CXCR3 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Intermediate (Δ distance (Å): 7.25 docs)

VERSION

2018-07-10

MAIN TEMPLATE

μ receptor (sequence similarity: 45%) PDB: 6DDE

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 71.0 22.0 7.0
Side-chains 20.7 57.7 21.7

Number of backbone templates: 7
Number of rotamer templates: 31

NGL is a WebGL based 3D viewer powered by MMTF.

4RWS
3ODU
6DDE
4ZUD
5UIW
5UNG
5X33
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 40 CXCR4 4RWS CXCR4 4RWS
N-term 41 CXCR4 4RWS CXCR4 4RWS
N-term 42 CXCR4 4RWS CXCR4 4RWS
N-term 43 CXCR4 4RWS CXCR4 4RWS
N-term 44 CXCR4 4RWS CXCR4 4RWS
TM1 45 1.24x24 CXCR4 4RWS - -
TM1 46 1.25x25 CXCR4 4RWS - -
TM1 47 1.26x26 CXCR4 4RWS - -
TM1 48 1.27x27 CXCR4 4RWS δ receptor 4N6H
TM1 49 1.28x28 CXCR4 4RWS US28 4XT1
TM1 50 1.29x29 CXCR4 4RWS CXCR4 4RWS
TM1 51 1.30x30 CXCR4 4RWS CXCR4 4RWS
TM1 52 1.31x31 μ receptor 6DDE - -
TM1 53 1.32x32 μ receptor 6DDE - -
TM1 54 1.33x33 μ receptor 6DDE apelin receptor 5VBL
TM1 55 1.34x34 μ receptor 6DDE PAR2 5NDD
TM1 56 1.35x35 μ receptor 6DDE P2Y1 receptor 4XNW
TM1 57 1.36x36 μ receptor 6DDE P2Y1 receptor 4XNW
TM1 58 1.37x37 μ receptor 6DDE μ receptor 6DDE
TM1 59 1.38x38 μ receptor 6DDE P2Y12 receptor 4NTJ
TM1 60 1.39x39 μ receptor 6DDE μ receptor 6DDE
TM1 61 1.40x40 μ receptor 6DDE μ receptor 6DDE
TM1 62 1.41x41 μ receptor 6DDE P2Y1 receptor 4XNW
TM1 63 1.42x42 μ receptor 6DDE NTS1 receptor 4XES
TM1 64 1.43x43 μ receptor 6DDE P2Y1 receptor 4XNW
TM1 65 1.44x44 μ receptor 6DDE 5-HT1B receptor 4IAQ
TM1 66 1.45x45 μ receptor 6DDE PAF receptor 5ZKQ
TM1 67 1.46x46 μ receptor 6DDE μ receptor 6DDE
TM1 68 1.47x47 μ receptor 6DDE PAR2 5NDD
TM1 69 1.48x48 μ receptor 6DDE P2Y1 receptor 4XNW
TM1 70 1.49x49 μ receptor 6DDE μ receptor 6DDE
TM1 71 1.50x50 μ receptor 6DDE μ receptor 6DDE
TM1 72 1.51x51 μ receptor 6DDE PAR2 5NDD
TM1 73 1.52x52 μ receptor 6DDE LPA6 receptor 5XSZ
TM1 74 1.53x53 μ receptor 6DDE μ receptor 6DDE
TM1 75 1.54x54 μ receptor 6DDE - -
TM1 76 1.55x55 μ receptor 6DDE 5-HT1B receptor 4IAQ
TM1 77 1.56x56 μ receptor 6DDE μ receptor 6DDE
TM1 78 1.57x57 μ receptor 6DDE NTS1 receptor 4XES
TM1 79 1.58x58 μ receptor 6DDE PAR2 5NDD
