CXCR5 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive (Δ distance (Å): -1.18 docs)

VERSION

2018-07-10

MAIN TEMPLATE

CXCR4 (sequence similarity: 60%) PDB: 3ODU

TEMPLATES

Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 76.1 13.4 10.5
Side-chains 28.8 49.0 22.2

Number of backbone templates: 6
Number of rotamer templates: 39

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4RWS
3ODU
4ZUD
5UIW
4N6H
5LWE
None

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

Segment Seq.num. GPCRdb# Backbone PDB Rotamer PDB
N-term 38 CXCR4 4RWS CXCR4 4RWS
N-term 39 CXCR4 4RWS CXCR4 4RWS
N-term 40 CXCR4 4RWS CXCR4 4RWS
N-term 41 CXCR4 4RWS CXCR4 4RWS
N-term 42 CXCR4 4RWS CXCR4 4RWS
TM1 43 1.24x24 CXCR4 4RWS - -
TM1 44 1.25x25 CXCR4 4RWS - -
TM1 45 1.26x26 CXCR4 4RWS - -
TM1 46 1.27x27 CXCR4 4RWS - -
TM1 47 1.28x28 CXCR4 3ODU CXCR4 3ODU
TM1 48 1.29x29 CXCR4 3ODU A1 receptor 5UEN
TM1 49 1.30x30 CXCR4 3ODU CXCR4 3ODU
TM1 50 1.31x31 CXCR4 3ODU - -
TM1 51 1.32x32 CXCR4 3ODU CCR5 5UIW
TM1 52 1.33x33 CXCR4 3ODU AT1 receptor 4ZUD
TM1 53 1.34x34 CXCR4 3ODU CXCR4 3ODU
TM1 54 1.35x35 CXCR4 3ODU NTS1 receptor 4BUO
TM1 55 1.36x36 CXCR4 3ODU CXCR4 3ODU
TM1 56 1.37x37 CXCR4 3ODU C5a1 receptor 5O9H
TM1 57 1.38x38 CXCR4 3ODU OX1 receptor 4ZJ8
TM1 58 1.39x39 CXCR4 3ODU CXCR4 3ODU
TM1 59 1.40x40 CXCR4 3ODU CXCR4 3ODU
TM1 60 1.41x41 CXCR4 3ODU CCR9 5LWE
TM1 61 1.42x42 CXCR4 3ODU CXCR4 3ODU
TM1 62 1.43x43 CXCR4 3ODU CXCR4 3ODU
TM1 63 1.44x44 CXCR4 3ODU CXCR4 3ODU
TM1 64 1.45x45 CXCR4 3ODU apelin receptor 5VBL
TM1 65 1.46x46 CXCR4 3ODU CXCR4 3ODU
TM1 66 1.47x47 CXCR4 3ODU C5a1 receptor 5O9H
TM1 67 1.48x48 CXCR4 3ODU OX2 receptor 5WS3
TM1 68 1.49x49 CXCR4 3ODU CXCR4 3ODU
TM1 69 1.50x50 CXCR4 3ODU CXCR4 3ODU
TM1 70 1.51x51 CXCR4 3ODU δ receptor 4N6H
TM1 71 1.52x52 CXCR4 3ODU CXCR4 3ODU
TM1 72 1.53x53 CXCR4 3ODU CXCR4 3ODU
TM1 73 1.54x54 CXCR4 3ODU apelin receptor 5VBL
TM1 74 1.55x55 CXCR4 3ODU OX2 receptor 5WS3
TM1 75 1.56x56 CXCR4 3ODU CCR5 5UIW
