CCR4 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate (Δ distance (Å): 7.28 docs)

VERSION

2018-07-10

MAIN TEMPLATE

μ receptor (sequence similarity: 49%) PDB: 6DDE

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 74.3 18.7 7.0
Side-chains 20.0 64.3 15.7

Number of backbone templates: 4
Number of rotamer templates: 36

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5UIW
4MBS
6DDE
4ZUD
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 26 CCR5 5UIW CCR5 5UIW
N-term 27 CCR5 5UIW CCR5 5UIW
N-term 28 CCR5 5UIW CCR5 5UIW
N-term 29 CCR5 5UIW CCR5 5UIW
N-term 30 CCR5 5UIW CCR5 5UIW
TM1 31 1.24x24 CCR5 5UIW - -
TM1 32 1.25x25 CCR5 5UIW CXCR4 4RWS
TM1 33 1.26x26 CCR5 5UIW - -
TM1 34 1.27x27 CCR5 5UIW ETB receptor 5X93
TM1 35 1.28x28 CCR5 5UIW CCR5 5UIW
TM1 36 1.29x29 CCR5 5UIW - -
TM1 37 1.30x30 CCR5 5UIW P2Y1 receptor 4XNW
TM1 38 1.31x31 μ receptor 6DDE A2A receptor 5WF5
TM1 39 1.32x32 μ receptor 6DDE OX2 receptor 5WS3
TM1 40 1.33x33 μ receptor 6DDE PAR1 3VW7
TM1 41 1.34x34 μ receptor 6DDE PAR1 3VW7
TM1 42 1.35x35 μ receptor 6DDE P2Y1 receptor 4XNW
TM1 43 1.36x36 μ receptor 6DDE P2Y1 receptor 4XNW
TM1 44 1.37x37 μ receptor 6DDE CCR5 5UIW
TM1 45 1.38x38 μ receptor 6DDE P2Y12 receptor 4NTJ
TM1 46 1.39x39 μ receptor 6DDE μ receptor 6DDE
TM1 47 1.40x40 μ receptor 6DDE μ receptor 6DDE
TM1 48 1.41x41 μ receptor 6DDE P2Y1 receptor 4XNW
TM1 49 1.42x42 μ receptor 6DDE μ receptor 6DDE
TM1 50 1.43x43 μ receptor 6DDE P2Y1 receptor 4XNW
TM1 51 1.44x44 μ receptor 6DDE PAR1 3VW7
TM1 52 1.45x45 μ receptor 6DDE CCR5 5UIW
TM1 53 1.46x46 μ receptor 6DDE μ receptor 6DDE
TM1 54 1.47x47 μ receptor 6DDE PAR1 3VW7
TM1 55 1.48x48 μ receptor 6DDE P2Y1 receptor 4XNW
TM1 56 1.49x49 μ receptor 6DDE μ receptor 6DDE
TM1 57 1.50x50 μ receptor 6DDE μ receptor 6DDE
TM1 58 1.51x51 μ receptor 6DDE P2Y1 receptor 4XNW
TM1 59 1.52x52 μ receptor 6DDE P2Y1 receptor 4XNW
TM1 60 1.53x53 μ receptor 6DDE μ receptor 6DDE
TM1 61 1.54x54 μ receptor 6DDE CCR2 5T1A
TM1 62 1.55x55 μ receptor 6DDE 5-HT2B receptor 4IB4
TM1 63 1.56x56 μ receptor 6DDE μ receptor 6DDE
TM1 64 1.57x57 μ receptor 6DDE NTS1 receptor 4XES
TM1 65 1.58x58 μ receptor 6DDE P2Y12 receptor 4NTJ
TM1 66 1.59x59 μ receptor 6DDE OX2 receptor 5WS3