TM1 80 1.59x59 μ receptor 6DDE H1 receptor 3RZE
TM1 81 1.60x60 μ receptor 6DDE PAR2 5NDD
ICL1 82 12.48x48 - - - -
ICL1 83 12.49x49 AT1 receptor 4ZUD - -
ICL1 84 12.50x50 AT1 receptor 4ZUD - -
ICL1 85 12.51x51 - - - -
TM2 86 2.37x37 CXCR4 3ODU CXCR4 3ODU
TM2 87 2.38x38 μ receptor 6DDE US28 4XT1
TM2 88 2.39x39 μ receptor 6DDE μ receptor 6DDE
TM2 89 2.40x40 μ receptor 6DDE CXCR4 3ODU
TM2 90 2.41x41 μ receptor 6DDE LPA6 receptor 5XSZ
TM2 91 2.42x42 μ receptor 6DDE PAF receptor 5ZKQ
TM2 92 2.43x43 μ receptor 6DDE NTS1 receptor 4XES
TM2 93 2.44x44 μ receptor 6DDE PAR1 3VW7
TM2 94 2.45x45 μ receptor 6DDE PAR1 3VW7
TM2 95 2.46x46 μ receptor 6DDE μ receptor 6DDE
TM2 96 2.47x47 μ receptor 6DDE μ receptor 6DDE
TM2 97 2.48x48 μ receptor 6DDE 5-HT2B receptor 4IB4
TM2 98 2.49x49 μ receptor 6DDE μ receptor 6DDE
TM2 99 2.50x50 μ receptor 6DDE μ receptor 6DDE
TM2 100 2.51x51 μ receptor 6DDE NOP receptor 5DHG
TM2 101 2.52x52 μ receptor 6DDE μ receptor 6DDE
TM2 102 2.53x53 μ receptor 6DDE FFA1 receptor 5TZY
TM2 103 2.54x54 μ receptor 6DDE P2Y1 receptor 4XNW
TM2 104 2.55x55 μ receptor 6DDE P2Y1 receptor 4XNW
TM2 105 2.56x56 μ receptor 6DDE μ receptor 6DDE
TM2 106 2.57x57 μ receptor 6DDE μ receptor 6DDE
TM2 107 2.58x58 μ receptor 6DDE μ receptor 6DDE
TM2 108 2.59x59 μ receptor 6DDE PAR2 5NDD
TM2 109 2.60x60 μ receptor 6DDE PAF receptor 5ZKQ
TM2 110 2.61x61 μ receptor 6DDE FFA1 receptor 5TZY
TM2 111 2.62x62 μ receptor 6DDE μ receptor 6DDE
TM2 112 2.63x63 μ receptor 6DDE CXCR4 3ODU
TM2 113 2.64x64 μ receptor 6DDE FFA1 receptor 5TZY
TM2 114 2.65x65 μ receptor 6DDE P2Y12 receptor 4NTJ
TM2 115 2.66x66 μ receptor 6DDE D2 receptor 6CM4
ECL1 116 23.49x49 - - - -
ECL1 117 23.50x50 CXCR4 3ODU CXCR4 3ODU
ECL1 118 23.51x51 CXCR4 3ODU CCR2 5T1A
ECL1 119 23.52x52 - - - -
TM3 120 3.21x21 μ receptor 6DDE μ receptor 6DDE
TM3 121 3.22x22 μ receptor 6DDE PAR1 3VW7
TM3 122 3.23x23 μ receptor 6DDE - -
TM3 123 3.24x24 μ receptor 6DDE μ receptor 6DDE
TM3 124 3.25x25 μ receptor 6DDE μ receptor 6DDE
TM3 125 3.26x26 μ receptor 6DDE μ receptor 6DDE
TM3 126 3.27x27 μ receptor 6DDE PAR2 5NDD
TM3 127 3.28x28 μ receptor 6DDE PAF receptor 5ZKQ
TM3 128 3.29x29 μ receptor 6DDE PAF receptor 5ZKQ
TM3 129 3.30x30 μ receptor 6DDE PAR1 3VW7
