CXCR3 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive (Δ distance (Å): -1.28 docs)

VERSION

2018-07-10

MAIN TEMPLATE

CXCR4 (sequence similarity: 60%) PDB: 3ODU

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 77.7 16.7 5.7
Side-chains 30.7 48.0 21.3

Number of backbone templates: 6
Number of rotamer templates: 35

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4RWS
3ODU
4ZUD
5UIW
5UNG
5X33
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 40 CXCR4 4RWS CXCR4 4RWS
N-term 41 CXCR4 4RWS CXCR4 4RWS
N-term 42 CXCR4 4RWS CXCR4 4RWS
N-term 43 CXCR4 4RWS CXCR4 4RWS
N-term 44 CXCR4 4RWS CXCR4 4RWS
TM1 45 1.24x24 CXCR4 4RWS - -
TM1 46 1.25x25 CXCR4 4RWS - -
TM1 47 1.26x26 CXCR4 4RWS - -
TM1 48 1.27x27 CXCR4 4RWS δ receptor 4N6H
TM1 49 1.28x28 CXCR4 3ODU US28 4XT1
TM1 50 1.29x29 CXCR4 3ODU CXCR4 3ODU
TM1 51 1.30x30 CXCR4 3ODU CXCR4 3ODU
TM1 52 1.31x31 CXCR4 3ODU - -
TM1 53 1.32x32 CXCR4 3ODU - -
TM1 54 1.33x33 CXCR4 3ODU apelin receptor 5VBL
TM1 55 1.34x34 CXCR4 3ODU CXCR4 3ODU
TM1 56 1.35x35 CXCR4 3ODU CXCR4 3ODU
TM1 57 1.36x36 CXCR4 3ODU CXCR4 3ODU
TM1 58 1.37x37 CXCR4 3ODU apelin receptor 5VBL
TM1 59 1.38x38 CXCR4 3ODU CCR5 5UIW
TM1 60 1.39x39 CXCR4 3ODU CXCR4 3ODU
TM1 61 1.40x40 CXCR4 3ODU CXCR4 3ODU
TM1 62 1.41x41 CXCR4 3ODU CCR5 5UIW
TM1 63 1.42x42 CXCR4 3ODU NTS1 receptor 4BUO
TM1 64 1.43x43 CXCR4 3ODU CXCR4 3ODU
TM1 65 1.44x44 CXCR4 3ODU CXCR4 3ODU
TM1 66 1.45x45 CXCR4 3ODU apelin receptor 5VBL
TM1 67 1.46x46 CXCR4 3ODU CXCR4 3ODU
TM1 68 1.47x47 CXCR4 3ODU μ receptor 4DKL
TM1 69 1.48x48 CXCR4 3ODU CCR9 5LWE
TM1 70 1.49x49 CXCR4 3ODU CXCR4 3ODU
TM1 71 1.50x50 CXCR4 3ODU CXCR4 3ODU
TM1 72 1.51x51 CXCR4 3ODU CXCR4 3ODU
TM1 73 1.52x52 CXCR4 3ODU Y1 receptor 5ZBH
TM1 74 1.53x53 CXCR4 3ODU CXCR4 3ODU
TM1 75 1.54x54 CXCR4 3ODU - -
TM1 76 1.55x55 CXCR4 3ODU 5-HT1B receptor 4IAQ
TM1 77 1.56x56 CXCR4 3ODU CXCR4 3ODU
TM1 78 1.57x57 CXCR4 3ODU CCR5 5UIW
TM1 79 1.58x58 CXCR4 3ODU NOP receptor 5DHG