TM1 76 1.57x57 CXCR4 3ODU CCR5 5UIW
TM1 77 1.58x58 CXCR4 3ODU - -
TM1 78 1.59x59 CXCR4 3ODU δ receptor 4N6H
TM1 79 1.60x60 CXCR4 3ODU NOP receptor 5DHG
ICL1 80 12.48x48 - - - -
ICL1 81 12.49x49 AT1 receptor 4ZUD M3 receptor 4U15
ICL1 82 12.50x50 AT1 receptor 4ZUD - -
ICL1 83 12.51x51 - - - -
TM2 84 2.37x37 CXCR4 3ODU CXCR4 3ODU
TM2 85 2.38x38 CXCR4 3ODU apelin receptor 5VBL
TM2 86 2.39x39 CXCR4 3ODU CXCR4 3ODU
TM2 87 2.40x40 CXCR4 3ODU - -
TM2 88 2.41x41 CXCR4 3ODU LPA6 receptor 5XSZ
TM2 89 2.42x42 CXCR4 3ODU CCR9 5LWE
TM2 90 2.43x43 CXCR4 3ODU CCR9 5LWE
TM2 91 2.44x44 CXCR4 3ODU δ receptor 4N6H
TM2 92 2.45x45 CXCR4 3ODU CXCR4 3ODU
TM2 93 2.46x46 CXCR4 3ODU CXCR4 3ODU
TM2 94 2.47x47 CXCR4 3ODU CCR9 5LWE
TM2 95 2.48x48 CXCR4 3ODU CXCR4 3ODU
TM2 96 2.49x49 CXCR4 3ODU CXCR4 3ODU
TM2 97 2.50x50 CXCR4 3ODU CXCR4 3ODU
TM2 98 2.51x51 CXCR4 3ODU CXCR4 3ODU
TM2 99 2.52x52 CXCR4 3ODU CXCR4 3ODU
TM2 100 2.53x53 CXCR4 3ODU D4 receptor 5WIV
TM2 101 2.54x54 CXCR4 3ODU CXCR4 3ODU
TM2 102 2.55x55 CXCR4 3ODU Rhodopsin 1GZM
TM2 103 2.56x56 CXCR4 3ODU CB1 receptor 5TGZ
TM2 104 2.57x57 CXCR4 3ODU CXCR4 3ODU
TM2 105 2.58x58 CXCR4 3ODU CXCR4 3ODU
TM2 106 2.59x59 CXCR4 3ODU CXCR4 3ODU
TM2 107 2.60x60 CXCR4 3ODU A1 receptor 5UEN
TM2 108 2.61x61 CXCR4 3ODU D4 receptor 5WIV
TM2 109 2.62x62 CXCR4 3ODU δ receptor 4N6H
TM2 110 2.63x63 CXCR4 3ODU FFA1 receptor 5TZY
TM2 111 2.64x64 CXCR4 3ODU - -
TM2 112 2.65x65 CXCR4 3ODU AT2 receptor 5UNG
TM2 113 2.66x66 CXCR4 3ODU D2 receptor 6CM4
ECL1 114 23.49x49 CXCR4 3ODU - -
ECL1 115 23.50x50 CXCR4 3ODU CXCR4 3ODU
ECL1 116 23.51x51 CXCR4 3ODU CCR2 5T1A
ECL1 117 23.52x52 CXCR4 3ODU M3 receptor 4U15
TM3 118 3.21x21 CXCR4 3ODU CXCR4 3ODU
TM3 119 3.22x22 CXCR4 3ODU apelin receptor 5VBL
TM3 120 3.23x23 CXCR4 3ODU CXCR4 3ODU
TM3 121 3.24x24 CXCR4 3ODU CXCR4 3ODU
TM3 122 3.25x25 CXCR4 3ODU CXCR4 3ODU
TM3 123 3.26x26 CXCR4 3ODU CXCR4 3ODU
TM3 124 3.27x27 CXCR4 3ODU NOP receptor 5DHG
TM3 125 3.28x28 CXCR4 3ODU CXCR4 3ODU