TM3 130 3.31x31 μ receptor 6DDE PAF receptor 5ZKQ
TM3 131 3.32x32 μ receptor 6DDE P2Y1 receptor 4XNW
TM3 132 3.33x33 μ receptor 6DDE - -
TM3 133 3.34x34 μ receptor 6DDE PAF receptor 5ZKQ
TM3 134 3.35x35 μ receptor 6DDE μ receptor 6DDE
TM3 135 3.36x36 μ receptor 6DDE CCR5 5UIW
TM3 136 3.37x37 μ receptor 6DDE P2Y1 receptor 4XNW
TM3 137 3.38x38 μ receptor 6DDE PAR1 3VW7
TM3 138 3.39x39 μ receptor 6DDE FFA1 receptor 5TZY
TM3 139 3.40x40 μ receptor 6DDE NTS1 receptor 4XES
TM3 140 3.41x41 μ receptor 6DDE P2Y1 receptor 4XNW
TM3 141 3.42x42 μ receptor 6DDE PAR1 3VW7
TM3 142 3.43x43 μ receptor 6DDE μ receptor 6DDE
TM3 143 3.44x44 μ receptor 6DDE NTS1 receptor 4XES
TM3 144 3.45x45 μ receptor 6DDE P2Y1 receptor 4XNW
TM3 145 3.46x46 μ receptor 6DDE P2Y1 receptor 4XNW
TM3 146 3.47x47 μ receptor 6DDE μ receptor 6DDE
TM3 147 3.48x48 μ receptor 6DDE apelin receptor 5VBL
TM3 148 3.49x49 μ receptor 6DDE μ receptor 6DDE
TM3 149 3.50x50 μ receptor 6DDE μ receptor 6DDE
TM3 150 3.51x51 μ receptor 6DDE μ receptor 6DDE
TM3 151 3.52x52 μ receptor 6DDE PAR1 3VW7
TM3 152 3.53x53 μ receptor 6DDE - -
TM3 153 3.54x54 μ receptor 6DDE PAR2 5NDD
TM3 154 3.55x55 μ receptor 6DDE P2Y1 receptor 4XNW
TM3 155 3.56x56 μ receptor 6DDE μ receptor 6DDE
ICL2 156 34.50x50 - - - -
ICL2 157 34.51x51 CCR5 5UIW - -
ICL2 158 34.52x52 CCR5 5UIW - -
ICL2 159 34.53x53 CCR5 5UIW - -
ICL2 160 34.54x54 CCR5 5UIW - -
ICL2 161 34.55x55 CCR5 5UIW C5a1 receptor 5O9H
ICL2 162 34.56x56 CCR5 5UIW P2Y1 receptor 4XNW
ICL2 163 34.57x57 - - - -
TM4 164 4.38x38 μ receptor 6DDE US28 4XT1
TM4 165 4.39x39 μ receptor 6DDE μ receptor 6DDE
TM4 166 4.40x40 μ receptor 6DDE 5-HT2B receptor 4IB4
TM4 167 4.41x41 μ receptor 6DDE PAF receptor 5ZKQ
TM4 168 4.42x42 μ receptor 6DDE D2 receptor 6CM4
TM4 169 4.43x43 μ receptor 6DDE D2 receptor 6CM4
TM4 170 4.44x44 μ receptor 6DDE US28 4XT1
TM4 171 4.45x45 μ receptor 6DDE PAR1 3VW7
TM4 172 4.46x46 μ receptor 6DDE PAR1 3VW7
TM4 173 4.47x47 μ receptor 6DDE PAR2 5NDD
TM4 174 4.48x48 μ receptor 6DDE PAR2 5NDD
TM4 175 4.49x49 μ receptor 6DDE P2Y1 receptor 4XNW
TM4 176 4.50x50 μ receptor 6DDE μ receptor 6DDE
TM4 177 4.51x51 μ receptor 6DDE C5a1 receptor 5O9H
TM4 178 4.52x52 μ receptor 6DDE μ receptor 6DDE