TM1 80 1.59x59 CXCR4 3ODU H1 receptor 3RZE
TM1 81 1.60x60 CXCR4 3ODU US28 4XT1
ICL1 82 12.48x48 - - - -
ICL1 83 12.49x49 AT1 receptor 4ZUD - -
ICL1 84 12.50x50 AT1 receptor 4ZUD - -
ICL1 85 12.51x51 - - - -
TM2 86 2.37x37 CXCR4 3ODU CXCR4 3ODU
TM2 87 2.38x38 CXCR4 3ODU apelin receptor 5VBL
TM2 88 2.39x39 CXCR4 3ODU CXCR4 3ODU
TM2 89 2.40x40 CXCR4 3ODU CXCR4 3ODU
TM2 90 2.41x41 CXCR4 3ODU LPA6 receptor 5XSZ
TM2 91 2.42x42 CXCR4 3ODU CCR9 5LWE
TM2 92 2.43x43 CXCR4 3ODU CCR5 5UIW
TM2 93 2.44x44 CXCR4 3ODU CXCR4 3ODU
TM2 94 2.45x45 CXCR4 3ODU CXCR4 3ODU
TM2 95 2.46x46 CXCR4 3ODU CXCR4 3ODU
TM2 96 2.47x47 CXCR4 3ODU CCR5 5UIW
TM2 97 2.48x48 CXCR4 3ODU CXCR4 3ODU
TM2 98 2.49x49 CXCR4 3ODU CXCR4 3ODU
TM2 99 2.50x50 CXCR4 3ODU CXCR4 3ODU
TM2 100 2.51x51 CXCR4 3ODU NOP receptor 5DHG
TM2 101 2.52x52 CXCR4 3ODU CXCR4 3ODU
TM2 102 2.53x53 CXCR4 3ODU D4 receptor 5WIV
TM2 103 2.54x54 CXCR4 3ODU CXCR4 3ODU
TM2 104 2.55x55 CXCR4 3ODU CCR5 5UIW
TM2 105 2.56x56 CXCR4 3ODU CXCR4 3ODU
TM2 106 2.57x57 CXCR4 3ODU CXCR4 3ODU
TM2 107 2.58x58 CXCR4 3ODU CXCR4 3ODU
TM2 108 2.59x59 CXCR4 3ODU CCR2 5T1A
TM2 109 2.60x60 CXCR4 3ODU CXCR4 3ODU
TM2 110 2.61x61 CXCR4 3ODU CXCR4 3ODU
TM2 111 2.62x62 CXCR4 3ODU CXCR4 3ODU
TM2 112 2.63x63 CXCR4 3ODU CXCR4 3ODU
TM2 113 2.64x64 CXCR4 3ODU CXCR4 3ODU
TM2 114 2.65x65 CXCR4 3ODU CCR5 5UIW
TM2 115 2.66x66 CXCR4 3ODU D2 receptor 6CM4
ECL1 116 23.49x49 CXCR4 3ODU CCR5 5UIW
ECL1 117 23.50x50 CXCR4 3ODU CXCR4 3ODU
ECL1 118 23.51x51 CXCR4 3ODU CCR2 5T1A
ECL1 119 23.52x52 CXCR4 3ODU CXCR4 3ODU
TM3 120 3.21x21 CXCR4 3ODU CXCR4 3ODU
TM3 121 3.22x22 CXCR4 3ODU US28 5WB1
TM3 122 3.23x23 CXCR4 3ODU - -
TM3 123 3.24x24 CXCR4 3ODU CXCR4 3ODU
TM3 124 3.25x25 CXCR4 3ODU CXCR4 3ODU
TM3 125 3.26x26 CXCR4 3ODU CXCR4 3ODU
TM3 126 3.27x27 CXCR4 3ODU CCR9 5LWE
TM3 127 3.28x28 CXCR4 3ODU AT1 receptor 4ZUD
TM3 128 3.29x29 CXCR4 3ODU Rhodopsin 1GZM
TM3 129 3.30x30 CXCR4 3ODU AT1 receptor 4ZUD
TM3 130 3.31x31 CXCR4 3ODU CCR5 5UIW