TM3 126 3.29x29 CXCR4 3ODU μ receptor 4DKL
TM3 127 3.30x30 CXCR4 3ODU AT1 receptor 4ZUD
TM3 128 3.31x31 CXCR4 3ODU CCR5 5UIW
TM3 129 3.32x32 CXCR4 3ODU FFA1 receptor 5TZY
TM3 130 3.33x33 CXCR4 3ODU CCR9 5LWE
TM3 131 3.34x34 CXCR4 3ODU CXCR4 3ODU
TM3 132 3.35x35 CXCR4 3ODU CXCR4 3ODU
TM3 133 3.36x36 CXCR4 3ODU CCR9 5LWE
TM3 134 3.37x37 CXCR4 3ODU CXCR4 3ODU
TM3 135 3.38x38 CXCR4 3ODU PAR2 5NDD
TM3 136 3.39x39 CXCR4 3ODU CXCR4 3ODU
TM3 137 3.40x40 CXCR4 3ODU - -
TM3 138 3.41x41 CXCR4 3ODU CCR9 5LWE
TM3 139 3.42x42 CXCR4 3ODU CCR9 5LWE
TM3 140 3.43x43 CXCR4 3ODU CXCR4 3ODU
TM3 141 3.44x44 CXCR4 3ODU CXCR4 3ODU
TM3 142 3.45x45 CXCR4 3ODU CCR9 5LWE
TM3 143 3.46x46 CXCR4 3ODU CXCR4 3ODU
TM3 144 3.47x47 CXCR4 3ODU OX2 receptor 5WS3
TM3 145 3.48x48 CXCR4 3ODU CCR9 5LWE
TM3 146 3.49x49 CXCR4 3ODU CXCR4 3ODU
TM3 147 3.50x50 CXCR4 3ODU CXCR4 3ODU
TM3 148 3.51x51 CXCR4 3ODU CXCR4 3ODU
TM3 149 3.52x52 CXCR4 3ODU CXCR4 3ODU
TM3 150 3.53x53 CXCR4 3ODU CXCR4 3ODU
TM3 151 3.54x54 CXCR4 3ODU CXCR4 3ODU
TM3 152 3.55x55 CXCR4 3ODU CXCR4 3ODU
TM3 153 3.56x56 CXCR4 3ODU CXCR4 3ODU
ICL2 154 34.50x50 - - - -
ICL2 155 34.51x51 CCR5 5UIW CCR2 5T1A
ICL2 156 34.52x52 CCR5 5UIW D3 receptor 3PBL
ICL2 157 34.53x53 CCR5 5UIW CCR5 5UIW
ICL2 158 34.54x54 CCR5 5UIW - -
ICL2 159 34.55x55 CCR5 5UIW C5a1 receptor 5O9H
ICL2 160 34.56x56 CCR5 5UIW - -
ICL2 161 34.57x57 - - - -
TM4 162 4.38x38 CXCR4 3ODU CCR9 5LWE
TM4 163 4.39x39 CXCR4 3ODU CXCR4 3ODU
TM4 164 4.40x40 CXCR4 3ODU CXCR4 3ODU
TM4 165 4.41x41 CXCR4 3ODU apelin receptor 5VBL
TM4 166 4.42x42 CXCR4 3ODU - -
TM4 167 4.43x43 CXCR4 3ODU - -
TM4 168 4.44x44 CXCR4 3ODU κ receptor 4DJH
TM4 169 4.45x45 CXCR4 3ODU CCR5 5UIW
TM4 170 4.46x46 CXCR4 3ODU CCR9 5LWE
TM4 171 4.47x47 CXCR4 3ODU D4 receptor 5WIV
TM4 172 4.48x48 CXCR4 3ODU CCR9 5LWE
TM4 173 4.49x49 CXCR4 3ODU CCR9 5LWE
TM4 174 4.50x50 CXCR4 3ODU CXCR4 3ODU
TM4 175 4.51x51 CXCR4 3ODU CCR2 5T1A
TM4 176 4.52x52 CXCR4 3ODU CCR5 5UIW
TM4 177 4.53x53 CXCR4 3ODU - -