TM4 179 4.53x53 μ receptor 6DDE - -
TM4 180 4.54x54 μ receptor 6DDE PAR2 5NDD
TM4 181 4.55x55 μ receptor 6DDE PAR2 5NDD
TM4 182 4.56x56 μ receptor 6DDE - -
TM4 183 4.57x57 CXCR4 3ODU PAF receptor 5ZKQ
TM4 184 4.58x59 CXCR4 3ODU FFA1 receptor 5TZY
TM4 185 4.59x60 μ receptor 6DDE PAR2 5NDD
TM4 186 4.60x61 μ receptor 6DDE CXCR4 3ODU
TM4 187 4.61x62 μ receptor 6DDE μ receptor 6DDE
TM4 188 4.62x63 CXCR4 3ODU CXCR4 3ODU
TM4 189 4.63x64 CXCR4 3ODU CXCR4 3ODU
TM4 190 4.64x65 CXCR4 3ODU - -
ECL2 191 - - - -
ECL2 192 AT2 receptor 5UNG - -
ECL2 193 AT2 receptor 5UNG - -
ECL2 194 AT2 receptor 5UNG - -
ECL2 195 AT2 receptor 5UNG - -
ECL2 196 AT2 receptor 5UNG - -
ECL2 197 AT2 receptor 5UNG - -
ECL2 198 AT2 receptor 5UNG AT2 receptor 5UNG
ECL2 199 AT2 receptor 5UNG - -
ECL2 200 AT2 receptor 5UNG - -
ECL2 201 AT2 receptor 5UNG - -
ECL2 202 - - - -
ECL2 203 45.50x50 μ receptor 6DDE μ receptor 6DDE
ECL2 204 45.51x51 μ receptor 6DDE - -
ECL2 205 45.52x52 μ receptor 6DDE - -
ECL2 206 - - - -
ECL2 207 BLT1 receptor 5X33 - -
ECL2 208 - - - -
TM5 209 5.32x33 CXCR4 3ODU CCR5 5UIW
TM5 210 5.33x34 μ receptor 6DDE PAF receptor 5ZKQ
TM5 211 5.34x35 μ receptor 6DDE - -
TM5 212 5.35x36 μ receptor 6DDE Y1 receptor 5ZBH
TM5 213 5.36x37 μ receptor 6DDE δ receptor 4N6H
TM5 214 5.37x38 μ receptor 6DDE C5a1 receptor 5O9H
TM5 215 5.38x39 μ receptor 6DDE μ receptor 6DDE
TM5 216 5.39x40 μ receptor 6DDE FFA1 receptor 5TZY
TM5 217 5.40x41 μ receptor 6DDE 5-HT1B receptor 4IAQ
TM5 218 5.41x42 μ receptor 6DDE Y1 receptor 5ZBH
TM5 219 5.42x43 μ receptor 6DDE - -
TM5 220 5.43x44 μ receptor 6DDE C5a1 receptor 5O9H
TM5 221 5.44x45 μ receptor 6DDE P2Y1 receptor 4XNW
TM5 222 5.45x46 μ receptor 6DDE P2Y1 receptor 4XNW
TM5 223 5.46x461 μ receptor 6DDE CXCR4 3ODU
TM5 224 5.47x47 μ receptor 6DDE μ receptor 6DDE
TM5 225 5.48x48 μ receptor 6DDE PAR2 5NDD
TM5 226 5.49x49 μ receptor 6DDE PAF receptor 5ZKQ
TM5 227 5.50x50 μ receptor 6DDE μ receptor 6DDE
TM5 228 5.51x51 μ receptor 6DDE P2Y1 receptor 4XNW
TM5 229 5.52x52 μ receptor 6DDE PAF receptor 5ZKQ
TM5 230 5.53x53 μ receptor 6DDE NTS1 receptor 4XES
TM5 231 5.54x54 μ receptor 6DDE 5-HT2B receptor 4IB4
TM5 232 5.55x55 μ receptor 6DDE PAR2 5NDD
