CCR2 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate (Δ distance (Å): 7.24 docs)

VERSION

2018-07-10

MAIN TEMPLATE

μ receptor (sequence similarity: 48%) PDB: 6DDE

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 76.5 15.6 7.8
Side-chains 19.4 68.0 12.6

Number of backbone templates: 4
Number of rotamer templates: 22

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5T1A
6DDE
4ZUD
5UIW
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 32 - - - -
N-term 33 - - - -
N-term 34 - - - -
N-term 35 - - - -
N-term 36 - - - -
TM1 37 1.27x27 CCR2 5T1A CCR2 5T1A
TM1 38 1.28x28 CCR2 5T1A CCR5 5UIW
TM1 39 1.29x29 CCR2 5T1A CCR5 5UIW
TM1 40 1.30x30 CCR2 5T1A CCR2 5T1A
TM1 41 1.31x31 μ receptor 6DDE A2A receptor 5WF5
TM1 42 1.32x32 μ receptor 6DDE μ receptor 6DDE
TM1 43 1.33x33 μ receptor 6DDE FFA1 receptor 5TZR
TM1 44 1.34x34 μ receptor 6DDE PAF receptor 5ZKQ
TM1 45 1.35x35 μ receptor 6DDE P2Y1 receptor 4XNW
TM1 46 1.36x36 μ receptor 6DDE P2Y1 receptor 4XNW
TM1 47 1.37x37 μ receptor 6DDE CCR2 5T1A
TM1 48 1.38x38 μ receptor 6DDE P2Y12 receptor 4NTJ
TM1 49 1.39x39 μ receptor 6DDE μ receptor 6DDE
TM1 50 1.40x40 μ receptor 6DDE μ receptor 6DDE
TM1 51 1.41x41 μ receptor 6DDE P2Y1 receptor 4XNW
TM1 52 1.42x42 μ receptor 6DDE μ receptor 6DDE
TM1 53 1.43x43 μ receptor 6DDE P2Y1 receptor 4XNW
TM1 54 1.44x44 μ receptor 6DDE P2Y1 receptor 4XNW
TM1 55 1.45x45 μ receptor 6DDE CCR2 5T1A
TM1 56 1.46x46 μ receptor 6DDE μ receptor 6DDE
TM1 57 1.47x47 μ receptor 6DDE P2Y1 receptor 4XNW
TM1 58 1.48x48 μ receptor 6DDE NTS1 receptor 4XES
TM1 59 1.49x49 μ receptor 6DDE μ receptor 6DDE
TM1 60 1.50x50 μ receptor 6DDE μ receptor 6DDE
TM1 61 1.51x51 μ receptor 6DDE CCR2 5T1A
TM1 62 1.52x52 μ receptor 6DDE μ receptor 6DDE
TM1 63 1.53x53 μ receptor 6DDE μ receptor 6DDE
TM1 64 1.54x54 μ receptor 6DDE CCR2 5T1A
TM1 65 1.55x55 μ receptor 6DDE 5-HT2B receptor 4IB4
TM1 66 1.56x56 μ receptor 6DDE P2Y12 receptor 4NTJ
TM1 67 1.57x57 μ receptor 6DDE NTS1 receptor 4XES
TM1 68 1.58x58 μ receptor 6DDE PAR1 3VW7
TM1 69 1.59x59 μ receptor 6DDE CCR2 5T1A
TM1 70 1.60x60 μ receptor 6DDE CCR2 5T1A
ICL1 71 12.48x48 - - - -
ICL1 72 12.49x49 AT1 receptor 4ZUD 5-HT2B receptor 4NC3