TM4 178 4.54x54 CXCR4 3ODU BLT1 receptor 5X33
TM4 179 4.55x55 CXCR4 3ODU CXCR4 3ODU
TM4 180 4.56x56 CXCR4 3ODU CXCR4 3ODU
TM4 181 4.57x57 CXCR4 3ODU apelin receptor 5VBL
TM4 182 4.58x59 CXCR4 3ODU CCR5 5UIW
TM4 183 4.59x60 CXCR4 3ODU CXCR4 3ODU
TM4 184 4.60x61 CXCR4 3ODU CCR9 5LWE
TM4 185 4.61x62 CXCR4 3ODU CCR9 5LWE
TM4 186 4.62x63 CXCR4 3ODU κ receptor 4DJH
TM4 187 4.63x64 CXCR4 3ODU CXCR4 3ODU
TM4 188 4.64x65 CXCR4 3ODU CXCR4 3ODU
ECL2 189 - - - -
ECL2 190 - - - -
ECL2 191 - - - -
ECL2 192 - - - -
ECL2 193 - - - -
ECL2 194 - - - -
ECL2 195 - - - -
ECL2 196 - - - -
ECL2 197 - - - -
ECL2 198 - - - -
ECL2 199 - - - -
ECL2 200 - - - -
ECL2 201 - - - -
ECL2 202 45.50x50 CXCR4 3ODU CXCR4 3ODU
ECL2 203 45.51x51 CXCR4 3ODU μ receptor 4DKL
ECL2 204 45.52x52 CXCR4 3ODU AT1 receptor 4ZUD
ECL2 205 - - - -
ECL2 206 - - - -
ECL2 207 - - - -
ECL2 208 - - - -
ECL2 209 - - - -
ECL2 210 - - - -
ECL2 211 - - - -
TM5 212 5.32x33 CXCR4 3ODU NTS1 receptor 4BUO
TM5 213 5.33x34 CXCR4 3ODU - -
TM5 214 5.34x35 CXCR4 3ODU - -
TM5 215 5.35x36 CXCR4 3ODU - -
TM5 216 5.36x37 CXCR4 3ODU P2Y1 receptor 4XNW
TM5 217 5.37x38 CXCR4 3ODU M3 receptor 4U15
TM5 218 5.38x39 CXCR4 3ODU - -
TM5 219 5.39x40 CXCR4 3ODU FFA1 receptor 5TZY
TM5 220 5.40x41 CXCR4 3ODU CXCR4 3ODU
TM5 221 5.41x42 CXCR4 3ODU Y1 receptor 5ZBH
TM5 222 5.42x43 CXCR4 3ODU - -
TM5 223 5.43x44 CXCR4 3ODU - -
TM5 224 5.44x45 CXCR4 3ODU C5a1 receptor 5O9H
TM5 225 5.45x46 CXCR4 3ODU M3 receptor 4U15
TM5 226 5.46x461 CXCR4 3ODU CXCR4 3ODU
TM5 227 5.47x47 CXCR4 3ODU AT1 receptor 4YAY
TM5 228 5.48x48 CXCR4 3ODU AT1 receptor 4ZUD
TM5 229 5.49x49 CXCR4 3ODU CXCR4 3ODU
TM5 230 5.50x50 CXCR4 3ODU CXCR4 3ODU
TM5 231 5.51x51 CXCR4 3ODU NTS1 receptor 4BUO
TM5 232 5.52x52 CXCR4 3ODU CCR5 5UIW
TM5 233 5.53x53 CXCR4 3ODU CXCR4 3ODU
TM5 234 5.54x54 CXCR4 3ODU CCR5 5UIW
TM5 235 5.55x55 CXCR4 3ODU - -
TM5 236 5.56x56 CXCR4 3ODU H1 receptor 3RZE
TM5 237 5.57x57 CXCR4 3ODU CXCR4 3ODU
TM5 238 5.58x58 CXCR4 3ODU CXCR4 3ODU