TM1 67 1.60x60 μ receptor 6DDE μ receptor 6DDE
ICL1 68 12.48x48 - - - -
ICL1 69 12.49x49 AT1 receptor 4ZUD β2-adrenoceptor 5JQH
ICL1 70 12.50x50 AT1 receptor 4ZUD AT1 receptor 4ZUD
ICL1 71 12.51x51 - - - -
TM2 72 2.37x37 CCR5 5UIW CCR5 5UIW
TM2 73 2.38x38 μ receptor 6DDE CCR5 5UIW
TM2 74 2.39x39 μ receptor 6DDE μ receptor 6DDE
TM2 75 2.40x40 μ receptor 6DDE CCR5 5UIW
TM2 76 2.41x41 μ receptor 6DDE P2Y1 receptor 4XNW
TM2 77 2.42x42 μ receptor 6DDE μ receptor 6DDE
TM2 78 2.43x43 μ receptor 6DDE P2Y12 receptor 4NTJ
TM2 79 2.44x44 μ receptor 6DDE PAR1 3VW7
TM2 80 2.45x45 μ receptor 6DDE μ receptor 6DDE
TM2 81 2.46x46 μ receptor 6DDE μ receptor 6DDE
TM2 82 2.47x47 μ receptor 6DDE μ receptor 6DDE
TM2 83 2.48x48 μ receptor 6DDE P2Y12 receptor 4NTJ
TM2 84 2.49x49 μ receptor 6DDE P2Y12 receptor 4NTJ
TM2 85 2.50x50 μ receptor 6DDE μ receptor 6DDE
TM2 86 2.51x51 μ receptor 6DDE P2Y12 receptor 4NTJ
TM2 87 2.52x52 μ receptor 6DDE μ receptor 6DDE
TM2 88 2.53x53 μ receptor 6DDE PAR1 3VW7
TM2 89 2.54x54 μ receptor 6DDE P2Y1 receptor 4XNW
TM2 90 2.55x55 μ receptor 6DDE Rhodopsin 5DYS
TM2 91 2.56x56 μ receptor 6DDE FFA1 receptor 5TZY
TM2 92 2.57x57 μ receptor 6DDE μ receptor 6DDE
TM2 93 2.58x58 μ receptor 6DDE μ receptor 6DDE
TM2 94 2.59x59 μ receptor 6DDE μ receptor 6DDE
TM2 95 2.60x60 μ receptor 6DDE PAF receptor 5ZKQ
TM2 96 2.61x61 μ receptor 6DDE NOP receptor 5DHG
TM2 97 2.62x62 μ receptor 6DDE NTS1 receptor 4XES
TM2 98 2.63x63 μ receptor 6DDE P2Y1 receptor 4XNW
TM2 99 2.64x64 μ receptor 6DDE FFA1 receptor 5TZY
TM2 100 2.65x65 μ receptor 6DDE P2Y12 receptor 4NTJ
TM2 101 2.66x66 μ receptor 6DDE US28 4XT1
ECL1 102 23.49x49 - - - -
ECL1 103 23.50x50 CCR5 5UIW CCR5 5UIW
ECL1 104 23.51x51 CCR5 5UIW CCR2 5T1A
ECL1 105 23.52x52 - - - -
TM3 106 3.21x21 μ receptor 6DDE μ receptor 6DDE
TM3 107 3.22x22 μ receptor 6DDE 5-HT2B receptor 4IB4
TM3 108 3.23x23 μ receptor 6DDE - -
TM3 109 3.24x24 μ receptor 6DDE μ receptor 6DDE
TM3 110 3.25x25 μ receptor 6DDE μ receptor 6DDE
TM3 111 3.26x26 μ receptor 6DDE μ receptor 6DDE
TM3 112 3.27x27 μ receptor 6DDE A1 receptor 5UEN
TM3 113 3.28x28 μ receptor 6DDE A2A receptor 4UHR
TM3 114 3.29x29 μ receptor 6DDE P2Y12 receptor 4NTJ
TM3 115 3.30x30 μ receptor 6DDE - -