ICL1 73 12.50x50 AT1 receptor 4ZUD AT1 receptor 4ZUD
ICL1 74 12.51x51 - - - -
TM2 75 2.37x37 CCR2 5T1A CCR2 5T1A
TM2 76 2.38x38 μ receptor 6DDE CCR2 5T1A
TM2 77 2.39x39 μ receptor 6DDE μ receptor 6DDE
TM2 78 2.40x40 μ receptor 6DDE CCR2 5T1A
TM2 79 2.41x41 μ receptor 6DDE μ receptor 6DDE
TM2 80 2.42x42 μ receptor 6DDE μ receptor 6DDE
TM2 81 2.43x43 μ receptor 6DDE P2Y12 receptor 4NTJ
TM2 82 2.44x44 μ receptor 6DDE PAR1 3VW7
TM2 83 2.45x45 μ receptor 6DDE μ receptor 6DDE
TM2 84 2.46x46 μ receptor 6DDE μ receptor 6DDE
TM2 85 2.47x47 μ receptor 6DDE μ receptor 6DDE
TM2 86 2.48x48 μ receptor 6DDE P2Y12 receptor 4NTJ
TM2 87 2.49x49 μ receptor 6DDE P2Y12 receptor 4NTJ
TM2 88 2.50x50 μ receptor 6DDE μ receptor 6DDE
TM2 89 2.51x51 μ receptor 6DDE PAR2 5NDD
TM2 90 2.52x52 μ receptor 6DDE μ receptor 6DDE
TM2 91 2.53x53 μ receptor 6DDE PAR1 3VW7
TM2 92 2.54x54 μ receptor 6DDE PAF receptor 5ZKQ
TM2 93 2.55x55 μ receptor 6DDE PAR2 5NDD
TM2 94 2.56x56 μ receptor 6DDE μ receptor 6DDE
TM2 95 2.57x57 μ receptor 6DDE μ receptor 6DDE
TM2 96 2.58x58 μ receptor 6DDE μ receptor 6DDE
TM2 97 2.59x59 μ receptor 6DDE PAR2 5NDD
TM2 98 2.60x60 μ receptor 6DDE PAF receptor 5ZKQ
TM2 99 2.61x61 μ receptor 6DDE FFA1 receptor 5TZY
TM2 100 2.62x62 μ receptor 6DDE CCR2 5T1A
TM2 101 2.63x63 μ receptor 6DDE P2Y12 receptor 4NTJ
TM2 102 2.64x64 μ receptor 6DDE FFA1 receptor 5TZY
TM2 103 2.65x65 μ receptor 6DDE P2Y12 receptor 4NTJ
TM2 104 2.66x66 μ receptor 6DDE P2Y1 receptor 4XNW
ECL1 105 23.49x49 - - - -
ECL1 106 23.50x50 CCR2 5T1A CCR2 5T1A
ECL1 107 23.51x51 CCR2 5T1A CCR2 5T1A
ECL1 108 23.52x52 - - - -
TM3 109 3.21x21 μ receptor 6DDE μ receptor 6DDE
TM3 110 3.22x22 μ receptor 6DDE μ receptor 6DDE
TM3 111 3.23x23 μ receptor 6DDE P2Y1 receptor 4XNW
TM3 112 3.24x24 μ receptor 6DDE P2Y1 receptor 4XNW
TM3 113 3.25x25 μ receptor 6DDE μ receptor 6DDE
TM3 114 3.26x26 μ receptor 6DDE μ receptor 6DDE
TM3 115 3.27x27 μ receptor 6DDE P2Y1 receptor 4XNW
TM3 116 3.28x28 μ receptor 6DDE FFA1 receptor 5TZY
TM3 117 3.29x29 μ receptor 6DDE PAR1 3VW7
TM3 118 3.30x30 μ receptor 6DDE PAR2 5NDD
TM3 119 3.31x31 μ receptor 6DDE PAF receptor 5ZKQ