TM5 239 5.59x59 CXCR4 3ODU PAR1 3VW7
TM5 240 5.60x60 CXCR4 3ODU CCR5 5UIW
TM5 241 5.61x61 CXCR4 3ODU β2-adrenoceptor 5JQH
TM5 242 5.62x62 CXCR4 3ODU Rhodopsin 1GZM
TM5 243 5.63x63 CXCR4 3ODU 5-HT2B receptor 4IB4
TM5 244 5.64x64 CXCR4 3ODU δ receptor 4N6H
TM5 245 5.65x65 δ receptor 4N6H δ receptor 4N6H
TM5 246 5.66x66 δ receptor 4N6H δ receptor 4N6H
TM5 247 5.67x67 δ receptor 4N6H - -
TM5 248 5.68x68 δ receptor 4N6H C5a1 receptor 5O9H
ICL3 249 - - - -
ICL3 250 - - - -
ICL3 251 - - - -
TM6 252 6.28x28 CCR5 5UIW - -
TM6 253 6.29x29 CCR5 5UIW CXCR4 3ODU
TM6 254 6.30x30 CXCR4 3ODU CCR5 5UIW
TM6 255 6.31x31 CXCR4 3ODU 5-HT2B receptor 4IB4
TM6 256 6.32x32 CXCR4 3ODU CXCR4 3ODU
TM6 257 6.33x33 CXCR4 3ODU CXCR4 3ODU
TM6 258 6.34x34 CXCR4 3ODU CCR5 5UIW
TM6 259 6.35x35 CXCR4 3ODU CCR5 5UIW
TM6 260 6.36x36 CXCR4 3ODU CCR2 5T1A
TM6 261 6.37x37 CXCR4 3ODU D2 receptor 6CM4
TM6 262 6.38x38 CXCR4 3ODU CCR9 5LWE
TM6 263 6.39x39 CXCR4 3ODU CB1 receptor 5TGZ
TM6 264 6.40x40 CXCR4 3ODU CCR9 5LWE
TM6 265 6.41x41 CXCR4 3ODU - -
TM6 266 6.42x42 CXCR4 3ODU S1P1 receptor 3V2Y
TM6 267 6.43x43 CXCR4 3ODU LPA6 receptor 5XSZ
TM6 268 6.44x44 CXCR4 3ODU CXCR4 3ODU
TM6 269 6.45x45 CXCR4 3ODU CXCR4 3ODU
TM6 270 6.46x46 CXCR4 3ODU CCR9 5LWE
TM6 271 6.47x47 CXCR4 3ODU CXCR4 3ODU
TM6 272 6.48x48 CXCR4 3ODU CXCR4 3ODU
TM6 273 6.49x49 CXCR4 3ODU - -
TM6 274 6.50x50 CXCR4 3ODU CXCR4 3ODU
TM6 275 6.51x51 CXCR4 3ODU CXCR4 3ODU
TM6 276 6.52x52 CXCR4 3ODU δ receptor 4N6H
TM6 277 6.53x53 CXCR4 3ODU CXCR4 3ODU
TM6 278 6.54x54 CXCR4 3ODU CCR5 5UIW
TM6 279 6.55x55 CXCR4 3ODU CXCR4 3ODU
TM6 280 6.56x56 CXCR4 3ODU AT1 receptor 4ZUD
TM6 281 6.57x57 CXCR4 3ODU CCR5 5UIW
TM6 282 6.58x58 CXCR4 3ODU CXCR4 3ODU
TM6 283 6.59x59 CXCR4 3ODU CCR9 5LWE
TM6 284 6.60x60 CXCR4 3ODU AT1 receptor 4ZUD
TM6 285 6.61x61 CXCR4 3ODU AT2 receptor 5UNG
TM6 286 6.62x62 CXCR4 3ODU P2Y1 receptor 4XNW
TM6 287 6.63x63 CXCR4 3ODU CXCR4 3ODU
TM6 288 6.64x64 CXCR4 3ODU US28 4XT1
