CRF2 receptor homology model

PROTEIN CLASS

Class B1 (Secretin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Active (Δ distance (Å): 7.89 docs)

VERSION

2018-07-10

MAIN TEMPLATE

CT receptor (sequence similarity: 52%) PDB: 5UZ7

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 79.9 8.0 12.0
Side-chains 27.4 38.8 33.8

Number of backbone templates: 3
Number of rotamer templates: 8

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5UZ7
4Z9G
4L6R
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 95 - - - -
N-term 96 - - - -
N-term 97 - - - -
N-term 98 - - - -
N-term 99 - - - -
TM1 100 1.23x23 - - - -
TM1 101 1.24x24 - - - -
TM1 102 1.25x25 - - - -
TM1 103 1.26x26 - - - -
TM1 104 1.27x27 CT receptor 5UZ7 - -
TM1 105 1.28x28 CT receptor 5UZ7 - -
TM1 106 1.29x29 CT receptor 5UZ7 glucagon receptor 5YQZ
TM1 107 1.30x30 CT receptor 5UZ7 - -
TM1 108 1.31x31 CT receptor 5UZ7 - -
TM1 109 1.32x32 CT receptor 5UZ7 - -
TM1 110 1.33x33 CT receptor 5UZ7 - -
TM1 111 1.34x34 CT receptor 5UZ7 - -
TM1 112 1.35x35 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM1 113 1.36x36 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM1 114 1.37x37 CT receptor 5UZ7 - -
TM1 115 1.38x38 CT receptor 5UZ7 - -
TM1 116 1.39x39 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM1 117 1.40x40 CT receptor 5UZ7 - -
TM1 118 1.41x41 CT receptor 5UZ7 glucagon receptor 5XEZ
TM1 119 1.42x42 CT receptor 5UZ7 - -
TM1 120 1.43x43 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM1 121 1.44x44 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM1 122 1.45x45 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM1 123 1.46x46 CT receptor 5UZ7 CT receptor 5UZ7
TM1 124 1.47x47 CT receptor 5UZ7 CT receptor 5UZ7
TM1 125 1.48x48 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM1 126 1.49x49 CT receptor 5UZ7 - -
TM1 127 1.50x50 CT receptor 5UZ7 CT receptor 5UZ7
TM1 128 1.51x51 CT receptor 5UZ7 - -
TM1 129 1.52x52 CT receptor 5UZ7 glucagon receptor 5EE7
TM1 130 1.53x53 CT receptor 5UZ7 GLP-1 receptor 6B3J
TM1 131 1.54x54 CT receptor 5UZ7 CT receptor 5UZ7
TM1 132 1.55x55 CT receptor 5UZ7 CT receptor 5UZ7
TM1 133 1.56x56 CT receptor 5UZ7 - -
TM1 134 1.57x57 CT receptor 5UZ7 GLP-1 receptor 6B3J
TM1 135 1.58x58 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM1 136 1.59x59 CT receptor 5UZ7 - -
TM1 137 1.60x60 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM1 138 1.61x61 CT receptor 5UZ7 CT receptor 5UZ7
TM1 139 1.62x62 CT receptor 5UZ7 GLP-1 receptor 6B3J
TM1 140 1.63x63 CT receptor 5UZ7 - -
TM1 141 1.64x64 CT receptor 5UZ7 glucagon receptor 5EE7
ICL1 142 12.48x48 - - - -
ICL1 143 12.49x49 CRF1 receptor 4Z9G CRF1 receptor 4Z9G
ICL1 144 12.50x50 CRF1 receptor 4Z9G CRF1 receptor 4Z9G
ICL1 145 12.51x51 - - - -
TM2 146 2.44x44 CT receptor 5UZ7 CT receptor 5UZ7
TM2 147 2.45x45 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM2 148 2.46x46 CT receptor 5UZ7 CT receptor 5UZ7