TM3 116 3.31x31 μ receptor 6DDE CCR9 5LWE
TM3 117 3.32x32 μ receptor 6DDE CCR5 5UIW
TM3 118 3.33x33 μ receptor 6DDE A2A receptor 4UHR
TM3 119 3.34x34 μ receptor 6DDE P2Y1 receptor 4XNW
TM3 120 3.35x35 μ receptor 6DDE CCR5 5UIW
TM3 121 3.36x36 μ receptor 6DDE CCR5 5UIW
TM3 122 3.37x37 μ receptor 6DDE P2Y1 receptor 4XNW
TM3 123 3.38x38 μ receptor 6DDE A2A receptor 4UHR
TM3 124 3.39x39 μ receptor 6DDE FFA1 receptor 5TZY
TM3 125 3.40x40 μ receptor 6DDE μ receptor 6DDE
TM3 126 3.41x41 μ receptor 6DDE μ receptor 6DDE
TM3 127 3.42x42 μ receptor 6DDE P2Y1 receptor 4XNW
TM3 128 3.43x43 μ receptor 6DDE NTS1 receptor 4XES
TM3 129 3.44x44 μ receptor 6DDE CCR9 5LWE
TM3 130 3.45x45 μ receptor 6DDE P2Y12 receptor 4NTJ
TM3 131 3.46x46 μ receptor 6DDE μ receptor 6DDE
TM3 132 3.47x47 μ receptor 6DDE μ receptor 6DDE
TM3 133 3.48x48 μ receptor 6DDE PAR1 3VW7
TM3 134 3.49x49 μ receptor 6DDE μ receptor 6DDE
TM3 135 3.50x50 μ receptor 6DDE μ receptor 6DDE
TM3 136 3.51x51 μ receptor 6DDE μ receptor 6DDE
TM3 137 3.52x52 μ receptor 6DDE PAR1 3VW7
TM3 138 3.53x53 μ receptor 6DDE μ receptor 6DDE
TM3 139 3.54x54 μ receptor 6DDE PAR2 5NDD
TM3 140 3.55x55 μ receptor 6DDE P2Y1 receptor 4XNW
TM3 141 3.56x56 μ receptor 6DDE μ receptor 6DDE
ICL2 142 34.50x50 - - - -
ICL2 143 34.51x51 CCR5 5UIW μ receptor 6DDE
ICL2 144 34.52x52 CCR5 5UIW CCR5 5UIW
ICL2 145 34.53x53 CCR5 5UIW P2Y1 receptor 4XNW
ICL2 146 34.54x54 CCR5 5UIW μ receptor 6DDE
ICL2 147 34.55x55 CCR5 5UIW C5a1 receptor 5O9H
ICL2 148 34.56x56 CCR5 5UIW CCR5 5UIW
ICL2 149 34.57x57 - - - -
TM4 150 4.38x38 μ receptor 6DDE μ receptor 6DDE
TM4 151 4.39x39 μ receptor 6DDE PAR1 3VW7
TM4 152 4.40x40 μ receptor 6DDE A2A receptor 4UHR
TM4 153 4.41x41 μ receptor 6DDE FFA1 receptor 5TZY
TM4 154 4.42x42 μ receptor 6DDE PAF receptor 5ZKQ
TM4 155 4.43x43 μ receptor 6DDE CCR5 5UIW
TM4 156 4.44x44 μ receptor 6DDE μ receptor 6DDE
TM4 157 4.45x45 μ receptor 6DDE PAR1 3VW7
TM4 158 4.46x46 μ receptor 6DDE P2Y1 receptor 4XNW
TM4 159 4.47x47 μ receptor 6DDE PAR1 3VW7
TM4 160 4.48x48 μ receptor 6DDE PAR1 3VW7
TM4 161 4.49x49 μ receptor 6DDE CCR5 5UIW
TM4 162 4.50x50 μ receptor 6DDE μ receptor 6DDE
TM4 163 4.51x51 μ receptor 6DDE - -
TM4 164 4.52x52 μ receptor 6DDE CCR5 5UIW