ECL3 289 CXCR4 3ODU - -
ECL3 290 CXCR4 3ODU - -
ECL3 291 CXCR4 3ODU - -
ECL3 292 CXCR4 3ODU - -
TM7 293 7.24x23 CXCR4 3ODU NTS1 receptor 4BUO
TM7 294 7.25x24 CXCR4 3ODU CXCR4 3ODU
TM7 295 7.26x25 CXCR4 3ODU - -
TM7 296 7.27x26 CXCR4 3ODU ETB receptor 5X93
TM7 297 7.28x27 CXCR4 3ODU P2Y1 receptor 4XNW
TM7 298 7.29x28 CXCR4 3ODU - -
TM7 299 7.30x29 CXCR4 3ODU US28 4XT1
TM7 300 7.31x30 CXCR4 3ODU CCR5 5UIW
TM7 301 7.32x31 CXCR4 3ODU D4 receptor 5WIV
TM7 302 7.33x32 CXCR4 3ODU μ receptor 4DKL
TM7 303 7.34x33 CXCR4 3ODU CCR5 5UIW
TM7 304 7.35x34 CXCR4 3ODU CXCR4 3ODU
TM7 305 7.36x35 CXCR4 3ODU OX2 receptor 5WS3
TM7 306 7.37x36 CXCR4 3ODU - -
TM7 307 7.38x37 CXCR4 3ODU δ receptor 4N6H
TM7 308 7.39x38 CXCR4 3ODU CXCR4 3ODU
TM7 309 7.40x39 CXCR4 3ODU Rhodopsin 1GZM
TM7 310 7.41x40 CXCR4 3ODU CXCR4 3ODU
TM7 311 7.42x41 CXCR4 3ODU CCR5 5UIW
TM7 312 7.43x42 CXCR4 3ODU CB1 receptor 5TGZ
TM7 313 7.44x43 CXCR4 3ODU δ receptor 4N6H
TM7 314 7.45x45 CXCR4 3ODU CXCR4 3ODU
TM7 315 7.46x46 CXCR4 3ODU CXCR4 3ODU
TM7 316 7.47x47 CXCR4 3ODU CXCR4 3ODU
TM7 317 7.48x48 CXCR4 3ODU CXCR4 3ODU
TM7 318 7.49x49 CXCR4 3ODU CXCR4 3ODU
TM7 319 7.50x50 CXCR4 3ODU CXCR4 3ODU
TM7 320 7.51x51 CXCR4 3ODU M1 receptor 5CXV
TM7 321 7.52x52 CCR9 5LWE CCR9 5LWE
TM7 322 7.53x53 CCR9 5LWE CCR9 5LWE
TM7 323 7.54x54 CCR9 5LWE D4 receptor 5WIV
TM7 324 7.55x55 CCR9 5LWE CCR9 5LWE
TM7 325 7.56x56 CCR9 5LWE C5a1 receptor 5O9H
H8 326 8.47x47 CCR9 5LWE CCR9 5LWE
H8 327 8.48x48 CCR9 5LWE - -
H8 328 8.49x49 CCR9 5LWE CCR2 5T1A
H8 329 8.50x50 CCR9 5LWE CCR9 5LWE
H8 330 8.51x51 CCR9 5LWE CCR9 5LWE
H8 331 8.52x52 CCR9 5LWE - -
H8 332 8.53x53 CCR9 5LWE CCR9 5LWE
H8 333 8.54x54 CCR9 5LWE CCR9 5LWE
H8 334 8.55x55 CCR9 5LWE CCR2 5T1A
H8 335 8.56x56 CCR9 5LWE 5-HT2B receptor 4IB4
H8 336 8.57x57 CCR9 5LWE δ receptor 4N6H
H8 337 8.58x58 CCR9 5LWE CCR9 5LWE
H8 338 8.59x59 CCR9 5LWE 5-HT2B receptor 5TUD
C-term 339 - - - -
C-term 340 - - - -
C-term 341 - - - -
C-term 342 - - - -
C-term 343 - - - -