TM3 131 3.32x32 CXCR4 3ODU US28 4XT1
TM3 132 3.33x33 CXCR4 3ODU - -
TM3 133 3.34x34 CXCR4 3ODU CCR5 5UIW
TM3 134 3.35x35 CXCR4 3ODU CXCR4 3ODU
TM3 135 3.36x36 CXCR4 3ODU CCR5 5UIW
TM3 136 3.37x37 CXCR4 3ODU CXCR4 3ODU
TM3 137 3.38x38 CXCR4 3ODU AT1 receptor 4ZUD
TM3 138 3.39x39 CXCR4 3ODU CCR5 5UIW
TM3 139 3.40x40 CXCR4 3ODU apelin receptor 5VBL
TM3 140 3.41x41 CXCR4 3ODU CCR9 5LWE
TM3 141 3.42x42 CXCR4 3ODU CCR9 5LWE
TM3 142 3.43x43 CXCR4 3ODU CXCR4 3ODU
TM3 143 3.44x44 CXCR4 3ODU CXCR4 3ODU
TM3 144 3.45x45 CXCR4 3ODU CCR9 5LWE
TM3 145 3.46x46 CXCR4 3ODU CXCR4 3ODU
TM3 146 3.47x47 CXCR4 3ODU CXCR4 3ODU
TM3 147 3.48x48 CXCR4 3ODU apelin receptor 5VBL
TM3 148 3.49x49 CXCR4 3ODU CXCR4 3ODU
TM3 149 3.50x50 CXCR4 3ODU CXCR4 3ODU
TM3 150 3.51x51 CXCR4 3ODU CXCR4 3ODU
TM3 151 3.52x52 CXCR4 3ODU CXCR4 3ODU
TM3 152 3.53x53 CXCR4 3ODU - -
TM3 153 3.54x54 CXCR4 3ODU CXCR4 3ODU
TM3 154 3.55x55 CXCR4 3ODU CXCR4 3ODU
TM3 155 3.56x56 CXCR4 3ODU CXCR4 3ODU
ICL2 156 34.50x50 - - - -
ICL2 157 34.51x51 CCR5 5UIW - -
ICL2 158 34.52x52 CCR5 5UIW - -
ICL2 159 34.53x53 CCR5 5UIW - -
ICL2 160 34.54x54 CCR5 5UIW - -
ICL2 161 34.55x55 CCR5 5UIW C5a1 receptor 5O9H
ICL2 162 34.56x56 CCR5 5UIW P2Y1 receptor 4XNW
ICL2 163 34.57x57 - - - -
TM4 164 4.38x38 CXCR4 3ODU - -
TM4 165 4.39x39 CXCR4 3ODU μ receptor 4DKL
TM4 166 4.40x40 CXCR4 3ODU δ receptor 4N6H
TM4 167 4.41x41 CXCR4 3ODU OX2 receptor 5WS3
TM4 168 4.42x42 CXCR4 3ODU D2 receptor 6CM4
TM4 169 4.43x43 CXCR4 3ODU D2 receptor 6CM4
TM4 170 4.44x44 CXCR4 3ODU δ receptor 4N6H
TM4 171 4.45x45 CXCR4 3ODU CCR5 5UIW
TM4 172 4.46x46 CXCR4 3ODU CCR9 5LWE
TM4 173 4.47x47 CXCR4 3ODU OX1 receptor 4ZJ8
TM4 174 4.48x48 CXCR4 3ODU NOP receptor 5DHG
TM4 175 4.49x49 CXCR4 3ODU CXCR4 3ODU
TM4 176 4.50x50 CXCR4 3ODU CXCR4 3ODU
TM4 177 4.51x51 CXCR4 3ODU C5a1 receptor 5O9H
TM4 178 4.52x52 CXCR4 3ODU CCR9 5LWE
TM4 179 4.53x53 CXCR4 3ODU - -
TM4 180 4.54x54 CXCR4 3ODU CXCR4 3ODU
TM4 181 4.55x55 CXCR4 3ODU CXCR4 3ODU