TM4 165 4.53x53 μ receptor 6DDE PAR1 3VW7
TM4 166 4.54x54 μ receptor 6DDE P2Y1 receptor 4XNW
TM4 167 4.55x55 μ receptor 6DDE CCR5 5UIW
TM4 168 4.56x56 μ receptor 6DDE P2Y1 receptor 4XNW
TM4 169 4.57x57 CCR5 5UIW P2Y12 receptor 4NTJ
TM4 170 4.58x59 CCR5 5UIW FFA1 receptor 5TZY
TM4 171 4.59x60 μ receptor 6DDE PAR1 3VW7
TM4 172 4.60x61 μ receptor 6DDE CCR2 5T1A
TM4 173 4.61x62 μ receptor 6DDE μ receptor 6DDE
TM4 174 4.62x63 CCR5 5UIW PAR1 3VW7
TM4 175 4.63x64 CCR5 5UIW CCR5 5UIW
TM4 176 4.64x65 CCR5 5UIW - -
ECL2 177 μ receptor 6DDE - -
ECL2 178 μ receptor 6DDE - -
ECL2 179 μ receptor 6DDE - -
ECL2 180 μ receptor 6DDE - -
ECL2 181 μ receptor 6DDE - -
ECL2 182 μ receptor 6DDE - -
ECL2 183 μ receptor 6DDE - -
ECL2 184 μ receptor 6DDE - -
ECL2 185 μ receptor 6DDE - -
ECL2 186 μ receptor 6DDE - -
ECL2 187 45.50x50 μ receptor 6DDE μ receptor 6DDE
ECL2 188 45.51x51 μ receptor 6DDE - -
ECL2 189 45.52x52 μ receptor 6DDE US28 4XT1
ECL2 190 - - - -
ECL2 191 - - - -
ECL2 192 - - - -
ECL2 193 - - - -
TM5 194 5.30x31 CCR5 5UIW - -
TM5 195 5.31x32 CCR5 5UIW δ receptor 4N6H
TM5 196 5.32x33 CCR5 5UIW NTS1 receptor 4XES
TM5 197 5.33x34 μ receptor 6DDE - -
TM5 198 5.34x35 μ receptor 6DDE μ receptor 6DDE
TM5 199 5.35x36 μ receptor 6DDE CCR5 5UIW
TM5 200 5.36x37 μ receptor 6DDE CXCR4 3ODU
TM5 201 5.37x38 μ receptor 6DDE μ receptor 6DDE
TM5 202 5.38x39 μ receptor 6DDE - -
TM5 203 5.39x40 μ receptor 6DDE P2Y1 receptor 4XNW
TM5 204 5.40x41 μ receptor 6DDE PAR2 5NDD
TM5 205 5.41x42 μ receptor 6DDE US28 4XT1
TM5 206 5.42x43 μ receptor 6DDE PAF receptor 5ZKQ
TM5 207 5.43x44 μ receptor 6DDE CCR2 5T1A
TM5 208 5.44x45 μ receptor 6DDE PAR2 5NDD
TM5 209 5.45x46 μ receptor 6DDE FFA1 receptor 5TZY
TM5 210 5.46x461 μ receptor 6DDE CCR5 5UIW
TM5 211 5.47x47 μ receptor 6DDE CCR5 5UIW
TM5 212 5.48x48 μ receptor 6DDE CCR5 5UIW
TM5 213 5.49x49 μ receptor 6DDE P2Y12 receptor 4NTJ
TM5 214 5.50x50 μ receptor 6DDE μ receptor 6DDE
TM5 215 5.51x51 μ receptor 6DDE P2Y1 receptor 4XNW
TM5 216 5.52x52 μ receptor 6DDE OX1 receptor 4ZJ8
TM5 217 5.53x53 μ receptor 6DDE μ receptor 6DDE
TM5 218 5.54x54 μ receptor 6DDE 5-HT2B receptor 4IB4
TM5 219 5.55x55 μ receptor 6DDE P2Y1 receptor 4XNW
TM5 220 5.56x56 μ receptor 6DDE PAF receptor 5ZKQ
