM7 402 7x55 D2 receptor 6CM4 A2A receptor 3VG9
TM7 403 7x56 D2 receptor 6CM4 D2 receptor 6CM4
H8 404 8x47 D2 receptor 6CM4 D2 receptor 6CM4
H8 405 8x48 D2 receptor 6CM4 5-HT2C receptor 6BQH
H8 406 8x49 D2 receptor 6CM4 β2-adrenoceptor 5JQH
H8 407 8x50 D2 receptor 6CM4 D2 receptor 6CM4
H8 408 8x51 D2 receptor 6CM4 AT2 receptor 5UNF
H8 409 8x52 D2 receptor 6CM4 D4 receptor 5WIV
H8 410 8x53 D2 receptor 6CM4 D2 receptor 6CM4
H8 411 8x54 D2 receptor 6CM4 D2 receptor 6CM4
H8 412 8x55 D2 receptor 6CM4 M2 receptor 3UON
H8 413 8x56 D2 receptor 6CM4 D3 receptor 3PBL
H8 414 8x57 D2 receptor 6CM4 D2 receptor 6CM4
H8 415 8x58 D2 receptor 6CM4 A2A receptor 3VG9
C-term 416 - - - -
C-term 417 - - - -
C-term 418 - - - -
C-term 419 - - - -
C-term 420 - - - -