TM4 182 4.56x56 CXCR4 3ODU - -
TM4 183 4.57x57 CXCR4 3ODU apelin receptor 5VBL
TM4 184 4.58x59 CXCR4 3ODU CCR5 5UIW
TM4 185 4.59x60 CXCR4 3ODU CXCR4 3ODU
TM4 186 4.60x61 CXCR4 3ODU CXCR4 3ODU
TM4 187 4.61x62 CXCR4 3ODU CXCR4 3ODU
TM4 188 4.62x63 CXCR4 3ODU CXCR4 3ODU
TM4 189 4.63x64 CXCR4 3ODU CXCR4 3ODU
TM4 190 4.64x65 CXCR4 3ODU - -
ECL2 191 - - - -
ECL2 192 AT2 receptor 5UNG - -
ECL2 193 AT2 receptor 5UNG - -
ECL2 194 AT2 receptor 5UNG - -
ECL2 195 AT2 receptor 5UNG - -
ECL2 196 AT2 receptor 5UNG - -
ECL2 197 AT2 receptor 5UNG - -
ECL2 198 AT2 receptor 5UNG AT2 receptor 5UNG
ECL2 199 AT2 receptor 5UNG - -
ECL2 200 AT2 receptor 5UNG - -
ECL2 201 AT2 receptor 5UNG - -
ECL2 202 - - - -
ECL2 203 45.50x50 CXCR4 3ODU CXCR4 3ODU
ECL2 204 45.51x51 CXCR4 3ODU - -
ECL2 205 45.52x52 CXCR4 3ODU - -
ECL2 206 - - - -
ECL2 207 BLT1 receptor 5X33 - -
ECL2 208 - - - -
TM5 209 5.32x33 CXCR4 3ODU CCR5 5UIW
TM5 210 5.33x34 CXCR4 3ODU PAF receptor 5ZKQ
TM5 211 5.34x35 CXCR4 3ODU - -
TM5 212 5.35x36 CXCR4 3ODU Y1 receptor 5ZBH
TM5 213 5.36x37 CXCR4 3ODU δ receptor 4N6H
TM5 214 5.37x38 CXCR4 3ODU C5a1 receptor 5O9H
TM5 215 5.38x39 CXCR4 3ODU AT1 receptor 4ZUD
TM5 216 5.39x40 CXCR4 3ODU FFA1 receptor 5TZY
TM5 217 5.40x41 CXCR4 3ODU apelin receptor 5VBL
TM5 218 5.41x42 CXCR4 3ODU Y1 receptor 5ZBH
TM5 219 5.42x43 CXCR4 3ODU - -
TM5 220 5.43x44 CXCR4 3ODU C5a1 receptor 5O9H
TM5 221 5.44x45 CXCR4 3ODU C5a1 receptor 5O9H
TM5 222 5.45x46 CXCR4 3ODU M4 receptor 5DSG
TM5 223 5.46x461 CXCR4 3ODU CXCR4 3ODU
TM5 224 5.47x47 CXCR4 3ODU AT1 receptor 4YAY
TM5 225 5.48x48 CXCR4 3ODU AT1 receptor 4ZUD
TM5 226 5.49x49 CXCR4 3ODU CXCR4 3ODU
TM5 227 5.50x50 CXCR4 3ODU CXCR4 3ODU
TM5 228 5.51x51 CXCR4 3ODU CCR5 5UIW
TM5 229 5.52x52 CXCR4 3ODU CCR5 5UIW
TM5 230 5.53x53 CXCR4 3ODU CXCR4 3ODU
TM5 231 5.54x54 CXCR4 3ODU CCR5 5UIW
TM5 232 5.55x55 CXCR4 3ODU ETB receptor 5X93
TM5 233 5.56x56 CXCR4 3ODU CB1 receptor 5TGZ
TM5 234 5.57x57 CXCR4 3ODU CXCR4 3ODU