TM5 221 5.57x57 μ receptor 6DDE μ receptor 6DDE
TM5 222 5.58x58 μ receptor 6DDE μ receptor 6DDE
TM5 223 5.59x59 μ receptor 6DDE CCR5 5UIW
TM5 224 5.60x60 μ receptor 6DDE LPA6 receptor 5XSZ
TM5 225 5.61x61 μ receptor 6DDE P2Y1 receptor 4XNW
TM5 226 5.62x62 μ receptor 6DDE μ receptor 6DDE
TM5 227 5.63x63 μ receptor 6DDE P2Y1 receptor 4XNW
TM5 228 5.64x64 μ receptor 6DDE PAF receptor 5ZKQ
TM5 229 5.65x65 μ receptor 6DDE μ receptor 6DDE
TM5 230 5.66x66 μ receptor 6DDE 5-HT2B receptor 4IB4
TM5 231 5.67x67 μ receptor 6DDE CXCR4 3OE0
TM5 232 5.68x68 μ receptor 6DDE - -
ICL3 233 - - - -
ICL3 234 - - - -
ICL3 235 - - - -
ICL3 236 - - - -
TM6 237 6.30x30 μ receptor 6DDE PAR1 3VW7
TM6 238 6.31x31 μ receptor 6DDE - -
TM6 239 6.32x32 μ receptor 6DDE PAR2 5NDD
TM6 240 6.33x33 μ receptor 6DDE 5-HT2B receptor 4IB4
TM6 241 6.34x34 μ receptor 6DDE NTS1 receptor 4XES
TM6 242 6.35x35 μ receptor 6DDE 5-HT1B receptor 5V54
TM6 243 6.36x36 μ receptor 6DDE μ receptor 6DDE
TM6 244 6.37x37 μ receptor 6DDE CCR5 5UIW
TM6 245 6.38x38 μ receptor 6DDE CCR5 5UIW
TM6 246 6.39x39 μ receptor 6DDE PAR1 3VW7
TM6 247 6.40x40 μ receptor 6DDE μ receptor 6DDE
TM6 248 6.41x41 μ receptor 6DDE μ receptor 6DDE
TM6 249 6.42x42 μ receptor 6DDE apelin receptor 5VBL
TM6 250 6.43x43 μ receptor 6DDE 5-HT2B receptor 4IB4
TM6 251 6.44x44 μ receptor 6DDE μ receptor 6DDE
TM6 252 6.45x45 μ receptor 6DDE 5-HT2B receptor 4IB4
TM6 253 6.46x46 μ receptor 6DDE NOP receptor 5DHG
TM6 254 6.47x47 μ receptor 6DDE CCR5 5UIW
TM6 255 6.48x48 μ receptor 6DDE μ receptor 6DDE
TM6 256 6.49x49 μ receptor 6DDE PAR2 5NDD
TM6 257 6.50x50 μ receptor 6DDE μ receptor 6DDE
TM6 258 6.51x51 μ receptor 6DDE NTS1 receptor 4XES
TM6 259 6.52x52 μ receptor 6DDE PAR1 3VW7
TM6 260 6.53x53 μ receptor 6DDE μ receptor 6DDE
TM6 261 6.54x54 μ receptor 6DDE PAF receptor 5ZKQ
TM6 262 6.55x55 μ receptor 6DDE PAR1 3VW7
TM6 263 6.56x56 μ receptor 6DDE AT1 receptor 4ZUD
TM6 264 6.57x57 μ receptor 6DDE CCR5 5UIW
TM6 265 6.58x58 μ receptor 6DDE κ receptor 4DJH
TM6 266 6.59x59 μ receptor 6DDE PAF receptor 5ZKQ
TM6 267 6.60x60 μ receptor 6DDE PAF receptor 5ZKQ
TM6 268 6.61x61 μ receptor 6DDE δ receptor 4N6H
TM6 269 6.62x62 CCR5 4MBS PAF receptor 5ZKQ
TM6 270 6.63x63 CCR5 4MBS P2Y1 receptor 4XNW