TM3 120 3.32x32 μ receptor 6DDE CCR2 5T1A
TM3 121 3.33x33 μ receptor 6DDE P2Y1 receptor 4XNW
TM3 122 3.34x34 μ receptor 6DDE PAF receptor 5ZKQ
TM3 123 3.35x35 μ receptor 6DDE CCR2 5T1A
TM3 124 3.36x36 μ receptor 6DDE CCR2 5T1A
TM3 125 3.37x37 μ receptor 6DDE μ receptor 6DDE
TM3 126 3.38x38 μ receptor 6DDE P2Y1 receptor 4XNW
TM3 127 3.39x39 μ receptor 6DDE FFA1 receptor 5TZY
TM3 128 3.40x40 μ receptor 6DDE μ receptor 6DDE
TM3 129 3.41x41 μ receptor 6DDE μ receptor 6DDE
TM3 130 3.42x42 μ receptor 6DDE P2Y1 receptor 4XNW
TM3 131 3.43x43 μ receptor 6DDE CCR2 5T1A
TM3 132 3.44x44 μ receptor 6DDE CCR2 5T1A
TM3 133 3.45x45 μ receptor 6DDE P2Y12 receptor 4NTJ
TM3 134 3.46x46 μ receptor 6DDE PAR2 5NDD
TM3 135 3.47x47 μ receptor 6DDE PAF receptor 5ZKQ
TM3 136 3.48x48 μ receptor 6DDE PAR1 3VW7
TM3 137 3.49x49 μ receptor 6DDE μ receptor 6DDE
TM3 138 3.50x50 μ receptor 6DDE μ receptor 6DDE
TM3 139 3.51x51 μ receptor 6DDE μ receptor 6DDE
TM3 140 3.52x52 μ receptor 6DDE PAR1 3VW7
TM3 141 3.53x53 μ receptor 6DDE μ receptor 6DDE
TM3 142 3.54x54 μ receptor 6DDE PAR2 5NDD
TM3 143 3.55x55 μ receptor 6DDE P2Y1 receptor 4XNW
TM3 144 3.56x56 μ receptor 6DDE μ receptor 6DDE
ICL2 145 34.50x50 - - - -
ICL2 146 34.51x51 CCR2 5T1A CCR2 5T1A
ICL2 147 34.52x52 CCR2 5T1A CCR2 5T1A
ICL2 148 34.53x53 CCR2 5T1A CCR2 5T1A
ICL2 149 34.54x54 CCR2 5T1A CCR2 5T1A
ICL2 150 34.55x55 CCR2 5T1A BLT1 receptor 5X33
ICL2 151 34.56x56 CCR2 5T1A CCR2 5T1A
ICL2 152 34.57x57 - - - -
TM4 153 4.38x38 μ receptor 6DDE μ receptor 6DDE
TM4 154 4.39x39 μ receptor 6DDE CCR2 5T1A
TM4 155 4.40x40 μ receptor 6DDE A2A receptor 4UHR
TM4 156 4.41x41 μ receptor 6DDE CCR2 5T1A
TM4 157 4.42x42 μ receptor 6DDE PAF receptor 5ZKQ
TM4 158 4.43x43 μ receptor 6DDE CCR2 5T1A
TM4 159 4.44x44 μ receptor 6DDE 5-HT1B receptor 4IAQ
TM4 160 4.45x45 μ receptor 6DDE PAR1 3VW7
TM4 161 4.46x46 μ receptor 6DDE P2Y1 receptor 4XNW
TM4 162 4.47x47 μ receptor 6DDE μ receptor 6DDE
TM4 163 4.48x48 μ receptor 6DDE A2A receptor 4UHR
TM4 164 4.49x49 μ receptor 6DDE CCR2 5T1A
TM4 165 4.50x50 μ receptor 6DDE μ receptor 6DDE
TM4 166 4.51x51 μ receptor 6DDE P2Y1 receptor 4XNW
TM4 167 4.52x52 μ receptor 6DDE CCR2 5T1A