TM5 235 5.58x58 CXCR4 3ODU CXCR4 3ODU
TM5 236 5.59x59 CXCR4 3ODU BLT1 receptor 5X33
TM5 237 5.60x60 CXCR4 3ODU M4 receptor 5DSG
TM5 238 5.61x61 CXCR4 3ODU CXCR4 3ODU
TM5 239 5.62x62 CXCR4 3ODU CCR5 5UIW
TM5 240 5.63x63 CXCR4 3ODU A1 receptor 5N2S
TM5 241 5.64x64 CXCR4 3ODU D2 receptor 6CM4
TM5 242 5.65x65 AT2 receptor 5UNG AT2 receptor 5UNG
TM5 243 5.66x66 AT2 receptor 5UNG AT2 receptor 5UNG
TM5 244 5.67x67 AT2 receptor 5UNG BLT1 receptor 5X33
TM5 245 5.68x68 AT2 receptor 5UNG P2Y12 receptor 4NTJ
ICL3 246 - - - -
ICL3 247 - - - -
ICL3 248 - - - -
ICL3 249 - - - -
TM6 250 6.30x30 CXCR4 3ODU CCR5 5UIW
TM6 251 6.31x31 CXCR4 3ODU A1 receptor 5UEN
TM6 252 6.32x32 CXCR4 3ODU CCR5 5UIW
TM6 253 6.33x33 CXCR4 3ODU CXCR4 3ODU
TM6 254 6.34x34 CXCR4 3ODU - -
TM6 255 6.35x35 CXCR4 3ODU CCR5 5UIW
TM6 256 6.36x36 CXCR4 3ODU CCR5 5UIW
TM6 257 6.37x37 CXCR4 3ODU μ receptor 4DKL
TM6 258 6.38x38 CXCR4 3ODU CXCR4 3ODU
TM6 259 6.39x39 CXCR4 3ODU apelin receptor 5VBL
TM6 260 6.40x40 CXCR4 3ODU CCR9 5LWE
TM6 261 6.41x41 CXCR4 3ODU AT1 receptor 4ZUD
TM6 262 6.42x42 CXCR4 3ODU apelin receptor 5VBL
TM6 263 6.43x43 CXCR4 3ODU CXCR4 3ODU
TM6 264 6.44x44 CXCR4 3ODU CXCR4 3ODU
TM6 265 6.45x45 CXCR4 3ODU apelin receptor 5VBL
TM6 266 6.46x46 CXCR4 3ODU CCR5 5UIW
TM6 267 6.47x47 CXCR4 3ODU CXCR4 3ODU
TM6 268 6.48x48 CXCR4 3ODU CXCR4 3ODU
TM6 269 6.49x49 CXCR4 3ODU CCR2 5T1A
TM6 270 6.50x50 CXCR4 3ODU CXCR4 3ODU
TM6 271 6.51x51 CXCR4 3ODU CXCR4 3ODU
TM6 272 6.52x52 CXCR4 3ODU apelin receptor 5VBL
TM6 273 6.53x53 CXCR4 3ODU apelin receptor 5VBL
TM6 274 6.54x54 CXCR4 3ODU CCR5 5UIW
TM6 275 6.55x55 CXCR4 3ODU μ receptor 4DKL
TM6 276 6.56x56 CXCR4 3ODU CCR5 5UIW
TM6 277 6.57x57 CXCR4 3ODU CCR9 5LWE
TM6 278 6.58x58 CXCR4 3ODU CXCR4 3ODU
TM6 279 6.59x59 CXCR4 3ODU D2 receptor 6CM4
TM6 280 6.60x60 CXCR4 3ODU AT1 receptor 4ZUD
TM6 281 6.61x61 CXCR4 3ODU - -
TM6 282 6.62x62 CXCR4 3ODU - -
TM6 283 6.63x63 CXCR4 3ODU CXCR4 3ODU