TM2 149 2.47x47 CT receptor 5UZ7 GLP-1 receptor 6B3J
TM2 150 2.48x48 CT receptor 5UZ7 - -
TM2 151 2.49x49 CT receptor 5UZ7 GLP-1 receptor 6B3J
TM2 152 2.50x50 CT receptor 5UZ7 CT receptor 5UZ7
TM2 153 2.51x51 CT receptor 5UZ7 - -
TM2 154 2.52x52 CT receptor 5UZ7 CT receptor 5UZ7
TM2 155 2.53x53 CT receptor 5UZ7 GLP-1 receptor 6B3J
TM2 156 2.54x54 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM2 157 2.55x55 CT receptor 5UZ7 - -
TM2 158 2.56x56 CT receptor 5UZ7 CT receptor 5UZ7
TM2 159 2.57x57 CT receptor 5UZ7 GLP-1 receptor 6B3J
TM2 160 2.58x58 CT receptor 5UZ7 CT receptor 5UZ7
TM2 161 2.59x59 CT receptor 5UZ7 CT receptor 5UZ7
TM2 162 2.60x60 CT receptor 5UZ7 GLP-1 receptor 6B3J
TM2 163 2.61x61 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM2 164 2.62x62 CT receptor 5UZ7 - -
TM2 165 2.63x63 CT receptor 5UZ7 - -
TM2 166 2.64x64 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM2 167 2.65x65 CT receptor 5UZ7 GLP-1 receptor 6B3J
TM2 168 2.66x66 CT receptor 5UZ7 - -
TM2 169 2.67x67 CT receptor 5UZ7 - -
TM2 170 2.68x68 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM2 171 2.69x69 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM2 172 2.70x70 CT receptor 5UZ7 - -
ECL1 173 - - - -
ECL1 174 - - - -
ECL1 175 - - - -
ECL1 176 - - - -
ECL1 177 - - - -
ECL1 178 - - - -
ECL1 179 - - - -
ECL1 180 - - - -
TM3 181 3.26x26 CT receptor 5UZ7 - -
TM3 182 3.27x27 CT receptor 5UZ7 CT receptor 5UZ7
TM3 183 3.28x28 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM3 184 3.29x29 CT receptor 5UZ7 CT receptor 5UZ7
TM3 185 3.30x30 CT receptor 5UZ7 GLP-1 receptor 6B3J
TM3 186 3.31x31 CT receptor 5UZ7 - -
TM3 187 3.32x32 CT receptor 5UZ7 - -
TM3 188 3.33x33 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM3 189 3.34x34 CT receptor 5UZ7 - -
TM3 190 3.35x35 CT receptor 5UZ7 - -
TM3 191 3.36x36 CT receptor 5UZ7 - -
TM3 192 3.37x37 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM3 193 3.38x38 CT receptor 5UZ7 CT receptor 5UZ7
TM3 194 3.39x39 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM3 195 3.40x40 CT receptor 5UZ7 GLP-1 receptor 6B3J
TM3 196 3.41x41 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM3 197 3.42x42 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM3 198 3.43x43 CT receptor 5UZ7 CT receptor 5UZ7
TM3 199 3.44x44 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM3 200 3.45x45 CT receptor 5UZ7 CT receptor 5UZ7
TM3 201 3.46x46 CT receptor 5UZ7 CT receptor 5UZ7
TM3 202 3.47x47 CT receptor 5UZ7 CT receptor 5UZ7
TM3 203 3.48x48 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM3 204 3.49x49 CT receptor 5UZ7 GLP-1 receptor 6B3J
TM3 205 3.50x50 CT receptor 5UZ7 CT receptor 5UZ7
TM3 206 3.51x51 CT receptor 5UZ7 CT receptor 5UZ7
TM3 207 3.52x52 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM3 208 3.53x53 CT receptor 5UZ7 CT receptor 5UZ7
TM3 209 3.54x54 CT receptor 5UZ7 CT receptor 5UZ7
TM3 210 3.55x55 CT receptor 5UZ7 CT receptor 5UZ7