TM4 168 4.53x53 μ receptor 6DDE PAR1 3VW7
TM4 169 4.54x54 μ receptor 6DDE P2Y1 receptor 4XNW
TM4 170 4.55x55 μ receptor 6DDE CCR2 5T1A
TM4 171 4.56x56 μ receptor 6DDE P2Y1 receptor 4XNW
TM4 172 4.57x57 CCR2 5T1A P2Y12 receptor 4NTJ
TM4 173 4.58x59 CCR2 5T1A PAR1 3VW7
TM4 174 4.59x60 μ receptor 6DDE PAR1 3VW7
TM4 175 4.60x61 μ receptor 6DDE CCR2 5T1A
TM4 176 4.61x62 μ receptor 6DDE PAF receptor 5ZKQ
TM4 177 4.62x63 CCR2 5T1A CCR2 5T1A
TM4 178 4.63x64 CCR2 5T1A CCR2 5T1A
TM4 179 4.64x65 CCR2 5T1A CCR2 5T1A
ECL2 180 μ receptor 6DDE - -
ECL2 181 μ receptor 6DDE - -
ECL2 182 μ receptor 6DDE - -
ECL2 183 μ receptor 6DDE - -
ECL2 184 μ receptor 6DDE - -
ECL2 185 μ receptor 6DDE - -
ECL2 186 μ receptor 6DDE - -
ECL2 187 μ receptor 6DDE - -
ECL2 188 μ receptor 6DDE - -
ECL2 189 μ receptor 6DDE - -
ECL2 190 45.50x50 μ receptor 6DDE μ receptor 6DDE
ECL2 191 45.51x51 μ receptor 6DDE CCR2 5T1A
ECL2 192 45.52x52 μ receptor 6DDE NTS1 receptor 4XES
ECL2 193 - - - -
ECL2 194 - - - -
TM5 195 5.31x32 CCR2 5T1A CCR2 5T1A
TM5 196 5.32x33 CCR2 5T1A - -
TM5 197 5.33x34 μ receptor 6DDE PAR2 5NDD
TM5 198 5.34x35 μ receptor 6DDE μ receptor 6DDE
TM5 199 5.35x36 μ receptor 6DDE CCR2 5T1A
TM5 200 5.36x37 μ receptor 6DDE μ receptor 6DDE
TM5 201 5.37x38 μ receptor 6DDE CCR2 5T1A
TM5 202 5.38x39 μ receptor 6DDE CCR2 5T1A
TM5 203 5.39x40 μ receptor 6DDE 5-HT1B receptor 4IAQ
TM5 204 5.40x41 μ receptor 6DDE μ receptor 6DDE
TM5 205 5.41x42 μ receptor 6DDE CCR2 5T1A
TM5 206 5.42x43 μ receptor 6DDE CCR2 5T1A
TM5 207 5.43x44 μ receptor 6DDE CCR2 5T1A
TM5 208 5.44x45 μ receptor 6DDE PAR2 5NDD
TM5 209 5.45x46 μ receptor 6DDE FFA1 receptor 5TZY
TM5 210 5.46x461 μ receptor 6DDE CCR2 5T1A
TM5 211 5.47x47 μ receptor 6DDE CCR2 5T1A
TM5 212 5.48x48 μ receptor 6DDE CCR2 5T1A
TM5 213 5.49x49 μ receptor 6DDE PAF receptor 5ZKQ
TM5 214 5.50x50 μ receptor 6DDE μ receptor 6DDE
TM5 215 5.51x51 μ receptor 6DDE P2Y1 receptor 4XNW
TM5 216 5.52x52 μ receptor 6DDE PAF receptor 5ZKQ
TM5 217 5.53x53 μ receptor 6DDE μ receptor 6DDE
TM5 218 5.54x54 μ receptor 6DDE 5-HT2B receptor 4IB4
TM5 219 5.55x55 μ receptor 6DDE CCR2 5T1A
TM5 220 5.56x56 μ receptor 6DDE NTS1 receptor 4XES
TM5 221 5.57x57 μ receptor 6DDE μ receptor 6DDE