TM6 271 6.64x64 CCR5 4MBS CXCR4 3ODU
TM6 272 6.65x65 CCR5 4MBS - -
ECL3 273 - - - -
ECL3 274 - - - -
TM7 275 7.24x23 CCR5 5UIW PAF receptor 5ZKQ
TM7 276 7.25x24 CCR5 5UIW CCR5 5UIW
TM7 277 7.26x25 CCR5 5UIW P2Y12 receptor 4NTJ
TM7 278 7.27x26 CCR5 5UIW P2Y1 receptor 4XNW
TM7 279 7.28x27 CCR5 5UIW P2Y12 receptor 4NTJ
TM7 280 7.29x28 CCR5 5UIW US28 4XT1
TM7 281 7.30x29 μ receptor 6DDE - -
TM7 282 7.31x30 μ receptor 6DDE P2Y12 receptor 4NTJ
TM7 283 7.32x31 μ receptor 6DDE CCR5 5UIW
TM7 284 7.33x32 μ receptor 6DDE P2Y12 receptor 4NTJ
TM7 285 7.34x33 μ receptor 6DDE PAR1 3VW7
TM7 286 7.35x34 μ receptor 6DDE CXCR4 3ODU
TM7 287 7.36x35 μ receptor 6DDE P2Y1 receptor 4XNW
TM7 288 7.37x36 μ receptor 6DDE D4 receptor 5WIV
TM7 289 7.38x37 μ receptor 6DDE P2Y1 receptor 4XNW
TM7 290 7.39x38 μ receptor 6DDE CCR5 5UIW
TM7 291 7.40x39 μ receptor 6DDE CCR5 5UIW
TM7 292 7.41x40 μ receptor 6DDE μ receptor 6DDE
TM7 293 7.42x41 μ receptor 6DDE P2Y1 receptor 4XNW
TM7 294 7.43x42 μ receptor 6DDE CXCR4 3ODU
TM7 295 7.44x43 μ receptor 6DDE 5-HT2B receptor 4IB4
TM7 296 7.45x45 μ receptor 6DDE CCR5 5UIW
TM7 297 7.46x46 μ receptor 6DDE PAR1 3VW7
TM7 298 7.47x47 μ receptor 6DDE μ receptor 6DDE
TM7 299 7.48x48 μ receptor 6DDE μ receptor 6DDE
TM7 300 7.49x49 μ receptor 6DDE μ receptor 6DDE
TM7 301 7.50x50 μ receptor 6DDE μ receptor 6DDE
TM7 302 7.51x51 μ receptor 6DDE P2Y1 receptor 4XNW
TM7 303 7.52x52 μ receptor 6DDE PAR1 3VW7
TM7 304 7.53x53 μ receptor 6DDE μ receptor 6DDE
TM7 305 7.54x54 μ receptor 6DDE P2Y1 receptor 4XNW
TM7 306 7.55x55 CCR5 5UIW CCR5 5UIW
TM7 307 7.56x56 CCR5 5UIW PAF receptor 5ZKQ
H8 308 8.47x47 CCR5 5UIW CCR5 5UIW
H8 309 8.48x48 CCR5 5UIW 5-HT1B receptor 4IAQ
H8 310 8.49x49 CCR5 5UIW CCR2 5T1A
H8 311 8.50x50 CCR5 5UIW P2Y12 receptor 4NTJ
H8 312 8.51x51 CCR5 5UIW P2Y12 receptor 4NTJ
H8 313 8.52x52 CCR5 5UIW H1 receptor 3RZE
H8 314 8.53x53 CCR5 5UIW CCR5 5UIW
H8 315 8.54x54 CCR5 5UIW - -
H8 316 8.55x55 CCR5 5UIW CCR5 5UIW
H8 317 8.56x56 CCR5 5UIW LPA1 receptor 4Z36
H8 318 8.57x57 CCR5 5UIW 5-HT1B receptor 4IAQ
H8 319 8.58x58 CCR5 5UIW CCR5 5UIW
H8 320 8.59x59 CCR5 5UIW CCR9 5LWE
C-term 321 - - - -
C-term 322 - - - -
C-term 323 - - - -
C-term 324 - - - -
C-term 325 - - - -