TM3 211 3.56x56 CT receptor 5UZ7 CT receptor 5UZ7
TM3 212 3.57x57 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM3 213 3.58x58 CT receptor 5UZ7 CT receptor 5UZ7
TM3 214 3.59x59 CT receptor 5UZ7 CT receptor 5UZ7
TM3 215 3.60x60 CT receptor 5UZ7 - -
ICL2 216 - - - -
ICL2 217 - - - -
ICL2 218 - - - -
ICL2 219 - - - -
ICL2 220 - - - -
ICL2 221 - - - -
TM4 222 4.40x41 CRF1 receptor 4Z9G CRF1 receptor 4Z9G
TM4 223 4.41x42 CT receptor 5UZ7 - -
TM4 224 4.42x43 CT receptor 5UZ7 - -
TM4 225 4.43x44 CT receptor 5UZ7 - -
TM4 226 4.44x45 CT receptor 5UZ7 GLP-1 receptor 6B3J
TM4 227 4.45x46 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM4 228 4.46x47 CT receptor 5UZ7 GLP-1 receptor 5VAI
TM4 229 4.47x48 CT receptor 5UZ7 - -
TM4 230 4.48x49 CT receptor 5UZ7 GLP-1 receptor 6B3J
TM4 231 4.49x491 CT receptor 5UZ7 CT receptor 5UZ7
TM4 232 4.50x50 CT receptor 5UZ7 CT receptor 5UZ7
TM4 233 4.51x51 CT receptor 5UZ7 - -
TM4 234 4.52x52 CT receptor 5UZ7 - -
TM4 235 4.53x53 CT receptor 5UZ7 CT receptor 5UZ7
TM4 236 4.54x54 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM4 237 4.55x55 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM4 238 4.56x56 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM4 239 4.57x57 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM4 240 4.58x58 CT receptor 5UZ7 GLP-1 receptor 6B3J
TM4 241 4.59x59 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM4 242 4.60x60 CT receptor 5UZ7 GLP-1 receptor 6B3J
TM4 243 4.61x61 CT receptor 5UZ7 CT receptor 5UZ7
TM4 244 4.62x62 CT receptor 5UZ7 CT receptor 5UZ7
TM4 245 4.63x63 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM4 246 4.64x64 CT receptor 5UZ7 GLP-1 receptor 6B3J
TM4 247 4.65x65 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM4 248 4.66x66 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM4 249 4.67x67 CT receptor 5UZ7 CT receptor 5UZ7
TM4 250 4.68x68 CT receptor 5UZ7 GLP-1 receptor 5VAI
ECL2 251 CT receptor 5UZ7 - -
ECL2 252 CT receptor 5UZ7 - -
ECL2 253 CT receptor 5UZ7 - -
ECL2 254 45.50x50 CT receptor 5UZ7 CT receptor 5UZ7
ECL2 255 45.51x51 CT receptor 5UZ7 GLP-1 receptor 6B3J
ECL2 256 45.52x52 CT receptor 5UZ7 - -
ECL2 257 - - - -
ECL2 258 CRF1 receptor 4Z9G CRF1 receptor 4Z9G
ECL2 259 CRF1 receptor 4Z9G - -
ECL2 260 CRF1 receptor 4Z9G CRF1 receptor 4Z9G
ECL2 261 CRF1 receptor 4Z9G CRF1 receptor 4Z9G
ECL2 262 CRF1 receptor 4Z9G - -
ECL2 263 - - - -
TM5 264 5.35x36 CRF1 receptor 4Z9G - -
TM5 265 5.36x37 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM5 266 5.37x38 CT receptor 5UZ7 CT receptor 5UZ7
TM5 267 5.38x381 CT receptor 5UZ7 CT receptor 5UZ7
TM5 268 5.39x39 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM5 269 5.40x40 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM5 270 5.41x41 CT receptor 5UZ7 CT receptor 5UZ7
TM5 271 5.42x42 CT receptor 5UZ7 CT receptor 5UZ7
TM5 272 5.43x43 CT receptor 5UZ7 GLP-1 receptor 6B3J
TM5 273 5.44x44 CT receptor 5UZ7 - -