TM5 222 5.58x58 μ receptor 6DDE μ receptor 6DDE
TM5 223 5.59x59 μ receptor 6DDE CCR5 5UIW
TM5 224 5.60x60 μ receptor 6DDE FFA1 receptor 5TZY
TM5 225 5.61x61 μ receptor 6DDE P2Y1 receptor 4XNW
TM5 226 5.62x62 μ receptor 6DDE FFA1 receptor 5TZY
TM5 227 5.63x63 μ receptor 6DDE P2Y12 receptor 4NTJ
TM5 228 5.64x64 μ receptor 6DDE PAF receptor 5ZKQ
TM5 229 5.65x65 μ receptor 6DDE μ receptor 6DDE
TM5 230 5.66x66 μ receptor 6DDE PAF receptor 5ZKQ
TM5 231 5.67x67 μ receptor 6DDE P2Y12 receptor 4NTJ
TM5 232 5.68x68 μ receptor 6DDE - -
ICL3 233 - - - -
ICL3 234 - - - -
ICL3 235 - - - -
TM6 236 6.28x28 μ receptor 6DDE CCR5 5UIW
TM6 237 6.29x29 μ receptor 6DDE PAR2 5NDD
TM6 238 6.30x30 μ receptor 6DDE FFA1 receptor 5TZY
TM6 239 6.31x31 μ receptor 6DDE CCR5 4MBS
TM6 240 6.32x32 μ receptor 6DDE μ receptor 6DDE
TM6 241 6.33x33 μ receptor 6DDE 5-HT2B receptor 4IB4
TM6 242 6.34x34 μ receptor 6DDE NTS1 receptor 4XES
TM6 243 6.35x35 μ receptor 6DDE μ receptor 6DDE
TM6 244 6.36x36 μ receptor 6DDE P2Y12 receptor 4PXZ
TM6 245 6.37x37 μ receptor 6DDE CCR2 5T1A
TM6 246 6.38x38 μ receptor 6DDE CCR2 5T1A
TM6 247 6.39x39 μ receptor 6DDE CCR2 5T1A
TM6 248 6.40x40 μ receptor 6DDE P2Y1 receptor 4XNW
TM6 249 6.41x41 μ receptor 6DDE CCR2 5T1A
TM6 250 6.42x42 μ receptor 6DDE P2Y12 receptor 4NTJ
TM6 251 6.43x43 μ receptor 6DDE μ receptor 6DDE
TM6 252 6.44x44 μ receptor 6DDE CCR2 5T1A
TM6 253 6.45x45 μ receptor 6DDE P2Y1 receptor 4XNW
TM6 254 6.46x46 μ receptor 6DDE PAR2 5NDD
TM6 255 6.47x47 μ receptor 6DDE CCR2 5T1A
TM6 256 6.48x48 μ receptor 6DDE μ receptor 6DDE
TM6 257 6.49x49 μ receptor 6DDE PAR2 5NDD
TM6 258 6.50x50 μ receptor 6DDE μ receptor 6DDE
TM6 259 6.51x51 μ receptor 6DDE NTS1 receptor 4XES
TM6 260 6.52x52 μ receptor 6DDE PAR1 3VW7
TM6 261 6.53x53 μ receptor 6DDE μ receptor 6DDE
TM6 262 6.54x54 μ receptor 6DDE PAF receptor 5ZKQ
TM6 263 6.55x55 μ receptor 6DDE CCR2 5T1A
TM6 264 6.56x56 μ receptor 6DDE PAF receptor 5ZKQ
TM6 265 6.57x57 μ receptor 6DDE CCR2 5T1A
TM6 266 6.58x58 μ receptor 6DDE P2Y1 receptor 4XNW
TM6 267 6.59x59 μ receptor 6DDE PAF receptor 5ZKQ
TM6 268 6.60x60 μ receptor 6DDE PAR2 5NDD
TM6 269 6.61x61 μ receptor 6DDE β2-adrenoceptor 2RH1