TM5 233 5.56x56 μ receptor 6DDE US28 4XT1
TM5 234 5.57x57 μ receptor 6DDE μ receptor 6DDE
TM5 235 5.58x58 μ receptor 6DDE μ receptor 6DDE
TM5 236 5.59x59 μ receptor 6DDE LPA6 receptor 5XSZ
TM5 237 5.60x60 μ receptor 6DDE M4 receptor 5DSG
TM5 238 5.61x61 μ receptor 6DDE P2Y1 receptor 4XNW
TM5 239 5.62x62 μ receptor 6DDE FFA1 receptor 5TZY
TM5 240 5.63x63 μ receptor 6DDE A1 receptor 5N2S
TM5 241 5.64x64 μ receptor 6DDE D2 receptor 6CM4
TM5 242 5.65x65 μ receptor 6DDE μ receptor 6DDE
TM5 243 5.66x66 μ receptor 6DDE PAF receptor 5ZKQ
TM5 244 5.67x67 μ receptor 6DDE NTS1 receptor 4XES
TM5 245 5.68x68 μ receptor 6DDE PAR1 3VW7
ICL3 246 - - - -
ICL3 247 - - - -
ICL3 248 - - - -
ICL3 249 - - - -
TM6 250 6.30x30 μ receptor 6DDE FFA1 receptor 5TZY
TM6 251 6.31x31 μ receptor 6DDE A1 receptor 5UEN
TM6 252 6.32x32 μ receptor 6DDE μ receptor 6DDE
TM6 253 6.33x33 μ receptor 6DDE 5-HT2B receptor 4IB4
TM6 254 6.34x34 μ receptor 6DDE - -
TM6 255 6.35x35 μ receptor 6DDE μ receptor 6DDE
TM6 256 6.36x36 μ receptor 6DDE CCR5 5UIW
TM6 257 6.37x37 μ receptor 6DDE μ receptor 6DDE
TM6 258 6.38x38 μ receptor 6DDE P2Y1 receptor 4XNW
TM6 259 6.39x39 μ receptor 6DDE μ receptor 6DDE
TM6 260 6.40x40 μ receptor 6DDE μ receptor 6DDE
TM6 261 6.41x41 μ receptor 6DDE μ receptor 6DDE
TM6 262 6.42x42 μ receptor 6DDE apelin receptor 5VBL
TM6 263 6.43x43 μ receptor 6DDE PAR2 5NDD
TM6 264 6.44x44 μ receptor 6DDE μ receptor 6DDE
TM6 265 6.45x45 μ receptor 6DDE A2A receptor 4UHR
TM6 266 6.46x46 μ receptor 6DDE PAR2 5NDD
TM6 267 6.47x47 μ receptor 6DDE PAR2 5NDD
TM6 268 6.48x48 μ receptor 6DDE μ receptor 6DDE
TM6 269 6.49x49 μ receptor 6DDE PAR2 5NDD
TM6 270 6.50x50 μ receptor 6DDE μ receptor 6DDE
TM6 271 6.51x51 μ receptor 6DDE NTS1 receptor 4XES
TM6 272 6.52x52 μ receptor 6DDE μ receptor 6DDE
TM6 273 6.53x53 μ receptor 6DDE PAR2 5NDD
TM6 274 6.54x54 μ receptor 6DDE PAF receptor 5ZKQ
TM6 275 6.55x55 μ receptor 6DDE μ receptor 6DDE
TM6 276 6.56x56 μ receptor 6DDE PAF receptor 5ZKQ
TM6 277 6.57x57 μ receptor 6DDE PAR2 5NDD
TM6 278 6.58x58 μ receptor 6DDE CXCR4 3ODU
TM6 279 6.59x59 μ receptor 6DDE D2 receptor 6CM4
TM6 280 6.60x60 μ receptor 6DDE PAF receptor 5ZKQ
TM6 281 6.61x61 μ receptor 6DDE - -
TM6 282 6.62x62 CXCR4 3ODU - -