TM5 274 5.45x45 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM5 275 5.46x46 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM5 276 5.47x47 CT receptor 5UZ7 CT receptor 5UZ7
TM5 277 5.48x48 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM5 278 5.49x49 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM5 279 5.50x50 CT receptor 5UZ7 CT receptor 5UZ7
TM5 280 5.51x51 CT receptor 5UZ7 CT receptor 5UZ7
TM5 281 5.52x52 CT receptor 5UZ7 - -
TM5 282 5.53x53 CT receptor 5UZ7 CT receptor 5UZ7
TM5 283 5.54x54 CT receptor 5UZ7 CT receptor 5UZ7
TM5 284 5.55x55 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM5 285 5.56x56 CT receptor 5UZ7 CT receptor 5UZ7
TM5 286 5.57x57 CT receptor 5UZ7 CT receptor 5UZ7
TM5 287 5.58x58 CT receptor 5UZ7 CT receptor 5UZ7
TM5 288 5.59x59 CT receptor 5UZ7 CT receptor 5UZ7
TM5 289 5.60x60 CT receptor 5UZ7 GLP-1 receptor 6B3J
TM5 290 5.61x61 CT receptor 5UZ7 CT receptor 5UZ7
TM5 291 5.62x62 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM5 292 5.63x63 CT receptor 5UZ7 CT receptor 5UZ7
TM5 293 5.64x64 CT receptor 5UZ7 CT receptor 5UZ7
TM5 294 5.65x65 CT receptor 5UZ7 GLP-1 receptor 6B3J
ICL3 295 - - - -
ICL3 296 CRF1 receptor 4Z9G CRF1 receptor 4Z9G
ICL3 297 CRF1 receptor 4Z9G CRF1 receptor 4Z9G
ICL3 298 CRF1 receptor 4Z9G CRF1 receptor 4Z9G
ICL3 299 - - - -
TM6 300 6.30x30 CRF1 receptor 4Z9G CRF1 receptor 4Z9G
TM6 301 6.31x31 CRF1 receptor 4Z9G CRF1 receptor 4Z9G
TM6 302 6.32x32 CRF1 receptor 4Z9G CRF1 receptor 4Z9G
TM6 303 6.33x33 CRF1 receptor 4Z9G CRF1 receptor 4Z9G
TM6 304 6.34x34 CRF1 receptor 4Z9G CRF1 receptor 4Z9G
TM6 305 6.35x35 CT receptor 5UZ7 CT receptor 5UZ7
TM6 306 6.36x36 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM6 307 6.37x37 CT receptor 5UZ7 CT receptor 5UZ7
TM6 308 6.38x38 CT receptor 5UZ7 CT receptor 5UZ7
TM6 309 6.39x39 CT receptor 5UZ7 CT receptor 5UZ7
TM6 310 6.40x40 CT receptor 5UZ7 CT receptor 5UZ7
TM6 311 6.41x41 CT receptor 5UZ7 CT receptor 5UZ7
TM6 312 6.42x42 CT receptor 5UZ7 CT receptor 5UZ7
TM6 313 6.43x43 CT receptor 5UZ7 GLP-1 receptor 6B3J
TM6 314 6.44x44 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM6 315 6.45x45 CT receptor 5UZ7 CT receptor 5UZ7
TM6 316 6.46x46 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM6 317 6.47x47 CT receptor 5UZ7 CT receptor 5UZ7
TM6 318 6.48x48 CT receptor 5UZ7 CT receptor 5UZ7
TM6 319 6.49x49 CT receptor 5UZ7 CT receptor 5UZ7
TM6 320 6.50x50 CT receptor 5UZ7 CT receptor 5UZ7
TM6 321 6.51x51 CT receptor 5UZ7 CT receptor 5UZ7
TM6 322 6.52x52 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM6 323 6.53x53 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM6 324 6.54x54 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM6 325 6.55x55 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM6 326 6.56x56 CT receptor 5UZ7 CT receptor 5UZ7
TM6 327 6.57x57 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM6 328 6.58x58 CRF1 receptor 4Z9G CRF1 receptor 4Z9G