TM6 284 6.64x64 CXCR4 3ODU AT1 receptor 4ZUD
ECL3 285 CXCR4 3ODU - -
ECL3 286 CXCR4 3ODU - -
ECL3 287 CXCR4 3ODU - -
ECL3 288 CXCR4 3ODU - -
TM7 289 7.24x23 CXCR4 3ODU CCR5 5UIW
TM7 290 7.25x24 CXCR4 3ODU CXCR4 3ODU
TM7 291 7.26x25 CXCR4 3ODU - -
TM7 292 7.27x26 CXCR4 3ODU - -
TM7 293 7.28x27 CXCR4 3ODU CXCR4 3ODU
TM7 294 7.29x28 CXCR4 3ODU CCR2 5T1A
TM7 295 7.30x29 CXCR4 3ODU CCR5 5UIW
TM7 296 7.31x30 CXCR4 3ODU CXCR4 3ODU
TM7 297 7.32x31 CXCR4 3ODU CCR5 5UIW
TM7 298 7.33x32 CXCR4 3ODU μ receptor 4DKL
TM7 299 7.34x33 CXCR4 3ODU CCR5 5UIW
TM7 300 7.35x34 CXCR4 3ODU P2Y12 receptor 4NTJ
TM7 301 7.36x35 CXCR4 3ODU CXCR4 3ODU
TM7 302 7.37x36 CXCR4 3ODU CCR5 5UIW
TM7 303 7.38x37 CXCR4 3ODU CXCR4 3ODU
TM7 304 7.39x38 CXCR4 3ODU CB1 receptor 5TGZ
TM7 305 7.40x39 CXCR4 3ODU P2Y1 receptor 4XNW
TM7 306 7.41x40 CXCR4 3ODU CXCR4 3ODU
TM7 307 7.42x41 CXCR4 3ODU CCR5 5UIW
TM7 308 7.43x42 CXCR4 3ODU AT1 receptor 4ZUD
TM7 309 7.44x43 CXCR4 3ODU - -
TM7 310 7.45x45 CXCR4 3ODU CXCR4 3ODU
TM7 311 7.46x46 CXCR4 3ODU CXCR4 3ODU
TM7 312 7.47x47 CXCR4 3ODU CXCR4 3ODU
TM7 313 7.48x48 CXCR4 3ODU CXCR4 3ODU
TM7 314 7.49x49 CXCR4 3ODU CXCR4 3ODU
TM7 315 7.50x50 CXCR4 3ODU CXCR4 3ODU
TM7 316 7.51x51 CXCR4 3ODU AT1 receptor 4ZUD
TM7 317 7.52x52 CCR5 5UIW CCR9 5LWE
TM7 318 7.53x53 CCR5 5UIW CCR5 5UIW
TM7 319 7.54x54 CCR5 5UIW CCR5 5UIW
TM7 320 7.55x55 CCR5 5UIW CCR5 5UIW
TM7 321 7.56x56 CCR5 5UIW CCR5 5UIW
H8 322 8.47x47 CCR5 5UIW CCR5 5UIW
H8 323 8.48x48 CCR5 5UIW - -
H8 324 8.49x49 CCR5 5UIW CCR5 5UIW
H8 325 8.50x50 CCR5 5UIW CCR5 5UIW
H8 326 8.51x51 CCR5 5UIW CCR5 5UIW
H8 327 8.52x52 CCR5 5UIW OX2 receptor 5WS3
H8 328 8.53x53 CCR5 5UIW - -
H8 329 8.54x54 CCR5 5UIW Rhodopsin 1GZM
H8 330 8.55x55 CCR5 5UIW - -
H8 331 8.56x56 CCR5 5UIW - -
H8 332 8.57x57 CCR5 5UIW δ receptor 4N6H
H8 333 8.58x58 CCR5 5UIW CCR9 5LWE
H8 334 8.59x59 CCR5 5UIW apelin receptor 5VBL
C-term 335 - - - -
C-term 336 - - - -
C-term 337 - - - -
C-term 338 - - - -
C-term 339 - - - -