TM6 283 6.63x63 CXCR4 3ODU CXCR4 3ODU
TM6 284 6.64x64 CXCR4 3ODU PAF receptor 5ZKQ
ECL3 285 - - - -
ECL3 286 CXCR4 3ODU - -
ECL3 287 CXCR4 3ODU - -
ECL3 288 - - - -
TM7 289 7.24x23 CXCR4 3ODU CCR5 5UIW
TM7 290 7.25x24 CXCR4 3ODU CXCR4 3ODU
TM7 291 7.26x25 CXCR4 3ODU - -
TM7 292 7.27x26 CXCR4 3ODU - -
TM7 293 7.28x27 CXCR4 3ODU CXCR4 3ODU
TM7 294 7.29x28 CXCR4 3ODU CCR2 5T1A
TM7 295 7.30x29 μ receptor 6DDE P2Y1 receptor 4XNW
TM7 296 7.31x30 μ receptor 6DDE P2Y1 receptor 4XNW
TM7 297 7.32x31 μ receptor 6DDE CCR5 5UIW
TM7 298 7.33x32 μ receptor 6DDE μ receptor 6DDE
TM7 299 7.34x33 μ receptor 6DDE PAF receptor 5ZKQ
TM7 300 7.35x34 μ receptor 6DDE P2Y12 receptor 4NTJ
TM7 301 7.36x35 μ receptor 6DDE CXCR4 3ODU
TM7 302 7.37x36 μ receptor 6DDE P2Y1 receptor 4XNW
TM7 303 7.38x37 μ receptor 6DDE P2Y1 receptor 4XNW
TM7 304 7.39x38 μ receptor 6DDE CB1 receptor 5XRA
TM7 305 7.40x39 μ receptor 6DDE P2Y1 receptor 4XNW
TM7 306 7.41x40 μ receptor 6DDE μ receptor 6DDE
TM7 307 7.42x41 μ receptor 6DDE μ receptor 6DDE
TM7 308 7.43x42 μ receptor 6DDE μ receptor 6DDE
TM7 309 7.44x43 μ receptor 6DDE - -
TM7 310 7.45x45 μ receptor 6DDE CXCR4 3ODU
TM7 311 7.46x46 μ receptor 6DDE PAF receptor 5ZKQ
TM7 312 7.47x47 μ receptor 6DDE μ receptor 6DDE
TM7 313 7.48x48 μ receptor 6DDE μ receptor 6DDE
TM7 314 7.49x49 μ receptor 6DDE μ receptor 6DDE
TM7 315 7.50x50 μ receptor 6DDE μ receptor 6DDE
TM7 316 7.51x51 μ receptor 6DDE PAR1 3VW7
TM7 317 7.52x52 μ receptor 6DDE μ receptor 6DDE
TM7 318 7.53x53 μ receptor 6DDE μ receptor 6DDE
TM7 319 7.54x54 μ receptor 6DDE μ receptor 6DDE
TM7 320 7.55x55 CCR5 5UIW CCR5 5UIW
TM7 321 7.56x56 CCR5 5UIW CCR5 5UIW
H8 322 8.47x47 CCR5 5UIW CCR5 5UIW
H8 323 8.48x48 CCR5 5UIW - -
H8 324 8.49x49 CCR5 5UIW CCR2 5T1A
H8 325 8.50x50 CCR5 5UIW CCR5 5UIW
H8 326 8.51x51 CCR5 5UIW CCR5 5UIW
H8 327 8.52x52 CCR5 5UIW OX2 receptor 5WS3
H8 328 8.53x53 CCR5 5UIW - -
H8 329 8.54x54 CCR5 5UIW Rhodopsin 5DYS
H8 330 8.55x55 CCR5 5UIW - -
H8 331 8.56x56 CCR5 5UIW - -
H8 332 8.57x57 CCR5 5UIW 5-HT1B receptor 4IAQ
H8 333 8.58x58 CCR5 5UIW PAR2 5NDD
H8 334 8.59x59 CCR5 5UIW apelin receptor 5VBL
C-term 335 - - - -
C-term 336 - - - -
C-term 337 - - - -
C-term 338 - - - -
C-term 339 - - - -