ECL3 329 - - - -
ECL3 330 CRF1 receptor 4Z9G CRF1 receptor 4Z9G
ECL3 331 CRF1 receptor 4Z9G CRF1 receptor 4Z9G
ECL3 332 CRF1 receptor 4Z9G CRF1 receptor 4Z9G
ECL3 333 CRF1 receptor 4Z9G CRF1 receptor 4Z9G
ECL3 334 - - - -
TM7 335 7.33x32 CT receptor 5UZ7 - -
TM7 336 7.34x33 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM7 337 7.35x34 CT receptor 5UZ7 - -
TM7 338 7.36x35 CT receptor 5UZ7 - -
TM7 339 7.37x36 CT receptor 5UZ7 - -
TM7 340 7.38x37 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM7 341 7.39x38 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM7 342 7.40x39 CT receptor 5UZ7 CT receptor 5UZ7
TM7 343 7.41x40 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM7 344 7.42x41 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM7 345 7.43x42 CT receptor 5UZ7 - -
TM7 346 7.44x43 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM7 347 7.45x44 CT receptor 5UZ7 CT receptor 5UZ7
TM7 348 7.46x45 CT receptor 5UZ7 - -
TM7 349 7.47x46 CT receptor 5UZ7 GLP-1 receptor 6B3J
TM7 350 7.48x47 CT receptor 5UZ7 CT receptor 5UZ7
TM7 351 7.49x49 CT receptor 5UZ7 CT receptor 5UZ7
TM7 352 7.50x50 CT receptor 5UZ7 CT receptor 5UZ7
TM7 353 7.51x51 CT receptor 5UZ7 CT receptor 5UZ7
TM7 354 7.52x52 CT receptor 5UZ7 CT receptor 5UZ7
TM7 355 7.53x53 CT receptor 5UZ7 CT receptor 5UZ7
TM7 356 7.54x54 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM7 357 7.55x55 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM7 358 7.56x56 CT receptor 5UZ7 CRF1 receptor 4Z9G
TM7 359 7.57x57 CT receptor 5UZ7 CT receptor 5UZ7
TM7 360 7.58x58 CT receptor 5UZ7 CT receptor 5UZ7
TM7 361 7.59x59 CT receptor 5UZ7 CT receptor 5UZ7
TM7 362 7.60x60 CT receptor 5UZ7 - -
H8 363 8.47x47 CT receptor 5UZ7 CT receptor 5UZ7
H8 364 8.48x48 CT receptor 5UZ7 - -
H8 365 8.49x49 CT receptor 5UZ7 CT receptor 5UZ7
H8 366 8.50x50 CT receptor 5UZ7 CT receptor 5UZ7
H8 367 8.51x51 CT receptor 5UZ7 - -
H8 368 8.52x52 CT receptor 5UZ7 glucagon receptor 5XEZ
H8 369 8.53x53 CT receptor 5UZ7 - -
H8 370 8.54x54 CT receptor 5UZ7 CT receptor 5UZ7
H8 371 8.55x55 CT receptor 5UZ7 GLP-1 receptor 6B3J
H8 372 8.56x56 CT receptor 5UZ7 GLP-1 receptor 6B3J
H8 373 8.57x57 CT receptor 5UZ7 glucagon receptor 5EE7
H8 374 8.58x58 CT receptor 5UZ7 CT receptor 5UZ7
H8 375 8.59x59 CT receptor 5UZ7 glucagon receptor 5EE7
H8 376 8.60x60 CT receptor 5UZ7 GLP-1 receptor 6B3J
H8 377 8.61x61 CT receptor 5UZ7 GLP-1 receptor 6B3J
H8 378 8.62x62 CT receptor 5UZ7 - -
H8 379 8.63x63 CT receptor 5UZ7 - -
H8 380 8.64x64 CT receptor 5UZ7 - -
H8 381 8.65x65 CT receptor 5UZ7 - -
H8 382 8.66x66 CT receptor 5UZ7 - -
H8 383 8.67x67 CT receptor 5UZ7 glucagon receptor 4L6R
H8 384 8.68x68 CT receptor 5UZ7 CT receptor 5UZ7
H8 385 8.69x69 CT receptor 5UZ7 - -
H8 386 8.70x70 CT receptor 5UZ7 - -
H8 387 8.71x71 glucagon receptor 4L6R - -
H8 388 8.72x72 glucagon receptor 4L6R - -
C-term 389 - - - -
C-term 390 - - - -
C-term 391 - - - -
C-term 392 - - - -
C-term 393 - - - -