TM6 270 6.62x62 CCR2 5T1A CCR2 5T1A
TM6 271 6.63x63 CCR2 5T1A - -
TM6 272 6.64x64 CCR2 5T1A CCR2 5T1A
TM6 273 6.65x65 CCR2 5T1A CCR2 5T1A
ECL3 274 - - - -
ECL3 275 - - - -
TM7 276 7.24x23 CCR5 5UIW CCR5 5UIW
TM7 277 7.25x24 CCR5 5UIW CCR5 5UIW
TM7 278 7.26x25 CCR5 5UIW CXCR4 3ODU
TM7 279 7.27x26 CCR5 5UIW CCR5 5UIW
TM7 280 7.28x27 CCR5 5UIW CCR2 5T1A
TM7 281 7.29x28 CCR5 5UIW CCR2 5T1A
TM7 282 7.30x29 μ receptor 6DDE CCR2 5T1A
TM7 283 7.31x30 μ receptor 6DDE P2Y12 receptor 4NTJ
TM7 284 7.32x31 μ receptor 6DDE CCR2 5T1A
TM7 285 7.33x32 μ receptor 6DDE CCR5 5UIW
TM7 286 7.34x33 μ receptor 6DDE PAR1 3VW7
TM7 287 7.35x34 μ receptor 6DDE CCR2 5T1A
TM7 288 7.36x35 μ receptor 6DDE P2Y1 receptor 4XNW
TM7 289 7.37x36 μ receptor 6DDE P2Y1 receptor 4XNW
TM7 290 7.38x37 μ receptor 6DDE P2Y1 receptor 4XNW
TM7 291 7.39x38 μ receptor 6DDE CCR2 5T1A
TM7 292 7.40x39 μ receptor 6DDE CCR2 5T1A
TM7 293 7.41x40 μ receptor 6DDE μ receptor 6DDE
TM7 294 7.42x41 μ receptor 6DDE μ receptor 6DDE
TM7 295 7.43x42 μ receptor 6DDE CCR2 5T1A
TM7 296 7.44x43 μ receptor 6DDE PAF receptor 5ZKQ
TM7 297 7.45x45 μ receptor 6DDE CCR2 5T1A
TM7 298 7.46x46 μ receptor 6DDE PAR1 3VW7
TM7 299 7.47x47 μ receptor 6DDE μ receptor 6DDE
TM7 300 7.48x48 μ receptor 6DDE PAR1 3VW7
TM7 301 7.49x49 μ receptor 6DDE μ receptor 6DDE
TM7 302 7.50x50 μ receptor 6DDE μ receptor 6DDE
TM7 303 7.51x51 μ receptor 6DDE P2Y1 receptor 4XNW
TM7 304 7.52x52 μ receptor 6DDE PAR1 3VW7
TM7 305 7.53x53 μ receptor 6DDE μ receptor 6DDE
TM7 306 7.54x54 μ receptor 6DDE μ receptor 6DDE
TM7 307 7.55x55 CCR2 5T1A CCR2 5T1A
TM7 308 7.56x56 CCR2 5T1A CCR2 5T1A
H8 309 8.47x47 CCR2 5T1A CCR2 5T1A
H8 310 8.48x48 CCR2 5T1A CCR2 5T1A
H8 311 8.49x49 CCR2 5T1A CCR2 5T1A
H8 312 8.50x50 CCR2 5T1A CCR2 5T1A
H8 313 8.51x51 CCR2 5T1A CCR2 5T1A
H8 314 8.52x52 CCR2 5T1A CCR2 5T1A
H8 315 8.53x53 CCR2 5T1A CCR2 5T1A
H8 316 8.54x54 CCR2 5T1A 5-HT2B receptor 4IB4
H8 317 8.55x55 CCR2 5T1A 5-HT1B receptor 4IAQ
H8 318 8.56x56 CCR2 5T1A - -
H8 319 8.57x57 CCR2 5T1A CCR2 5T1A
H8 320 8.58x58 CCR2 5T1A CCR2 5T1A
C-term 321 - - - -
C-term 322 - - - -
C-term 323 - - - -
C-term 324 - - - -
C-term 325 - - - -